Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine-rich repeat neuronal protein 3

Gene

Lrrn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat neuronal protein 3
Alternative name(s):
Neuronal leucine-rich repeat protein 3
Short name:
NLRR-3
Gene namesi
Name:Lrrn3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:106036 Lrrn3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 626ExtracellularSequence analysisAdd BLAST604
Transmembranei627 – 647HelicalSequence analysisAdd BLAST21
Topological domaini648 – 707CytoplasmicSequence analysisAdd BLAST60

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000004582423 – 707Leucine-rich repeat neuronal protein 3Add BLAST685

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi223N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi382N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi444 ↔ 496PROSITE-ProRule annotation
Glycosylationi522N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi579N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi608N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi624N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8CBC6
PaxDbiQ8CBC6
PRIDEiQ8CBC6

PTM databases

iPTMnetiQ8CBC6
PhosphoSitePlusiQ8CBC6
SwissPalmiQ8CBC6

Expressioni

Tissue specificityi

Expressed in the brain, in Stronger expression in the ventricular zone and anlage of thalamus, spinal cord, and dorsal root ganglion in E11-17 cerebellum and cerebral cortex in adults.1 Publication

Gene expression databases

BgeeiENSMUSG00000036295 Expressed in 202 organ(s), highest expression level in superior cervical ganglion
CleanExiMM_LRRN3
GenevisibleiQ8CBC6 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043818

Structurei

3D structure databases

ProteinModelPortaliQ8CBC6
SMRiQ8CBC6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 69LRRNTAdd BLAST47
Repeati70 – 91LRR 1Add BLAST22
Repeati93 – 114LRR 2Add BLAST22
Repeati117 – 138LRR 3Add BLAST22
Repeati141 – 162LRR 4Add BLAST22
Repeati165 – 186LRR 5Add BLAST22
Repeati189 – 210LRR 6Add BLAST22
Repeati213 – 234LRR 7Add BLAST22
Repeati237 – 258LRR 8Add BLAST22
Repeati261 – 282LRR 9Add BLAST22
Repeati285 – 304LRR 10Add BLAST20
Repeati310 – 332LRR 11Add BLAST23
Repeati335 – 358LRR 12Add BLAST24
Domaini368 – 421LRRCTAdd BLAST54
Domaini421 – 514Ig-like C2-typeAdd BLAST94
Domaini523 – 614Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST92

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118831
HOGENOMiHOG000252914
HOVERGENiHBG052361
InParanoidiQ8CBC6
OMAiPQLCTCE
OrthoDBiEOG091G066E
PhylomeDBiQ8CBC6
TreeFamiTF334360

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF00041 fn3, 1 hit
PF07679 I-set, 1 hit
PF13855 LRR_8, 3 hits
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00369 LRR_TYP, 8 hits
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 9 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8CBC6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKDTPLQVHV LLGLAITTLV QAIDKKVDCP QLCTCEIRPW FTPRSIYMEA
60 70 80 90 100
STVDCNDLGL LNFPARLPAD TQILLLQTNN IARIEHSTDF PVNLTGLDLS
110 120 130 140 150
QNNLSSVTNI NVQKMSQLLS VYLEENKLTE LPEKCLYGLS NLQELYVNHN
160 170 180 190 200
LLSTISPGAF IGLHNLLRLH LNSNRLQMIN SQWFDALPNL EILMLGDNPI
210 220 230 240 250
IRIKDMNFQP LVKLRSLVIA GINLTEIPDD ALAGLENLES ISFYDNRLSK
260 270 280 290 300
VPQVALQKAV NLKFLDLNKN PINRIRRGDF SNMLHLKELG INNMPELVSI
310 320 330 340 350
DSLAVDNLPD LRKIEATNNP RLSYIHPNAF FRLPKLESLM LNTNALSALY
360 370 380 390 400
HGTIESLPNL KEISIHSNPI RCDCVIRWIN MNKTNIRFME PDSLFCVDPP
410 420 430 440 450
EFQGQNVRQV HFRDMMEICL PLIAPESFPS DLDVEADSYV SLHCRATAEP
460 470 480 490 500
QPEIYWITPS GKKLLPNTMR EKFYVHSEGT LEIRGITPKE GGLYTCIATN
510 520 530 540 550
LVGADLKSIM IKVGGSVPQD NNGSLNIKIR DIRANSVLVS WKASSKILKS
560 570 580 590 600
SVKWTAFVKT EDSHAAQSAR IPFDVKVYNL THLKPSTEYK ICIDIPTVYQ
610 620 630 640 650
KSRKQCVNVT TKSLEHDGKE YGKNHTVFVA CVGGLLGIIG VMCLFSCVSQ
660 670 680 690 700
EGSSEGEHSY AVNHCHKPAL AFSELYPPLI NLWESSKEKR ATLEVKATAI

GVPTNMS
Length:707
Mass (Da):79,176
Last modified:March 1, 2003 - v1
Checksum:iDFCA009A2553E0FC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti551S → R in BAA08622 (PubMed:9011764).Curated1
Sequence conflicti556A → G in BAA08622 (PubMed:9011764).Curated1
Sequence conflicti573F → S in BAA08622 (PubMed:9011764).Curated1
Sequence conflicti639I → V in BAA08622 (PubMed:9011764).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49802 mRNA Translation: BAA08622.1
AK036316 mRNA Translation: BAC29381.1
BC069041 mRNA Translation: AAH69041.1
CCDSiCCDS25896.1
RefSeqiNP_001258637.1, NM_001271708.1
NP_001258638.1, NM_001271709.1
NP_034863.1, NM_010733.3
UniGeneiMm.404786
Mm.491383

Genome annotation databases

EnsembliENSMUST00000043884; ENSMUSP00000043818; ENSMUSG00000036295
GeneIDi16981
KEGGimmu:16981
UCSCiuc007nln.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49802 mRNA Translation: BAA08622.1
AK036316 mRNA Translation: BAC29381.1
BC069041 mRNA Translation: AAH69041.1
CCDSiCCDS25896.1
RefSeqiNP_001258637.1, NM_001271708.1
NP_001258638.1, NM_001271709.1
NP_034863.1, NM_010733.3
UniGeneiMm.404786
Mm.491383

3D structure databases

ProteinModelPortaliQ8CBC6
SMRiQ8CBC6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043818

PTM databases

iPTMnetiQ8CBC6
PhosphoSitePlusiQ8CBC6
SwissPalmiQ8CBC6

Proteomic databases

MaxQBiQ8CBC6
PaxDbiQ8CBC6
PRIDEiQ8CBC6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043884; ENSMUSP00000043818; ENSMUSG00000036295
GeneIDi16981
KEGGimmu:16981
UCSCiuc007nln.2 mouse

Organism-specific databases

CTDi54674
MGIiMGI:106036 Lrrn3

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118831
HOGENOMiHOG000252914
HOVERGENiHBG052361
InParanoidiQ8CBC6
OMAiPQLCTCE
OrthoDBiEOG091G066E
PhylomeDBiQ8CBC6
TreeFamiTF334360

Miscellaneous databases

PROiPR:Q8CBC6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036295 Expressed in 202 organ(s), highest expression level in superior cervical ganglion
CleanExiMM_LRRN3
GenevisibleiQ8CBC6 MM

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF00041 fn3, 1 hit
PF07679 I-set, 1 hit
PF13855 LRR_8, 3 hits
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00369 LRR_TYP, 8 hits
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 9 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLRRN3_MOUSE
AccessioniPrimary (citable) accession number: Q8CBC6
Secondary accession number(s): P97860
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again