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Protein

Leukocyte receptor cluster member 8 homolog

Gene

Leng8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte receptor cluster member 8 homolog
Gene namesi
Name:Leng8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2142195 Leng8

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003063922 – 785Leukocyte receptor cluster member 8 homologAdd BLAST784

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei352PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8CBY3
PaxDbiQ8CBY3
PRIDEiQ8CBY3

PTM databases

iPTMnetiQ8CBY3
PhosphoSitePlusiQ8CBY3

Expressioni

Gene expression databases

BgeeiENSMUSG00000035545
CleanExiMM_LENG8
ExpressionAtlasiQ8CBY3 baseline and differential
GenevisibleiQ8CBY3 MM

Interactioni

Subunit structurei

May be part of a SEM1-containing complex.By similarity

Protein-protein interaction databases

BioGridi231296, 1 interactor
IntActiQ8CBY3, 1 interactor
MINTiQ8CBY3
STRINGi10090.ENSMUSP00000046465

Structurei

3D structure databases

ProteinModelPortaliQ8CBY3
SMRiQ8CBY3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini637 – 785PCIPROSITE-ProRule annotationAdd BLAST149

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi70 – 174Gln-richAdd BLAST105
Compositional biasi413 – 447Ser-richAdd BLAST35

Phylogenomic databases

eggNOGiKOG1861 Eukaryota
ENOG410YVEM LUCA
GeneTreeiENSGT00390000008006
HOGENOMiHOG000001575
HOVERGENiHBG070702
InParanoidiQ8CBY3
TreeFamiTF312927

Family and domain databases

InterProiView protein in InterPro
IPR000717 PCI_dom
IPR005062 SAC3/GANP/THP3
PfamiView protein in Pfam
PF03399 SAC3_GANP, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8CBY3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAANVGDQRA ADWSSQYSMV TGNSRENGME TPMHENPEWE KARQALASIS
60 70 80 90 100
KAGATSSSKA SSSGPVASAQ YVSQAEASAL QQQQQQYYQW YQQYNYAYPY
110 120 130 140 150
SYYYPMSMYQ SYGSPSQYGM ASSYGSATAQ QPSAPQHQGT LNQPPVPGMD
160 170 180 190 200
ESMAYQASPQ QLPAAQPPQP SNSQHGTHSL SNGPQPGTAP STQHSQAGAP
210 220 230 240 250
TGQAYGPHSY SEPAKPKKGQ QLWTRMKPAP GTGGLKFNIQ KRPFAVTSQS
260 270 280 290 300
FSSNSEGQHS SFGPQPNSEN TQNRSGPSGR GNLSGKPDDW PQDMKEYVER
310 320 330 340 350
CFTACESEED KDRTEKLLKE VLQARLQDGS AYTIDWSREP LPGLTREPVA
360 370 380 390 400
ESPKKKRWEA PSSLHPSRGA GSVTRGGGAQ SQRGTPGAGG AGRARGSSFT
410 420 430 440 450
KFGNRNVFMK DNSSSSSTDS RSRSSSRSPT RHFRRSDSHS DSDSSYSGNE
460 470 480 490 500
CHPVGRRNPP PKGRGGRGAH MDRGRGRAQR GKRHDLAPTK RSRKKMAALE
510 520 530 540 550
CEDPERELKK QKRAARFQHG HSRRLRLEPL VLQMSNLESS GADPDWQELQ
560 570 580 590 600
IVGTCPDITK HYLRLTCAPD PSTVRPVAVL KKSLCMVKSH WKEKQDYAFA
610 620 630 640 650
CEQMKSIRQD LTVQGIRTEF TVEVYETHAR IALEKGDHEE FNQCQTQLKS
660 670 680 690 700
LYAENLAGNV GEFTAYRILY YIFTKNSGDI TTELAYLTRE MKADPCVAHA
710 720 730 740 750
LALRAAWALG NYHRFFRLYC HAPCMSGYLV DKFADRERKA ALKAMIKTYV
760 770 780
ALHSAAFCAV ALPRPLRILV SLQLLCWSPL PVPCS
Length:785
Mass (Da):86,767
Last modified:March 1, 2003 - v1
Checksum:iD2C6AA92B0D5AC25
GO
Isoform 3 (identifier: Q8CBY3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     107-126: SMYQSYGSPSQYGMASSYGS → VRTWLQGGSLLSGWANGWLG
     127-785: Missing.

Show »
Length:126
Mass (Da):14,031
Checksum:iA263E7DF30960B61
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti754S → P in BAE41922 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_028464107 – 126SMYQS…SSYGS → VRTWLQGGSLLSGWANGWLG in isoform 3. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_028465127 – 785Missing in isoform 3. 1 PublicationAdd BLAST659

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034310 mRNA Translation: BAC28671.1
AK085304 mRNA Translation: BAC39415.1
AK170629 mRNA Translation: BAE41922.1
BC042658 mRNA Translation: AAH42658.1
BC066768 mRNA Translation: AAH66768.1
CCDSiCCDS20731.1 [Q8CBY3-1]
RefSeqiNP_766324.1, NM_172736.3 [Q8CBY3-1]
UniGeneiMm.22831

Genome annotation databases

EnsembliENSMUST00000037472; ENSMUSP00000046465; ENSMUSG00000035545 [Q8CBY3-1]
ENSMUST00000117274; ENSMUSP00000113223; ENSMUSG00000035545 [Q8CBY3-3]
GeneIDi232798
KEGGimmu:232798
UCSCiuc009exb.1 mouse [Q8CBY3-3]
uc009exc.1 mouse [Q8CBY3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiLENG8_MOUSE
AccessioniPrimary (citable) accession number: Q8CBY3
Secondary accession number(s): Q3TCN4, Q8C3P0, Q8CGB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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