Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Low-density lipoprotein receptor-related protein 11

Gene

Lrp11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processEndocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Low-density lipoprotein receptor-related protein 11
Short name:
LRP-11
Gene namesi
Name:Lrp11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2442989 Lrp11

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini33 – 433ExtracellularSequence analysisAdd BLAST401
Transmembranei434 – 456HelicalSequence analysisAdd BLAST23
Topological domaini457 – 483CytoplasmicSequence analysisAdd BLAST27

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000001733833 – 483Low-density lipoprotein receptor-related protein 11Add BLAST451

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi152N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi275N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi294 ↔ 306PROSITE-ProRule annotation
Disulfide bondi301 ↔ 319PROSITE-ProRule annotation
Disulfide bondi313 ↔ 328PROSITE-ProRule annotation
Glycosylationi403N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei474PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8CB67
PaxDbiQ8CB67
PRIDEiQ8CB67

PTM databases

iPTMnetiQ8CB67
PhosphoSitePlusiQ8CB67

Expressioni

Gene expression databases

BgeeiENSMUSG00000019796 Expressed in 219 organ(s), highest expression level in islet of Langerhans
ExpressionAtlasiQ8CB67 baseline and differential
GenevisibleiQ8CB67 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019931

Structurei

3D structure databases

ProteinModelPortaliQ8CB67
SMRiQ8CB67
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 172MANSCPROSITE-ProRule annotationAdd BLAST88
Domaini193 – 287PKDAdd BLAST95
Domaini293 – 329LDL-receptor class APROSITE-ProRule annotationAdd BLAST37

Sequence similaritiesi

Belongs to the LDLR family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIM4 Eukaryota
ENOG410XSFD LUCA
GeneTreeiENSGT00880000137941
HOGENOMiHOG000113387
HOVERGENiHBG052354
InParanoidiQ8CB67
OMAiKMVTHTA
OrthoDBiEOG091G0ET0
PhylomeDBiQ8CB67
TreeFamiTF325867

Family and domain databases

CDDicd00112 LDLa, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR013980 MANSC_dom
IPR011106 MANSC_N
IPR035986 PKD_dom_sf
PfamiView protein in Pfam
PF00057 Ldl_recept_a, 1 hit
PF07502 MANEC, 1 hit
SMARTiView protein in SMART
SM00192 LDLa, 1 hit
SM00765 MANEC, 1 hit
SUPFAMiSSF49299 SSF49299, 1 hit
SSF57424 SSF57424, 1 hit
PROSITEiView protein in PROSITE
PS01209 LDLRA_1, 1 hit
PS50068 LDLRA_2, 1 hit
PS50986 MANSC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8CB67-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATRGGGPGP GFRHRALRGL LLLCLWLPGS RPGEPAAPSS GVDRLLQDFR
60 70 80 90 100
RQLQRARPRE ELEPELLGGP REDCPGAGGT AVYRAVPDTI IRTQDSIAAG
110 120 130 140 150
ASFLRAPGSV RGWRQCVTAC CSEPSCSVAV VQLPRGPSVP APMPAPRCYL
160 170 180 190 200
FNCTARGRSV CKFAPLRGYR TYTLSRAEDA AGIPPRPDED KPPVSKAGKD
210 220 230 240 250
VVLHLPTDGV VLDGRESSDD HAIVLYEWTL QQGDPSSVDM KVPQPGTLRL
260 270 280 290 300
SRLKEGAYIF QLTVTDSVGQ RSSDNVSVTV LPRPYSTGGC SSACSRYHFF
310 320 330 340 350
CDSGCCIDIA LACDGVRQCP DGSDEDFCQN LALDRKLVTH TVATSAQPGA
360 370 380 390 400
MGLNEGEGDP KLEKSQRATT HNQPATVSHP ETRIHSTQKA PESQINPVQP
410 420 430 440 450
DSNSSGKNQE EGNYDLKSKS GQAGGEHPAP EAGAVLPLAL GLAITVLLLL
460 470 480
MVTCRLRLVK QKLKKARPIT SEESDYLING MYL
Length:483
Mass (Da):51,814
Last modified:March 1, 2003 - v1
Checksum:i7AC8F124DD30CC82
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z2B1D3Z2B1_MOUSE
Low-density lipoprotein receptor-re...
Lrp11
438Annotation score:
D3Z3A7D3Z3A7_MOUSE
Low-density lipoprotein receptor-re...
Lrp11
413Annotation score:
F7AX87F7AX87_MOUSE
Low-density lipoprotein receptor-re...
Lrp11
245Annotation score:
F6XYG6F6XYG6_MOUSE
Low-density lipoprotein receptor-re...
Lrp11
217Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25L → H in BAC33492 (PubMed:16141072).Curated1
Sequence conflicti241K → KLFVWQ in BAC33492 (PubMed:16141072).Curated1
Sequence conflicti401 – 483DSNSS…NGMYL → AIPQERTKKKEIMISSPRVA KQEGSTRPRKQVRCYLWH in BC059874 (PubMed:15489334).CuratedAdd BLAST83

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036676 mRNA Translation: BAC29532.1
AK048919 mRNA Translation: BAC33492.1
BC059874 mRNA No translation available.
CCDSiCCDS23686.1
RefSeqiNP_766372.1, NM_172784.3
UniGeneiMm.206759

Genome annotation databases

EnsembliENSMUST00000019931; ENSMUSP00000019931; ENSMUSG00000019796
ENSMUST00000229554; ENSMUSP00000155207; ENSMUSG00000116377
GeneIDi237253
KEGGimmu:237253
UCSCiuc007ehw.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036676 mRNA Translation: BAC29532.1
AK048919 mRNA Translation: BAC33492.1
BC059874 mRNA No translation available.
CCDSiCCDS23686.1
RefSeqiNP_766372.1, NM_172784.3
UniGeneiMm.206759

3D structure databases

ProteinModelPortaliQ8CB67
SMRiQ8CB67
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019931

PTM databases

iPTMnetiQ8CB67
PhosphoSitePlusiQ8CB67

Proteomic databases

MaxQBiQ8CB67
PaxDbiQ8CB67
PRIDEiQ8CB67

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019931; ENSMUSP00000019931; ENSMUSG00000019796
ENSMUST00000229554; ENSMUSP00000155207; ENSMUSG00000116377
GeneIDi237253
KEGGimmu:237253
UCSCiuc007ehw.2 mouse

Organism-specific databases

CTDi84918
MGIiMGI:2442989 Lrp11

Phylogenomic databases

eggNOGiENOG410IIM4 Eukaryota
ENOG410XSFD LUCA
GeneTreeiENSGT00880000137941
HOGENOMiHOG000113387
HOVERGENiHBG052354
InParanoidiQ8CB67
OMAiKMVTHTA
OrthoDBiEOG091G0ET0
PhylomeDBiQ8CB67
TreeFamiTF325867

Miscellaneous databases

ChiTaRSiLrp11 mouse
PROiPR:Q8CB67
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019796 Expressed in 219 organ(s), highest expression level in islet of Langerhans
ExpressionAtlasiQ8CB67 baseline and differential
GenevisibleiQ8CB67 MM

Family and domain databases

CDDicd00112 LDLa, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR013980 MANSC_dom
IPR011106 MANSC_N
IPR035986 PKD_dom_sf
PfamiView protein in Pfam
PF00057 Ldl_recept_a, 1 hit
PF07502 MANEC, 1 hit
SMARTiView protein in SMART
SM00192 LDLa, 1 hit
SM00765 MANEC, 1 hit
SUPFAMiSSF49299 SSF49299, 1 hit
SSF57424 SSF57424, 1 hit
PROSITEiView protein in PROSITE
PS01209 LDLRA_1, 1 hit
PS50068 LDLRA_2, 1 hit
PS50986 MANSC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLRP11_MOUSE
AccessioniPrimary (citable) accession number: Q8CB67
Secondary accession number(s): Q8C7Y7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again