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Protein

SPARC-related modular calcium-binding protein 2

Gene

Smoc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Can stimulate endothelial cell proliferation, migration, as well as angiogenesis (By similarity). Promotes matrix assembly and cell adhesiveness.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi360 – 3711PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi397 – 4082PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • glycosaminoglycan binding Source: MGI
  • heparin binding Source: MGI

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
SPARC-related modular calcium-binding protein 2
Alternative name(s):
Secreted modular calcium-binding protein 2
Short name:
SMOC-2
Gene namesi
Name:Smoc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1929881 Smoc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002031922 – 447SPARC-related modular calcium-binding protein 2Add BLAST426

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 71PROSITE-ProRule annotation
Disulfide bondi44 ↔ 64PROSITE-ProRule annotation
Disulfide bondi53 ↔ 84PROSITE-ProRule annotation
Disulfide bondi90 ↔ 113By similarity
Disulfide bondi124 ↔ 131By similarity
Disulfide bondi133 ↔ 153By similarity
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi216 ↔ 240By similarity
Disulfide bondi251 ↔ 258By similarity
Disulfide bondi260 ↔ 281By similarity
Glycosylationi362N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8CD91
PRIDEiQ8CD91

PTM databases

PhosphoSitePlusiQ8CD91

Expressioni

Tissue specificityi

Strongly expressed in ovary, followed by heart, muscle, spleen, brain, thymus, lung, liver, kidney, spleen, testis, ovary and skeletal muscle.1 Publication

Developmental stagei

At E16.5, present in rib cartilage, choroid plexus epithelium and associated blood vessels, and developing oral and tooth germ epithelia (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000023886 Expressed in 261 organ(s), highest expression level in sciatic nerve
CleanExiMM_SMOC2
GenevisibleiQ8CD91 MM

Interactioni

Subunit structurei

Binds various proteins from the extracellular matrix.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024660

Structurei

3D structure databases

ProteinModelPortaliQ8CD91
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 86Kazal-likePROSITE-ProRule annotationAdd BLAST53
Domaini87 – 153Thyroglobulin type-1 1PROSITE-ProRule annotationAdd BLAST67
Domaini213 – 281Thyroglobulin type-1 2PROSITE-ProRule annotationAdd BLAST69
Domaini347 – 382EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini384 – 419EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG4578 Eukaryota
ENOG410YP7C LUCA
GeneTreeiENSGT00390000018436
HOGENOMiHOG000234328
HOVERGENiHBG058558
InParanoidiQ8CD91
OMAiPRCPGSI
OrthoDBiEOG091G083O
PhylomeDBiQ8CD91
TreeFamiTF320666

Family and domain databases

CDDicd16241 EFh_SPARC_SMOC2, 1 hit
cd00191 TY, 2 hits
Gene3Di4.10.800.10, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR002350 Kazal_dom
IPR037640 SMOC2_EC
IPR019577 SPARC/Testican_Ca-bd-dom
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PfamiView protein in Pfam
PF07648 Kazal_2, 1 hit
PF10591 SPARC_Ca_bdg, 1 hit
PF00086 Thyroglobulin_1, 2 hits
SMARTiView protein in SMART
SM00280 KAZAL, 1 hit
SM00211 TY, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
SSF57610 SSF57610, 2 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
PS51465 KAZAL_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 2 hits
PS51162 THYROGLOBULIN_1_2, 2 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8CD91-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLPPQLCWLP LLAALLPPVP AQKFSALTFL RVDQDKDRDC SLDCPSSPQK
60 70 80 90 100
PLCASDGRTF LSRCEFQRAK CKDPQLEIAH RGNCKDVSRC VAERKYTQEQ
110 120 130 140 150
ARKEFQQVFI PECNDDGTYS QVQCHSYTGY CWCVTPNGRP ISGTAVAHKT
160 170 180 190 200
PRCPGSINEK VPQREGAGKA DDAAAPALET QPQGDEEDIA SRYPTLWTEQ
210 220 230 240 250
VKSRQNKTNK NSASSCDQEH QSALEEAKQP KNDNVVIPEC AHGGLYKPVQ
260 270 280 290 300
CHPSTGYCWC VLVDTGRPIP GTSTRYEQPK CDNTARAHPA KARDLYKNRP
310 320 330 340 350
LQGCPGAKKH EFLTSVLDAL STDMVHAVSD PSSSSGRLSE PDPSHTLEER
360 370 380 390 400
VVHWYFKLLD KNSSGDIGKK EIKPFKRFLR KKSKPKKCVK KFVEYCDMNN
410 420 430 440
DKSITVQELM GCLGVTREEG KANTRKRHTP RGNAESSSSN RQPRKQG
Length:447
Mass (Da):49,891
Last modified:March 1, 2003 - v1
Checksum:i26AB802F9D13A00C
GO
Isoform 2 (identifier: Q8CD91-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-336: MLPPQLCWLP...AVSDPSSSSG → MLLFLDLSPGL

Note: No experimental confirmation available.
Show »
Length:122
Mass (Da):14,077
Checksum:iCBD913F9F984CF06
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti351V → D in BAB24753 (PubMed:16141072).Curated1
Sequence conflicti437 – 438SS → T (PubMed:12741954).Curated2
Sequence conflicti439S → F in BAB24753 (PubMed:16141072).Curated1
Sequence conflicti440N → Y in AAH19527 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0087231 – 336MLPPQ…SSSSG → MLLFLDLSPGL in isoform 2. 1 PublicationAdd BLAST336

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030958 mRNA Translation: BAC27193.1
AK006809 mRNA Translation: BAB24753.1
AJ249901 mRNA Translation: CAC10355.1
BC019527 mRNA Translation: AAH19527.1
CCDSiCCDS37442.1 [Q8CD91-1]
RefSeqiNP_071710.2, NM_022315.2 [Q8CD91-1]
UniGeneiMm.30162

Genome annotation databases

EnsembliENSMUST00000024660; ENSMUSP00000024660; ENSMUSG00000023886 [Q8CD91-1]
GeneIDi64074
KEGGimmu:64074
UCSCiuc008amy.2 mouse [Q8CD91-1]
uc008ana.2 mouse [Q8CD91-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSMOC2_MOUSE
AccessioniPrimary (citable) accession number: Q8CD91
Secondary accession number(s): Q8VCM1, Q9D9K2, Q9ER95
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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