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Entry version 157 (07 Oct 2020)
Sequence version 2 (18 Mar 2008)
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Protein

Transcription factor E4F1

Gene

E4f1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription.4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.By similarity EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri193 – 215C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri221 – 243C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri249 – 273C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri434 – 456C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri462 – 484C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri490 – 512C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri518 – 540C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri546 – 568C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri574 – 596C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor, Transferase
Biological processCell cycle, Cell division, Growth regulation, Mitosis, Transcription, Transcription regulation, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription factor E4F1 (EC:2.3.2.27By similarity)
Alternative name(s):
E4F transcription factor 1
Putative E3 ubiquitin-protein ligase E4F1
RING-type E3 ubiquitin transferase E4F1Curated
Transcription factor E4F
Transcription factor phi AP3
p120E4F
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:E4f1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:109530, E4f1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Death before 7.5 dpc probably at the peri-implantation stage. Blastocysts display defects in mitotic progression and chromosomal segregation and increased apoptosis.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003243081 – 783Transcription factor E4F1Add BLAST783

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei49PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated; phosphorylation is cell cycle-dependent and regulates DNA-binding activity and function.1 Publication
May be sumoylated by UBE2I upon interaction with CDKN2A.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8CCE9

PRoteomics IDEntifications database

More...
PRIDEi
Q8CCE9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8CCE9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8CCE9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Continuously expressed during embryogenesis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000024137, Expressed in head and 317 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8CCE9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8CCE9, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; binds DNA as a dimer (By similarity).

Forms a complex with CDKN2A and TP53.

Interacts with HDAC1, HMGA2 and RASSF1 (By similarity). Interactions with TP53, RB1, ANP32A and probably BMI1 and FHL2 regulate E4F1 activity.

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
199353, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q8CCE9, 1 interactor

Molecular INTeraction database

More...
MINTi
Q8CCE9

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000062344

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8CCE9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8CCE9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni40 – 84Required for ubiquitin ligase activityBy similarityAdd BLAST45
Regioni185 – 264Mediates dimerization, DNA-binding, transcription repression of CCNA2 and interaction with HMGA2By similarityAdd BLAST80
Regioni368 – 565Mediates interaction with CDKN2ABy similarityAdd BLAST198
Regioni434 – 598Interaction with BMI1By similarityAdd BLAST165
Regioni520 – 579Mediates interaction with TP53By similarityAdd BLAST60
Regioni574 – 596Mediates interaction with RASSF1By similarityAdd BLAST23

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri193 – 215C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri221 – 243C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri249 – 273C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri434 – 456C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri462 – 484C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri490 – 512C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri518 – 540C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri546 – 568C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri574 – 596C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00840000129970

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_50_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8CCE9

KEGG Orthology (KO)

More...
KOi
K22401

Identification of Orthologs from Complete Genome Data

More...
OMAi
MITHSSK

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8CCE9

TreeFam database of animal gene trees

More...
TreeFami
TF315387

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096, zf-C2H2, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355, ZnF_C2H2, 10 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667, SSF57667, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 7 hits
PS50157, ZINC_FINGER_C2H2_2, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8CCE9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGAMAVRVT AAHTAEARAE AGREAGEGGV AAAAALSSGG FLGLPAPFSE
60 70 80 90 100
EDEDDVHRCG RCQVEFTALE DFVQHKIQKT CHRAPQEALP TTPAATALLD
110 120 130 140 150
QEVVPTAAEG GPDEPITVAH IVVEATSLAE DISHAPDLVG SGHIKEVIVA
160 170 180 190 200
AEAEPGDVEM AEAPGSPNHQ ELGLLGEGEQ AHVKLLVNKE GRYVCMLCHK
210 220 230 240 250
TFKTGSILKA HMVTHSSRKD HECKLCGASF RTKGSLIRHH RRHTDERPYK
260 270 280 290 300
CAKCGKSFRE SGALTRHLKS LTPCTEKIRF SISKDTAVGK EEVPAGSSAS
310 320 330 340 350
TVGTVTSSVA GDPMETSPVI HLVTDAKGTV IHEVHVQMQE LPLGMKALTP
360 370 380 390 400
ESPDSEELPC SSENSRENLL HQAMQNSGIV LERVAGEESA LEPAPPSGSS
410 420 430 440 450
PQCLGDGSPE LPLLKVEQIE TQVASEAATV PRTHPCPQCS ETFPTAATLE
460 470 480 490 500
AHKRGHIAPR PFTCTQCGKA FPKAYLLKKH QEVHVHERRF RCGDCGKLYK
510 520 530 540 550
TIAHVRGHRR VHSDERPFPC PQCGKRYKTK NAQQVHFRTH LEEKPHVCQF
560 570 580 590 600
CSRGFREKGS LVRHVRHHTG EKPFKCYKCG RGFAEHGTLN RHLRTKGGCL
610 620 630 640 650
LEVEELLVSE ESPSAAATVL AEDPHTVLVE FSSVVADTQE YIIEATADDT
660 670 680 690 700
ETSEATEIIE GTQTEVDSHI MKVVQQIVHQ AGAGHQIIVQ NVTMDQETAL
710 720 730 740 750
GSEATAADTI TIATPESLTE QVAMTLASAI SEGTVLTARA GPNSTEQATV
760 770 780
TMVSSEDIEI LEHGGELVIA SPEGQLEVQT VIV
Length:783
Mass (Da):84,296
Last modified:March 18, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i59E47F7A64A224A4
GO
Isoform 2 (identifier: Q8CCE9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     667-684: DSHIMKVVQQIVHQAGAG → RVWVRDGRITGLLGSPSG
     685-783: Missing.

Show »
Length:684
Mass (Da):74,060
Checksum:i62B9E2973ACA07C3
GO
Isoform 3 (identifier: Q8CCE9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     422-422: Missing.

Show »
Length:782
Mass (Da):84,168
Checksum:iF0CEA4AC61FE5BDA
GO
Isoform 4 (identifier: Q8CCE9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     458-458: A → VWQGLPQSLP...AWHTQPAPAH
     459-783: Missing.

Show »
Length:586
Mass (Da):62,553
Checksum:i03DE21745C393119
GO
Isoform 5 (identifier: Q8CCE9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     244-274: Missing.

Show »
Length:752
Mass (Da):80,830
Checksum:iBC7A27C32B98E325
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BPE3A0A2I3BPE3_MOUSE
Transcription factor E4F1
E4f1
586Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BRE9A0A2I3BRE9_MOUSE
Transcription factor E4F1
E4f1
427Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BR50A0A2I3BR50_MOUSE
Transcription factor E4F1
E4f1
675Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF22563 differs from that shown. Reason: Frameshift.Curated
The sequence AAH71228 differs from that shown. Reason: Frameshift.Curated
The sequence BAE25748 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA54188 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti13H → D in BAE25748 (PubMed:16141072).Curated1
Sequence conflicti18R → G in AAF22563 (Ref. 1) Curated1
Sequence conflicti18R → G in BAE25748 (PubMed:16141072).Curated1
Sequence conflicti18R → G in AAH46459 (PubMed:15489334).Curated1
Sequence conflicti18R → G in AAH71228 (PubMed:15489334).Curated1
Sequence conflicti30V → VA in AAF22563 (Ref. 1) Curated1
Sequence conflicti30V → VA in BAE25748 (PubMed:16141072).Curated1
Sequence conflicti62C → F in BAE25748 (PubMed:16141072).Curated1
Sequence conflicti139V → A in CAA54188 (PubMed:8262041).Curated1
Sequence conflicti148I → V in CAA54188 (PubMed:8262041).Curated1
Sequence conflicti158V → G in AAF22563 (Ref. 1) Curated1
Sequence conflicti158V → G in BAE25748 (PubMed:16141072).Curated1
Sequence conflicti158V → G in AAH46459 (PubMed:15489334).Curated1
Sequence conflicti158V → G in AAH71228 (PubMed:15489334).Curated1
Sequence conflicti158V → G in CAA54188 (PubMed:8262041).Curated1
Sequence conflicti224 – 225KL → NF in AAF22563 (Ref. 1) Curated2
Sequence conflicti281S → N in AAF22563 (Ref. 1) Curated1
Sequence conflicti281S → N in BAE25748 (PubMed:16141072).Curated1
Sequence conflicti380V → L in AAF22563 (Ref. 1) Curated1
Sequence conflicti390A → V in AAF22563 (Ref. 1) Curated1
Sequence conflicti395 – 400PPSGSS → LPFGST in AAF22563 (Ref. 1) Curated6
Sequence conflicti412P → L in AAF22563 (Ref. 1) Curated1
Sequence conflicti479 – 480KH → ND in CAA54188 (PubMed:8262041).Curated2
Sequence conflicti585 – 586EH → DD in CAA54188 (PubMed:8262041).Curated2
Sequence conflicti630E → Q in AAF22563 (Ref. 1) Curated1
Sequence conflicti630E → Q in BAE25748 (PubMed:16141072).Curated1
Sequence conflicti630E → Q in AAH46459 (PubMed:15489334).Curated1
Sequence conflicti630E → Q in CAA54188 (PubMed:8262041).Curated1
Sequence conflicti705T → A in AAF22563 (Ref. 1) Curated1
Sequence conflicti705T → A in BAE25748 (PubMed:16141072).Curated1
Sequence conflicti705T → A in CAA54188 (PubMed:8262041).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_032192244 – 274Missing in isoform 5. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_032193422Missing in isoform 3. 1 Publication1
Alternative sequenceiVSP_032194458A → VWQGLPQSLPAQEAPGGARA RAPLPLWRLWEALQDHRSCA GPPACSLRREAFPLSPVRQA LQNQECPASTLPDTSGRKAP RVPVLQPRLPGEGLSGAACE APHRRETFQVLQVWPWLRGA WHTQPAPAH in isoform 4. 1 Publication1
Alternative sequenceiVSP_032195459 – 783Missing in isoform 4. 1 PublicationAdd BLAST325
Alternative sequenceiVSP_032196667 – 684DSHIM…QAGAG → RVWVRDGRITGLLGSPSG in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_032197685 – 783Missing in isoform 2. 1 PublicationAdd BLAST99

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF126967 mRNA Translation: AAF22563.1 Frameshift.
AK033285 mRNA Translation: BAC28222.1
AK144176 mRNA Translation: BAE25748.1 Different initiation.
BC046459 mRNA Translation: AAH46459.1
BC057011 mRNA Translation: AAH57011.1
BC071228 mRNA Translation: AAH71228.1 Frameshift.
X76858 mRNA Translation: CAA54188.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS28481.1 [Q8CCE9-3]

Protein sequence database of the Protein Information Resource

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PIRi
S41688

NCBI Reference Sequences

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RefSeqi
NP_001288713.1, NM_001301784.1 [Q8CCE9-1]
NP_031919.2, NM_007893.4 [Q8CCE9-3]
XP_011244570.1, XM_011246268.2 [Q8CCE9-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000056032; ENSMUSP00000062344; ENSMUSG00000024137 [Q8CCE9-3]
ENSMUST00000226941; ENSMUSP00000154444; ENSMUSG00000024137 [Q8CCE9-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
13560

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:13560

UCSC genome browser

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UCSCi
uc008avy.2, mouse [Q8CCE9-3]
uc008awa.2, mouse [Q8CCE9-1]
uc008awb.2, mouse [Q8CCE9-2]
uc012ami.2, mouse [Q8CCE9-5]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126967 mRNA Translation: AAF22563.1 Frameshift.
AK033285 mRNA Translation: BAC28222.1
AK144176 mRNA Translation: BAE25748.1 Different initiation.
BC046459 mRNA Translation: AAH46459.1
BC057011 mRNA Translation: AAH57011.1
BC071228 mRNA Translation: AAH71228.1 Frameshift.
X76858 mRNA Translation: CAA54188.1 Different initiation.
CCDSiCCDS28481.1 [Q8CCE9-3]
PIRiS41688
RefSeqiNP_001288713.1, NM_001301784.1 [Q8CCE9-1]
NP_031919.2, NM_007893.4 [Q8CCE9-3]
XP_011244570.1, XM_011246268.2 [Q8CCE9-5]

3D structure databases

SMRiQ8CCE9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi199353, 4 interactors
IntActiQ8CCE9, 1 interactor
MINTiQ8CCE9
STRINGi10090.ENSMUSP00000062344

PTM databases

iPTMnetiQ8CCE9
PhosphoSitePlusiQ8CCE9

Proteomic databases

PaxDbiQ8CCE9
PRIDEiQ8CCE9

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
23652, 101 antibodies

Genome annotation databases

EnsembliENSMUST00000056032; ENSMUSP00000062344; ENSMUSG00000024137 [Q8CCE9-3]
ENSMUST00000226941; ENSMUSP00000154444; ENSMUSG00000024137 [Q8CCE9-2]
GeneIDi13560
KEGGimmu:13560
UCSCiuc008avy.2, mouse [Q8CCE9-3]
uc008awa.2, mouse [Q8CCE9-1]
uc008awb.2, mouse [Q8CCE9-2]
uc012ami.2, mouse [Q8CCE9-5]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1877
MGIiMGI:109530, E4f1

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00840000129970
HOGENOMiCLU_002678_50_0_1
InParanoidiQ8CCE9
KOiK22401
OMAiMITHSSK
OrthoDBi1318335at2759
PhylomeDBiQ8CCE9
TreeFamiTF315387

Enzyme and pathway databases

UniPathwayiUPA00143

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
13560, 5 hits in 20 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
E4f1, mouse

Protein Ontology

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PROi
PR:Q8CCE9
RNActiQ8CCE9, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000024137, Expressed in head and 317 other tissues
ExpressionAtlasiQ8CCE9, baseline and differential
GenevisibleiQ8CCE9, MM

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 10 hits
SUPFAMiSSF57667, SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 7 hits
PS50157, ZINC_FINGER_C2H2_2, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE4F1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CCE9
Secondary accession number(s): Q05BH7
, Q3UNJ9, Q62065, Q6IR08, Q6PGI1, Q9QY56
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: October 7, 2020
This is version 157 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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