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Protein

WD repeat-containing protein 37

Gene

Wdr37

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 37
Gene namesi
Name:Wdr37
Synonyms:Kiaa0982
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1920393 Wdr37

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513881 – 496WD repeat-containing protein 37Add BLAST496

Proteomic databases

EPDiQ8CBE3
MaxQBiQ8CBE3
PaxDbiQ8CBE3
PeptideAtlasiQ8CBE3
PRIDEiQ8CBE3

PTM databases

iPTMnetiQ8CBE3
PhosphoSitePlusiQ8CBE3

Expressioni

Gene expression databases

BgeeiENSMUSG00000021147 Expressed in 248 organ(s), highest expression level in central nervous system
CleanExiMM_WDR37
ExpressionAtlasiQ8CBE3 baseline and differential
GenevisibleiQ8CBE3 MM

Interactioni

Protein-protein interaction databases

BioGridi228908, 3 interactors
IntActiQ8CBE3, 3 interactors
MINTiQ8CBE3
STRINGi10090.ENSMUSP00000021572

Structurei

3D structure databases

ProteinModelPortaliQ8CBE3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati154 – 194WD 1Add BLAST41
Repeati197 – 236WD 2Add BLAST40
Repeati281 – 320WD 3Add BLAST40
Repeati323 – 362WD 4Add BLAST40
Repeati367 – 405WD 5Add BLAST39
Repeati408 – 447WD 6Add BLAST40
Repeati454 – 495WD 7Add BLAST42

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0300 Eukaryota
ENOG410XSES LUCA
GeneTreeiENSGT00930000150950
HOGENOMiHOG000013185
HOVERGENiHBG057072
InParanoidiQ8CBE3
OMAiWDFREAI
OrthoDBiEOG091G06KJ
PhylomeDBiQ8CBE3
TreeFamiTF105876

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 4 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All

Q8CBE3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPTESGSCST ARQAKQKRKS HSLSIRRTNS SEQERTGLPR EMLEGQDSKL
60 70 80 90 100
PSSVRSTLLE LFGQIEREFE NLYIENLELR REIDTLNERL AGEGQAIDGA
110 120 130 140 150
ELSKGQLKTK ASHSTSQLSQ KLKTTYKAST SKIVSSFKTT TSRAICQLVK
160 170 180 190 200
EYIGHRDGIW DVSVTRTQPI VLGTASADHT ALLWSIETGK CLVKYAGHVG
210 220 230 240 250
SVNSIKFHPS EQLALTASGD QTAHIWRYVV QLPTPQPVAD TSQQISGEDE
260 270 280 290 300
IECSDKDEPD IDGDVSSDCP TVRVPLTSLK SHQGVVIAAD WLVGGKQVVT
310 320 330 340 350
ASWDRTANLY DVETSELVHS LTGHDQELTH CCTHPTQRLV VTSSRDTTFR
360 370 380 390 400
LWDFRDPSIH SVNVFQGHTD TVTSAVFTVG DNVVSGSDDR TVKVWDLKNM
410 420 430 440 450
RSPIATIRTD SAINRINVCV GQKIIALPHD NRQVRLFDMS GVRLARLPRS
460 470 480 490
SRQGHRRMVC CSAWSEDHPI CNLFTCGFDR QAIGWNINIP ALLQEK
Length:496
Mass (Da):55,046
Last modified:March 1, 2003 - v1
Checksum:iD647D239E5F6EA08
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BJS1H3BJS1_MOUSE
WD repeat-containing protein 37
Wdr37
185Annotation score:
H3BJR4H3BJR4_MOUSE
WD repeat-containing protein 37
Wdr37
78Annotation score:
H3BKY3H3BKY3_MOUSE
WD repeat-containing protein 37
Wdr37
66Annotation score:
H3BJB3H3BJB3_MOUSE
WD repeat-containing protein 37
Wdr37
193Annotation score:
Q05BF4Q05BF4_MOUSE
WD repeat-containing protein 37
Wdr37
170Annotation score:
H3BJR7H3BJR7_MOUSE
WD repeat-containing protein 37
Wdr37
179Annotation score:
H3BK66H3BK66_MOUSE
WD repeat-containing protein 37
Wdr37
133Annotation score:
H3BJH4H3BJH4_MOUSE
WD repeat-containing protein 37
Wdr37
57Annotation score:
H3BLH1H3BLH1_MOUSE
WD repeat-containing protein 37
Wdr37
30Annotation score:
H3BJZ0H3BJZ0_MOUSE
WD repeat-containing protein 37
Wdr37
49Annotation score:

Sequence cautioni

The sequence BAC98064 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69F → L in BAC27934 (PubMed:16141072).Curated1
Sequence conflicti139T → I in AAH46236 (PubMed:15489334).Curated1
Sequence conflicti224H → N in BAC27934 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129254 mRNA Translation: BAC98064.1 Different initiation.
AK032582 mRNA Translation: BAC27934.1
AK036203 mRNA Translation: BAC29346.1
BC046236 mRNA Translation: AAH46236.1
CCDSiCCDS26232.1
RefSeqiNP_001034477.1, NM_001039388.2
NP_766033.1, NM_172445.3
XP_006516532.1, XM_006516469.3
XP_006516533.1, XM_006516470.3
UniGeneiMm.284654

Genome annotation databases

EnsembliENSMUST00000021572; ENSMUSP00000021572; ENSMUSG00000021147
ENSMUST00000054251; ENSMUSP00000062174; ENSMUSG00000021147
GeneIDi207615
KEGGimmu:207615
UCSCiuc007pki.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129254 mRNA Translation: BAC98064.1 Different initiation.
AK032582 mRNA Translation: BAC27934.1
AK036203 mRNA Translation: BAC29346.1
BC046236 mRNA Translation: AAH46236.1
CCDSiCCDS26232.1
RefSeqiNP_001034477.1, NM_001039388.2
NP_766033.1, NM_172445.3
XP_006516532.1, XM_006516469.3
XP_006516533.1, XM_006516470.3
UniGeneiMm.284654

3D structure databases

ProteinModelPortaliQ8CBE3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228908, 3 interactors
IntActiQ8CBE3, 3 interactors
MINTiQ8CBE3
STRINGi10090.ENSMUSP00000021572

PTM databases

iPTMnetiQ8CBE3
PhosphoSitePlusiQ8CBE3

Proteomic databases

EPDiQ8CBE3
MaxQBiQ8CBE3
PaxDbiQ8CBE3
PeptideAtlasiQ8CBE3
PRIDEiQ8CBE3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021572; ENSMUSP00000021572; ENSMUSG00000021147
ENSMUST00000054251; ENSMUSP00000062174; ENSMUSG00000021147
GeneIDi207615
KEGGimmu:207615
UCSCiuc007pki.2 mouse

Organism-specific databases

CTDi22884
MGIiMGI:1920393 Wdr37
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0300 Eukaryota
ENOG410XSES LUCA
GeneTreeiENSGT00930000150950
HOGENOMiHOG000013185
HOVERGENiHBG057072
InParanoidiQ8CBE3
OMAiWDFREAI
OrthoDBiEOG091G06KJ
PhylomeDBiQ8CBE3
TreeFamiTF105876

Miscellaneous databases

ChiTaRSiWdr37 mouse
PROiPR:Q8CBE3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021147 Expressed in 248 organ(s), highest expression level in central nervous system
CleanExiMM_WDR37
ExpressionAtlasiQ8CBE3 baseline and differential
GenevisibleiQ8CBE3 MM

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 4 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWDR37_MOUSE
AccessioniPrimary (citable) accession number: Q8CBE3
Secondary accession number(s): Q80Y96, Q8CCL2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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