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Protein

Consortin

Gene

Cnst

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for targeting of connexins to the plasma membrane.By similarity

GO - Molecular functioni

  • connexin binding Source: UniProtKB
  • phosphatase binding Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Consortin
Gene namesi
Name:Cnst
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2445141 Cnst

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 650CytoplasmicSequence analysisAdd BLAST650
Transmembranei651 – 671HelicalSequence analysisAdd BLAST21
Topological domaini672 – 711ExtracellularSequence analysisAdd BLAST40

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi558 – 562DSDLL → NSDAA: Does not affect binding to connexins but results in their intracellular accumulation. 1 Publication5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002889071 – 711ConsortinAdd BLAST711

Proteomic databases

PaxDbiQ8CBC4
PeptideAtlasiQ8CBC4
PRIDEiQ8CBC4

PTM databases

iPTMnetiQ8CBC4
PhosphoSitePlusiQ8CBC4
SwissPalmiQ8CBC4

Expressioni

Gene expression databases

BgeeiENSMUSG00000038949 Expressed in 243 organ(s), highest expression level in oocyte
CleanExiMM_9630058J23RIK
GenevisibleiQ8CBC4 MM

Interactioni

Subunit structurei

Interacts with connexins GJA1/CX43, GJB1/CX32, GJB2/CX26, GJB3/CX31, GJB6/CX30 and GJC1/CX45. Also interacts with GGA1 and GGA2. Does not interact with PANX1.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8CBC4, 9 interactors
STRINGi10090.ENSMUSP00000048205

Structurei

3D structure databases

ProteinModelPortaliQ8CBC4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CNST family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHAY Eukaryota
ENOG411023R LUCA
GeneTreeiENSGT00390000005861
HOGENOMiHOG000111226
HOVERGENiHBG098332
InParanoidiQ8CBC4
KOiK17581
OMAiVCTDFAD
OrthoDBiEOG091G02MI
PhylomeDBiQ8CBC4
TreeFamiTF351172

Family and domain databases

InterProiView protein in InterPro
IPR028129 Consortin_C
PfamiView protein in Pfam
PF15281 Consortin_C, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8CBC4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDDSDPPTYS LQIEPQDGCH PGDSVERRVT RLPSVSDENE NQLAGDGPAG
60 70 80 90 100
LTTSEGAMGR ATVSEQDSLN NNESFPSSCE AAPTENAENT PSEGPKDDPP
110 120 130 140 150
SLGQDQKLPA KRSPRAKKSS PKSAPPGDAV PVMQTQNATS QAAGEEEAAG
160 170 180 190 200
VNANDPPKAP ALQPLFSLIR GEVAQMDSRA LPLFLHQVAE TYFQEEDYEK
210 220 230 240 250
AMKFIQLERL YHEQLLANLS AIQEQWETKW KAVQPRTVTP LRNSEKGFNG
260 270 280 290 300
EDFEQLAKIC TTHQDPLLSK LKTAPVEPSP ERKSLARAIM SEEAVGTEAA
310 320 330 340 350
AKEPEIETCP STDPSGDRHE EEPQESSPGC HQMEWQTASP ELPGTAGKDH
360 370 380 390 400
TEELPSSTNA TLDLHTQSLE TAGSRSGPAA ASNACKDSSC VPAPPTEDHC
410 420 430 440 450
GVARDPKVAP PSESVAEQKL STGDDGALPG LISEGKYSQA HRKELCLPLQ
460 470 480 490 500
DAFEALPRDQ PHSSEVAEPR QPDVTASDGK SAQSQAGLET GPESALCGDR
510 520 530 540 550
KACDVSTLCL EVCMAPEERR DSEDRVSKET EDYLHSLLER CLKDAEDSLS
560 570 580 590 600
YEDIQDDDSD LLQDLSPEEA SYSLQEDLPP DESTLSLDDL AKKIEIAEAI
610 620 630 640 650
PAEGLVSILK KRNDTVGSHP AQMQQKPAKR RVRFQEIDDN LEQDEVGGGS
660 670 680 690 700
CILLILLCIA TVFLSVGGTA LYCTLGNIES PVCTDFADNV DFYYTKLLQG
710
VAGLKHWVYL S
Length:711
Mass (Da):76,866
Last modified:March 1, 2003 - v1
Checksum:iB117F1FA8648E8EC
GO
Isoform 2 (identifier: Q8CBC4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     128-197: DAVPVMQTQN...VAETYFQEED → EAFRLSLLSF...PSLRHGGFAL
     198-711: Missing.

Show »
Length:201
Mass (Da):21,495
Checksum:iF439F01E6FF16D28
GO
Isoform 3 (identifier: Q8CBC4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-289: Missing.

Show »
Length:422
Mass (Da):45,414
Checksum:i63ECC182B66CFF30
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0386571 – 289Missing in isoform 3. 1 PublicationAdd BLAST289
Alternative sequenceiVSP_025821128 – 197DAVPV…FQEED → EAFRLSLLSFNKNKHFFWCC SAAAPVAPLCGSCIPFVPAV TVYREITTCLVCFLYRPHHG VLTLPSLRHGGFAL in isoform 2. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_025822198 – 711Missing in isoform 2. 1 PublicationAdd BLAST514

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036332 mRNA Translation: BAC29388.1
AK040666 mRNA Translation: BAC30660.1
AK040899 mRNA Translation: BAC30736.1
AK146681 mRNA Translation: BAE27356.1
BC034107 mRNA Translation: AAH34107.1
BC054802 mRNA Translation: AAH54802.1
CCDSiCCDS15562.1 [Q8CBC4-1]
RefSeqiNP_666217.2, NM_146105.3 [Q8CBC4-1]
UniGeneiMm.87662

Genome annotation databases

EnsembliENSMUST00000040706; ENSMUSP00000048205; ENSMUSG00000038949 [Q8CBC4-1]
GeneIDi226744
KEGGimmu:226744
UCSCiuc007dvm.1 mouse [Q8CBC4-2]
uc007dvo.1 mouse [Q8CBC4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036332 mRNA Translation: BAC29388.1
AK040666 mRNA Translation: BAC30660.1
AK040899 mRNA Translation: BAC30736.1
AK146681 mRNA Translation: BAE27356.1
BC034107 mRNA Translation: AAH34107.1
BC054802 mRNA Translation: AAH54802.1
CCDSiCCDS15562.1 [Q8CBC4-1]
RefSeqiNP_666217.2, NM_146105.3 [Q8CBC4-1]
UniGeneiMm.87662

3D structure databases

ProteinModelPortaliQ8CBC4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8CBC4, 9 interactors
STRINGi10090.ENSMUSP00000048205

PTM databases

iPTMnetiQ8CBC4
PhosphoSitePlusiQ8CBC4
SwissPalmiQ8CBC4

Proteomic databases

PaxDbiQ8CBC4
PeptideAtlasiQ8CBC4
PRIDEiQ8CBC4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040706; ENSMUSP00000048205; ENSMUSG00000038949 [Q8CBC4-1]
GeneIDi226744
KEGGimmu:226744
UCSCiuc007dvm.1 mouse [Q8CBC4-2]
uc007dvo.1 mouse [Q8CBC4-1]

Organism-specific databases

CTDi163882
MGIiMGI:2445141 Cnst

Phylogenomic databases

eggNOGiENOG410IHAY Eukaryota
ENOG411023R LUCA
GeneTreeiENSGT00390000005861
HOGENOMiHOG000111226
HOVERGENiHBG098332
InParanoidiQ8CBC4
KOiK17581
OMAiVCTDFAD
OrthoDBiEOG091G02MI
PhylomeDBiQ8CBC4
TreeFamiTF351172

Miscellaneous databases

PROiPR:Q8CBC4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038949 Expressed in 243 organ(s), highest expression level in oocyte
CleanExiMM_9630058J23RIK
GenevisibleiQ8CBC4 MM

Family and domain databases

InterProiView protein in InterPro
IPR028129 Consortin_C
PfamiView protein in Pfam
PF15281 Consortin_C, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCNST_MOUSE
AccessioniPrimary (citable) accession number: Q8CBC4
Secondary accession number(s): Q8BFS5, Q8K053
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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