Zinc finger protein ZFPM2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: UniProtKB-KW
• metal ion binding Source: UniProtKB-KW
• proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • 21873635
• RNA polymerase II transcription factor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• transcription corepressor activity Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 12606418
  • 17445768
  • 9927675
• transcription factor binding Source: MGI <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 10225993
  • 17445768

GO - Biological processⁱ

• atrioventricular valve morphogenesis Source: BHF-UCL <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • 14614148
• cardiac muscle tissue development Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 16103912
• cardiac muscle tissue morphogenesis Source: BHF-UCLTraceable author statementⁱ
  • 14614148
• embryonic organ development Source: MGIInferred from mutant phenotypeⁱ
  • 16103912
• heart development Source: MGIInferred from direct assayⁱ
  • 10892744
• in utero embryonic development Source: MGIInferred from mutant phenotypeⁱ
  • 16103912
• lung development Source: MGIInferred from mutant phenotypeⁱ
  • 16103912
• mitral valve formation Source: BHF-UCLTraceable author statementⁱ
  • 14614148
• negative regulation of cell death Source: UniProtKBInferred from mutant phenotypeⁱ
  • 20705609
• negative regulation of fat cell differentiation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 20705609
• negative regulation of female gonad development Source: UniProtKBInferred from mutant phenotypeⁱ
  • 19301398
• negative regulation of transcription, DNA-templated Source: MGI
• negative regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • 12606418
  • 17445768
  • 9927675
• outflow tract morphogenesis Source: BHF-UCLTraceable author statementⁱ
  • 14614148
• outflow tract septum morphogenesis Source: MGI
• positive regulation of cardiac muscle cell proliferation Source: BHF-UCL <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • 22267003
• positive regulation of male gonad development Source: UniProtKBInferred from mutant phenotypeⁱ
  • 19301398
• positive regulation of transcription, DNA-templated Source: UniProtKBInferred from mutant phenotypeⁱ
  • 19301398
• positive regulation of transcription by RNA polymerase II Source: MGIInferred from genetic interactionⁱ
  • 15766748
• right ventricular cardiac muscle tissue morphogenesis Source: MGI
• tricuspid valve formation Source: BHF-UCLTraceable author statementⁱ
  • 14614148
• vasculogenesis Source: MGIInferred from direct assayⁱ
  • 10892744
• vasculogenesis involved in coronary vascular morphogenesis Source: DFLATTraceable author statementⁱ
  • 20299672
• ventricular septum morphogenesis Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

Keywords - Diseaseⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• RNA polymerase II transcription factor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• transcription factor binding Source: MGIInferred from physical interactionⁱ
  • 10225993
  • 17445768

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MSRRKQSKPR QIKRPLEDAI DDEEEECPVE EAEVISKGDF PLEGSFPAGF 
        60         70         80         90        100
EPENLSCEDV EFFCNKGDDE GIQEPAESDG DSHSDKPGQP GVETDDWDGP 
       110        120        130        140        150
GELEVFQRDG ERKIQSRQQL PVGTTWGPFA GKMDLNNNSL KTKAQVPMVL 
       160        170        180        190        200
TAGPKWLLDV TWQGVEDSKN NCIVYSKGGQ LWCTTTKAIS EGEELVAFVV 
       210        220        230        240        250
DFDSRLQAAS HMTLTEGMYP ARLLDSIQLL PQQAAMASIL PTAIVNKDIF 
       260        270        280        290        300
PCKSCGIWYR SERNLQAHLM YYCSGRQREA APVSEENEDN SHQVSSLCPF 
       310        320        330        340        350
PQCTKSFSNA RALEMHLNSH SGVKMEEFLP PGASLKCTVC SYTADSVINF 
       360        370        380        390        400
HQHLFSHLTQ AAFRCNHCHF GFQTQRELLQ HQELHVPSGK LPRESDMEHS 
       410        420        430        440        450
PSGTEDSLQP ATDLLARSDL SQSQKAMPTK DASSDTELDK CEKKTQLFLT 
       460        470        480        490        500
NQRPEIQPAA NKQNFSYTKI KSEPSSPRLA SSPVQPNIGP SFPVGPFLSQ 
       510        520        530        540        550
FAFPQDITMV PQASEILAKM SELVHRRLRH GSSSYPPVIY SPLMPKGATC 
       560        570        580        590        600
FECNITFNNL DNYLVHKKHY CSSRWQQMAK SPEFPSVSEK MPEAVSPNTG 
       610        620        630        640        650
QTSINLLNPA AHSSDPENPL LQTSCINSST VLDLIGPNGK GHEKDFSTQV 
       660        670        680        690        700
KKLPTSNSSD DKINGKPVDV KNPSGPLVDG ESDPNKTTCE ACNITFSRHE 
       710        720        730        740        750
TYMVHKQYYC ATRHDPPLKR SASNKVPAMQ RTMRTRKRRK MYEMCLPEQE 
       760        770        780        790        800
QRPPLVQQRF LDVANLSNPC SSTQEPTEGL GECYHPRCDI FPGIVSKHLE 
       810        820        830        840        850
TSLAMNKCVP VPKCDTTHSN VSCLEMDVPI DLSKKCLSQS ERTTASPKRL 
       860        870        880        890        900
LDYHECTVCK ISFNKVENYL AHKQNFCPVT AHQRNDLGQL DGKVFPNPES 
       910        920        930        940        950
ERSSPEVSFE RNMIKCEKNG NPKQPSPNGN LFSSHLATLQ GLKVFSEAAQ 
       960        970        980        990       1000
LIATKEENKH LFLPQCLYPG AIKKTKGADQ LSPYYGIKPS DYIASSLVIH 
      1010       1020       1030       1040       1050
NTDVEQSTNT ENESPKGQAS SNGCAVPKKD SLPLLPKNRG MVIVNGGLKQ 
      1060       1070       1080       1090       1100
DERPTANPQQ ENISQNTQHE DGHKSPSWIS ENPLAANENV SPGIPCAEEQ 
      1110       1120       1130       1140       1150
LSSIAKGVNG ASQAPSSGKY CRLCDIQFNN LSNFITHKKF YCSSHAAEHV 

K                                                      

        10         20         30         40         50
MSRRKQSKPR QIKRPLEDAI DDEEEECPVE EAEVISKGDF PLEGSFPAGF 
        60         70         80         90        100
EPENLSCEDV EFFCNKGDDE GIQEPAESDG DSHSDKPGQP GVETDDWDGP 
       110 
GRTESTAFNP L                                           

        10         20         30         40         50
MSRRKQSKPR QIKRPLEDAI DDEEEECPVE EAEVISKGDF PLEGSFPAGF 
        60         70         80         90        100
EPENLSCEDV EFFCNKGDDE GIQEPAESDG DSHSDKPGQP GVETDDWDGP 
       110        120        130        140        150
GELEVFQRDG ERKIQSRQQL PVGTTWGPFA GKMDLNNNSL KTKAQVPMVL 
       160        170        180        190        200
TAGPKWLLDV TWQGVEDSKN NCIVYSKGGQ LWCTTTKAIS EGEELVAFVV 
       210        220        230        240        250
DFDSRLQAAS HMTLTEGMYP ARLLDSIQLL PQQAAMASIL PTAIVNKDIF 
       260        270        280        290        300
PCKSCGIWYR SERNLQAHLM YYCSGRQREA APVSEENEDN SHQVSSLCPF 
       310        320        330        340        350
PQCTKSFSNA RALEMHLNSH SGVKMEEFLP PGASLKCTVC SYTADSVINF 
       360        370        380        390        400
HQHLFSHLTQ AAFRCNHCHF GFQTQRELLQ HSPSGTEDSL QPATDLLARS 
       410        420        430        440        450
DLSQSQKAMP TKDASSDTEL DKCEKKTQLF LTNQRPEIQP AANKQNFSYT 
       460        470        480        490        500
KIKSEPSSPR LASSPVQPNI GPSFPVGPFL SQFAFPQDIT MVPQASEILA 
       510        520        530        540        550
KMSELVHRRL RHGSSSYPPV IYSPLMPKGA TCFECNITFN NLDNYLVHKK 
       560        570        580        590        600
HYCSSRWQQM AKSPEFPSVS EKMPEAVSPN TGQTSINLLN PAAHSSDPEN 
       610        620        630        640        650
PLLQTSCINS STVLDLIGPN GKGHEKDFST QVKKLPTSNS SDDKINGKPV 
       660        670        680        690        700
DVKNPSGPLV DGESDPNKTT CEACNITFSR HETYMVHKQY YCATRHDPPL 
       710        720        730        740        750
KRSASNKVPA MQRTMRTRKR RKMYEMCLPE QEQRPPLVQQ RFLDVANLSN 
       760        770        780        790        800
PCSSTQEPTE GLGECYHPRC DIFPGIVSKH LETSLAMNKC VPVPKCDTTH 
       810        820        830        840        850
SNVSCLEMDV PIDLSKKCLS QSERTTASPK RLLDYHECTV CKISFNKVEN 
       860        870        880        890        900
YLAHKQNFCP VTAHQRNDLG QLDGKVFPNP ESERSSPEVS FERNMIKCEK 
       910        920        930        940        950
NGNPKQPSPN GNLFSSHLAT LQGLKVFSEA AQLIATKEEN KHLFLPQCLY 
       960        970        980        990       1000
PGAIKKTKGA DQLSPYYGIK PSDYIASSLV IHNTDVEQST NTENESPKGQ 
      1010       1020       1030       1040       1050
ASSNGCAVPK KDSLPLLPKN RGMVIVNGGL KQDERPTANP QQENISQNTQ 
      1060       1070       1080       1090       1100
HEDGHKSPSW ISENPLAANE NVSPGIPCAE EQLSSIAKGV NGASQAPSSG 
      1110       1120       1130 
KYCRLCDIQF NNLSNFITHK KFYCSSHAAE HVK                   

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot