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Entry version 135 (29 Sep 2021)
Sequence version 1 (01 Mar 2003)
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Protein

E3 ubiquitin-protein ligase RNF170

Gene

Rnf170

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells.

1 Publication

Caution

It is uncertain whether Met-1 or Met-30 is the initiator. Initiation at Met-30 is supported by sequence similarity with mammalian orthologs and by a Kozak context more favorable compared to that at Met-1.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri115 – 158RING-typePROSITE-ProRule annotationAdd BLAST44

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF170 (EC:2.3.2.27)
Alternative name(s):
RING finger protein 170
RING-type E3 ubiquitin transferase RNF170Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rnf170
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1924983, Rnf170

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000013878

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 52LumenalSequence analysisAdd BLAST52
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 229CytoplasmicSequence analysisAdd BLAST156
Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
Topological domaini251LumenalSequence analysis1
Transmembranei252 – 272HelicalSequence analysisAdd BLAST21
Topological domaini273 – 286CytoplasmicSequence analysisAdd BLAST14

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi130C → S: Loss of E3 ligase activity. 1 Publication1
Mutagenesisi132H → S: Loss of E3 ligase activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002807011 – 286E3 ubiquitin-protein ligase RNF170Add BLAST286

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8CBG9

PeptideAtlas

More...
PeptideAtlasi
Q8CBG9

PRoteomics IDEntifications database

More...
PRIDEi
Q8CBG9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
300445 [Q8CBG9-1]
300446 [Q8CBG9-2]
300447 [Q8CBG9-3]
300448 [Q8CBG9-4]
300449 [Q8CBG9-5]

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8CBG9

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8CBG9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000013878, Expressed in embryo and 262 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8CBG9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8CBG9, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Constitutively associated with the ERLIN1/ERLIN 2 complex.

Interacts with activated ITPR1.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
218881, 4 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000014022

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8CBG9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8CBG9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri115 – 158RING-typePROSITE-ProRule annotationAdd BLAST44

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2164, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017123

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_072335_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8CBG9

Identification of Orthologs from Complete Genome Data

More...
OMAi
CRQEEQN

Database of Orthologous Groups

More...
OrthoDBi
1563172at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8CBG9

TreeFam database of animal gene trees

More...
TreeFami
TF328342

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010652, DUF1232
IPR038896, RNF170
IPR018957, Znf_C3HC4_RING-type
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS

The PANTHER Classification System

More...
PANTHERi
PTHR22894, PTHR22894, 1 hit
PTHR22894:SF1, PTHR22894:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06803, DUF1232, 1 hit
PF00097, zf-C3HC4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00184, RING, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8CBG9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQRYWRFQDN KIQDICFGVL GESWIQRPVM ARYYSEGQSL QQDDSFIEGV
60 70 80 90 100
SDQVLVAVVV SLALTATLLY ALLRNVQQNI HPENQELVRV LREQFQTEQD
110 120 130 140 150
VPAPARQQFY TEMYCPICLH QASFPVETNC GHLFCGSCII AYWRYGSWLG
160 170 180 190 200
AISCPICRQT VTLLLTVFGE DDQSQDVIRL RQDVNDYNRR FSGQPRSIME
210 220 230 240 250
RIMDLPTLLR HAFREVFSVG GLFWMFRIRI MLCLMGAFFY LISPLDFVPE
260 270 280
ALFGILGFLD DFFVIFLLLI YISIMYREVI TQRLTR
Length:286
Mass (Da):33,414
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i17294042B9C5CD49
GO
Isoform 2 (identifier: Q8CBG9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-74: Missing.

Show »
Length:239
Mass (Da):28,301
Checksum:iA65DEAC072DE4145
GO
Isoform 3 (identifier: Q8CBG9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     137-216: SCIIAYWRYG...TLLRHAFREV → EQIMSDLVRV...CLAIMQKPWA
     217-286: Missing.

Show »
Length:216
Mass (Da):24,858
Checksum:i420F4A164BF20E6F
GO
Isoform 4 (identifier: Q8CBG9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-142: GSCIIAY → VLQLFPH
     143-286: Missing.

Show »
Length:142
Mass (Da):16,525
Checksum:iCF63A92FE00A8B77
GO
Isoform 5 (identifier: Q8CBG9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     136-140: GSCII → ENCGF
     141-286: Missing.

Show »
Length:140
Mass (Da):16,240
Checksum:i3920A869F2A7D13F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GR51A0A1B0GR51_MOUSE
E3 ubiquitin-protein ligase RNF170
Rnf170
249Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z7W3D3Z7W3_MOUSE
E3 ubiquitin-protein ligase RNF170
Rnf170
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PUJ5E9PUJ5_MOUSE
E3 ubiquitin-protein ligase RNF170
Rnf170
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6UDR6F6UDR6_MOUSE
E3 ubiquitin-protein ligase RNF170
Rnf170
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti105A → V in BAC31147 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02385828 – 74Missing in isoform 2. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_023859136 – 142GSCIIAY → VLQLFPH in isoform 4. 1 Publication7
Alternative sequenceiVSP_023860136 – 140GSCII → ENCGF in isoform 5. 1 Publication5
Alternative sequenceiVSP_023861137 – 216SCIIA…AFREV → EQIMSDLVRVTSLRPLWIGS GLDCSFSFYHIYVLRRVDCF TSPALVATQIIAYCLVYSIL RSEDIAQLVECLAIMQKPWA in isoform 3. 1 PublicationAdd BLAST80
Alternative sequenceiVSP_023862141 – 286Missing in isoform 5. 1 PublicationAdd BLAST146
Alternative sequenceiVSP_023863143 – 286Missing in isoform 4. 1 PublicationAdd BLAST144
Alternative sequenceiVSP_023864217 – 286Missing in isoform 3. 1 PublicationAdd BLAST70

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK036051 mRNA Translation: BAC29287.1
AK042063 mRNA Translation: BAC31147.1
AK044579 mRNA Translation: BAC31988.1
AK080591 mRNA Translation: BAC37951.1
AK152760 mRNA Translation: BAE31474.1
CH466580 Genomic DNA Translation: EDL32805.1
BC031383 mRNA Translation: AAH31383.1
BC114210 mRNA Translation: AAI14211.1
BC138930 mRNA Translation: AAI38931.1
BC145718 mRNA Translation: AAI45719.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS90380.1 [Q8CBG9-2]

NCBI Reference Sequences

More...
RefSeqi
NP_084241.1, NM_029965.2
XP_006509278.1, XM_006509215.3
XP_006509279.1, XM_006509216.3
XP_006509280.1, XM_006509217.3
XP_006509281.1, XM_006509218.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000014022; ENSMUSP00000014022; ENSMUSG00000013878 [Q8CBG9-1]
ENSMUST00000110575; ENSMUSP00000106204; ENSMUSG00000013878 [Q8CBG9-3]
ENSMUST00000110579; ENSMUSP00000106208; ENSMUSG00000013878 [Q8CBG9-5]
ENSMUST00000153528; ENSMUSP00000118689; ENSMUSG00000013878 [Q8CBG9-2]
ENSMUST00000209300; ENSMUSP00000147842; ENSMUSG00000013878 [Q8CBG9-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
77733

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:77733

UCSC genome browser

More...
UCSCi
uc009lhl.1, mouse [Q8CBG9-3]
uc009lhm.1, mouse [Q8CBG9-1]
uc009lhp.1, mouse [Q8CBG9-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036051 mRNA Translation: BAC29287.1
AK042063 mRNA Translation: BAC31147.1
AK044579 mRNA Translation: BAC31988.1
AK080591 mRNA Translation: BAC37951.1
AK152760 mRNA Translation: BAE31474.1
CH466580 Genomic DNA Translation: EDL32805.1
BC031383 mRNA Translation: AAH31383.1
BC114210 mRNA Translation: AAI14211.1
BC138930 mRNA Translation: AAI38931.1
BC145718 mRNA Translation: AAI45719.1
CCDSiCCDS90380.1 [Q8CBG9-2]
RefSeqiNP_084241.1, NM_029965.2
XP_006509278.1, XM_006509215.3
XP_006509279.1, XM_006509216.3
XP_006509280.1, XM_006509217.3
XP_006509281.1, XM_006509218.3

3D structure databases

SMRiQ8CBG9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi218881, 4 interactors
STRINGi10090.ENSMUSP00000014022

PTM databases

PhosphoSitePlusiQ8CBG9
SwissPalmiQ8CBG9

Proteomic databases

PaxDbiQ8CBG9
PeptideAtlasiQ8CBG9
PRIDEiQ8CBG9
ProteomicsDBi300445 [Q8CBG9-1]
300446 [Q8CBG9-2]
300447 [Q8CBG9-3]
300448 [Q8CBG9-4]
300449 [Q8CBG9-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
77733

Genome annotation databases

EnsembliENSMUST00000014022; ENSMUSP00000014022; ENSMUSG00000013878 [Q8CBG9-1]
ENSMUST00000110575; ENSMUSP00000106204; ENSMUSG00000013878 [Q8CBG9-3]
ENSMUST00000110579; ENSMUSP00000106208; ENSMUSG00000013878 [Q8CBG9-5]
ENSMUST00000153528; ENSMUSP00000118689; ENSMUSG00000013878 [Q8CBG9-2]
ENSMUST00000209300; ENSMUSP00000147842; ENSMUSG00000013878 [Q8CBG9-4]
GeneIDi77733
KEGGimmu:77733
UCSCiuc009lhl.1, mouse [Q8CBG9-3]
uc009lhm.1, mouse [Q8CBG9-1]
uc009lhp.1, mouse [Q8CBG9-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
81790
MGIiMGI:1924983, Rnf170
VEuPathDBiHostDB:ENSMUSG00000013878

Phylogenomic databases

eggNOGiKOG2164, Eukaryota
GeneTreeiENSGT00390000017123
HOGENOMiCLU_072335_0_0_1
InParanoidiQ8CBG9
OMAiCRQEEQN
OrthoDBi1563172at2759
PhylomeDBiQ8CBG9
TreeFamiTF328342

Enzyme and pathway databases

UniPathwayiUPA00143

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
77733, 0 hits in 62 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Rnf170, mouse

Protein Ontology

More...
PROi
PR:Q8CBG9
RNActiQ8CBG9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000013878, Expressed in embryo and 262 other tissues
ExpressionAtlasiQ8CBG9, baseline and differential
GenevisibleiQ8CBG9, MM

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR010652, DUF1232
IPR038896, RNF170
IPR018957, Znf_C3HC4_RING-type
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS
PANTHERiPTHR22894, PTHR22894, 1 hit
PTHR22894:SF1, PTHR22894:SF1, 1 hit
PfamiView protein in Pfam
PF06803, DUF1232, 1 hit
PF00097, zf-C3HC4, 1 hit
SMARTiView protein in SMART
SM00184, RING, 1 hit
PROSITEiView protein in PROSITE
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRN170_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CBG9
Secondary accession number(s): A6H618
, Q3U796, Q78QX6, Q8C8S1, Q8C9I0, Q8K0H6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 1, 2003
Last modified: September 29, 2021
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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