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Protein

Dynactin subunit 4

Gene

Dctn4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.

GO - Molecular functioni

GO - Biological processi

  • nuclear migration Source: GO_Central

Enzyme and pathway databases

ReactomeiR-MMU-2132295 MHC class II antigen presentation
R-MMU-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811436 COPI-independent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Dynactin subunit 4
Alternative name(s):
Dynactin subunit p62
Gene namesi
Name:Dctn4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1914915 Dctn4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000798242 – 467Dynactin subunit 4Add BLAST466

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei203PhosphoserineBy similarity1
Cross-linki222Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei414PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ8CBY8
PeptideAtlasiQ8CBY8
PRIDEiQ8CBY8

PTM databases

iPTMnetiQ8CBY8
PhosphoSitePlusiQ8CBY8
SwissPalmiQ8CBY8

Expressioni

Gene expression databases

BgeeiENSMUSG00000024603 Expressed in 265 organ(s), highest expression level in cumulus cell
CleanExiMM_DCTN4
ExpressionAtlasiQ8CBY8 baseline and differential
GenevisibleiQ8CBY8 MM

Interactioni

Subunit structurei

Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10 (By similarity). Binds directly to the ACTR1A subunit of dynactin (By similarity). Interacts with ATP7B, but not ATP7A, in a copper-dependent manner (By similarity). Interacts with ANK2; this interaction is required for localization at costameres.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212349, 14 interactors
IntActiQ8CBY8, 17 interactors
MINTiQ8CBY8
STRINGi10090.ENSMUSP00000025505

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili152 – 172Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the dynactin subunit 4 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3896 Eukaryota
ENOG410ZCK8 LUCA
GeneTreeiENSGT00390000006954
HOGENOMiHOG000007947
HOVERGENiHBG051324
InParanoidiQ8CBY8
KOiK10426
OMAiNCLENIP
PhylomeDBiQ8CBY8
TreeFamiTF105249

Family and domain databases

InterProiView protein in InterPro
IPR008603 DCTN4
PANTHERiPTHR13034 PTHR13034, 1 hit
PfamiView protein in Pfam
PF05502 Dynactin_p62, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8CBY8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASLLQSERV LYLVQGEKKV RAPLSQLYFC RYCSELRSLE CVSHEVDSHY
60 70 80 90 100
CPSCLENMPS AEAKLKKNRC ANCFDCPGCM HTLSTRATSI STQLPDDPAK
110 120 130 140 150
TTMKKAYYLA CGFCRWTSRD VGMADKSVAS GGWQEPENPH TQRMNKLIEY
160 170 180 190 200
YQQLAQKEKV ERDRKKLARR RNYMPLAFSQ HTIHVVDKYS LGTRLQRPRA
210 220 230 240 250
GASISTLAGL SLREGEDQKE VKIEPAQAVA EVEPLPEDYY TRPVNLTEVT
260 270 280 290 300
TLQQRLLQPD LQPVSASQLY PRHKHLLIKR SLRCRKCEHN LSKPEFNPTS
310 320 330 340 350
IKFKIQLVAV NYIPEVRIMS IPNLRYMKES QVLLTLTNPV ENLTHVTLLE
360 370 380 390 400
CDEGDPDNIN STAKVVVPPK ELILAGKDAA AEYDELAEPQ DFQDDPDIVA
410 420 430 440 450
FRKANKVGIF IKVTPQREEG EVTVCFKMKH DFKNLAAPIR PVEEGDQGTE
460
VIWLTQHVEL SFGPLLP
Length:467
Mass (Da):53,057
Last modified:March 1, 2003 - v1
Checksum:iEE026ABB13B62F9E
GO
Isoform 2 (identifier: Q8CBY8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     180-186: Missing.

Show »
Length:460
Mass (Da):52,242
Checksum:iB9CC87B4D447082B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3TRR2Q3TRR2_MOUSE
Dynactin subunit 4
Dctn4
48Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013573180 – 186Missing in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016059 mRNA Translation: BAB30095.1
AK034292 mRNA Translation: BAC28661.1
BC006677 mRNA Translation: AAH06677.1
BC034725 mRNA Translation: AAH34725.1
CCDSiCCDS37832.1 [Q8CBY8-2]
RefSeqiNP_080578.1, NM_026302.3 [Q8CBY8-2]
XP_006526252.1, XM_006526189.3
UniGeneiMm.272801

Genome annotation databases

EnsembliENSMUST00000025505; ENSMUSP00000025505; ENSMUSG00000024603 [Q8CBY8-2]
ENSMUST00000223984; ENSMUSP00000153008; ENSMUSG00000024603 [Q8CBY8-1]
GeneIDi67665
KEGGimmu:67665
UCSCiuc008fak.1 mouse [Q8CBY8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016059 mRNA Translation: BAB30095.1
AK034292 mRNA Translation: BAC28661.1
BC006677 mRNA Translation: AAH06677.1
BC034725 mRNA Translation: AAH34725.1
CCDSiCCDS37832.1 [Q8CBY8-2]
RefSeqiNP_080578.1, NM_026302.3 [Q8CBY8-2]
XP_006526252.1, XM_006526189.3
UniGeneiMm.272801

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212349, 14 interactors
IntActiQ8CBY8, 17 interactors
MINTiQ8CBY8
STRINGi10090.ENSMUSP00000025505

PTM databases

iPTMnetiQ8CBY8
PhosphoSitePlusiQ8CBY8
SwissPalmiQ8CBY8

Proteomic databases

PaxDbiQ8CBY8
PeptideAtlasiQ8CBY8
PRIDEiQ8CBY8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025505; ENSMUSP00000025505; ENSMUSG00000024603 [Q8CBY8-2]
ENSMUST00000223984; ENSMUSP00000153008; ENSMUSG00000024603 [Q8CBY8-1]
GeneIDi67665
KEGGimmu:67665
UCSCiuc008fak.1 mouse [Q8CBY8-1]

Organism-specific databases

CTDi51164
MGIiMGI:1914915 Dctn4

Phylogenomic databases

eggNOGiKOG3896 Eukaryota
ENOG410ZCK8 LUCA
GeneTreeiENSGT00390000006954
HOGENOMiHOG000007947
HOVERGENiHBG051324
InParanoidiQ8CBY8
KOiK10426
OMAiNCLENIP
PhylomeDBiQ8CBY8
TreeFamiTF105249

Enzyme and pathway databases

ReactomeiR-MMU-2132295 MHC class II antigen presentation
R-MMU-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811436 COPI-independent Golgi-to-ER retrograde traffic

Miscellaneous databases

PROiPR:Q8CBY8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024603 Expressed in 265 organ(s), highest expression level in cumulus cell
CleanExiMM_DCTN4
ExpressionAtlasiQ8CBY8 baseline and differential
GenevisibleiQ8CBY8 MM

Family and domain databases

InterProiView protein in InterPro
IPR008603 DCTN4
PANTHERiPTHR13034 PTHR13034, 1 hit
PfamiView protein in Pfam
PF05502 Dynactin_p62, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiDCTN4_MOUSE
AccessioniPrimary (citable) accession number: Q8CBY8
Secondary accession number(s): Q923A0, Q9D4X0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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