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Protein

Core histone macro-H2A.2

Gene

H2afy2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Core histone macro-H2A.2
Short name:
Histone macroH2A2
Short name:
mH2A2
Gene namesi
Name:H2afy2
Synonyms:H2afy3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:3037658 H2afy2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002279061 – 372Core histone macro-H2A.2Add BLAST372

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki239Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ8CCK0
PaxDbiQ8CCK0
PeptideAtlasiQ8CCK0
PRIDEiQ8CCK0

PTM databases

iPTMnetiQ8CCK0
PhosphoSitePlusiQ8CCK0

Expressioni

Tissue specificityi

Present in liver, kidney and adrenal gland (at protein level). In the liver, present in cells of the bile ducts and parenchymal cells, but not in hepatocytes. In the kidney, present in proximal and distal convoluted tubules and in glomeruli. Present at highest levels in the parietal layer of Bowman capsule. In the adrenal gland, present in the outer cells of the capsule.1 Publication

Gene expression databases

BgeeiENSMUSG00000020086 Expressed in 236 organ(s), highest expression level in embryo
CleanExiMM_H2AFY2
GenevisibleiQ8CCK0 MM

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8CCK0, 2 interactors
STRINGi10090.ENSMUSP00000020283

Structurei

3D structure databases

ProteinModelPortaliQ8CCK0
SMRiQ8CCK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 117Histone H2AAdd BLAST116
Domaini184 – 370MacroPROSITE-ProRule annotationAdd BLAST187

Phylogenomic databases

eggNOGiENOG410IV3A Eukaryota
KOG1756 Eukaryota
KOG2633 Eukaryota
COG2110 LUCA
COG5262 LUCA
GeneTreeiENSGT00910000143981
HOGENOMiHOG000234653
HOVERGENiHBG009342
InParanoidiQ8CCK0
KOiK11251
OMAiMKVEGIV
OrthoDBiEOG091G0XGD
PhylomeDBiQ8CCK0
TreeFamiTF332276

Family and domain databases

CDDicd00074 H2A, 1 hit
cd02904 Macro_H2A_like, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR021171 Core_histone_macro-H2A
IPR009072 Histone-fold
IPR002119 Histone_H2A
IPR007125 Histone_H2A/H2B/H3
IPR032454 Histone_H2A_C
IPR002589 Macro_dom
IPR035796 Macro_H2A
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PF16211 Histone_H2A_C, 1 hit
PF01661 Macro, 1 hit
PIRSFiPIRSF037942 Core_histone_macro-H2A, 1 hit
PRINTSiPR00620 HISTONEH2A
SMARTiView protein in SMART
SM00506 A1pp, 1 hit
SM00414 H2A, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS51154 MACRO, 1 hit

Sequencei

Sequence statusi: Complete.

Q8CCK0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGRSGKKKM SKLSRSARAG VIFPVGRLMR YLKKGTFKYR ISVGAPVYMA
60 70 80 90 100
AVIEYLAAEI LELAGNAARD NKKARIAPRH ILLAVANDEE LNQLLKGVTI
110 120 130 140 150
ASGGVLPRIH PELLAKKRGT KGKSETILSP PPEKRGRKAA SGKKGGKKSK
160 170 180 190 200
ATKPRTSKKS KAKDSDKEGT SNSTSEDGPG DGFTILSSKS LVLGQKLSLT
210 220 230 240 250
QSDISHIGSM RVEGIVHPTT AEIDLKEEIG KALEKAGGKE FLETVKELRK
260 270 280 290 300
SQGPLEVAEA AVSQSSGLAA KFVIHCHIPQ WGSDKCEEQL EETIKNCLSA
310 320 330 340 350
AEDKKLKSVA FPPFPSGRNC FPKQTAAQVT LKAISAHFDD SSSSSLKNVY
360 370
FLLFDSESIG IYVQEMAKLD TK
Length:372
Mass (Da):40,092
Last modified:January 23, 2007 - v3
Checksum:i471E3CDCE28F4A1D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti90E → D in BAC27963 (PubMed:16141072).Curated1
Sequence conflicti239K → E in BAE38003 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF336305 mRNA Translation: AAK52472.1
AK032636 mRNA Translation: BAC27963.1
AK165020 mRNA Translation: BAE38003.1
BC045140 mRNA Translation: AAH45140.1
BC046794 mRNA Translation: AAH46794.1
BC107279 mRNA Translation: AAI07280.1
BC107280 mRNA Translation: AAI07281.1
BC127144 mRNA Translation: AAI27145.1
CCDSiCCDS23885.1
RefSeqiNP_996883.1, NM_207000.2
UniGeneiMm.272870

Genome annotation databases

EnsembliENSMUST00000020283; ENSMUSP00000020283; ENSMUSG00000020086
GeneIDi404634
KEGGimmu:404634
UCSCiuc007fgm.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF336305 mRNA Translation: AAK52472.1
AK032636 mRNA Translation: BAC27963.1
AK165020 mRNA Translation: BAE38003.1
BC045140 mRNA Translation: AAH45140.1
BC046794 mRNA Translation: AAH46794.1
BC107279 mRNA Translation: AAI07280.1
BC107280 mRNA Translation: AAI07281.1
BC127144 mRNA Translation: AAI27145.1
CCDSiCCDS23885.1
RefSeqiNP_996883.1, NM_207000.2
UniGeneiMm.272870

3D structure databases

ProteinModelPortaliQ8CCK0
SMRiQ8CCK0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8CCK0, 2 interactors
STRINGi10090.ENSMUSP00000020283

PTM databases

iPTMnetiQ8CCK0
PhosphoSitePlusiQ8CCK0

Proteomic databases

MaxQBiQ8CCK0
PaxDbiQ8CCK0
PeptideAtlasiQ8CCK0
PRIDEiQ8CCK0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020283; ENSMUSP00000020283; ENSMUSG00000020086
GeneIDi404634
KEGGimmu:404634
UCSCiuc007fgm.1 mouse

Organism-specific databases

CTDi55506
MGIiMGI:3037658 H2afy2

Phylogenomic databases

eggNOGiENOG410IV3A Eukaryota
KOG1756 Eukaryota
KOG2633 Eukaryota
COG2110 LUCA
COG5262 LUCA
GeneTreeiENSGT00910000143981
HOGENOMiHOG000234653
HOVERGENiHBG009342
InParanoidiQ8CCK0
KOiK11251
OMAiMKVEGIV
OrthoDBiEOG091G0XGD
PhylomeDBiQ8CCK0
TreeFamiTF332276

Miscellaneous databases

PROiPR:Q8CCK0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020086 Expressed in 236 organ(s), highest expression level in embryo
CleanExiMM_H2AFY2
GenevisibleiQ8CCK0 MM

Family and domain databases

CDDicd00074 H2A, 1 hit
cd02904 Macro_H2A_like, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR021171 Core_histone_macro-H2A
IPR009072 Histone-fold
IPR002119 Histone_H2A
IPR007125 Histone_H2A/H2B/H3
IPR032454 Histone_H2A_C
IPR002589 Macro_dom
IPR035796 Macro_H2A
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PF16211 Histone_H2A_C, 1 hit
PF01661 Macro, 1 hit
PIRSFiPIRSF037942 Core_histone_macro-H2A, 1 hit
PRINTSiPR00620 HISTONEH2A
SMARTiView protein in SMART
SM00506 A1pp, 1 hit
SM00414 H2A, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS51154 MACRO, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH2AW_MOUSE
AccessioniPrimary (citable) accession number: Q8CCK0
Secondary accession number(s): A0JP36, Q3TNT4, Q925I6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 129 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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