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Protein

Nuclear receptor-interacting protein 1

Gene

Nrip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Modulates transcriptional repression by nuclear hormone receptors such as NR2C1, thyroid hormone receptor and retinoic acid receptor/RARA. Essential for cumulus expansion and follicle rupture during ovulation. Also controls the balance between fat accumulation and energy expenditure. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC.7 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Receptor, Repressor
Biological processBiological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-3899300 SUMOylation of transcription cofactors
R-MMU-9018519 Estrogen-dependent gene expression

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear receptor-interacting protein 1
Alternative name(s):
Nuclear factor RIP140
Receptor-interacting protein 140
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nrip1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1315213 Nrip1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1067N → G: Reduces binding to RAR, RXR and RAR/RXR. 1 Publication1
Mutagenesisi1068P → A: Abolishes binding to RAR, RXR and RAR/RXR. 1 Publication1
Mutagenesisi1073M → I: Reduces binding to RAR, RXR and RAR/RXR. 1 Publication1
Mutagenesisi1073M → K: Abolishes binding to RAR, RXR and RAR/RXR. 1 Publication1
Mutagenesisi1073M → L: Reduces binding to RAR, RXR and RAR/RXR. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000579521 – 1161Nuclear receptor-interacting protein 1Add BLAST1161

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei104Phosphoserine1 Publication1
Modified residuei111N6-acetyllysine; alternate1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki111Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei158N6-acetyllysine1 Publication1
Cross-linki170Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki195Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki198Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei207Phosphothreonine1 Publication1
Modified residuei218PhosphoserineBy similarity1
Modified residuei287N6-acetyllysine1 Publication1
Modified residuei311N6-acetyllysine1 Publication1
Modified residuei358Phosphoserine1 Publication1
Cross-linki374Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei380Phosphoserine1 Publication1
Modified residuei447N6-acetyllysineBy similarity1
Modified residuei482N6-acetyllysine1 Publication1
Modified residuei488Phosphoserine1 Publication1
Cross-linki509Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei519Phosphoserine1 Publication1
Modified residuei529N6-acetyllysine1 Publication1
Modified residuei531Phosphoserine1 Publication1
Modified residuei543Phosphoserine1 Publication1
Modified residuei565PhosphoserineBy similarity1
Modified residuei607N6-acetyllysine1 Publication1
Modified residuei672Phosphoserine1 Publication1
Cross-linki757Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki803Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei808PhosphoserineBy similarity1
Cross-linki851Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki902Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei932N6-acetyllysine; alternate1 Publication1
Cross-linki932Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei1003Phosphoserine1 Publication1
Cross-linki1108Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1118Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1157Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Acetylation abolishes interaction with CTBP1. Phosphorylation enhances interaction with YWHAH (By similarity). Acetylation regulates its nuclear translocation and corepressive activity.By similarity2 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8CBD1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8CBD1

PeptideAtlas

More...
PeptideAtlasi
Q8CBD1

PRoteomics IDEntifications database

More...
PRIDEi
Q8CBD1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8CBD1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8CBD1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the embryonic placenta. In the adult, expression is strong in the testis and brain. Also expressed at a high level in the white adipose tissue. Expressed constantly but at a weaker level in the adult heart, lung, stomach and kidney. Expressed moderately in the skeletal muscle. Expressed at a low level in the adult spleen, liver and brown adipose tissue. Expressed in the ovary at a high level in granulosa cells and at a lower level in the thecal and interstitial compartments.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000048490 Expressed in 333 organ(s), highest expression level in female gonad

CleanEx database of gene expression profiles

More...
CleanExi
MM_NRIP1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8CBD1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8CBD1 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CTBP1, CTBP2, ERS1, HDAC1, HDAC2, HDAC5, HDAC6, NR2C2, NR3C1, NR3C2, YWHAH, JUN and FOS. Found in a complex with both NR3C1 and YWHAH (By similarity). Interacts with NR2C1 (sumoylated form and via the ligand-binding domain); the interaction results in promoting the repressor activity of NR2C1. Interacts with RARA and RXRB homodimers and RARA/RXRB heterodimers in the presence of ligand. Interacts with HDAC1 and HDAC3 via its N-terminal domain. Interacts with ZNF366 (By similarity). Interacts with RORA.By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
234576, 12 interactors

Database of interacting proteins

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DIPi
DIP-29280N

Protein interaction database and analysis system

More...
IntActi
Q8CBD1, 5 interactors

Molecular INTeraction database

More...
MINTi
Q8CBD1

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000051726

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8CBD1

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 416Interaction with ZNF366By similarityAdd BLAST416
Regioni78 – 335Repression domain 1By similarityAdd BLAST258
Regioni411 – 701Repression domain 2By similarityAdd BLAST291
Regioni432 – 473Required for targeting to small nuclear fociBy similarityAdd BLAST42
Regioni736 – 886Repression domain 3By similarityAdd BLAST151
Regioni754 – 1161Interaction with ZNF366By similarityAdd BLAST408
Regioni1063 – 1076Ligand-dependent nuclear receptor bindingAdd BLAST14
Regioni1121 – 1161Repression domain 4By similarityAdd BLAST41

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi21 – 25LXXLL motif 1Sequence analysis5
Motifi133 – 137LXXLL motif 2Sequence analysis5
Motifi185 – 189LXXLL motif 3Sequence analysis5
Motifi267 – 271LXXLL motif 4Sequence analysis5
Motifi382 – 386LXXLL motif 5Sequence analysis5
Motifi441 – 447CTBP-binding; principal siteBy similarity7
Motifi501 – 505LXXLL motif 6Sequence analysis5
Motifi566 – 570CTBP-bindingBy similarity5
Motifi714 – 718LXXLL motif 7Sequence analysis5
Motifi820 – 824LXXLL motif 8Sequence analysis5
Motifi937 – 941LXXLL motif 9Sequence analysis5
Motifi947 – 951CTBP-bindingBy similarity5

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains at least 4 autonomous repression domains (RD1-4).By similarity
The Ligand-dependent nuclear receptor binding region is required for ligand-dependent interaction with RAAR and RXRB homo- and heterodimers, for the corepressor activity, and for the formation of an HDAC3 complex with RARA/RXRB.

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IFW7 Eukaryota
ENOG410XPVS LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000007999

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000236277

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG052667

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8CBD1

KEGG Orthology (KO)

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KOi
K17965

Identification of Orthologs from Complete Genome Data

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OMAi
CDDLHIH

Database of Orthologous Groups

More...
OrthoDBi
EOG091G07UX

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8CBD1

TreeFam database of animal gene trees

More...
TreeFami
TF332210

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026649 NRIP1
IPR031405 NRIP1_RD1
IPR031406 NRIP1_RD2
IPR031407 NRIP1_RD3
IPR031408 NRIP1_RD4

The PANTHER Classification System

More...
PANTHERi
PTHR15088 PTHR15088, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15687 NRIP1_repr_1, 1 hit
PF15688 NRIP1_repr_2, 1 hit
PF15689 NRIP1_repr_3, 1 hit
PF15690 NRIP1_repr_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8CBD1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTHGEELGSD VHQDSIVLTY LEGLLMHQAA GGSGTAINKK SAGHKEEDQN
60 70 80 90 100
FNLSGSAFPS CQSNGPTVST QTYQGSGMLH LKKARLLQSS EDWNAAKRKR
110 120 130 140 150
LSDSIVNLNV KKEALLAGMV DSVPKGKQDS TLLASLLQSF SSRLQTVALS
160 170 180 190 200
QQIRQSLKEQ GYALSHESLK VEKDLRCYGV ASSHLKTLLK KSKTKDQKSG
210 220 230 240 250
PTLPDVTPNL IRDSFVESSH PAVGQSGTKV MSEPLSCAAR LQAVASMVEK
260 270 280 290 300
RASPAASPKP SVACSQLALL LSSEAHLQQY SREHALKTQN AHQVASERLA
310 320 330 340 350
AMARLQENGQ KDVGSSQLSK GVSGHLNGQA RALPASKLVA NKNNAATFQS
360 370 380 390 400
PMGVVPSSPK NTSYKNSLER NNLKQAANNS LLLHLLKSQT IPTPMNGHSQ
410 420 430 440 450
NERASSFESS TPTTIDEYSD NNPSFTDDSS GDESSYSNCV PIDLSCKHRI
460 470 480 490 500
EKPEAERPVS LENLTQSLLN TWDPKIPGVD IKEDQDTSTN SKLNSHQKVT
510 520 530 540 550
LLQLLLGHKS EETVERNASP QDIHSDGTKF SPQNYTRTSV IESPSTNRTT
560 570 580 590 600
PVSTPPLYTA SQAESPINLS QHSLVIKWNS PPYACSTPAS KLTNTAPSHL
610 620 630 640 650
MDLTKGKESQ AEKPAPSEGA QNSATFSASK LLQNLAQCGL QSSGPGEEQR
660 670 680 690 700
PCKQLLSGNP DKPLGLIDRL NSPLLSNKTN AAEESKAFSS QPAGPEPGLP
710 720 730 740 750
GCEIENLLER RTVLQLLLGN SSKGKNEKKE KTPARDEAPQ EHSERAANEQ
760 770 780 790 800
ILMVKIKSEP CDDFQTHNTN LPLNHDAKSA PFLGVTPAIH RSTAALPVSE
810 820 830 840 850
DFKSEPASPQ DFSFSKNGLL SRLLRQNQES YPADEQDKSH RNSELPTLES
860 870 880 890 900
KNICMVPKKR KLYTEPLENP FKKMKNTAVD TANHHSGPEV LYGSLLHQEE
910 920 930 940 950
LKFSRNELDY KYPAGHSSAS DGDHRSWARE SKSFNVLKQL LLSENCVRDL
960 970 980 990 1000
SPHRSDSVPD TKKKGHKNNA PGSKPEFGIS SLNGLMYSSP QPGSCVTDHR
1010 1020 1030 1040 1050
TFSYPGMVKT PLSPPFPEHL GCVGSRPEPG LLNGCSVPGE KGPIKWVIAD
1060 1070 1080 1090 1100
MDKNEYEKDS PRLTKTNPIL YYMLQKGGGN SVTTQETQDK DIWREPASAE
1110 1120 1130 1140 1150
SLSQVTVKEE LLPAAETKAS FFNLRSPYNS HMGNNASRPH STNGEVYGLL
1160
GNALTIKKES E
Length:1,161
Mass (Da):126,337
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i56ABD0C2A5AAC0A1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A338P7D1A0A338P7D1_MOUSE
Nuclear receptor-interacting protei...
Nrip1
34Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VG73A0A1Y7VG73_MOUSE
Nuclear receptor-interacting protei...
Nrip1
7Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti106V → N AA sequence (PubMed:15879431).Curated1
Sequence conflicti107N → NN AA sequence (PubMed:15846843).Curated1
Sequence conflicti119 – 120MV → IL in AAC69611 (PubMed:9774688).Curated2
Sequence conflicti190K → R in AAC69611 (PubMed:9774688).Curated1
Sequence conflicti197Q → E in AAC69611 (PubMed:9774688).Curated1
Sequence conflicti200G → D in AAC69611 (PubMed:9774688).Curated1
Sequence conflicti522D → V in AAC69611 (PubMed:9774688).Curated1
Sequence conflicti596A → V in AAC69611 (PubMed:9774688).Curated1
Sequence conflicti617S → N in AAC69611 (PubMed:9774688).Curated1
Sequence conflicti629S → K AA sequence (PubMed:15879431).Curated1
Sequence conflicti674L → Q in AAC69611 (PubMed:9774688).Curated1
Sequence conflicti818G → F in AAC69611 (PubMed:9774688).Curated1
Sequence conflicti855M → I in BAE33634 (PubMed:16141072).Curated1
Sequence conflicti886S → R in AAC69611 (PubMed:9774688).Curated1
Sequence conflicti1049A → T in AAC69611 (PubMed:9774688).Curated1

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF053062 mRNA Translation: AAC69611.1
AK036273 mRNA Translation: BAC29368.1
AK084498 mRNA Translation: BAC39197.1
AK156233 mRNA Translation: BAE33634.1
BC060232 mRNA Translation: AAH60232.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS28274.1

NCBI Reference Sequences

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RefSeqi
NP_775616.1, NM_173440.2
XP_006523113.1, XM_006523050.2
XP_006523114.1, XM_006523051.3
XP_006523117.1, XM_006523054.2
XP_017172509.1, XM_017317020.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.447018
Mm.455873
Mm.74711

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000054178; ENSMUSP00000051726; ENSMUSG00000048490
ENSMUST00000121927; ENSMUSP00000112959; ENSMUSG00000048490

Database of genes from NCBI RefSeq genomes

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GeneIDi
268903

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:268903

UCSC genome browser

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UCSCi
uc007zrx.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053062 mRNA Translation: AAC69611.1
AK036273 mRNA Translation: BAC29368.1
AK084498 mRNA Translation: BAC39197.1
AK156233 mRNA Translation: BAE33634.1
BC060232 mRNA Translation: AAH60232.1
CCDSiCCDS28274.1
RefSeqiNP_775616.1, NM_173440.2
XP_006523113.1, XM_006523050.2
XP_006523114.1, XM_006523051.3
XP_006523117.1, XM_006523054.2
XP_017172509.1, XM_017317020.1
UniGeneiMm.447018
Mm.455873
Mm.74711

3D structure databases

ProteinModelPortaliQ8CBD1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi234576, 12 interactors
DIPiDIP-29280N
IntActiQ8CBD1, 5 interactors
MINTiQ8CBD1
STRINGi10090.ENSMUSP00000051726

PTM databases

iPTMnetiQ8CBD1
PhosphoSitePlusiQ8CBD1

Proteomic databases

MaxQBiQ8CBD1
PaxDbiQ8CBD1
PeptideAtlasiQ8CBD1
PRIDEiQ8CBD1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054178; ENSMUSP00000051726; ENSMUSG00000048490
ENSMUST00000121927; ENSMUSP00000112959; ENSMUSG00000048490
GeneIDi268903
KEGGimmu:268903
UCSCiuc007zrx.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8204
MGIiMGI:1315213 Nrip1

Phylogenomic databases

eggNOGiENOG410IFW7 Eukaryota
ENOG410XPVS LUCA
GeneTreeiENSGT00390000007999
HOGENOMiHOG000236277
HOVERGENiHBG052667
InParanoidiQ8CBD1
KOiK17965
OMAiCDDLHIH
OrthoDBiEOG091G07UX
PhylomeDBiQ8CBD1
TreeFamiTF332210

Enzyme and pathway databases

ReactomeiR-MMU-3899300 SUMOylation of transcription cofactors
R-MMU-9018519 Estrogen-dependent gene expression

Miscellaneous databases

Protein Ontology

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PROi
PR:Q8CBD1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000048490 Expressed in 333 organ(s), highest expression level in female gonad
CleanExiMM_NRIP1
ExpressionAtlasiQ8CBD1 baseline and differential
GenevisibleiQ8CBD1 MM

Family and domain databases

InterProiView protein in InterPro
IPR026649 NRIP1
IPR031405 NRIP1_RD1
IPR031406 NRIP1_RD2
IPR031407 NRIP1_RD3
IPR031408 NRIP1_RD4
PANTHERiPTHR15088 PTHR15088, 1 hit
PfamiView protein in Pfam
PF15687 NRIP1_repr_1, 1 hit
PF15688 NRIP1_repr_2, 1 hit
PF15689 NRIP1_repr_3, 1 hit
PF15690 NRIP1_repr_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNRIP1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8CBD1
Secondary accession number(s): Q3U166, Q8C3Y8, Q9Z2K2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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