UniProtKB - Q8CBW3 (ABI1_MOUSE)
Abl interactor 1
Abi1
Functioni
GO - Molecular functioni
- protein tyrosine kinase activator activity Source: MGI
- SH3 domain binding Source: MGI
- transcription factor binding Source: MGI
GO - Biological processi
- actin polymerization or depolymerization Source: InterPro
- dendrite morphogenesis Source: MGI
- lamellipodium morphogenesis Source: MGI
- megakaryocyte development Source: MGI
- peptidyl-tyrosine phosphorylation Source: MGI
- postsynapse to nucleus signaling pathway Source: MGI
- somitogenesis Source: MGI
Names & Taxonomyi
Protein namesi | Recommended name: Abl interactor 1Alternative name(s): Abelson interactor 1 Short name: Abi-1 Ablphilin-1 Eps8 SH3 domain-binding protein Short name: Eps8-binding protein Spectrin SH3 domain-binding protein 1 e3B1 |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:104913, Abi1 |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Nucleus
- Nucleus By similarity
Other locations
- Cytoplasm By similarity
- lamellipodium By similarity
- filopodium By similarity
- growth cone By similarity
- postsynaptic density By similarity
Note: Localized to protruding lamellipodia and filopodia tips. Also localized to neuronal growth cones and synaptosomes. May shuttle from the postsynaptic densities to the nucleus (By similarity).By similarity
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Cytosol
- cytosol Source: MGI
Nucleus
- nucleus Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- aggresome Source: MGI
- cell junction Source: MGI
- cell leading edge Source: MGI
- filopodium tip Source: MGI
- glutamatergic synapse Source: MGI
- growth cone Source: UniProtKB-SubCell
- lamellipodium Source: MGI
- neuron projection Source: BHF-UCL
- postsynaptic density Source: MGI
- SCAR complex Source: MGI
Keywords - Cellular componenti
Cell junction, Cell projection, Cytoplasm, Cytoskeleton, Nucleus, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000191788 | 2 – 481 | Abl interactor 1Add BLAST | 480 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 53 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 174 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 178 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 183 | PhosphoserineCombined sources | 1 | |
Modified residuei | 187 | PhosphoserineBy similarity | 1 | |
Modified residuei | 213 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 215 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 216 | PhosphoserineBy similarity | 1 | |
Modified residuei | 222 | PhosphoserineBy similarity | 1 | |
Modified residuei | 225 | PhosphoserineBy similarity | 1 | |
Modified residuei | 292 | PhosphoserineBy similarity | 1 | |
Modified residuei | 296 | PhosphoserineBy similarity | 1 | |
Modified residuei | 428 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 439 | PhosphoserineBy similarity | 1 | |
Modified residuei | 480 | PhosphothreonineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
jPOSTi | Q8CBW3 |
PaxDbi | Q8CBW3 |
PRIDEi | Q8CBW3 |
PTM databases
iPTMneti | Q8CBW3 |
PhosphoSitePlusi | Q8CBW3 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSMUSG00000058835, Expressed in CA1 field of hippocampus and 294 other tissues |
ExpressionAtlasi | Q8CBW3, baseline and differential |
Genevisiblei | Q8CBW3, MM |
Interactioni
Subunit structurei
Interacts with ENAH, Abelson murine leukemia virus V-ABL, ABL1, STX1A, SNAP25, VAMP2, and through its N-terminus with WASF1.
Part of a complex consisting of ABI1, STX1A and SNAP25.
Part of a complex consisting of ABI1, EPS8 and SOS1.
Interacts with EPS8, SOS1, SOS2, GRB2, SPTA1, and the first SH3 domain of NCK1 (By similarity).
Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 (NCKAP1l/HEM1 in hematopoietic cells) and WASF2/WAVE2.
Interacts (via SH3 domain) with SHANK2 and SHANK3, but not SHANK1; the interaction is direct.
Interacts with the heterodimer MYC:MAX; the interaction may enhance MYC:MAX transcriptional activity.
Interacts with FNBP1L (via the SH3 domain), WASF2, and CDC42, but only in the presence of FNBP1L (By similarity).
By similarity5 PublicationsBinary interactionsi
Hide detailsQ8CBW3
With | #Exp. | IntAct |
---|---|---|
Diaph3 [Q9Z207] | 2 | EBI-375511,EBI-6550123 |
Eps8 [Q08509] | 3 | EBI-375511,EBI-375596 |
Sos2 [Q02384] | 2 | EBI-375511,EBI-395573 |
Wasf2 [Q8BH43] | 2 | EBI-375511,EBI-643162 |
GO - Molecular functioni
- SH3 domain binding Source: MGI
- transcription factor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 197905, 28 interactors |
CORUMi | Q8CBW3 |
DIPi | DIP-29534N |
IntActi | Q8CBW3, 37 interactors |
MINTi | Q8CBW3 |
STRINGi | 10090.ENSMUSP00000118491 |
Miscellaneous databases
RNActi | Q8CBW3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 45 – 107 | t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST | 63 | |
Domaini | 419 – 478 | SH3PROSITE-ProRule annotationAdd BLAST | 60 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 18 – 79 | Required for binding to WASF1Add BLAST | 62 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 337 – 391 | Pro-richAdd BLAST | 55 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coil, SH3 domainPhylogenomic databases
eggNOGi | KOG2546, Eukaryota |
GeneTreei | ENSGT00940000154811 |
HOGENOMi | CLU_035421_0_0_1 |
InParanoidi | Q8CBW3 |
OMAi | VGHGVKE |
PhylomeDBi | Q8CBW3 |
TreeFami | TF314303 |
Family and domain databases
CDDi | cd11971, SH3_Abi1, 1 hit |
InterProi | View protein in InterPro IPR028457, ABI IPR028456, ABI1 IPR035725, Abi1_SH3 IPR012849, Abl-interactor_HHR_dom IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR000727, T_SNARE_dom |
PANTHERi | PTHR10460, PTHR10460, 2 hits PTHR10460:SF2, PTHR10460:SF2, 2 hits |
Pfami | View protein in Pfam PF07815, Abi_HHR, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS50002, SH3, 1 hit PS50192, T_SNARE, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAELQMLLEE EIPSGKRALI ESYQNLTRVA DYCENNYIQA TDKRKALEET
60 70 80 90 100
KAYTTQSLAS VAYQINALAN NVLQLLDIQA SQLRRMESSI NHISQTVDIH
110 120 130 140 150
KEKVARREIG ILTTNKNTSR THKIIAPANM ERPVRYIRKP IDYTVLDDVG
160 170 180 190 200
HGVKWLKAKH GNNQPARTGT LSRTNPPTQK PPSPPVSGRG TLGRNTPYKT
210 220 230 240 250
LEPVKPPTVP NDYMTSPARL GSQHSPGRTA SLNQRPRTHS GSSGGSGSRE
260 270 280 290 300
NSGSSSIGIP IAVPTPSPPT AGPAAPGAAP GSQYGTMTRQ ISRHNSTTSS
310 320 330 340 350
TSSGGYRRTP SVAAQFSAQP HVNGGPLYSQ NSISVAPPPP PMPQLTPQIP
360 370 380 390 400
LTGFVARVQE NIADSPTPPP PPPPDDIPMF DDSPPPPPPP PVDYEDEEAA
410 420 430 440 450
VVQYSDPYAD GDPAWAPKNY IEKVVAIYDY TKDKDDELSF KEGAIIYVIK
460 470 480
KNDDGWFEGV CNRVTGLFPG NYVESIMHYT D
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB7ZCU0 | B7ZCU0_MOUSE | Abl interactor 1 | Abi1 | 480 | Annotation score: | ||
B7ZCU2 | B7ZCU2_MOUSE | Abl interactor 1 | Abi1 | 393 | Annotation score: | ||
B7ZCU3 | B7ZCU3_MOUSE | Abl interactor 1 | Abi1 | 452 | Annotation score: | ||
B7ZCU4 | B7ZCU4_MOUSE | Abl interactor 1 | Abi1 | 451 | Annotation score: | ||
J3QNK8 | J3QNK8_MOUSE | Abl interactor 1 | Abi1 | 481 | Annotation score: | ||
B7ZCU5 | B7ZCU5_MOUSE | Abl interactor 1 | Abi1 | 422 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 313 | A → T in AAH04657 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010756 | 154 – 158 | Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 5 Publications | 5 | |
Alternative sequenceiVSP_022636 | 274 – 362 | AAPGA…VQENI → V in isoform 5. 1 PublicationAdd BLAST | 89 | |
Alternative sequenceiVSP_010757 | 274 | Missing in isoform 2 and isoform 4. 3 Publications | 1 | |
Alternative sequenceiVSP_010758 | 333 – 361 | Missing in isoform 2. 1 PublicationAdd BLAST | 29 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF420251 mRNA Translation: AAL16036.1 AY033645 mRNA Translation: AAK59381.1 AK034476 mRNA Translation: BAC28722.1 AK152061 mRNA Translation: BAE30917.1 AK152184 mRNA Translation: BAE31015.1 AK151026 mRNA Translation: BAE30044.1 BC004657 mRNA Translation: AAH04657.1 U17698 mRNA Translation: AAB00373.1 Sequence problems. |
CCDSi | CCDS38058.1 [Q8CBW3-5] CCDS38059.1 [Q8CBW3-3] CCDS38060.1 [Q8CBW3-2] CCDS38061.1 [Q8CBW3-1] CCDS50513.1 [Q8CBW3-4] |
RefSeqi | NP_001070658.1, NM_001077190.3 [Q8CBW3-1] NP_001070660.1, NM_001077192.3 [Q8CBW3-2] NP_001070661.1, NM_001077193.3 [Q8CBW3-5] NP_031406.2, NM_007380.4 [Q8CBW3-4] |
Genome annotation databases
Ensembli | ENSMUST00000114544; ENSMUSP00000110191; ENSMUSG00000058835 [Q8CBW3-5] ENSMUST00000123948; ENSMUSP00000118491; ENSMUSG00000058835 [Q8CBW3-1] ENSMUST00000126112; ENSMUSP00000117335; ENSMUSG00000058835 [Q8CBW3-3] ENSMUST00000140164; ENSMUSP00000120462; ENSMUSG00000058835 [Q8CBW3-4] ENSMUST00000149719; ENSMUSP00000120621; ENSMUSG00000058835 [Q8CBW3-2] |
GeneIDi | 11308 |
KEGGi | mmu:11308 |
UCSCi | uc008ins.2, mouse [Q8CBW3-1] uc008inw.2, mouse [Q8CBW3-5] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF420251 mRNA Translation: AAL16036.1 AY033645 mRNA Translation: AAK59381.1 AK034476 mRNA Translation: BAC28722.1 AK152061 mRNA Translation: BAE30917.1 AK152184 mRNA Translation: BAE31015.1 AK151026 mRNA Translation: BAE30044.1 BC004657 mRNA Translation: AAH04657.1 U17698 mRNA Translation: AAB00373.1 Sequence problems. |
CCDSi | CCDS38058.1 [Q8CBW3-5] CCDS38059.1 [Q8CBW3-3] CCDS38060.1 [Q8CBW3-2] CCDS38061.1 [Q8CBW3-1] CCDS50513.1 [Q8CBW3-4] |
RefSeqi | NP_001070658.1, NM_001077190.3 [Q8CBW3-1] NP_001070660.1, NM_001077192.3 [Q8CBW3-2] NP_001070661.1, NM_001077193.3 [Q8CBW3-5] NP_031406.2, NM_007380.4 [Q8CBW3-4] |
3D structure databases
SMRi | Q8CBW3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 197905, 28 interactors |
CORUMi | Q8CBW3 |
DIPi | DIP-29534N |
IntActi | Q8CBW3, 37 interactors |
MINTi | Q8CBW3 |
STRINGi | 10090.ENSMUSP00000118491 |
PTM databases
iPTMneti | Q8CBW3 |
PhosphoSitePlusi | Q8CBW3 |
Proteomic databases
jPOSTi | Q8CBW3 |
PaxDbi | Q8CBW3 |
PRIDEi | Q8CBW3 |
Protocols and materials databases
Antibodypediai | 3646, 336 antibodies |
DNASUi | 11308 |
Genome annotation databases
Ensembli | ENSMUST00000114544; ENSMUSP00000110191; ENSMUSG00000058835 [Q8CBW3-5] ENSMUST00000123948; ENSMUSP00000118491; ENSMUSG00000058835 [Q8CBW3-1] ENSMUST00000126112; ENSMUSP00000117335; ENSMUSG00000058835 [Q8CBW3-3] ENSMUST00000140164; ENSMUSP00000120462; ENSMUSG00000058835 [Q8CBW3-4] ENSMUST00000149719; ENSMUSP00000120621; ENSMUSG00000058835 [Q8CBW3-2] |
GeneIDi | 11308 |
KEGGi | mmu:11308 |
UCSCi | uc008ins.2, mouse [Q8CBW3-1] uc008inw.2, mouse [Q8CBW3-5] |
Organism-specific databases
CTDi | 10006 |
MGIi | MGI:104913, Abi1 |
Phylogenomic databases
eggNOGi | KOG2546, Eukaryota |
GeneTreei | ENSGT00940000154811 |
HOGENOMi | CLU_035421_0_0_1 |
InParanoidi | Q8CBW3 |
OMAi | VGHGVKE |
PhylomeDBi | Q8CBW3 |
TreeFami | TF314303 |
Miscellaneous databases
BioGRID-ORCSi | 11308, 3 hits in 17 CRISPR screens |
ChiTaRSi | Abi1, mouse |
PROi | PR:Q8CBW3 |
RNActi | Q8CBW3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000058835, Expressed in CA1 field of hippocampus and 294 other tissues |
ExpressionAtlasi | Q8CBW3, baseline and differential |
Genevisiblei | Q8CBW3, MM |
Family and domain databases
CDDi | cd11971, SH3_Abi1, 1 hit |
InterProi | View protein in InterPro IPR028457, ABI IPR028456, ABI1 IPR035725, Abi1_SH3 IPR012849, Abl-interactor_HHR_dom IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR000727, T_SNARE_dom |
PANTHERi | PTHR10460, PTHR10460, 2 hits PTHR10460:SF2, PTHR10460:SF2, 2 hits |
Pfami | View protein in Pfam PF07815, Abi_HHR, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS50002, SH3, 1 hit PS50192, T_SNARE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ABI1_MOUSE | |
Accessioni | Q8CBW3Primary (citable) accession number: Q8CBW3 Secondary accession number(s): Q3U8V0 Q99KH4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 175 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families