UniProtKB - Q8CCI5 (RYBP_MOUSE)
RING1 and YY1-binding protein
Rybp
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 21 – 50 | RanBP2-typePROSITE-ProRule annotationAdd BLAST | 30 |
GO - Molecular functioni
- DNA binding Source: MGI
- metal ion binding Source: UniProtKB-KW
- transcription coregulator activity Source: GO_Central
- transcription corepressor activity Source: MGI
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- histone H2A monoubiquitination Source: MGI
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: MGI
- positive regulation of apoptotic process Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Apoptosis, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-MMU-8953750, Transcriptional Regulation by E2F6 |
Names & Taxonomyi
Protein namesi | Recommended name: RING1 and YY1-binding proteinAlternative name(s): Death effector domain-associated factor Short name: DED-associated factor |
Gene namesi | Name:Rybp Synonyms:Dedaf |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1929059, Rybp |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
- nucleoplasm 1 Publication
Other locations
- Cytoplasm By similarity
Note: Primarily found in the nucleus. Detected in a punctate pattern likely to represent Polycomb group (PcG) bodies.1 Publication
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: MGI
- PcG protein complex Source: Ensembl
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Disruption phenotypei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 31 – 32 | TF → AA: Loss of ubiquitin binding. 1 Publication | 2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000097551 | 1 – 228 | RING1 and YY1-binding proteinAdd BLAST | 228 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 77 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 99 | PhosphoserineBy similarity | 1 | |
Modified residuei | 123 | PhosphoserineCombined sources | 1 | |
Modified residuei | 127 | PhosphoserineCombined sources | 1 | |
Modified residuei | 130 | PhosphoserineCombined sources | 1 | |
Modified residuei | 227 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q8CCI5 |
jPOSTi | Q8CCI5 |
MaxQBi | Q8CCI5 |
PaxDbi | Q8CCI5 |
PeptideAtlasi | Q8CCI5 |
PRIDEi | Q8CCI5 |
PTM databases
iPTMneti | Q8CCI5 |
PhosphoSitePlusi | Q8CCI5 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSMUSG00000072872, Expressed in metanephros and 264 other tissues |
Genevisiblei | Q8CCI5, MM |
Interactioni
Subunit structurei
Monomer.
Component of repressive BCOR complex containing Polycomb group subcomplex at least composed of BCOR, PCGF1, RING1 and RNF2/RING2 (By similarity).
Component of PCR1-like complexes (PubMed:22325148, PubMed:28596365).
Interacts with PCGF1.
Part of a PCR1-like complex that contains AUTS2, PCGF5, RNF2, CSNK2B AND RYBP.
Interacts with RNF2; the interaction is direct (By similarity).
Interacts with CBX2, YAF2, RING1 and RNF2 (PubMed:10369680, PubMed:19170609, PubMed:22226355).
Interacts with ubiquitin and ubiquitinated proteins (PubMed:17070805).
Interacts with ubiquitinated histone H2A (PubMed:17070805).
Interacts with apoptin, DEDD, FADD, CASP8, CASP10, YY1 and GABPB1. Together with GABPB1 and YY1, it forms a ternary complex, probably being the bridge factor between these two transcription factors.
Interacts with MDM2, and thereby inhibits ubiquitination of TP53.
Identified in a ternary complex containing MDM2, TP53 and RYBP.
Interacts with FANK1; may prevent the ubiquitin-mediated proteasomal degradation of FANK1 (By similarity).
Interacts with IFT57 (PubMed:17874297).
By similarity7 PublicationsBinary interactionsi
Hide detailsQ8CCI5
With | #Exp. | IntAct |
---|---|---|
Cbx2 [P30658] | 3 | EBI-929290,EBI-360174 |
Ring1 [O35730] | 4 | EBI-929290,EBI-929310 |
Rnf2 [Q9CQJ4] | 8 | EBI-929290,EBI-927321 |
YY1 [P25490] from Homo sapiens. | 2 | EBI-929290,EBI-765538 |
Protein-protein interaction databases
BioGRIDi | 207918, 14 interactors |
IntActi | Q8CCI5, 14 interactors |
MINTi | Q8CCI5 |
STRINGi | 10090.ENSMUSP00000098677 |
Miscellaneous databases
RNActi | Q8CCI5, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 143 – 226 | Interaction with GABPB1 and FANK1By similarityAdd BLAST | 84 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 73 – 76 | Poly-Pro | 4 | |
Compositional biasi | 77 – 119 | Lys-richAdd BLAST | 43 | |
Compositional biasi | 179 – 214 | Ser-richAdd BLAST | 36 |
Domaini
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 21 – 50 | RanBP2-typePROSITE-ProRule annotationAdd BLAST | 30 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG4477, Eukaryota |
GeneTreei | ENSGT00390000013995 |
HOGENOMi | CLU_095374_0_0_1 |
InParanoidi | Q8CCI5 |
OMAi | TADDGYW |
OrthoDBi | 1634090at2759 |
PhylomeDBi | Q8CCI5 |
TreeFami | TF350501 |
Family and domain databases
InterProi | View protein in InterPro IPR039958, RYBP/YAF2 IPR033774, YAF2_RYBP IPR001876, Znf_RanBP2 IPR036443, Znf_RanBP2_sf |
PANTHERi | PTHR12920, PTHR12920, 1 hit |
Pfami | View protein in Pfam PF17219, YAF2_RYBP, 1 hit PF00641, zf-RanBP, 1 hit |
SMARTi | View protein in SMART SM00547, ZnF_RBZ, 1 hit |
SUPFAMi | SSF90209, SSF90209, 1 hit |
PROSITEi | View protein in PROSITE PS01358, ZF_RANBP2_1, 1 hit PS50199, ZF_RANBP2_2, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MTMGDKKSPT RPKRQAKPAA DEGFWDCSVC TFRNSAEAFK CSICDVRKGT
60 70 80 90 100
STRKPRINSQ LVAQQVAQQY ATPPPPKKEK KEKVEKPDKE KPEKDKDISP
110 120 130 140 150
SVTKKNTNKK TKPKSDILKD PPSEANSIQS ANATTKTSET NHTSRPRLKN
160 170 180 190 200
VDRSTAQQLA VTVGNVTVII TDFKEKTRSS STSSSTVTSS AGSEQQNQSS
210 220
SGSESTDKGS SRSSTPKGDM SAVNDESF
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 143 | T → S in AAD42945 (PubMed:10369680).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK033024 mRNA Translation: BAC28131.1 BC053016 mRNA Translation: AAH53016.1 BC080287 mRNA Translation: AAH80287.1 BC138324 mRNA Translation: AAI38325.1 BC138325 mRNA Translation: AAI38326.1 AF101779 mRNA Translation: AAD42945.1 Different initiation. |
CCDSi | CCDS39579.1 |
RefSeqi | NP_062717.2, NM_019743.3 |
Genome annotation databases
Ensembli | ENSMUST00000101118; ENSMUSP00000098677; ENSMUSG00000072872 |
GeneIDi | 56353 |
KEGGi | mmu:56353 |
UCSCi | uc009dbw.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK033024 mRNA Translation: BAC28131.1 BC053016 mRNA Translation: AAH53016.1 BC080287 mRNA Translation: AAH80287.1 BC138324 mRNA Translation: AAI38325.1 BC138325 mRNA Translation: AAI38326.1 AF101779 mRNA Translation: AAD42945.1 Different initiation. |
CCDSi | CCDS39579.1 |
RefSeqi | NP_062717.2, NM_019743.3 |
3D structure databases
SMRi | Q8CCI5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 207918, 14 interactors |
IntActi | Q8CCI5, 14 interactors |
MINTi | Q8CCI5 |
STRINGi | 10090.ENSMUSP00000098677 |
PTM databases
iPTMneti | Q8CCI5 |
PhosphoSitePlusi | Q8CCI5 |
Proteomic databases
EPDi | Q8CCI5 |
jPOSTi | Q8CCI5 |
MaxQBi | Q8CCI5 |
PaxDbi | Q8CCI5 |
PeptideAtlasi | Q8CCI5 |
PRIDEi | Q8CCI5 |
Protocols and materials databases
Antibodypediai | 7772, 460 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000101118; ENSMUSP00000098677; ENSMUSG00000072872 |
GeneIDi | 56353 |
KEGGi | mmu:56353 |
UCSCi | uc009dbw.1, mouse |
Organism-specific databases
CTDi | 23429 |
MGIi | MGI:1929059, Rybp |
Phylogenomic databases
eggNOGi | KOG4477, Eukaryota |
GeneTreei | ENSGT00390000013995 |
HOGENOMi | CLU_095374_0_0_1 |
InParanoidi | Q8CCI5 |
OMAi | TADDGYW |
OrthoDBi | 1634090at2759 |
PhylomeDBi | Q8CCI5 |
TreeFami | TF350501 |
Enzyme and pathway databases
Reactomei | R-MMU-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known R-MMU-8953750, Transcriptional Regulation by E2F6 |
Miscellaneous databases
BioGRID-ORCSi | 56353, 2 hits in 18 CRISPR screens |
ChiTaRSi | Rybp, mouse |
PROi | PR:Q8CCI5 |
RNActi | Q8CCI5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000072872, Expressed in metanephros and 264 other tissues |
Genevisiblei | Q8CCI5, MM |
Family and domain databases
InterProi | View protein in InterPro IPR039958, RYBP/YAF2 IPR033774, YAF2_RYBP IPR001876, Znf_RanBP2 IPR036443, Znf_RanBP2_sf |
PANTHERi | PTHR12920, PTHR12920, 1 hit |
Pfami | View protein in Pfam PF17219, YAF2_RYBP, 1 hit PF00641, zf-RanBP, 1 hit |
SMARTi | View protein in SMART SM00547, ZnF_RBZ, 1 hit |
SUPFAMi | SSF90209, SSF90209, 1 hit |
PROSITEi | View protein in PROSITE PS01358, ZF_RANBP2_1, 1 hit PS50199, ZF_RANBP2_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RYBP_MOUSE | |
Accessioni | Q8CCI5Primary (citable) accession number: Q8CCI5 Secondary accession number(s): B2RRB6, Q9WVK2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2005 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot