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Protein

Protein GAPT

Gene

Gapt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negatively regulates B-cell proliferation following stimulation through the B-cell receptor. May play an important role in maintenance of marginal zone (MZ) B-cells.1 Publication

GO - Biological processi

  • B cell homeostasis Source: MGI
  • B cell proliferation involved in immune response Source: MGI
  • immunoglobulin production involved in immunoglobulin mediated immune response Source: MGI

Keywordsi

Biological processB-cell activation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GAPT
Alternative name(s):
Growth factor receptor-bound protein 2-binding adapter protein, transmembrane
Gene namesi
Name:Gapt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:3608341 Gapt

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice are normal in appearance, size and fertility. In aged mice, the number of MZ B-cells is increased, and serum concentrations of IgM, IgG2b, and IgG3 are elevated.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002711241 – 157Protein GAPTAdd BLAST157

Proteomic databases

MaxQBiQ8CB93
PaxDbiQ8CB93
PRIDEiQ8CB93

PTM databases

iPTMnetiQ8CB93
PhosphoSitePlusiQ8CB93

Expressioni

Tissue specificityi

Expressed primarily in B220+ splenocytes and total bone marrow cells. Expressed at lower levels in mast cells and dendritic cells. Not detected in T-cells and macrophages (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000046006

Interactioni

Subunit structurei

Interacts with GRB2.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053775

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi140 – 145Poly-Pro6

Sequence similaritiesi

Belongs to the GAPT family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J43U Eukaryota
ENOG4111803 LUCA
GeneTreeiENSGT00390000011255
HOGENOMiHOG000290679
HOVERGENiHBG095160
InParanoidiQ8CB93
OMAiCGIGCVW
OrthoDBiEOG091G0YW4
PhylomeDBiQ8CB93
TreeFamiTF338585

Family and domain databases

InterProiView protein in InterPro
IPR021082 Protein_GAPT
PANTHERiPTHR37350 PTHR37350, 1 hit
PfamiView protein in Pfam
PF11770 GAPT, 1 hit
PRINTSiPR02077 PROTEINGAPT

Sequencei

Sequence statusi: Complete.

Q8CB93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLECFESSPV AVAVGVSLLV LLLLCGIGCA WHWNRRESTP FTLPKFMQRR
60 70 80 90 100
SSRQKDVTKT VSSSAYVISP SMKASVESKG HKSTAKRNKM HGNYENVEVC
110 120 130 140 150
PPCTEGTTEK ALYENTQPSN LEEHVYGNQT DPLYYNFQKP SPPPPQDDDI

YILPDCD
Length:157
Mass (Da):17,601
Last modified:March 1, 2003 - v1
Checksum:i61C4C15FBABC5410
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036534 mRNA Translation: BAC29466.1
AK155882 mRNA Translation: BAE33480.1
BC116629 mRNA Translation: AAI16630.1
BC118005 mRNA Translation: AAI18006.1
CCDSiCCDS26766.1
RefSeqiNP_808381.1, NM_177713.3
XP_006517713.1, XM_006517650.3
XP_006517714.1, XM_006517651.3
XP_006517715.1, XM_006517652.3
UniGeneiMm.30533

Genome annotation databases

EnsembliENSMUST00000058806; ENSMUSP00000053775; ENSMUSG00000046006
ENSMUST00000224534; ENSMUSP00000153170; ENSMUSG00000046006
GeneIDi238875
KEGGimmu:238875
UCSCiuc007rvq.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGAPT_MOUSE
AccessioniPrimary (citable) accession number: Q8CB93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2003
Last modified: November 22, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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