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Protein

Centrobin

Gene

Cntrob

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Centrobin
Alternative name(s):
Centrosomal BRCA2-interacting protein
LYST-interacting protein 8
Gene namesi
Name:Cntrob
Synonyms:Lip8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2443290 Cntrob

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000762411 – 887CentrobinAdd BLAST887

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei81PhosphoserineBy similarity1
Modified residuei782PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8CB62
PaxDbiQ8CB62
PeptideAtlasiQ8CB62
PRIDEiQ8CB62

PTM databases

iPTMnetiQ8CB62
PhosphoSitePlusiQ8CB62

Expressioni

Gene expression databases

BgeeiENSMUSG00000032782 Expressed in 275 organ(s), highest expression level in frontal cortex
CleanExiMM_CNTROB
ExpressionAtlasiQ8CB62 baseline and differential
GenevisibleiQ8CB62 MM

Interactioni

Subunit structurei

Interacts with LYST.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000090651

Structurei

3D structure databases

ProteinModelPortaliQ8CB62
SMRiQ8CB62
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni360 – 887Required for centrosome localizationBy similarityAdd BLAST528

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili191 – 557Sequence analysisAdd BLAST367

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi568 – 769Pro-richAdd BLAST202

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410ISM1 Eukaryota
ENOG4111JSV LUCA
GeneTreeiENSGT00610000086191
HOGENOMiHOG000056447
HOVERGENiHBG081290
InParanoidiQ8CB62
KOiK16468
OMAiFRVHELP
OrthoDBiEOG091G02O7
PhylomeDBiQ8CB62
TreeFamiTF337444

Family and domain databases

InterProiView protein in InterPro
IPR038923 Centrobin
PANTHERiPTHR34439 PTHR34439, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8CB62-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATAAPSPSS PLRPEDLLSD SSEPPGLNQV SSEVTSQLYT SLHLSRQAEA
60 70 80 90 100
TARAQLYLAP TSSPPNEGLD SLAQELSRSL SVGLENNLKK KDGSKHIFEM
110 120 130 140 150
ESVRGQLQTM LHTSRDTAYR TGSERREEDS FDSDSTATLL NTRPLQDLSP
160 170 180 190 200
SSSAPALEEL FPRYTSLRPG PPTNPPDFQG LRDALDAELT RRKHCERHIQ
210 220 230 240 250
SLQTRVLELQ QQLAVAVAAD HKKDLMIEQL DKTLARVVEG WNRHEAERTE
260 270 280 290 300
VLRGLQEERQ AAELTRSKQQ ETVTRLEQSL SEAMEALSRE QEGARLQQRE
310 320 330 340 350
KEALEEERQA LTLRLEVEQQ QCRTLQEERD EARAGQLSEH RKLEALQVAL
360 370 380 390 400
QEERQAWIKQ EHQLKERLQA LQEEGQAQLE REKGNSQREA QAAWETQQQF
410 420 430 440 450
ALLQTEVRRL EGDLDTVRRE RDALQLEMSL VQARYESQRI QMESELAVQL
460 470 480 490 500
EQRVTERLAE AQENSLRQAA SLRDHHRKQL QELSGQHQQE LAAQLAQFKV
510 520 530 540 550
EMADREERQQ QVAQDYELRL AREQARVRDL KSGNQQLEEQ RAELVERLQA
560 570 580 590 600
MLQAHWEEAN QLLSTTLLPP NPQAPLAEPS SPGPLEPEKG ERRTWAMPPM
610 620 630 640 650
AVALKPVLQQ SREVKGDVPG APSVLCSTSP DLSLLLGPPF QNQNSFQPLE
660 670 680 690 700
PKPDVTPPTA GPFSALEAFT DDHRAERPFP EEDPGSDGDA RLPPASQLEG
710 720 730 740 750
LKNFLQQLLE TAPQSNGNPS ADLLLPKAGS RAVSSWEEAP QVPRLPPPVH
760 770 780 790 800
KTKVPLAMAS SLFRVHGLPS TNLQGSGLST GSPEKDGLNL VDVSELLRLY
810 820 830 840 850
QARGWGALPA EDLLLYLKRL EHSGTDGQGE LVPRRNTDSR LGETTRKEIP
860 870 880
SQAVPRRLAS VPKTEKPARK KSGHPGPSMR SRGGIWR
Length:887
Mass (Da):99,404
Last modified:January 10, 2006 - v2
Checksum:i8E5F99097338EF00
GO
Isoform 2 (identifier: Q8CB62-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-225: Missing.

Note: No experimental confirmation available.
Show »
Length:662
Mass (Da):74,680
Checksum:iA9A564191AE650E5
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BK55H3BK55_MOUSE
Centrobin
Cntrob
51Annotation score:
D6RGB4D6RGB4_MOUSE
Centrobin
Cntrob
152Annotation score:
H3BJ47H3BJ47_MOUSE
Centrobin
Cntrob
75Annotation score:
F6TUD4F6TUD4_MOUSE
Centrobin
Cntrob
32Annotation score:

Sequence cautioni

The sequence AAH58512 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0168421 – 225Missing in isoform 2. 1 PublicationAdd BLAST225

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036710 mRNA Translation: BAC29545.1
AL645527 Genomic DNA No translation available.
BC058512 mRNA Translation: AAH58512.1 Different initiation.
CCDSiCCDS24888.2 [Q8CB62-1]
RefSeqiNP_766148.2, NM_172560.3 [Q8CB62-1]
UniGeneiMm.28774

Genome annotation databases

EnsembliENSMUST00000092973; ENSMUSP00000090651; ENSMUSG00000032782 [Q8CB62-1]
GeneIDi216846
KEGGimmu:216846
UCSCiuc007jpp.1 mouse [Q8CB62-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036710 mRNA Translation: BAC29545.1
AL645527 Genomic DNA No translation available.
BC058512 mRNA Translation: AAH58512.1 Different initiation.
CCDSiCCDS24888.2 [Q8CB62-1]
RefSeqiNP_766148.2, NM_172560.3 [Q8CB62-1]
UniGeneiMm.28774

3D structure databases

ProteinModelPortaliQ8CB62
SMRiQ8CB62
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000090651

PTM databases

iPTMnetiQ8CB62
PhosphoSitePlusiQ8CB62

Proteomic databases

EPDiQ8CB62
PaxDbiQ8CB62
PeptideAtlasiQ8CB62
PRIDEiQ8CB62

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000092973; ENSMUSP00000090651; ENSMUSG00000032782 [Q8CB62-1]
GeneIDi216846
KEGGimmu:216846
UCSCiuc007jpp.1 mouse [Q8CB62-1]

Organism-specific databases

CTDi116840
MGIiMGI:2443290 Cntrob

Phylogenomic databases

eggNOGiENOG410ISM1 Eukaryota
ENOG4111JSV LUCA
GeneTreeiENSGT00610000086191
HOGENOMiHOG000056447
HOVERGENiHBG081290
InParanoidiQ8CB62
KOiK16468
OMAiFRVHELP
OrthoDBiEOG091G02O7
PhylomeDBiQ8CB62
TreeFamiTF337444

Miscellaneous databases

PROiPR:Q8CB62
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032782 Expressed in 275 organ(s), highest expression level in frontal cortex
CleanExiMM_CNTROB
ExpressionAtlasiQ8CB62 baseline and differential
GenevisibleiQ8CB62 MM

Family and domain databases

InterProiView protein in InterPro
IPR038923 Centrobin
PANTHERiPTHR34439 PTHR34439, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCNTRB_MOUSE
AccessioniPrimary (citable) accession number: Q8CB62
Secondary accession number(s): B0QZN4, Q5NCF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: November 7, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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