UniProtKB - Q8CCH7 (FOG2_MOUSE)
Zinc finger protein ZFPM2
Zfpm2
Functioni
Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2.
6 PublicationsSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 252 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 255 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 268 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 273 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 550 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 553 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 566 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 571 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 689 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 692 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 705 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 710 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 856 | Zinc 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 859 | Zinc 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 872 | Zinc 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 877 | Zinc 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 1121 | Zinc 5PROSITE-ProRule annotation | 1 | |
Metal bindingi | 1124 | Zinc 5PROSITE-ProRule annotation | 1 | |
Metal bindingi | 1137 | Zinc 5PROSITE-ProRule annotation | 1 | |
Metal bindingi | 1142 | Zinc 5PROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 244 – 277 | CCHC FOG-type 1PROSITE-ProRule annotationAdd BLAST | 34 | |
Zinc fingeri | 296 – 320 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 335 – 357 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 363 – 385 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 542 – 575 | CCHC FOG-type 2PROSITE-ProRule annotationAdd BLAST | 34 | |
Zinc fingeri | 681 – 714 | CCHC FOG-type 3PROSITE-ProRule annotationAdd BLAST | 34 | |
Zinc fingeri | 848 – 881 | CCHC FOG-type 4PROSITE-ProRule annotationAdd BLAST | 34 | |
Zinc fingeri | 1113 – 1146 | CCHC FOG-type 5PROSITE-ProRule annotationAdd BLAST | 34 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II-specific DNA-binding transcription factor binding Source: Ensembl
- transcription coactivator activity Source: MGI
- transcription corepressor activity Source: MGI
GO - Biological processi
- atrioventricular valve morphogenesis Source: BHF-UCL
- cardiac muscle tissue development Source: MGI
- cardiac muscle tissue morphogenesis Source: BHF-UCL
- cell differentiation Source: GO_Central
- embryonic organ development Source: MGI
- heart development Source: MGI
- in utero embryonic development Source: MGI
- lung development Source: MGI
- mitral valve formation Source: BHF-UCL
- negative regulation of cell death Source: UniProtKB
- negative regulation of fat cell differentiation Source: BHF-UCL
- negative regulation of female gonad development Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- outflow tract morphogenesis Source: BHF-UCL
- outflow tract septum morphogenesis Source: MGI
- positive regulation of cardiac muscle cell proliferation Source: BHF-UCL
- positive regulation of male gonad development Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: MGI
- right ventricular cardiac muscle tissue morphogenesis Source: MGI
- tricuspid valve formation Source: BHF-UCL
- vasculogenesis Source: MGI
- vasculogenesis involved in coronary vascular morphogenesis Source: DFLAT
- ventricular septum morphogenesis Source: MGI
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-983231, Factors involved in megakaryocyte development and platelet production |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein ZFPM2Alternative name(s): Friend of GATA protein 2 Short name: FOG-2 Short name: Friend of GATA 2 Short name: mFOG-2 Zinc finger protein multitype 2 |
Gene namesi | Name:Zfpm2 Synonyms:Fog2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1334444, Zfpm2 |
VEuPathDBi | HostDB:ENSMUSG00000022306 |
Subcellular locationi
Nucleus
- Nucleus 3 Publications
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: MGI
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
Keywords - Diseasei
CardiomyopathyPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000221044 | 1 – 1151 | Zinc finger protein ZFPM2Add BLAST | 1151 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 324 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity | ||
Cross-linki | 444 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 471 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity | ||
Modified residuei | 532 | PhosphoserineBy similarity | 1 | |
Modified residuei | 581 | PhosphoserineBy similarity | 1 | |
Modified residuei | 904 | PhosphoserineBy similarity | 1 | |
Cross-linki | 915 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity | ||
Cross-linki | 955 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity | ||
Modified residuei | 1014 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
MaxQBi | Q8CCH7 |
PaxDbi | Q8CCH7 |
PRIDEi | Q8CCH7 |
ProteomicsDBi | 267388 [Q8CCH7-1] 267389 [Q8CCH7-2] 267390 [Q8CCH7-3] |
PTM databases
iPTMneti | Q8CCH7 |
PhosphoSitePlusi | Q8CCH7 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000022306, Expressed in ureter smooth muscle and 242 other tissues |
ExpressionAtlasi | Q8CCH7, baseline and differential |
Genevisiblei | Q8CCH7, MM |
Interactioni
Subunit structurei
Interacts with the N-terminal zinc-finger of GATA4, GATA5 and probably GATA6.
Interacts with retinoid nuclear receptor RXRA when ligand bound.
Interacts with corepressor CTBP2; this interaction is however not essential for corepressor activity.
Interacts with NR2F2 and NR2F6.
Interacts with ATOH8; mediates indirect interaction with GATA4.
7 PublicationsGO - Molecular functioni
Protein-protein interaction databases
BioGRIDi | 204688, 2 interactors |
STRINGi | 10090.ENSMUSP00000051335 |
Miscellaneous databases
RNActi | Q8CCH7, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 53 | DisorderedSequence analysisAdd BLAST | 53 | |
Regioni | 65 – 101 | DisorderedSequence analysisAdd BLAST | 37 | |
Regioni | 389 – 486 | DisorderedSequence analysisAdd BLAST | 98 | |
Regioni | 637 – 684 | DisorderedSequence analysisAdd BLAST | 48 | |
Regioni | 829 – 835 | Interaction with CTBP2Curated | 7 | |
Regioni | 1004 – 1035 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 1049 – 1093 | DisorderedSequence analysisAdd BLAST | 45 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 736 – 740 | Nuclear localization signal | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 65 – 92 | Basic and acidic residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 402 – 431 | Polar residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 432 – 446 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 447 – 486 | Polar residuesSequence analysisAdd BLAST | 40 | |
Compositional biasi | 1004 – 1025 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 1052 – 1073 | Polar residuesSequence analysisAdd BLAST | 22 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 244 – 277 | CCHC FOG-type 1PROSITE-ProRule annotationAdd BLAST | 34 | |
Zinc fingeri | 296 – 320 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 335 – 357 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 363 – 385 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 542 – 575 | CCHC FOG-type 2PROSITE-ProRule annotationAdd BLAST | 34 | |
Zinc fingeri | 681 – 714 | CCHC FOG-type 3PROSITE-ProRule annotationAdd BLAST | 34 | |
Zinc fingeri | 848 – 881 | CCHC FOG-type 4PROSITE-ProRule annotationAdd BLAST | 34 | |
Zinc fingeri | 1113 – 1146 | CCHC FOG-type 5PROSITE-ProRule annotationAdd BLAST | 34 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00530000063823 |
HOGENOMi | CLU_010755_0_0_1 |
InParanoidi | Q8CCH7 |
OMAi | LKHPMSI |
OrthoDBi | 76702at2759 |
PhylomeDBi | Q8CCH7 |
TreeFami | TF331342 |
Family and domain databases
InterProi | View protein in InterPro IPR039746, FOG IPR034731, ZF_CCHC_FOG IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR12958, PTHR12958, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 8 hits |
SUPFAMi | SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS51810, ZF_CCHC_FOG, 5 hits PS00028, ZINC_FINGER_C2H2_1, 2 hits PS50157, ZINC_FINGER_C2H2_2, 2 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSRRKQSKPR QIKRPLEDAI DDEEEECPVE EAEVISKGDF PLEGSFPAGF
60 70 80 90 100
EPENLSCEDV EFFCNKGDDE GIQEPAESDG DSHSDKPGQP GVETDDWDGP
110 120 130 140 150
GELEVFQRDG ERKIQSRQQL PVGTTWGPFA GKMDLNNNSL KTKAQVPMVL
160 170 180 190 200
TAGPKWLLDV TWQGVEDSKN NCIVYSKGGQ LWCTTTKAIS EGEELVAFVV
210 220 230 240 250
DFDSRLQAAS HMTLTEGMYP ARLLDSIQLL PQQAAMASIL PTAIVNKDIF
260 270 280 290 300
PCKSCGIWYR SERNLQAHLM YYCSGRQREA APVSEENEDN SHQVSSLCPF
310 320 330 340 350
PQCTKSFSNA RALEMHLNSH SGVKMEEFLP PGASLKCTVC SYTADSVINF
360 370 380 390 400
HQHLFSHLTQ AAFRCNHCHF GFQTQRELLQ HQELHVPSGK LPRESDMEHS
410 420 430 440 450
PSGTEDSLQP ATDLLARSDL SQSQKAMPTK DASSDTELDK CEKKTQLFLT
460 470 480 490 500
NQRPEIQPAA NKQNFSYTKI KSEPSSPRLA SSPVQPNIGP SFPVGPFLSQ
510 520 530 540 550
FAFPQDITMV PQASEILAKM SELVHRRLRH GSSSYPPVIY SPLMPKGATC
560 570 580 590 600
FECNITFNNL DNYLVHKKHY CSSRWQQMAK SPEFPSVSEK MPEAVSPNTG
610 620 630 640 650
QTSINLLNPA AHSSDPENPL LQTSCINSST VLDLIGPNGK GHEKDFSTQV
660 670 680 690 700
KKLPTSNSSD DKINGKPVDV KNPSGPLVDG ESDPNKTTCE ACNITFSRHE
710 720 730 740 750
TYMVHKQYYC ATRHDPPLKR SASNKVPAMQ RTMRTRKRRK MYEMCLPEQE
760 770 780 790 800
QRPPLVQQRF LDVANLSNPC SSTQEPTEGL GECYHPRCDI FPGIVSKHLE
810 820 830 840 850
TSLAMNKCVP VPKCDTTHSN VSCLEMDVPI DLSKKCLSQS ERTTASPKRL
860 870 880 890 900
LDYHECTVCK ISFNKVENYL AHKQNFCPVT AHQRNDLGQL DGKVFPNPES
910 920 930 940 950
ERSSPEVSFE RNMIKCEKNG NPKQPSPNGN LFSSHLATLQ GLKVFSEAAQ
960 970 980 990 1000
LIATKEENKH LFLPQCLYPG AIKKTKGADQ LSPYYGIKPS DYIASSLVIH
1010 1020 1030 1040 1050
NTDVEQSTNT ENESPKGQAS SNGCAVPKKD SLPLLPKNRG MVIVNGGLKQ
1060 1070 1080 1090 1100
DERPTANPQQ ENISQNTQHE DGHKSPSWIS ENPLAANENV SPGIPCAEEQ
1110 1120 1130 1140 1150
LSSIAKGVNG ASQAPSSGKY CRLCDIQFNN LSNFITHKKF YCSSHAAEHV
K
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA5HE91 | A5HE91_MOUSE | FOG-2S transcriptional co-factor | Zfpm2 | 1,019 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_009703 | 102 – 111 | ELEVFQRDGE → RTESTAFNPL in isoform 2. 1 Publication | 10 | |
Alternative sequenceiVSP_009704 | 112 – 1151 | Missing in isoform 2. 1 PublicationAdd BLAST | 1040 | |
Alternative sequenceiVSP_009705 | 381 – 398 | Missing in isoform 3. 1 PublicationAdd BLAST | 18 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF118845 mRNA Translation: AAD17251.1 AF107306 mRNA Translation: AAD12182.1 AF125166 mRNA Translation: AAD33250.1 AK033131 mRNA Translation: BAC28166.1 BC059241 mRNA Translation: AAH59241.1 |
CCDSi | CCDS27447.1 [Q8CCH7-1] |
PIRi | T18297 |
RefSeqi | NP_035896.1, NM_011766.5 [Q8CCH7-1] |
Genome annotation databases
Ensembli | ENSMUST00000053467; ENSMUSP00000051335; ENSMUSG00000022306 [Q8CCH7-1] |
GeneIDi | 22762 |
KEGGi | mmu:22762 |
UCSCi | uc007voq.1, mouse [Q8CCH7-2] uc007vos.1, mouse [Q8CCH7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF118845 mRNA Translation: AAD17251.1 AF107306 mRNA Translation: AAD12182.1 AF125166 mRNA Translation: AAD33250.1 AK033131 mRNA Translation: BAC28166.1 BC059241 mRNA Translation: AAH59241.1 |
CCDSi | CCDS27447.1 [Q8CCH7-1] |
PIRi | T18297 |
RefSeqi | NP_035896.1, NM_011766.5 [Q8CCH7-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 204688, 2 interactors |
STRINGi | 10090.ENSMUSP00000051335 |
PTM databases
iPTMneti | Q8CCH7 |
PhosphoSitePlusi | Q8CCH7 |
Proteomic databases
MaxQBi | Q8CCH7 |
PaxDbi | Q8CCH7 |
PRIDEi | Q8CCH7 |
ProteomicsDBi | 267388 [Q8CCH7-1] 267389 [Q8CCH7-2] 267390 [Q8CCH7-3] |
Protocols and materials databases
Antibodypediai | 1311, 143 antibodies from 27 providers |
DNASUi | 22762 |
Genome annotation databases
Ensembli | ENSMUST00000053467; ENSMUSP00000051335; ENSMUSG00000022306 [Q8CCH7-1] |
GeneIDi | 22762 |
KEGGi | mmu:22762 |
UCSCi | uc007voq.1, mouse [Q8CCH7-2] uc007vos.1, mouse [Q8CCH7-1] |
Organism-specific databases
CTDi | 23414 |
MGIi | MGI:1334444, Zfpm2 |
VEuPathDBi | HostDB:ENSMUSG00000022306 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00530000063823 |
HOGENOMi | CLU_010755_0_0_1 |
InParanoidi | Q8CCH7 |
OMAi | LKHPMSI |
OrthoDBi | 76702at2759 |
PhylomeDBi | Q8CCH7 |
TreeFami | TF331342 |
Enzyme and pathway databases
Reactomei | R-MMU-983231, Factors involved in megakaryocyte development and platelet production |
Miscellaneous databases
BioGRID-ORCSi | 22762, 2 hits in 65 CRISPR screens |
ChiTaRSi | Zfpm2, mouse |
PROi | PR:Q8CCH7 |
RNActi | Q8CCH7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022306, Expressed in ureter smooth muscle and 242 other tissues |
ExpressionAtlasi | Q8CCH7, baseline and differential |
Genevisiblei | Q8CCH7, MM |
Family and domain databases
InterProi | View protein in InterPro IPR039746, FOG IPR034731, ZF_CCHC_FOG IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR12958, PTHR12958, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 8 hits |
SUPFAMi | SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS51810, ZF_CCHC_FOG, 5 hits PS00028, ZINC_FINGER_C2H2_1, 2 hits PS50157, ZINC_FINGER_C2H2_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | FOG2_MOUSE | |
Accessioni | Q8CCH7Primary (citable) accession number: Q8CCH7 Secondary accession number(s): Q9Z0F2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 15, 2004 |
Last sequence update: | March 15, 2004 | |
Last modified: | February 23, 2022 | |
This is version 149 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families