Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

von Willebrand factor A domain-containing protein 8

Gene

Vwa8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Exhibits ATPase activity in vitro.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi446 – 453ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATPase activity Source: UniProtKB
  • ATP binding Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
von Willebrand factor A domain-containing protein 8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Vwa8
Synonyms:Kiaa0564
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1919008 Vwa8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi446 – 453Missing : Loss of in vitro ATPase activity. 1 Publication8
Mutagenesisi509 – 514Missing : Loss of in vitro ATPase activity. 1 Publication6

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 45MitochondrionSequence analysisAdd BLAST45
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000034389246 – 1905von Willebrand factor A domain-containing protein 8Sequence analysisAdd BLAST1860

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8CC88

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8CC88

PeptideAtlas

More...
PeptideAtlasi
Q8CC88

PRoteomics IDEntifications database

More...
PRIDEi
Q8CC88

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8CC88

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8CC88

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is predominantly expressed in liver, kidney, pancreas, heart, and skeletal muscle (at protein level).1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by high fat diet (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000058997 Expressed in 228 organ(s), highest expression level in liver

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8CC88 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer (By similarity). Interacts with PEX7. Interacts with PEX5 in a PEX7-dependent manner (By similarity).By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
230127, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q8CC88, 5 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000048925

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8CC88

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8CC88

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1714 – 1896VWFAPROSITE-ProRule annotationAdd BLAST183

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 260Interaction with PEX7By similarityAdd BLAST260

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410ITV6 Eukaryota
ENOG410XSKP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006601

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000021003

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108018

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8CC88

Identification of Orthologs from Complete Genome Data

More...
OMAi
HEQQSNV

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0OY4

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8CC88

TreeFam database of animal gene trees

More...
TreeFami
TF300317

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011704 ATPase_dyneun-rel_AAA
IPR027417 P-loop_NTPase
IPR039891 VWA8
IPR002035 VWF_A
IPR036465 vWFA_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR21610 PTHR21610, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07728 AAA_5, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits
SM00327 VWA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 3 hits
SSF53300 SSF53300, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50234 VWFA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8CC88-1) [UniParc]FASTAAdd to basket
Also known as: VWA8a1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQSRLLLLGA PGGLGDVASR RVRLLLRQVL RGRPGGDQQR LEVRLLHSGA
60 70 80 90 100
TDSGETVSIG DVSYKLKTPK NPELVPQNYI SDSPAQSIVQ HLRWLMQKDL
110 120 130 140 150
LGQDVFLIGP PGPLRRSVAM QYLELTKREV EYIALSRDTT ETDLKQRREI
160 170 180 190 200
RAGTAFYIDQ CAVRAATEGR TLVLEGLEKA ERNVLPVLNN LLENREMQLE
210 220 230 240 250
DGRFLMSAER YDKLLQDHTK EELDAWKIVR VSENFRVIAL GLPVPRYSGN
260 270 280 290 300
PLDPPLRSRF QARDIYFLPF QDQLKLLYSV GANVSAEKIS QLLSFATTLC
310 320 330 340 350
SQESSTLGLP DFPLDSLPEA VQILDSFPMM SIEHALQWVY PYTLLLGHEG
360 370 380 390 400
KMAVEGVLKR FELQGSGHSL LPKEIVRVER MTDSHGSYAH VTIRVAGKEV
410 420 430 440 450
TIKVPAGTRA VNQPCAPDHF IQTVSHKQLL AEMVQSHMVK DICLIGGKGC
460 470 480 490 500
GKTVIAKNFA ALLGYSIEPI MLYQDMTARD LLQQRYTLPN GDTAWRSSPL
510 520 530 540 550
VSAAREGKLV LLDGIHRVNA GTLAVLQRLI HDRELSLYDG SRLLREDRYL
560 570 580 590 600
SLKEKLQLTD EQLQNRSIFP IHPSFRIIAL AEPPIVGSTT QQWLGPEFLT
610 620 630 640 650
MFFFHHMKPL VKSEEIQVIK ETVPNVPQEA LEKLLSVTHK LRETQDPTAQ
660 670 680 690 700
SLAASLSTRQ LLRISRRLSK YPSENLHDAI TKACLSRFLP SLAQSALEKN
710 720 730 740 750
LADAAIETNT EDSLEPELEN YKCEVVAGSL KIGAVSVPVH NAHEKMKVPD
760 770 780 790 800
VLFYDNVQHM VVMEDMLKDF VLGEHLLLVG NQGVGKNKIV DRFLHLLNRP
810 820 830 840 850
REYIQLHRDT TVQSLTLQPT VKGGLIVYED SPLVKAVKLG HILVVDEADK
860 870 880 890 900
APTNVTCILK TLVENGEMIL ADGRRIVADA ANVDGRENLV AIHPDFRMLA
910 920 930 940 950
LANRPGFPFL GNDFFGTLGD IFSCHAIDNP KPHSELSMLK QYGPDVPEPV
960 970 980 990 1000
LQKLVAAFGE LRNLADQGII NYPYSTREVV NIVKHLQKFP TEGLSSVVRN
1010 1020 1030 1040 1050
VFDFDSYNND MREILMNTLH KYGIPIGAKP TNVQLAKEFP LPEKTFMGYW
1060 1070 1080 1090 1100
IVGQTGNGMQ KVLCPAETNH VDIKGPVLVN MEKYPIEKHE ARFLSFTEEC
1110 1120 1130 1140 1150
TSWKFPLDEV NLICDIAVSH ENGEQTLYVA ACNPVSLYFM NMTGKNGFFV
1160 1170 1180 1190 1200
DFFDIFPRMA SGSWRPFVTV APLGSPLRGQ VVLHEEQSNA VLLLDTTGSA
1210 1220 1230 1240 1250
IRRLVLPTEE FTSKKSSWWS KEEGETYRMC KEFSHKNWVV FYKQTGNSLT
1260 1270 1280 1290 1300
VLDVLEGLAH TISLPINLRT VFLVAEDKWL LVENETNQKY LLTKPAHIGS
1310 1320 1330 1340 1350
EDTGACQLYM LKEELPSTGF GVTQETEFCI PDKVSSDQLS SENLTSAVGQ
1360 1370 1380 1390 1400
KIASPNRILS DENSHATIVV GFPDLMSPSE VYSWKRSSSL RQPSVTSMTM
1410 1420 1430 1440 1450
YTGKRTNATP RHNNCVTLTH TNQVVRILPP GEVPLKDLYP KDVTPPQTAG
1460 1470 1480 1490 1500
YIEVTDLQAK KLRYIPVPSA ESLSPYTAWI SAISDTDALL AEWDKSSVVT
1510 1520 1530 1540 1550
VDMGGRVRLW ETGLERLQQS LMEWRNMIGQ DSDKHVQITI ERDSNEDVSD
1560 1570 1580 1590 1600
PKHGKEDPDN MPHVGGNTWA GGTGGRDTAG LGGKGGPYRL DAGHPVYQVS
1610 1620 1630 1640 1650
EVEKDAVPED VKRAAREMAQ KAFQQRLKEI QMSEYDAATY ERFSSAVQRQ
1660 1670 1680 1690 1700
VHALRIILDN LQAKGKERQW LRHQATGELD DAKIIDGLAG EKSIYKRRGD
1710 1720 1730 1740 1750
LEPQLGSPQQ KPKRLRLVVD VSGSMYRFNG VDRRLERSME AVCMVMEAFE
1760 1770 1780 1790 1800
NYEEKFKYDI AGHSGDGYNI KLVPVNQIPK NNKQRLEILK TMHEHSQFCM
1810 1820 1830 1840 1850
SGDHTLEGTE HAIKDITTEE ADEYFVIILS DANLSRYGIN PARFAQILTS
1860 1870 1880 1890 1900
DPQVNAFAIF IGSLGDQAAR LQRTLPAGRS FIAMDTKKIP QILQQIFTST

MLSSI
Length:1,905
Mass (Da):213,421
Last modified:July 22, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i52A4ADA5E3E64D4E
GO
Isoform 2 (identifier: Q8CC88-2) [UniParc]FASTAAdd to basket
Also known as: VWA8b1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1039-1905: Missing.

Show »
Length:1,038
Mass (Da):116,185
Checksum:i29CAEC56490274E6
GO
Isoform 3 (identifier: Q8CC88-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1560: Missing.

Note: No experimental confirmation available.
Show »
Length:345
Mass (Da):38,630
Checksum:iB91E9D82504760C8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti294S → P in BAE32382 (PubMed:16141072).Curated1
Sequence conflicti555K → R in AAH19143 (PubMed:15489334).Curated1
Sequence conflicti724E → K in AAH19143 (PubMed:15489334).Curated1
Sequence conflicti890V → I in AAH19143 (PubMed:15489334).Curated1
Sequence conflicti1014I → V in BAE32382 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0347071 – 1560Missing in isoform 3. 1 PublicationAdd BLAST1560
Alternative sequenceiVSP_0347081039 – 1905Missing in isoform 2. 2 PublicationsAdd BLAST867

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK030028 mRNA Translation: BAC26746.1
AK033642 mRNA Translation: BAC28404.1
AK154108 mRNA Translation: BAE32382.1
AC155167 Genomic DNA No translation available.
AC124709 Genomic DNA No translation available.
AC139758 Genomic DNA No translation available.
BC019143 mRNA Translation: AAH19143.1
AK129164 mRNA Translation: BAC97974.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS49550.1 [Q8CC88-1]

NCBI Reference Sequences

More...
RefSeqi
NP_082182.1, NM_027906.1 [Q8CC88-1]
NP_776119.2, NM_173758.3 [Q8CC88-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.159651

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000040990; ENSMUSP00000048925; ENSMUSG00000058997 [Q8CC88-1]
ENSMUST00000227255; ENSMUSP00000154270; ENSMUSG00000058997 [Q8CC88-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
219189

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:219189

UCSC genome browser

More...
UCSCi
uc007usp.2 mouse [Q8CC88-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030028 mRNA Translation: BAC26746.1
AK033642 mRNA Translation: BAC28404.1
AK154108 mRNA Translation: BAE32382.1
AC155167 Genomic DNA No translation available.
AC124709 Genomic DNA No translation available.
AC139758 Genomic DNA No translation available.
BC019143 mRNA Translation: AAH19143.1
AK129164 mRNA Translation: BAC97974.1
CCDSiCCDS49550.1 [Q8CC88-1]
RefSeqiNP_082182.1, NM_027906.1 [Q8CC88-1]
NP_776119.2, NM_173758.3 [Q8CC88-2]
UniGeneiMm.159651

3D structure databases

ProteinModelPortaliQ8CC88
SMRiQ8CC88
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230127, 1 interactor
IntActiQ8CC88, 5 interactors
STRINGi10090.ENSMUSP00000048925

PTM databases

iPTMnetiQ8CC88
PhosphoSitePlusiQ8CC88

Proteomic databases

EPDiQ8CC88
PaxDbiQ8CC88
PeptideAtlasiQ8CC88
PRIDEiQ8CC88

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040990; ENSMUSP00000048925; ENSMUSG00000058997 [Q8CC88-1]
ENSMUST00000227255; ENSMUSP00000154270; ENSMUSG00000058997 [Q8CC88-2]
GeneIDi219189
KEGGimmu:219189
UCSCiuc007usp.2 mouse [Q8CC88-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23078
MGIiMGI:1919008 Vwa8

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiENOG410ITV6 Eukaryota
ENOG410XSKP LUCA
GeneTreeiENSGT00390000006601
HOGENOMiHOG000021003
HOVERGENiHBG108018
InParanoidiQ8CC88
OMAiHEQQSNV
OrthoDBiEOG091G0OY4
PhylomeDBiQ8CC88
TreeFamiTF300317

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8CC88

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000058997 Expressed in 228 organ(s), highest expression level in liver
GenevisibleiQ8CC88 MM

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011704 ATPase_dyneun-rel_AAA
IPR027417 P-loop_NTPase
IPR039891 VWA8
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PANTHERiPTHR21610 PTHR21610, 1 hit
PfamiView protein in Pfam
PF07728 AAA_5, 3 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SM00327 VWA, 1 hit
SUPFAMiSSF52540 SSF52540, 3 hits
SSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50234 VWFA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVWA8_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CC88
Secondary accession number(s): Q3U4P9
, Q6ZQ94, Q8CDH8, Q8VCU3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: December 5, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again