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Protein

Codanin-1

Gene

Cdan1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a negative regulator of ASF1 in chromatin assembly.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Codanin-1
Gene namesi
Name:Cdan1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1916218 Cdan1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei317 – 337HelicalSequence analysisAdd BLAST21
Transmembranei631 – 651HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Embryonic lethal; embryos die before 7.5 days of gestation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000894402 – 1239Codanin-1Add BLAST1238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei70PhosphothreonineBy similarity1
Modified residuei270PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ8CC12
PeptideAtlasiQ8CC12
PRIDEiQ8CC12

PTM databases

iPTMnetiQ8CC12
PhosphoSitePlusiQ8CC12

Expressioni

Tissue specificityi

Widely expressed in adult mice, the highest levels can be measured in erythropoietic cells.1 Publication

Developmental stagei

Expressed ubiquitously during early embryogenesis.1 Publication

Gene expression databases

BgeeiENSMUSG00000027284 Expressed in 236 organ(s), highest expression level in embryo
ExpressionAtlasiQ8CC12 baseline and differential
GenevisibleiQ8CC12 MM

Interactioni

Subunit structurei

Interacts with ASF1A and ASF1B. Found in a cytosolic complex with ASF1A, ASF1B, IPO4 and histones H3.1 and H4.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000106329

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni193 – 213Interaction with ASF1A/BBy similarityAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi748 – 751Poly-Leu4

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGHV Eukaryota
ENOG410XXWY LUCA
GeneTreeiENSGT00390000000491
HOGENOMiHOG000111492
HOVERGENiHBG107631
InParanoidiQ8CC12
KOiK19531
OrthoDBiEOG091G03X8
PhylomeDBiQ8CC12
TreeFamiTF328405

Family and domain databases

InterProiView protein in InterPro
IPR040031 Codanin-1
IPR028171 Codanin-1_C
PANTHERiPTHR28678 PTHR28678, 1 hit
PfamiView protein in Pfam
PF15296 Codanin-1_C, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8CC12-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAVLESLLR EEVPVAAAVR WIARSTPSSE DSSEVAALSA LRPLRKEFVP
60 70 80 90 100
FLLNFLREQS SRVLPQGPST PAKTPVASAA LPARQGAPAR GGRGARSQLF
110 120 130 140 150
PAAEPLSAAA EAPLARRAGR RRGPGPGPSR ERGGRGSGAA EEGASGESPP
160 170 180 190 200
WAGGRKPKGS GSPGSPRLSL SDPPNLSNLE EFPPVGTVPP GSAGRTKPSR
210 220 230 240 250
RINPTPVSEE RSLSKPKTCF TSPPISCVPS SQPSTLDTSP WGLGLPPGCR
260 270 280 290 300
SLQEEREMLR KARTKQLQQS PTPASPIPES GSPVPSRTGN LTAEPADPAR
310 320 330 340 350
VSSRQRLELV ALIYSSCIAE NLVPNLFLEL FFVLQLLTAR RMVATKDSDL
360 370 380 390 400
ESSQGALDSL DTPLFRSIHD CVFFAVQVLE HQFQVLSYLD KGTLKLLAEN
410 420 430 440 450
ERLLCFSPAL QGRLRAAYEG SVAKVSLVIP PSAQAVSFQP ETDNRANFSS
460 470 480 490 500
DRAFHTFKKQ RDVFYEVLRE WEDHHEEPSW DFEKGLGSRI RAMMGQLSAA
510 520 530 540 550
CSHSHFVRLF QKQLLQMCQS PGGAGGSVLG EAPDVLNMLG ADKLGRLRQL
560 570 580 590 600
QERLIAPQSS GGPCPPPTFP GCQGFFRDFI MSASSFHFNQ HLMDSLSLKI
610 620 630 640 650
RELNGLRLPQ HEPGDEDGES DMDWQGERRQ FAVVLLSLRL LAKFLGFVAF
660 670 680 690 700
LPYRGHEPPP TRELQDSILA LRSQVPPVLD IRALLQQGLW ARRAVLTVPW
710 720 730 740 750
LVEFLSFADH IVPLLDYYRS VFTLLLRLHR SLVLSKENEG EMCFLNKLLL
760 770 780 790 800
LAVLGWLFQI PTVPEDLFFL EDGQVDAFEV TTTASEHGLD SVPVVDQQLL
810 820 830 840 850
YTCCPYIGEL RKLLASWVSG SSGRSGGFVR KITPTTTSSL GALPLQTSQG
860 870 880 890 900
LQAQLAEAFF HNQPPSLRRT VEFVAERIGS NCVKHIKATL VADLVHQAES
910 920 930 940 950
LLQEQLVARG QEGGDPAQLL ESLCSQLCPH GAQALTQGRE FCQRKSPTAV
960 970 980 990 1000
RALLPEETPA AVLSSAENIA VGLATEKACS WLSANITALI RREVKAAVSR
1010 1020 1030 1040 1050
MLRAQGPEPT ARVERRGCSR ACEHHAPLPS HLISEIKFHH CSLQDVLSLA
1060 1070 1080 1090 1100
AGPRDPEEGV SPEHLEQLLN QMGQSLRCRQ FLCPTAEQHL AKCSVELASL
1110 1120 1130 1140 1150
LVADQIPILG PPTQHRLERG HARRLLHMLL SLWKDDFQGP VPLQLLLSPR
1160 1170 1180 1190 1200
NVGLLADTRP REWDLLLFLL RELVEKDLMG HLEIEACLGR LNEAQWPGDF
1210 1220 1230
SEELSTLFRL FLAEPHLLEP QLRACELMQP NRGTVLAQS
Length:1,239
Mass (Da):135,883
Last modified:July 24, 2007 - v2
Checksum:i7A07DFAB1CBB7FB9
GO
Isoform 2 (identifier: Q8CC12-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1038-1044: Missing.

Show »
Length:1,232
Mass (Da):135,030
Checksum:i110402EDED275C4E
GO
Isoform 3 (identifier: Q8CC12-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-341: Missing.

Show »
Length:898
Mass (Da):99,996
Checksum:iCD697786539D2F18
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Z4YL55Z4YL55_MOUSE
Codanin-1
Cdan1
1,232Annotation score:

Sequence cautioni

The sequence BAE34023 differs from that shown. Reason: Frameshift at position 106.Curated
The sequence CAM21399 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti140A → P in BAE34023 (PubMed:19468303).Curated1
Sequence conflicti1220P → L in BAE34023 (PubMed:19468303).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0270991 – 341Missing in isoform 3. 1 PublicationAdd BLAST341
Alternative sequenceiVSP_0271001038 – 1044Missing in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034144 mRNA Translation: BAC28605.1
AK157271 mRNA Translation: BAE34023.1 Frameshift.
AL935168 Genomic DNA Translation: CAM21399.1 Sequence problems.
BC117555 mRNA Translation: AAI17556.1
CCDSiCCDS38212.1 [Q8CC12-1]
RefSeqiNP_081167.2, NM_026891.2 [Q8CC12-1]
UniGeneiMm.2289

Genome annotation databases

EnsembliENSMUST00000110701; ENSMUSP00000106329; ENSMUSG00000027284 [Q8CC12-1]
GeneIDi68968
KEGGimmu:68968
UCSCiuc008lwu.1 mouse [Q8CC12-1]
uc008lwv.1 mouse [Q8CC12-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034144 mRNA Translation: BAC28605.1
AK157271 mRNA Translation: BAE34023.1 Frameshift.
AL935168 Genomic DNA Translation: CAM21399.1 Sequence problems.
BC117555 mRNA Translation: AAI17556.1
CCDSiCCDS38212.1 [Q8CC12-1]
RefSeqiNP_081167.2, NM_026891.2 [Q8CC12-1]
UniGeneiMm.2289

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000106329

PTM databases

iPTMnetiQ8CC12
PhosphoSitePlusiQ8CC12

Proteomic databases

PaxDbiQ8CC12
PeptideAtlasiQ8CC12
PRIDEiQ8CC12

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000110701; ENSMUSP00000106329; ENSMUSG00000027284 [Q8CC12-1]
GeneIDi68968
KEGGimmu:68968
UCSCiuc008lwu.1 mouse [Q8CC12-1]
uc008lwv.1 mouse [Q8CC12-2]

Organism-specific databases

CTDi146059
MGIiMGI:1916218 Cdan1

Phylogenomic databases

eggNOGiENOG410IGHV Eukaryota
ENOG410XXWY LUCA
GeneTreeiENSGT00390000000491
HOGENOMiHOG000111492
HOVERGENiHBG107631
InParanoidiQ8CC12
KOiK19531
OrthoDBiEOG091G03X8
PhylomeDBiQ8CC12
TreeFamiTF328405

Miscellaneous databases

PROiPR:Q8CC12
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027284 Expressed in 236 organ(s), highest expression level in embryo
ExpressionAtlasiQ8CC12 baseline and differential
GenevisibleiQ8CC12 MM

Family and domain databases

InterProiView protein in InterPro
IPR040031 Codanin-1
IPR028171 Codanin-1_C
PANTHERiPTHR28678 PTHR28678, 1 hit
PfamiView protein in Pfam
PF15296 Codanin-1_C, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCDAN1_MOUSE
AccessioniPrimary (citable) accession number: Q8CC12
Secondary accession number(s): A2AW10, Q149P8, Q3U032
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: July 24, 2007
Last modified: November 7, 2018
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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