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Entry version 107 (16 Oct 2019)
Sequence version 1 (01 Mar 2003)
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Protein

Calcium permeable stress-gated cation channel 1

Gene

Tmem63c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as an osmosensitive calcium-permeable cation channel.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcium permeable stress-gated cation channel 1
Alternative name(s):
Transmembrane protein 63C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tmem63c
Synonyms:CSC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2444386 Tmem63c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Transmembranei135 – 155HelicalSequence analysisAdd BLAST21
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Transmembranei409 – 429HelicalSequence analysisAdd BLAST21
Transmembranei455 – 475HelicalSequence analysisAdd BLAST21
Transmembranei494 – 514HelicalSequence analysisAdd BLAST21
Transmembranei540 – 560HelicalSequence analysisAdd BLAST21
Transmembranei604 – 624HelicalSequence analysisAdd BLAST21
Transmembranei655 – 675HelicalSequence analysisAdd BLAST21
Transmembranei685 – 705HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002807311 – 802Calcium permeable stress-gated cation channel 1Add BLAST802

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei75PhosphoserineCombined sources1
Modified residuei78PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8CBX0

PRoteomics IDEntifications database

More...
PRIDEi
Q8CBX0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8CBX0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8CBX0

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8CBX0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000034145 Expressed in 72 organ(s), highest expression level in cerebellum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8CBX0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8CBX0 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000119872

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1134 Eukaryota
COG5594 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159072

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000006559

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8CBX0

KEGG Orthology (KO)

More...
KOi
K21989

Identification of Orthologs from Complete Genome Data

More...
OMAi
WPAFQTS

Database of Orthologous Groups

More...
OrthoDBi
395194at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8CBX0

TreeFam database of animal gene trees

More...
TreeFami
TF324300

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032880 Csc1_N
IPR027815 PHM7_cyt
IPR003864 RSN1_7TM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14703 PHM7_cyt, 1 hit
PF02714 RSN1_7TM, 1 hit
PF13967 RSN1_TM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8CBX0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAFPDSMDQ KFHNMTVNEC FQSRSTVLQG QPFGGIPTVL VLNIILWVFV
60 70 80 90 100
VLLYSFLRKA AWDYGRLALL IHNDSLTSLI YGEQSEKSSP SEVSLEAERR
110 120 130 140 150
DRGFSSWFFN SLTMRDRDLI NKCGDDARIY ITFQYHLIIF VLILCIPSLG
160 170 180 190 200
IILPVNYIGT VLDWNSHFGR TTIVNVSTES KFLWLHSLFA FLYFLINLAF
210 220 230 240 250
MGHHCLGFVP KKSLHFTRTL MITYVPTEIQ DPEIISKHFH EAYPGCVVTR
260 270 280 290 300
VHFCYDVRNL IDLDDQRRHA MRGRLYYTAK AKKTGKVMIK THPCSRLCFC
310 320 330 340 350
KCWTCFKEVD AEQYYSELEE QLTDEFNAEL NRVQLKRLDL IFVTFQDART
360 370 380 390 400
VRRIYDDYKY IHCGRHPKQS SVTTIVKNYH WRVAHAPHPK DIIWKHLSIR
410 420 430 440 450
RFSWWTRFIA INTFLFFLFF FLTTPAIIIN TIDIYNVTRP IEKLQSPIVT
460 470 480 490 500
QFFPSVLLWA FTVTMPLLVY LSAFLEAHWT RSSQNLIIVH KCYIFLVFMV
510 520 530 540 550
VILPSMGLTS LHVFLRWLFD IYYLEHATIR FQCVFLPDNG AFFINYVITA
560 570 580 590 600
ALLGTGMELM RLGSLCTYCT RLFLSKSEPE RVHIRKNQAT DFQFGREYAW
610 620 630 640 650
MLNVFSVVMA YSITCPIIVP FGLLYLCMKH ITDRYNMYYS YAPTKLNAQI
660 670 680 690 700
HMAAVYQAIF APLLGLFWML FFSILRVGSL HSITLFSMSS LIISVVIAFS
710 720 730 740 750
GVFLGKLRIA QRYEQPEEET ETVFDVEPSS TTSTPTSLLY VATVLQEPEL
760 770 780 790 800
NLTPASSPAR HTYGTINSQP EEGEEESGLR GFARELDSAQ FQEGLEMEGQ

SH
Length:802
Mass (Da):93,011
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i861020EE3B05EA5A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RI74D6RI74_MOUSE
Calcium permeable stress-gated cati...
Tmem63c mCG_19982
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z6R7D3Z6R7_MOUSE
Calcium permeable stress-gated cati...
Tmem63c
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK034410 mRNA Translation: BAC28698.1
BC056936 mRNA Translation: AAH56936.1
BC057088 mRNA Translation: AAH57088.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS26069.1

NCBI Reference Sequences

More...
RefSeqi
NP_766171.1, NM_172583.2
XP_006515779.1, XM_006515716.3
XP_006515780.1, XM_006515717.3
XP_006515781.1, XM_006515718.3
XP_006515783.1, XM_006515720.2
XP_011242383.1, XM_011244081.2
XP_011242384.1, XM_011244082.2
XP_011242385.1, XM_011244083.2
XP_011242386.1, XM_011244084.2
XP_011242387.1, XM_011244085.2
XP_011242388.1, XM_011244086.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000110187; ENSMUSP00000105816; ENSMUSG00000034145
ENSMUST00000131878; ENSMUSP00000117023; ENSMUSG00000034145
ENSMUST00000146292; ENSMUSP00000119872; ENSMUSG00000034145

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
217733

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:217733

UCSC genome browser

More...
UCSCi
uc007oig.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034410 mRNA Translation: BAC28698.1
BC056936 mRNA Translation: AAH56936.1
BC057088 mRNA Translation: AAH57088.1
CCDSiCCDS26069.1
RefSeqiNP_766171.1, NM_172583.2
XP_006515779.1, XM_006515716.3
XP_006515780.1, XM_006515717.3
XP_006515781.1, XM_006515718.3
XP_006515783.1, XM_006515720.2
XP_011242383.1, XM_011244081.2
XP_011242384.1, XM_011244082.2
XP_011242385.1, XM_011244083.2
XP_011242386.1, XM_011244084.2
XP_011242387.1, XM_011244085.2
XP_011242388.1, XM_011244086.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000119872

PTM databases

iPTMnetiQ8CBX0
PhosphoSitePlusiQ8CBX0
SwissPalmiQ8CBX0

Proteomic databases

PaxDbiQ8CBX0
PRIDEiQ8CBX0

Genome annotation databases

EnsembliENSMUST00000110187; ENSMUSP00000105816; ENSMUSG00000034145
ENSMUST00000131878; ENSMUSP00000117023; ENSMUSG00000034145
ENSMUST00000146292; ENSMUSP00000119872; ENSMUSG00000034145
GeneIDi217733
KEGGimmu:217733
UCSCiuc007oig.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57156
MGIiMGI:2444386 Tmem63c

Phylogenomic databases

eggNOGiKOG1134 Eukaryota
COG5594 LUCA
GeneTreeiENSGT00940000159072
HOGENOMiHOG000006559
InParanoidiQ8CBX0
KOiK21989
OMAiWPAFQTS
OrthoDBi395194at2759
PhylomeDBiQ8CBX0
TreeFamiTF324300

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Tmem63c mouse

Protein Ontology

More...
PROi
PR:Q8CBX0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000034145 Expressed in 72 organ(s), highest expression level in cerebellum
ExpressionAtlasiQ8CBX0 baseline and differential
GenevisibleiQ8CBX0 MM

Family and domain databases

InterProiView protein in InterPro
IPR032880 Csc1_N
IPR027815 PHM7_cyt
IPR003864 RSN1_7TM
PfamiView protein in Pfam
PF14703 PHM7_cyt, 1 hit
PF02714 RSN1_7TM, 1 hit
PF13967 RSN1_TM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSC1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CBX0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 1, 2003
Last modified: October 16, 2019
This is version 107 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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