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Protein

Zinc finger protein ZFPM2

Gene

Zfpm2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2.6 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri244 – 277CCHC FOG-type 1PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri296 – 320C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri335 – 357C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri542 – 575CCHC FOG-type 2PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri681 – 714CCHC FOG-type 3PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri848 – 881CCHC FOG-type 4PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri1113 – 1146CCHC FOG-type 5PROSITE-ProRule annotationAdd BLAST34

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific Source: GO_Central
  • RNA polymerase II transcription factor binding Source: GO_Central
  • transcription corepressor activity Source: MGI
  • transcription factor binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ZFPM2
Alternative name(s):
Friend of GATA protein 2
Short name:
FOG-2
Short name:
Friend of GATA 2
Short name:
mFOG-2
Zinc finger protein multitype 2
Gene namesi
Name:Zfpm2
Synonyms:Fog2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1334444 Zfpm2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice die of congestive heart failure at E13 with a syndrome of tricuspid atresia that includes an absent tricuspid valve, a large atrial and ventricular spetal defects, an elongated left ventricular outflow tract, rightward displacement of the aortic valve and pulmonic stenosis. These mice also display hypoplasia of the compact zone of the left ventricle.1 Publication

Keywords - Diseasei

Cardiomyopathy

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002210441 – 1151Zinc finger protein ZFPM2Add BLAST1151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki324Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki444Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki471Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Modified residuei532PhosphoserineBy similarity1
Modified residuei581PhosphoserineBy similarity1
Modified residuei904PhosphoserineBy similarity1
Cross-linki915Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki955Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Modified residuei1014PhosphoserineBy similarity1

Post-translational modificationi

Sumoylation reduces transcriptional repression activity.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ8CCH7
PRIDEiQ8CCH7

PTM databases

iPTMnetiQ8CCH7
PhosphoSitePlusiQ8CCH7

Expressioni

Tissue specificityi

Expressed in heart, brain and testis. Weakly expressed in lung and liver. First expressed at approximately E8.5 in the developing ventral heart tube and septum transversum. Cardiac expression persists throughout the remainder of embryonic development in the atria as well as in all layers of the ventricles (endocardium, myocardium, and pericardium). Expressed in the neuroepithelium of the developing midbrain and hindbrain from E11.5 and increased in intensity between E12 and E16.5. Also expressed in the urogenital ridge beginning at E11.5 and subsequently localized to the gonads by E16.5. Colocalizes with GATA4 GATA5 and GATA6 in the developing heart, GATA3 in the brain, and GATA4 in the gonads.3 Publications

Gene expression databases

BgeeiENSMUSG00000022306 Expressed in 213 organ(s), highest expression level in ureter smooth muscle
CleanExiMM_ZFPM2
ExpressionAtlasiQ8CCH7 baseline and differential
GenevisibleiQ8CCH7 MM

Interactioni

Subunit structurei

Interacts with the N-terminal zinc-finger of GATA4, GATA5 and probably GATA6. Interacts with retinoid nuclear receptor RXRA when ligand bound. Interacts with corepressor CTBP2; this interaction is however not essential for corepressor activity. Interacts with NR2F2 and NR2F6. Interacts with ATOH8; mediates indirect interaction with GATA4.7 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204688, 1 interactor
STRINGi10090.ENSMUSP00000051335

Structurei

3D structure databases

ProteinModelPortaliQ8CCH7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni829 – 835Interaction with CTBP2Curated7

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi736 – 740Nuclear localization signal5

Domaini

The CCHC FOG-type zinc fingers 1, 2, 3 and 5 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC FOG-type zinc finger is probably essential for the interaction with GATA-type zinc fingers.1 Publication

Sequence similaritiesi

Belongs to the FOG (Friend of GATA) family.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri244 – 277CCHC FOG-type 1PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri296 – 320C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri335 – 357C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri542 – 575CCHC FOG-type 2PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri681 – 714CCHC FOG-type 3PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri848 – 881CCHC FOG-type 4PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri1113 – 1146CCHC FOG-type 5PROSITE-ProRule annotationAdd BLAST34

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063823
HOGENOMiHOG000057275
HOVERGENiHBG048953
InParanoidiQ8CCH7
KOiK17442
OMAiTICNYTA
OrthoDBiEOG091G00RC
PhylomeDBiQ8CCH7
TreeFamiTF331342

Family and domain databases

InterProiView protein in InterPro
IPR039746 FOG
IPR034731 ZF_CCHC_FOG
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR12958 PTHR12958, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS51810 ZF_CCHC_FOG, 5 hits
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8CCH7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRRKQSKPR QIKRPLEDAI DDEEEECPVE EAEVISKGDF PLEGSFPAGF
60 70 80 90 100
EPENLSCEDV EFFCNKGDDE GIQEPAESDG DSHSDKPGQP GVETDDWDGP
110 120 130 140 150
GELEVFQRDG ERKIQSRQQL PVGTTWGPFA GKMDLNNNSL KTKAQVPMVL
160 170 180 190 200
TAGPKWLLDV TWQGVEDSKN NCIVYSKGGQ LWCTTTKAIS EGEELVAFVV
210 220 230 240 250
DFDSRLQAAS HMTLTEGMYP ARLLDSIQLL PQQAAMASIL PTAIVNKDIF
260 270 280 290 300
PCKSCGIWYR SERNLQAHLM YYCSGRQREA APVSEENEDN SHQVSSLCPF
310 320 330 340 350
PQCTKSFSNA RALEMHLNSH SGVKMEEFLP PGASLKCTVC SYTADSVINF
360 370 380 390 400
HQHLFSHLTQ AAFRCNHCHF GFQTQRELLQ HQELHVPSGK LPRESDMEHS
410 420 430 440 450
PSGTEDSLQP ATDLLARSDL SQSQKAMPTK DASSDTELDK CEKKTQLFLT
460 470 480 490 500
NQRPEIQPAA NKQNFSYTKI KSEPSSPRLA SSPVQPNIGP SFPVGPFLSQ
510 520 530 540 550
FAFPQDITMV PQASEILAKM SELVHRRLRH GSSSYPPVIY SPLMPKGATC
560 570 580 590 600
FECNITFNNL DNYLVHKKHY CSSRWQQMAK SPEFPSVSEK MPEAVSPNTG
610 620 630 640 650
QTSINLLNPA AHSSDPENPL LQTSCINSST VLDLIGPNGK GHEKDFSTQV
660 670 680 690 700
KKLPTSNSSD DKINGKPVDV KNPSGPLVDG ESDPNKTTCE ACNITFSRHE
710 720 730 740 750
TYMVHKQYYC ATRHDPPLKR SASNKVPAMQ RTMRTRKRRK MYEMCLPEQE
760 770 780 790 800
QRPPLVQQRF LDVANLSNPC SSTQEPTEGL GECYHPRCDI FPGIVSKHLE
810 820 830 840 850
TSLAMNKCVP VPKCDTTHSN VSCLEMDVPI DLSKKCLSQS ERTTASPKRL
860 870 880 890 900
LDYHECTVCK ISFNKVENYL AHKQNFCPVT AHQRNDLGQL DGKVFPNPES
910 920 930 940 950
ERSSPEVSFE RNMIKCEKNG NPKQPSPNGN LFSSHLATLQ GLKVFSEAAQ
960 970 980 990 1000
LIATKEENKH LFLPQCLYPG AIKKTKGADQ LSPYYGIKPS DYIASSLVIH
1010 1020 1030 1040 1050
NTDVEQSTNT ENESPKGQAS SNGCAVPKKD SLPLLPKNRG MVIVNGGLKQ
1060 1070 1080 1090 1100
DERPTANPQQ ENISQNTQHE DGHKSPSWIS ENPLAANENV SPGIPCAEEQ
1110 1120 1130 1140 1150
LSSIAKGVNG ASQAPSSGKY CRLCDIQFNN LSNFITHKKF YCSSHAAEHV

K
Length:1,151
Mass (Da):127,692
Last modified:March 15, 2004 - v2
Checksum:i2759B0AA65D84F9E
GO
Isoform 2 (identifier: Q8CCH7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     102-111: ELEVFQRDGE → RTESTAFNPL
     112-1151: Missing.

Note: No experimental confirmation available.
Show »
Length:111
Mass (Da):12,273
Checksum:iB4E98DF3567B913C
GO
Isoform 3 (identifier: Q8CCH7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     381-398: Missing.

Note: Splicing donor site between exon 3 and 4 is not canonical. No experimental confirmation available.
Show »
Length:1,133
Mass (Da):125,621
Checksum:i1E4D25871E61ED2D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A5HE91A5HE91_MOUSE
FOG-2S transcriptional co-factor
Zfpm2
1,019Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009703102 – 111ELEVFQRDGE → RTESTAFNPL in isoform 2. 1 Publication10
Alternative sequenceiVSP_009704112 – 1151Missing in isoform 2. 1 PublicationAdd BLAST1040
Alternative sequenceiVSP_009705381 – 398Missing in isoform 3. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF118845 mRNA Translation: AAD17251.1
AF107306 mRNA Translation: AAD12182.1
AF125166 mRNA Translation: AAD33250.1
AK033131 mRNA Translation: BAC28166.1
BC059241 mRNA Translation: AAH59241.1
CCDSiCCDS27447.1 [Q8CCH7-1]
PIRiT18297
RefSeqiNP_035896.1, NM_011766.5 [Q8CCH7-1]
UniGeneiMm.39496

Genome annotation databases

EnsembliENSMUST00000053467; ENSMUSP00000051335; ENSMUSG00000022306 [Q8CCH7-1]
GeneIDi22762
KEGGimmu:22762
UCSCiuc007voq.1 mouse [Q8CCH7-2]
uc007vos.1 mouse [Q8CCH7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF118845 mRNA Translation: AAD17251.1
AF107306 mRNA Translation: AAD12182.1
AF125166 mRNA Translation: AAD33250.1
AK033131 mRNA Translation: BAC28166.1
BC059241 mRNA Translation: AAH59241.1
CCDSiCCDS27447.1 [Q8CCH7-1]
PIRiT18297
RefSeqiNP_035896.1, NM_011766.5 [Q8CCH7-1]
UniGeneiMm.39496

3D structure databases

ProteinModelPortaliQ8CCH7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204688, 1 interactor
STRINGi10090.ENSMUSP00000051335

PTM databases

iPTMnetiQ8CCH7
PhosphoSitePlusiQ8CCH7

Proteomic databases

PaxDbiQ8CCH7
PRIDEiQ8CCH7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053467; ENSMUSP00000051335; ENSMUSG00000022306 [Q8CCH7-1]
GeneIDi22762
KEGGimmu:22762
UCSCiuc007voq.1 mouse [Q8CCH7-2]
uc007vos.1 mouse [Q8CCH7-1]

Organism-specific databases

CTDi23414
MGIiMGI:1334444 Zfpm2

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063823
HOGENOMiHOG000057275
HOVERGENiHBG048953
InParanoidiQ8CCH7
KOiK17442
OMAiTICNYTA
OrthoDBiEOG091G00RC
PhylomeDBiQ8CCH7
TreeFamiTF331342

Enzyme and pathway databases

ReactomeiR-MMU-983231 Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

PROiPR:Q8CCH7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022306 Expressed in 213 organ(s), highest expression level in ureter smooth muscle
CleanExiMM_ZFPM2
ExpressionAtlasiQ8CCH7 baseline and differential
GenevisibleiQ8CCH7 MM

Family and domain databases

InterProiView protein in InterPro
IPR039746 FOG
IPR034731 ZF_CCHC_FOG
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR12958 PTHR12958, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS51810 ZF_CCHC_FOG, 5 hits
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFOG2_MOUSE
AccessioniPrimary (citable) accession number: Q8CCH7
Secondary accession number(s): Q9Z0F2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: November 7, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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