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Protein

Ribosomal oxygenase 2

Gene

Riox2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39' (By similarity). May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.By similarity1 Publication

Catalytic activityi

L-histidine-[60S ribosomal protein L27a] + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-histidine-[60S ribosomal protein L27a] + succinate + CO2.

Cofactori

Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi179Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi181Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi240Iron; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processRibosome biogenesis, Transcription, Transcription regulation
LigandIron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-3214842 HDMs demethylate histones

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal oxygenase 2Imported
Alternative name(s):
Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA (EC:1.14.11.-)
Histone lysine demethylase MINA
MYC-induced nuclear antigen
Gene namesi
Name:Riox2Imported
Synonyms:Mina, Mina531 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1914264 Riox2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003083781 – 465Ribosomal oxygenase 2Add BLAST465

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei309PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8CD15
MaxQBiQ8CD15
PaxDbiQ8CD15
PeptideAtlasiQ8CD15
PRIDEiQ8CD15

PTM databases

iPTMnetiQ8CD15
PhosphoSitePlusiQ8CD15

Expressioni

Tissue specificityi

Predominantly expressed in testis. Expressed at high levels in spleen, thymus, and colon, but barely detectable in brain, skeletal muscle, and seminal vesicle (at protein level).1 Publication

Developmental stagei

In testis, expressed in the nuclei of spermatogonia at all stages of the seminiferous epithelial cycle, and in meiotic prophase cells such as preleptotene, leptotene and zygotene, and weakly in early pachytene spermatocytes, but is absent in late pachytene spermatocytes, spermatids and mature sperm (at protein level).1 Publication

Inductioni

Up-regulated in experimentally-induced cryptorchid testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000022724 Expressed in 288 organ(s), highest expression level in ear
CleanExiMM_MINA
ExpressionAtlasiQ8CD15 baseline and differential
GenevisibleiQ8CD15 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8CD15, 1 interactor
MINTiQ8CD15
STRINGi10090.ENSMUSP00000023407

Structurei

3D structure databases

ProteinModelPortaliQ8CD15
SMRiQ8CD15
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini139 – 271JmjCPROSITE-ProRule annotationAdd BLAST133

Sequence similaritiesi

Belongs to the ROX family. MINA53 subfamily.Curated

Phylogenomic databases

eggNOGiKOG3706 Eukaryota
ENOG410YNEJ LUCA
GeneTreeiENSGT00390000000083
HOGENOMiHOG000007965
HOVERGENiHBG055265
InParanoidiQ8CD15
KOiK21760
OMAiFDTAKED
OrthoDBiEOG091G04K2
PhylomeDBiQ8CD15
TreeFamiTF318659

Family and domain databases

InterProiView protein in InterPro
IPR003347 JmjC_dom
IPR039994 JmjC_protein
PANTHERiPTHR13096 PTHR13096, 1 hit
PfamiView protein in Pfam
PF08007 Cupin_4, 1 hit
PROSITEiView protein in PROSITE
PS51184 JMJC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8CD15-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKKVQPTGD ENEEASVPCK RVKEELPETL SVLNFDSPSS FFESLISPIK
60 70 80 90 100
VETFFKEFWE QKPLLIQRDD PVLAKYYQSL FSLSDLKRLC KKGVYYGRDV
110 120 130 140 150
NVCRSISGKK KVLNKDGRAH FLQLRKDFDQ KRATIQFHQP QRYKDELWRI
160 170 180 190 200
QEKLECYFGS LVGSNVYMTP AGSQGLPPHY DDVEVFILQL EGTKHWRLYS
210 220 230 240 250
PTVPLAHEYS VESEDRIGTP THDFLLKPGD LLYFPRGTIH QAETPSGLAY
260 270 280 290 300
SIHLTISTYQ NNSWGDCLLD SISGFVFDIA KEDVALRSGM PRRMLLNVET
310 320 330 340 350
PADVTRKLSG FLRTLADQLE GREELLSSDM KKDFVKHRLP PFFEGNGTET
360 370 380 390 400
MDPGKQLPRL DNIIRLQFKD HIVLTVGPDK NPFDEAQQKV VYIYHSLKNV
410 420 430 440 450
RQMHMIGEEE ESEIFGLRFP LSHVDALKQI WCGSPIRVKD LKLDTDEEKE
460
NLALSLWSES LIQVL
Length:465
Mass (Da):53,517
Last modified:October 23, 2007 - v2
Checksum:iE0504FE459FFC47A
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YTU3D3YTU3_MOUSE
Ribosomal oxygenase 2
Riox2 Mina
373Annotation score:
Q8CCK9Q8CCK9_MOUSE
Ribosomal oxygenase 2
Riox2 Mina
156Annotation score:
D3Z287D3Z287_MOUSE
Ribosomal oxygenase 2
Riox2 Mina
73Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15A → E in AAH25109 (PubMed:15489334).Curated1
Sequence conflicti15A → E in AAH23462 (PubMed:15489334).Curated1
Sequence conflicti107S → N in BAC27503 (PubMed:16141072).Curated1
Sequence conflicti440D → E in AAH25109 (PubMed:15489334).Curated1
Sequence conflicti440D → E in AAH23462 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB177385 mRNA Translation: BAD60965.1
AK007810 mRNA Translation: BAB25275.1
AK013451 mRNA Translation: BAB28860.1
AK031671 mRNA Translation: BAC27503.1
BC023462 mRNA Translation: AAH23462.1
BC025109 mRNA Translation: AAH25109.1
BC058242 mRNA Translation: AAH58242.1
CCDSiCCDS28257.1
RefSeqiNP_080186.3, NM_025910.3
XP_006522542.1, XM_006522479.3
UniGeneiMm.289150

Genome annotation databases

EnsembliENSMUST00000023407; ENSMUSP00000023407; ENSMUSG00000022724
ENSMUST00000160571; ENSMUSP00000125297; ENSMUSG00000022724
GeneIDi67014
KEGGimmu:67014
UCSCiuc007zph.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB177385 mRNA Translation: BAD60965.1
AK007810 mRNA Translation: BAB25275.1
AK013451 mRNA Translation: BAB28860.1
AK031671 mRNA Translation: BAC27503.1
BC023462 mRNA Translation: AAH23462.1
BC025109 mRNA Translation: AAH25109.1
BC058242 mRNA Translation: AAH58242.1
CCDSiCCDS28257.1
RefSeqiNP_080186.3, NM_025910.3
XP_006522542.1, XM_006522479.3
UniGeneiMm.289150

3D structure databases

ProteinModelPortaliQ8CD15
SMRiQ8CD15
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8CD15, 1 interactor
MINTiQ8CD15
STRINGi10090.ENSMUSP00000023407

PTM databases

iPTMnetiQ8CD15
PhosphoSitePlusiQ8CD15

Proteomic databases

EPDiQ8CD15
MaxQBiQ8CD15
PaxDbiQ8CD15
PeptideAtlasiQ8CD15
PRIDEiQ8CD15

Protocols and materials databases

DNASUi67014
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023407; ENSMUSP00000023407; ENSMUSG00000022724
ENSMUST00000160571; ENSMUSP00000125297; ENSMUSG00000022724
GeneIDi67014
KEGGimmu:67014
UCSCiuc007zph.2 mouse

Organism-specific databases

CTDi84864
MGIiMGI:1914264 Riox2

Phylogenomic databases

eggNOGiKOG3706 Eukaryota
ENOG410YNEJ LUCA
GeneTreeiENSGT00390000000083
HOGENOMiHOG000007965
HOVERGENiHBG055265
InParanoidiQ8CD15
KOiK21760
OMAiFDTAKED
OrthoDBiEOG091G04K2
PhylomeDBiQ8CD15
TreeFamiTF318659

Enzyme and pathway databases

ReactomeiR-MMU-3214842 HDMs demethylate histones

Miscellaneous databases

PROiPR:Q8CD15
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022724 Expressed in 288 organ(s), highest expression level in ear
CleanExiMM_MINA
ExpressionAtlasiQ8CD15 baseline and differential
GenevisibleiQ8CD15 MM

Family and domain databases

InterProiView protein in InterPro
IPR003347 JmjC_dom
IPR039994 JmjC_protein
PANTHERiPTHR13096 PTHR13096, 1 hit
PfamiView protein in Pfam
PF08007 Cupin_4, 1 hit
PROSITEiView protein in PROSITE
PS51184 JMJC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRIOX2_MOUSE
AccessioniPrimary (citable) accession number: Q8CD15
Secondary accession number(s): Q8QZX1, Q9CQ03
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: November 7, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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