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UniProtKB - Q8CBW3 (ABI1_MOUSE)

Entry version 180 (23 Feb 2022)
Sequence version 3 (23 Jan 2007)
Previous versions | rss
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Protein

Abl interactor 1

Gene

Abi1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. In vitro, at least isoform 2 and isoform 4 suppress the transforming activity of Abelson murine leukemia virus (v-Abl) after overexpression in fibroblasts. May play a role in regulation EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.

6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-2029482, Regulation of actin dynamics for phagocytic cup formation
R-MMU-4420097, VEGFA-VEGFR2 Pathway
R-MMU-5663213, RHO GTPases Activate WASPs and WAVEs
R-MMU-9013149, RAC1 GTPase cycle
R-MMU-9013404, RAC2 GTPase cycle
R-MMU-9013423, RAC3 GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Abl interactor 1
Alternative name(s):
Abelson interactor 1
Short name:
Abi-1
Ablphilin-1
Eps8 SH3 domain-binding protein
Short name:
Eps8-binding protein
Spectrin SH3 domain-binding protein 1
e3B1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Abi1Imported
Synonyms:Ssh3bp1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:104913, Abi1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000058835

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoskeleton, Nucleus, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001917882 – 481Abl interactor 1Add BLAST480

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei53PhosphotyrosineBy similarity1
Modified residuei174PhosphothreonineBy similarity1
Modified residuei178PhosphothreonineBy similarity1
Modified residuei183PhosphoserineCombined sources1
Modified residuei187PhosphoserineBy similarity1
Modified residuei213PhosphotyrosineCombined sources1
Modified residuei215PhosphothreonineCombined sources1
Modified residuei216PhosphoserineBy similarity1
Modified residuei222PhosphoserineBy similarity1
Modified residuei225PhosphoserineBy similarity1
Modified residuei292PhosphoserineBy similarity1
Modified residuei296PhosphoserineBy similarity1
Modified residuei428PhosphotyrosineCombined sources1
Modified residuei439PhosphoserineBy similarity1
Modified residuei480PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues after serum stimulation or induction by v-Abl. Seems to be phosphorylated at Tyr-53 by ABL1, required for nuclear but not for synaptic localization (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8CBW3

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8CBW3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8CBW3

PRoteomics IDEntifications database

More...PRIDEi		Q8CBW3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		286057 [Q8CBW3-1]
286058 [Q8CBW3-2]
286059 [Q8CBW3-3]
286060 [Q8CBW3-4]
286061 [Q8CBW3-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8CBW3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8CBW3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with highest levels in bone marrow, spleen, brain, testes, and embryonic brain. In adult brain prominently expressed in the neocortex, hippocampus and dentate gyrus.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected at 10 dpc and 12 dpc in developing brain, but does not appear more prominent in the neuroepithelium compared to the surrounding tissue.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000058835, Expressed in CA1 field of hippocampus and 301 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8CBW3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8CBW3, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ENAH, Abelson murine leukemia virus V-ABL, ABL1, STX1A, SNAP25, VAMP2, and through its N-terminus with WASF1.

Part of a complex consisting of ABI1, STX1A and SNAP25.

Part of a complex consisting of ABI1, EPS8 and SOS1.

Interacts with EPS8, SOS1, SOS2, GRB2, SPTA1, and the first SH3 domain of NCK1 (By similarity).

Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 (NCKAP1l/HEM1 in hematopoietic cells) and WASF2/WAVE2.

Interacts (via SH3 domain) with SHANK2 and SHANK3, but not SHANK1; the interaction is direct.

Interacts with the heterodimer MYC:MAX; the interaction may enhance MYC:MAX transcriptional activity.

Interacts with FNBP1L (via the SH3 domain), WASF2, and CDC42, but only in the presence of FNBP1L (By similarity).

By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		197905, 28 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q8CBW3

Database of interacting proteins

More...DIPi		DIP-29534N

Protein interaction database and analysis system

More...IntActi		Q8CBW3, 34 interactors

Molecular INTeraction database

More...MINTi		Q8CBW3

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000118491

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8CBW3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8CBW3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini45 – 107t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63
Domaini419 – 478SH3PROSITE-ProRule annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni18 – 79Required for binding to WASF1Add BLAST62
Regioni158 – 285DisorderedSequence analysisAdd BLAST128
Regioni318 – 348DisorderedSequence analysisAdd BLAST31
Regioni361 – 392DisorderedSequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi215 – 261Polar residuesSequence analysisAdd BLAST47
Compositional biasi318 – 332Polar residuesSequence analysisAdd BLAST15
Compositional biasi333 – 347Pro residuesSequence analysisAdd BLAST15
Compositional biasi364 – 392Pro residuesSequence analysisAdd BLAST29

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The t-SNARE coiled-coil homology domain is necessary and sufficient for interaction with STX1A.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ABI family.Curated

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2546, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154811

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_035421_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8CBW3

Identification of Orthologs from Complete Genome Data

More...OMAi		VGHGVKE

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8CBW3

TreeFam database of animal gene trees

More...TreeFami		TF314303

Family and domain databases

Conserved Domains Database

More...CDDi		cd11971, SH3_Abi1, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR028457, ABI
IPR028456, ABI1
IPR035725, Abi1_SH3
IPR012849, Abl-interactor_HHR_dom
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR000727, T_SNARE_dom

The PANTHER Classification System

More...PANTHERi		PTHR10460, PTHR10460, 1 hit
PTHR10460:SF2, PTHR10460:SF2, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07815, Abi_HHR, 1 hit
PF00018, SH3_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00452, SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50044, SSF50044, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50002, SH3, 1 hit
PS50192, T_SNARE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8CBW3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAELQMLLEE EIPSGKRALI ESYQNLTRVA DYCENNYIQA TDKRKALEET 
        60         70         80         90        100
KAYTTQSLAS VAYQINALAN NVLQLLDIQA SQLRRMESSI NHISQTVDIH 
       110        120        130        140        150
KEKVARREIG ILTTNKNTSR THKIIAPANM ERPVRYIRKP IDYTVLDDVG 
       160        170        180        190        200
HGVKWLKAKH GNNQPARTGT LSRTNPPTQK PPSPPVSGRG TLGRNTPYKT 
       210        220        230        240        250
LEPVKPPTVP NDYMTSPARL GSQHSPGRTA SLNQRPRTHS GSSGGSGSRE 
       260        270        280        290        300
NSGSSSIGIP IAVPTPSPPT AGPAAPGAAP GSQYGTMTRQ ISRHNSTTSS 
       310        320        330        340        350
TSSGGYRRTP SVAAQFSAQP HVNGGPLYSQ NSISVAPPPP PMPQLTPQIP 
       360        370        380        390        400
LTGFVARVQE NIADSPTPPP PPPPDDIPMF DDSPPPPPPP PVDYEDEEAA 
       410        420        430        440        450
VVQYSDPYAD GDPAWAPKNY IEKVVAIYDY TKDKDDELSF KEGAIIYVIK 
       460        470        480 
KNDDGWFEGV CNRVTGLFPG NYVESIMHYT D
Length:481
Mass (Da):52,288
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1654A1E89438BC1D
GO
Isoform 2 (identifier: Q8CBW3-2) [UniParc]FASTAAdd to basket
Also known as: short

The sequence of this isoform differs from the canonical sequence as follows:
     154-158: Missing.
     274-274: Missing.
     333-361: Missing.

Show »
Length:446
Mass (Da):48,512
Checksum:i805A2F6072F1D24B
GO
Isoform 3 (identifier: Q8CBW3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     154-158: Missing.

Show »
Length:476
Mass (Da):51,661
Checksum:iB7E38AA1E9ED7FA6
GO
Isoform 4 (identifier: Q8CBW3-4) [UniParc]FASTAAdd to basket
Also known as: long

The sequence of this isoform differs from the canonical sequence as follows:
     154-158: Missing.
     274-274: Missing.

Show »
Length:475
Mass (Da):51,590
Checksum:iA0A613AAD091B0F0
GO
Isoform 5 (identifier: Q8CBW3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     154-158: Missing.
     274-362: AAPGAAPGSQ...GFVARVQENI → V

Show »
Length:388
Mass (Da):42,548
Checksum:i27FAB95E05BCA655
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZCU2B7ZCU2_MOUSE
Abl interactor 1
Abi1
393Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7ZCU0B7ZCU0_MOUSE
Abl interactor 1
Abi1
480Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7ZCU3B7ZCU3_MOUSE
Abl interactor 1
Abi1
452Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7ZCU4B7ZCU4_MOUSE
Abl interactor 1
Abi1
451Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QNK8J3QNK8_MOUSE
Abl interactor 1
Abi1
481Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7ZCU5B7ZCU5_MOUSE
Abl interactor 1
Abi1
422Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti313A → T in AAH04657 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_010756154 – 158Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 5 Publications5
Alternative sequenceiVSP_022636274 – 362AAPGA…VQENI → V in isoform 5. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_010757274Missing in isoform 2 and isoform 4. 3 Publications1
Alternative sequenceiVSP_010758333 – 361Missing in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF420251 mRNA Translation: AAL16036.1
AY033645 mRNA Translation: AAK59381.1
AK034476 mRNA Translation: BAC28722.1
AK152061 mRNA Translation: BAE30917.1
AK152184 mRNA Translation: BAE31015.1
AK151026 mRNA Translation: BAE30044.1
BC004657 mRNA Translation: AAH04657.1
U17698 mRNA Translation: AAB00373.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS38058.1 [Q8CBW3-5]
CCDS38059.1 [Q8CBW3-3]
CCDS38060.1 [Q8CBW3-2]
CCDS38061.1 [Q8CBW3-1]
CCDS50513.1 [Q8CBW3-4]

NCBI Reference Sequences

More...RefSeqi		NP_001070658.1, NM_001077190.3 [Q8CBW3-1]
NP_001070660.1, NM_001077192.3 [Q8CBW3-2]
NP_001070661.1, NM_001077193.3 [Q8CBW3-5]
NP_031406.2, NM_007380.4 [Q8CBW3-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000114544; ENSMUSP00000110191; ENSMUSG00000058835 [Q8CBW3-5]
ENSMUST00000123948; ENSMUSP00000118491; ENSMUSG00000058835 [Q8CBW3-1]
ENSMUST00000126112; ENSMUSP00000117335; ENSMUSG00000058835 [Q8CBW3-3]
ENSMUST00000140164; ENSMUSP00000120462; ENSMUSG00000058835 [Q8CBW3-4]
ENSMUST00000149719; ENSMUSP00000120621; ENSMUSG00000058835 [Q8CBW3-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		11308

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:11308

UCSC genome browser

More...UCSCi		uc008ins.2, mouse [Q8CBW3-1]
uc008inw.2, mouse [Q8CBW3-5]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF420251 mRNA Translation: AAL16036.1
AY033645 mRNA Translation: AAK59381.1
AK034476 mRNA Translation: BAC28722.1
AK152061 mRNA Translation: BAE30917.1
AK152184 mRNA Translation: BAE31015.1
AK151026 mRNA Translation: BAE30044.1
BC004657 mRNA Translation: AAH04657.1
U17698 mRNA Translation: AAB00373.1 Sequence problems.
CCDSiCCDS38058.1 [Q8CBW3-5]
CCDS38059.1 [Q8CBW3-3]
CCDS38060.1 [Q8CBW3-2]
CCDS38061.1 [Q8CBW3-1]
CCDS50513.1 [Q8CBW3-4]
RefSeqiNP_001070658.1, NM_001077190.3 [Q8CBW3-1]
NP_001070660.1, NM_001077192.3 [Q8CBW3-2]
NP_001070661.1, NM_001077193.3 [Q8CBW3-5]
NP_031406.2, NM_007380.4 [Q8CBW3-4]

3D structure databases

SMRiQ8CBW3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi197905, 28 interactors
CORUMiQ8CBW3
DIPiDIP-29534N
IntActiQ8CBW3, 34 interactors
MINTiQ8CBW3
STRINGi10090.ENSMUSP00000118491

PTM databases

iPTMnetiQ8CBW3
PhosphoSitePlusiQ8CBW3

Proteomic databases

jPOSTiQ8CBW3
MaxQBiQ8CBW3
PaxDbiQ8CBW3
PRIDEiQ8CBW3
ProteomicsDBi286057 [Q8CBW3-1]
286058 [Q8CBW3-2]
286059 [Q8CBW3-3]
286060 [Q8CBW3-4]
286061 [Q8CBW3-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3646, 351 antibodies from 39 providers

The DNASU plasmid repository

More...DNASUi		11308

Genome annotation databases

EnsembliENSMUST00000114544; ENSMUSP00000110191; ENSMUSG00000058835 [Q8CBW3-5]
ENSMUST00000123948; ENSMUSP00000118491; ENSMUSG00000058835 [Q8CBW3-1]
ENSMUST00000126112; ENSMUSP00000117335; ENSMUSG00000058835 [Q8CBW3-3]
ENSMUST00000140164; ENSMUSP00000120462; ENSMUSG00000058835 [Q8CBW3-4]
ENSMUST00000149719; ENSMUSP00000120621; ENSMUSG00000058835 [Q8CBW3-2]
GeneIDi11308
KEGGimmu:11308
UCSCiuc008ins.2, mouse [Q8CBW3-1]
uc008inw.2, mouse [Q8CBW3-5]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10006
MGIiMGI:104913, Abi1
VEuPathDBiHostDB:ENSMUSG00000058835

Phylogenomic databases

eggNOGiKOG2546, Eukaryota
GeneTreeiENSGT00940000154811
HOGENOMiCLU_035421_0_0_1
InParanoidiQ8CBW3
OMAiVGHGVKE
PhylomeDBiQ8CBW3
TreeFamiTF314303

Enzyme and pathway databases

ReactomeiR-MMU-2029482, Regulation of actin dynamics for phagocytic cup formation
R-MMU-4420097, VEGFA-VEGFR2 Pathway
R-MMU-5663213, RHO GTPases Activate WASPs and WAVEs
R-MMU-9013149, RAC1 GTPase cycle
R-MMU-9013404, RAC2 GTPase cycle
R-MMU-9013423, RAC3 GTPase cycle

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		11308, 3 hits in 64 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Abi1, mouse

Protein Ontology

More...PROi		PR:Q8CBW3
RNActiQ8CBW3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000058835, Expressed in CA1 field of hippocampus and 301 other tissues
ExpressionAtlasiQ8CBW3, baseline and differential
GenevisibleiQ8CBW3, MM

Family and domain databases

CDDicd11971, SH3_Abi1, 1 hit
InterProiView protein in InterPro
IPR028457, ABI
IPR028456, ABI1
IPR035725, Abi1_SH3
IPR012849, Abl-interactor_HHR_dom
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR000727, T_SNARE_dom
PANTHERiPTHR10460, PTHR10460, 1 hit
PTHR10460:SF2, PTHR10460:SF2, 1 hit
PfamiView protein in Pfam
PF07815, Abi_HHR, 1 hit
PF00018, SH3_1, 1 hit
PRINTSiPR00452, SH3DOMAIN
SMARTiView protein in SMART
SM00326, SH3, 1 hit
SUPFAMiSSF50044, SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002, SH3, 1 hit
PS50192, T_SNARE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABI1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CBW3
Secondary accession number(s): Q3U8V0
, Q60747, Q91ZM5, Q923I9, Q99KH4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 23, 2007
Last modified: February 23, 2022
This is version 180 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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