UniProtKB - Q8CD15 (RIOX2_MOUSE)

BLAST

>sp|Q8CD15|RIOX2_MOUSE Ribosomal oxygenase 2 OS=Mus musculus OX=10090 GN=Riox2 PE=1 SV=2
MPKKVQPTGDENEEASVPCKRVKEELPETLSVLNFDSPSSFFESLISPIKVETFFKEFWE
QKPLLIQRDDPVLAKYYQSLFSLSDLKRLCKKGVYYGRDVNVCRSISGKKKVLNKDGRAH
FLQLRKDFDQKRATIQFHQPQRYKDELWRIQEKLECYFGSLVGSNVYMTPAGSQGLPPHY
DDVEVFILQLEGTKHWRLYSPTVPLAHEYSVESEDRIGTPTHDFLLKPGDLLYFPRGTIH
QAETPSGLAYSIHLTISTYQNNSWGDCLLDSISGFVFDIAKEDVALRSGMPRRMLLNVET
PADVTRKLSGFLRTLADQLEGREELLSSDMKKDFVKHRLPPFFEGNGTETMDPGKQLPRL
DNIIRLQFKDHIVLTVGPDKNPFDEAQQKVVYIYHSLKNVRQMHMIGEEEESEIFGLRFP
LSHVDALKQIWCGSPIRVKDLKLDTDEEKENLALSLWSESLIQVL

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History
Entry version 114 (07 Nov 2018)
Sequence version 2 (23 Oct 2007)
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Protein

Ribosomal oxygenase 2

Gene

Riox2

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39' (By similarity). May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.By similarity1 Publication

Catalytic activityⁱ

L-histidine-[60S ribosomal protein L27a] + 2-oxoglutarate + O₂ = (3S)-3-hydroxy-L-histidine-[60S ribosomal protein L27a] + succinate + CO₂.

Cofactorⁱ

Fe²⁺By similarityNote: Binds 1 Fe²⁺ ion per subunit.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	179	Iron; catalyticPROSITE-ProRule annotation	1
Metal bindingⁱ	181	Iron; catalyticPROSITE-ProRule annotation	1
Metal bindingⁱ	240	Iron; catalyticPROSITE-ProRule annotation	1

GO - Molecular functionⁱ

dioxygenase activity Source: UniProtKB-KW
identical protein binding Source: MGI
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell proliferation Source: MGI
regulation of cell proliferation
Source: MGI
Inferred from sequence orthologyⁱ
- 12091391
ribosome biogenesis Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Dioxygenase, Oxidoreductase
Biological process	Ribosome biogenesis, Transcription, Transcription regulation
Ligand	Iron, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-3214842 HDMs demethylate histones

Reactomeⁱ

R-MMU-3214842 HDMs demethylate histones

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ribosomal oxygenase 2Imported Alternative name(s): Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA (EC:1.14.11.-) Histone lysine demethylase MINA MYC-induced nuclear antigen
Gene namesⁱ	Name:Riox2Imported Synonyms:Mina, Mina531 Publication
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 16

Organism-specific databases

MGIⁱ	MGI:1914264 Riox2

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000308378	1 – 465	Ribosomal oxygenase 2Add BLAST		465

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	309	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q8CD15
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8CD15
PaxDbⁱ	Q8CD15
PeptideAtlas More...PeptideAtlasⁱ	Q8CD15
PRIDEⁱ	Q8CD15

PTM databases

iPTMnetⁱ	Q8CD15
PhosphoSitePlusⁱ	Q8CD15

Expressionⁱ

Tissue specificityⁱ

Predominantly expressed in testis. Expressed at high levels in spleen, thymus, and colon, but barely detectable in brain, skeletal muscle, and seminal vesicle (at protein level).1 Publication

Developmental stageⁱ

In testis, expressed in the nuclei of spermatogonia at all stages of the seminiferous epithelial cycle, and in meiotic prophase cells such as preleptotene, leptotene and zygotene, and weakly in early pachytene spermatocytes, but is absent in late pachytene spermatocytes, spermatids and mature sperm (at protein level).1 Publication

Inductionⁱ

Up-regulated in experimentally-induced cryptorchid testis.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000022724 Expressed in 288 organ(s), highest expression level in ear
CleanExⁱ	MM_MINA
ExpressionAtlasⁱ	Q8CD15 baseline and differential
Genevisibleⁱ	Q8CD15 MM

Interactionⁱ

GO - Molecular functionⁱ

identical protein binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	Q8CD15, 1 interactor
Molecular INTeraction database More...MINTⁱ	Q8CD15
STRINGⁱ	10090.ENSMUSP00000023407

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8CD15
SMRⁱ	Q8CD15
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	139 – 271	JmjCPROSITE-ProRule annotationAdd BLAST		133

Sequence similaritiesⁱ

Belongs to the ROX family. MINA53 subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG3706 Eukaryota ENOG410YNEJ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000083
HOGENOMⁱ	HOG000007965
HOVERGENⁱ	HBG055265
InParanoidⁱ	Q8CD15
KEGG Orthology (KO) More...KOⁱ	K21760
OMAⁱ	FDTAKED
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04K2
PhylomeDBⁱ	Q8CD15
TreeFamⁱ	TF318659

Family and domain databases

InterProⁱ	View protein in InterPro IPR003347 JmjC_dom IPR039994 JmjC_protein
PANTHERⁱ	PTHR13096 PTHR13096, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08007 Cupin_4, 1 hit
PROSITEⁱ	View protein in PROSITE PS51184 JMJC, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q8CD15-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPKKVQPTGD ENEEASVPCK RVKEELPETL SVLNFDSPSS FFESLISPIK 
        60         70         80         90        100
VETFFKEFWE QKPLLIQRDD PVLAKYYQSL FSLSDLKRLC KKGVYYGRDV 
       110        120        130        140        150
NVCRSISGKK KVLNKDGRAH FLQLRKDFDQ KRATIQFHQP QRYKDELWRI 
       160        170        180        190        200
QEKLECYFGS LVGSNVYMTP AGSQGLPPHY DDVEVFILQL EGTKHWRLYS 
       210        220        230        240        250
PTVPLAHEYS VESEDRIGTP THDFLLKPGD LLYFPRGTIH QAETPSGLAY 
       260        270        280        290        300
SIHLTISTYQ NNSWGDCLLD SISGFVFDIA KEDVALRSGM PRRMLLNVET 
       310        320        330        340        350
PADVTRKLSG FLRTLADQLE GREELLSSDM KKDFVKHRLP PFFEGNGTET 
       360        370        380        390        400
MDPGKQLPRL DNIIRLQFKD HIVLTVGPDK NPFDEAQQKV VYIYHSLKNV 
       410        420        430        440        450
RQMHMIGEEE ESEIFGLRFP LSHVDALKQI WCGSPIRVKD LKLDTDEEKE 
       460 
NLALSLWSES LIQVL

Length:465

Mass (Da):53,517

Last modified:October 23, 2007 - v2

Checksum:ⁱE0504FE459FFC47A

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D3YTU3	D3YTU3_MOUSE	Ribosomal oxygenase 2 Ribosomal oxygenase 2	Riox2 Mina	373	Annotation score:
Q8CCK9	Q8CCK9_MOUSE	Ribosomal oxygenase 2 Ribosomal oxygenase 2	Riox2 Mina	156	Annotation score:
D3Z287	D3Z287_MOUSE	Ribosomal oxygenase 2 Ribosomal oxygenase 2	Riox2 Mina	73	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	15	A → E in AAH25109 (PubMed:15489334).Curated	1
Sequence conflictⁱ	15	A → E in AAH23462 (PubMed:15489334).Curated	1
Sequence conflictⁱ	107	S → N in BAC27503 (PubMed:16141072).Curated	1
Sequence conflictⁱ	440	D → E in AAH25109 (PubMed:15489334).Curated	1
Sequence conflictⁱ	440	D → E in AAH23462 (PubMed:15489334).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB177385 mRNA Translation: BAD60965.1 AK007810 mRNA Translation: BAB25275.1 AK013451 mRNA Translation: BAB28860.1 AK031671 mRNA Translation: BAC27503.1 BC023462 mRNA Translation: AAH23462.1 BC025109 mRNA Translation: AAH25109.1 BC058242 mRNA Translation: AAH58242.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS28257.1
NCBI Reference Sequences More...RefSeqⁱ	NP_080186.3, NM_025910.3 XP_006522542.1, XM_006522479.3
UniGeneⁱ	Mm.289150

Genome annotation databases

Ensemblⁱ	ENSMUST00000023407; ENSMUSP00000023407; ENSMUSG00000022724 ENSMUST00000160571; ENSMUSP00000125297; ENSMUSG00000022724
GeneIDⁱ	67014
KEGGⁱ	mmu:67014
UCSC genome browser More...UCSCⁱ	uc007zph.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8CD15	Ribosomal oxygenase 2 (Fragment)		MOUSE		73	UniRef100_Q8CD15
UPI0003D771A4		MOUSE		354

Protein	Similar proteins		Species	Score	Length	Source
Q8CD15	Ribosomal oxygenase 2 (Fragment)		MOUSE		73	UniRef90_Q8CD15
UPI000A30C619		MUSPA		466
UPI000A31A555		MUSCR		465
Ribosomal oxygenase 2		MOUSE		373
UPI0003D771A4		MOUSE		354

Protein	Similar proteins		Species	Score	Length	Source
Q8CD15	Ribosomal oxygenase 2	)	HUMAN		465	UniRef50_Q8IUF8
Ribosomal oxygenase 2		PONAB		465
Ribosomal oxygenase 2		BOVIN		462
Ribosomal oxygenase 2		RAT		465
Uncharacterized protein		RHIBE		518
+486

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB177385 mRNA Translation: BAD60965.1 AK007810 mRNA Translation: BAB25275.1 AK013451 mRNA Translation: BAB28860.1 AK031671 mRNA Translation: BAC27503.1 BC023462 mRNA Translation: AAH23462.1 BC025109 mRNA Translation: AAH25109.1 BC058242 mRNA Translation: AAH58242.1
CCDSⁱ	CCDS28257.1
RefSeqⁱ	NP_080186.3, NM_025910.3 XP_006522542.1, XM_006522479.3
UniGeneⁱ	Mm.289150

3D structure databases

ProteinModelPortalⁱ	Q8CD15
SMRⁱ	Q8CD15
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q8CD15, 1 interactor
MINTⁱ	Q8CD15
STRINGⁱ	10090.ENSMUSP00000023407

PTM databases

iPTMnetⁱ	Q8CD15
PhosphoSitePlusⁱ	Q8CD15

Proteomic databases

EPDⁱ	Q8CD15
MaxQBⁱ	Q8CD15
PaxDbⁱ	Q8CD15
PeptideAtlasⁱ	Q8CD15
PRIDEⁱ	Q8CD15

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	67014
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000023407; ENSMUSP00000023407; ENSMUSG00000022724 ENSMUST00000160571; ENSMUSP00000125297; ENSMUSG00000022724
GeneIDⁱ	67014
KEGGⁱ	mmu:67014
UCSCⁱ	uc007zph.2 mouse

Organism-specific databases

CTDⁱ	84864
MGIⁱ	MGI:1914264 Riox2

Phylogenomic databases

eggNOGⁱ	KOG3706 Eukaryota ENOG410YNEJ LUCA
GeneTreeⁱ	ENSGT00390000000083
HOGENOMⁱ	HOG000007965
HOVERGENⁱ	HBG055265
InParanoidⁱ	Q8CD15
KOⁱ	K21760
OMAⁱ	FDTAKED
OrthoDBⁱ	EOG091G04K2
PhylomeDBⁱ	Q8CD15
TreeFamⁱ	TF318659

Enzyme and pathway databases

Reactomeⁱ	R-MMU-3214842 HDMs demethylate histones

Reactomeⁱ

R-MMU-3214842 HDMs demethylate histones

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q8CD15
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000022724 Expressed in 288 organ(s), highest expression level in ear
CleanExⁱ	MM_MINA
ExpressionAtlasⁱ	Q8CD15 baseline and differential
Genevisibleⁱ	Q8CD15 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR003347 JmjC_dom IPR039994 JmjC_protein
PANTHERⁱ	PTHR13096 PTHR13096, 1 hit
Pfamⁱ	View protein in Pfam PF08007 Cupin_4, 1 hit
PROSITEⁱ	View protein in PROSITE PS51184 JMJC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RIOX2_MOUSE
Accessionⁱ	Q8CD15Primary (citable) accession number: Q8CD15 Secondary accession number(s): Q8QZX1, Q9CQ03
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
	Last sequence update:	October 23, 2007
	Last modified:	November 7, 2018
	This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8CD15 (RIOX2_MOUSE)

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Ribosomal oxygenase 2

Riox2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ