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Entry version 133 (07 Apr 2021)
Sequence version 2 (21 Jun 2005)
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Protein

E3 UFM1-protein ligase 1

Gene

Ufl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to lysine residues on target proteins, and which plays a key role in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress (By similarity). In response to endoplasmic reticulum stress, recruited to the endoplasmic reticulum membrane by DDRGK1, and mediates ufmylation of proteins such as RPN1 and RPL26/uL24, thereby promoting reticulophagy of endoplasmic reticulum sheets (By similarity). Ufmylation-dependent reticulophagy inhibits the unfolded protein response (UPR) via ERN1/IRE1-alpha (By similarity). Ufmylation in response to endoplasmic reticulum stress is essential for processes such as hematopoiesis, blood vessel morphogenesis or inflammatory response (PubMed:25952549, PubMed:29461087, PubMed:30701081). Regulates inflammation in response to endoplasmic reticulum stress by promoting reticulophagy, leading to inhibit the activity of the NF-kappa-B transcription factor (By similarity). Mediates ufmylation of DDRGK1 and CDK5RAP3; the role of these modifications is however unclear: as both DDRGK1 and CDK5RAP3 act as substrate adapters for ufmylation, it is uncertain whether ufmylation of these proteins is a collateral effect or is required for ufmylation (By similarity). Catalyzes ufmylation of various subunits of the ribosomal complex or associated components, such as RPS3/uS3, RPS20/uS10, RPL10/uL16, RPL26/uL24 and EIF6 (PubMed:28575669). Anchors CDK5RAP3 in the cytoplasm, preventing its translocation to the nucleus which allows expression of the CCND1 cyclin and progression of cells through the G1/S transition (By similarity). Also involved in the response to DNA damage: recruited to double-strand break sites following DNA damage and mediates monoufmylation of histone H4 (By similarity). Catalyzes ufmylation of TRIP4, thereby playing a role in nuclear receptor-mediated transcription (By similarity). Required for hematopoietic stem cell function and hematopoiesis (PubMed:25952549). Required for cardiac homeostasis (PubMed:30354401).By similarity5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processDNA damage, DNA repair, Ubl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 UFM1-protein ligase 1Curated (EC:2.3.2.-By similarity)
Alternative name(s):
E3 UFM1-protein transferase 1Curated
Multiple alpha-helix protein located at ER1 Publication
Regulator of C53/LZAP and DDRGK11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ufl11 PublicationImported
Synonyms:Kiaa07761 Publication, Maxer1 Publication, Rcad1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1914740, Ufl1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryonic lethality caused by impaired erythroid development (PubMed:25952549). Conditional deletion in adult mice results in severe anemia and cytopenia (PubMed:25952549). Cells show elevated endoplasmic reticulum stress and unfolded protein response in bone marrow cells and impaired autophagic degradation (PubMed:25952549). Conditional knockout in cardiomyocytes causes age-dependent cardiomyopathy and heart failure, characterized by elevated cardiac fetal gene expression, increased fibrosis, and impaired cardiac contractility (PubMed:30354401). When challenged with pressure overload, cardiac-specific knockout mice display greater hypertrophy, exacerbated fibrosis, and worsened cardiac contractility compared to wild-type mice counterparts (PubMed:30354401). Conditional knockout in adults causes a significant loss of both Paneth and goblet cells in intestine, which in turn results in dysbiotic microbiota and increased susceptibility to experimentally induced colitis (PubMed:30701081).3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000507722 – 793E3 UFM1-protein ligase 1Add BLAST792

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei433Omega-N-methylarginineCombined sources1
Modified residuei458PhosphoserineCombined sources1
Modified residuei462PhosphoserineBy similarity1
Modified residuei752PhosphoserineCombined sources1
Modified residuei753PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated, leading to its degradation by the proteasome. Interaction with CDK5RAP3 protects both proteins against ubiquitination and degradation via the proteasome.By similarity
Phosphorylated at Ser-462 by ATM, enhancing protein ligase activity and promoting ATM activation in a positive feedback loop.By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8CCJ3

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8CCJ3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8CCJ3

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8CCJ3

PeptideAtlas

More...
PeptideAtlasi
Q8CCJ3

PRoteomics IDEntifications database

More...
PRIDEi
Q8CCJ3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
297806 [Q8CCJ3-3]
297807 [Q8CCJ3-1]
297808 [Q8CCJ3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8CCJ3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8CCJ3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed with higher expression in pancreatic islets and other secretory tissues (PubMed:20228063, PubMed:21494687). In the embryonic brain at E17, detected in Sox2-positive neural stem cells and in Slc1a3/GLAST-positive radial glia (PubMed:20531390). In perinatal brain, highly expressed in Slc1a3-positive Bergmann glia of the cerebellum (PubMed:20531390). Continues to be expressed in Bergmann glia of adult brain at 16 weeks (PubMed:20531390). Expressed in adult heart (PubMed:30354401). Highly expressed in the intestinal exocrine cells (PubMed:30701081).5 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in hypertrophic hearts (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000040359, Expressed in spermatocyte and 252 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8CCJ3, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DDRGK1 (via PCI domain) (By similarity).

Interacts with UFC1 (By similarity).

Interacts with RELA (By similarity).

Interacts with TRIP4 (By similarity).

Interacts with CDK5RAP3; the interaction is direct (PubMed:21494687, PubMed:30635284).

Interacts with NBN; promoting recruitment to double-strand breaks following DNA damage (By similarity).

By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
212226, 61 interactors

Protein interaction database and analysis system

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IntActi
Q8CCJ3, 60 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000100059

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8CCJ3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8CCJ3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 212Required for E3 UFM1-protein ligase activityBy similarityAdd BLAST211
Regioni2 – 200Mediates interaction with DDRGK1By similarityAdd BLAST199
Regioni121 – 250Involved in CDK5RAP3-bindingBy similarityAdd BLAST130
Regioni200 – 400Mediates interaction with TRIP4By similarityAdd BLAST201
Regioni490 – 683Mediates interaction with CDK5RAP3By similarityAdd BLAST194

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UFL1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2235, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000002112

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012417_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8CCJ3

Identification of Orthologs from Complete Genome Data

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OMAi
RCKAKIR

Database of Orthologous Groups

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OrthoDBi
289380at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8CCJ3

TreeFam database of animal gene trees

More...
TreeFami
TF319116

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018611, Ufl1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09743, E3_UFM1_ligase, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8CCJ3-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADAWEEIRR LAADFQRAQF AESTQRLSER NCIEIVNKLI SQKQLEVVHT
60 70 80 90 100
LDGKEYITPA QISKEMRDEL HVRGGRVNIV DLQQVINVDL THIESRVSDI
110 120 130 140 150
IKSEKHVQMV LGQLIDENYL DQLSEEVNDK LQESGQVTVS ELCKAYDLPG
160 170 180 190 200
DFLTQALTQR LGRIINGHLD LDNRGVIFTE AFVARHKARI RGLFSAITRP
210 220 230 240 250
TPVNSLVSKY GFQEQLLYSV LEDLVSTGRL RGTVVGGRQD KAVFVPDIYS
260 270 280 290 300
RTQSTWVDSF FRQNGYLEFD ALSRLGIPDA VNYIKKRYKN TQLLFLKATC
310 320 330 340 350
VGQGLVDQVE ASVEEAISSG TWVDISPLLP SSLSVEDAAM LLQQVMRPFG
360 370 380 390 400
KLASAIVFSD TVVVSEKFIT DCTGLFSERM HQKAEKEMKN NPVHLITEED
410 420 430 440 450
LKQISILESV NTSKKDKKDE RRKKATEGSG SVRGGGGGNA REYKIKKTKK
460 470 480 490 500
KGRKDEDSDD ESQSSHGGKK KPDITFMFQD EIEDCLRKHI QDAPEEFISE
510 520 530 540 550
LAEYLIKPLN KMYLEVVRSV FMSSTSASGT GRKRTIKDLQ EEVSNLYNNI
560 570 580 590 600
RLFEKGMKYF ADDTQTALTK HLLKTVCTDI TNLMFNFLAS DFLMAVEEPA
610 620 630 640 650
AITSDIRKKI LSKLTEETKV ALTKLHNSLN EKSIEDFLSC LDSATEACDI
660 670 680 690 700
MVKKGDKKRE RQILFQHRQA LCEQLKVTED PALILHLTAV LLFQLSTHSM
710 720 730 740 750
LHAPGRCVPQ IIAFLHSKIP EDQHTLLVKY QGLVVKQLVS QNKKTGQGED
760 770 780 790
PSSDELDKEQ HDVTNATRKE LQELSLSIKD LVLKSRKSSV TEE
Length:793
Mass (Da):89,520
Last modified:June 21, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i182930A83D1F7155
GO
Isoform 2 (identifier: Q8CCJ3-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.
     81-84: DLQQ → MSEV

Show »
Length:713
Mass (Da):80,220
Checksum:i62216D414C1E4227
GO
Isoform 3 (identifier: Q8CCJ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-476: Missing.

Show »
Length:317
Mass (Da):36,084
Checksum:i530E7B2123DE1A2A
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC98021 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti122Q → R in BAC98021 (PubMed:14621295).Curated1
Sequence conflicti122Q → R in AAI38154 (PubMed:15489334).Curated1
Sequence conflicti122Q → R in AAI32196 (PubMed:15489334).Curated1
Sequence conflicti389K → N in BAC27976 (PubMed:16141072).Curated1
Sequence conflicti408E → G in BAB25395 (PubMed:16141072).Curated1
Sequence conflicti409S → C in BAC38618 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0142491 – 476Missing in isoform 3. 1 PublicationAdd BLAST476
Alternative sequenceiVSP_0142501 – 80Missing in isoform 2. 1 PublicationAdd BLAST80
Alternative sequenceiVSP_01425181 – 84DLQQ → MSEV in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK007993 mRNA Translation: BAB25395.1
AK013382 mRNA Translation: BAC25404.1
AK032663 mRNA Translation: BAC27976.1
AK082785 mRNA Translation: BAC38618.1
AK129211 mRNA Translation: BAC98021.1 Different initiation.
AK132697 mRNA Translation: BAE21308.1
AL831754 Genomic DNA No translation available.
AL935267 Genomic DNA No translation available.
CH466538 Genomic DNA Translation: EDL05527.1
BC138153 mRNA Translation: AAI38154.1
BC132195 mRNA Translation: AAI32196.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS18010.1 [Q8CCJ3-3]

NCBI Reference Sequences

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RefSeqi
NP_080470.2, NM_026194.4 [Q8CCJ3-3]
XP_006538266.1, XM_006538203.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000038705; ENSMUSP00000042118; ENSMUSG00000040359 [Q8CCJ3-1]
ENSMUST00000102994; ENSMUSP00000100059; ENSMUSG00000040359 [Q8CCJ3-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
67490

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:67490

UCSC genome browser

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UCSCi
uc008seg.2, mouse [Q8CCJ3-3]
uc012dbb.1, mouse [Q8CCJ3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007993 mRNA Translation: BAB25395.1
AK013382 mRNA Translation: BAC25404.1
AK032663 mRNA Translation: BAC27976.1
AK082785 mRNA Translation: BAC38618.1
AK129211 mRNA Translation: BAC98021.1 Different initiation.
AK132697 mRNA Translation: BAE21308.1
AL831754 Genomic DNA No translation available.
AL935267 Genomic DNA No translation available.
CH466538 Genomic DNA Translation: EDL05527.1
BC138153 mRNA Translation: AAI38154.1
BC132195 mRNA Translation: AAI32196.1
CCDSiCCDS18010.1 [Q8CCJ3-3]
RefSeqiNP_080470.2, NM_026194.4 [Q8CCJ3-3]
XP_006538266.1, XM_006538203.3

3D structure databases

SMRiQ8CCJ3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi212226, 61 interactors
IntActiQ8CCJ3, 60 interactors
STRINGi10090.ENSMUSP00000100059

PTM databases

iPTMnetiQ8CCJ3
PhosphoSitePlusiQ8CCJ3

Proteomic databases

EPDiQ8CCJ3
jPOSTiQ8CCJ3
MaxQBiQ8CCJ3
PaxDbiQ8CCJ3
PeptideAtlasiQ8CCJ3
PRIDEiQ8CCJ3
ProteomicsDBi297806 [Q8CCJ3-3]
297807 [Q8CCJ3-1]
297808 [Q8CCJ3-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
31948, 108 antibodies

Genome annotation databases

EnsembliENSMUST00000038705; ENSMUSP00000042118; ENSMUSG00000040359 [Q8CCJ3-1]
ENSMUST00000102994; ENSMUSP00000100059; ENSMUSG00000040359 [Q8CCJ3-3]
GeneIDi67490
KEGGimmu:67490
UCSCiuc008seg.2, mouse [Q8CCJ3-3]
uc012dbb.1, mouse [Q8CCJ3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23376
MGIiMGI:1914740, Ufl1

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG2235, Eukaryota
GeneTreeiENSGT00390000002112
HOGENOMiCLU_012417_1_0_1
InParanoidiQ8CCJ3
OMAiRCKAKIR
OrthoDBi289380at2759
PhylomeDBiQ8CCJ3
TreeFamiTF319116

Enzyme and pathway databases

ReactomeiR-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
67490, 22 hits in 54 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Cdh4, mouse

Protein Ontology

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PROi
PR:Q8CCJ3
RNActiQ8CCJ3, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000040359, Expressed in spermatocyte and 252 other tissues
GenevisibleiQ8CCJ3, MM

Family and domain databases

InterProiView protein in InterPro
IPR018611, Ufl1
PfamiView protein in Pfam
PF09743, E3_UFM1_ligase, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUFL1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CCJ3
Secondary accession number(s): A2RSP7
, B1AXU5, B1AXU6, Q3V145, Q6ZQ50, Q8BT70, Q8C484, Q9D8I8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: April 7, 2021
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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