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Protein

GRAM domain-containing protein 4

Gene

Gramd4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53.By similarity

Caution

It is uncertain whether Met-1 or Met-52 is the initiator.Curated

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
GRAM domain-containing protein 4
Alternative name(s):
Death-inducing protein
Gene namesi
Name:Gramd4
Synonyms:Dip, Kiaa0767
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2676308 Gramd4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei295 – 315HelicalSequence analysisAdd BLAST21
Transmembranei389 – 409HelicalSequence analysisAdd BLAST21
Transmembranei411 – 431HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003287431 – 633GRAM domain-containing protein 4Add BLAST633

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei75PhosphoserineCombined sources1
Modified residuei79PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8CB44
MaxQBiQ8CB44
PaxDbiQ8CB44
PeptideAtlasiQ8CB44
PRIDEiQ8CB44

PTM databases

iPTMnetiQ8CB44
PhosphoSitePlusiQ8CB44

Expressioni

Gene expression databases

BgeeiENSMUSG00000035900 Expressed in 262 organ(s), highest expression level in interventricular septum
ExpressionAtlasiQ8CB44 baseline and differential
GenevisibleiQ8CB44 MM

Interactioni

Protein-protein interaction databases

BioGridi230188, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ8CB44
SMRiQ8CB44
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini500 – 578GRAMAdd BLAST79

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili134 – 190Sequence analysisAdd BLAST57

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEG4 Eukaryota
ENOG410ZXGG LUCA
GeneTreeiENSGT00390000010968
HOGENOMiHOG000060209
HOVERGENiHBG098114
InParanoidiQ8CB44
OMAiVKFFLID
OrthoDBiEOG091G06UI
PhylomeDBiQ8CB44
TreeFamiTF320445

Family and domain databases

CDDicd13221 PH-GRAM_GRAMDC4, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR004182 GRAM
IPR037847 GRAMDC4
IPR037845 GRAMDC4_PH-GRAM
IPR011993 PH-like_dom_sf
PANTHERiPTHR44704 PTHR44704, 1 hit
PfamiView protein in Pfam
PF02893 GRAM, 1 hit
SMARTiView protein in SMART
SM00568 GRAM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8CB44-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGIASHSAFR ERESSPTGAS LDASPRPWDK GLSGREPPRH VQVRPRSAVL
60 70 80 90 100
NMLRRLDRIR FRGHKREDLL DLAESPNASD TECGDEIPLK TPRPSPRDSE
110 120 130 140 150
ELRDPAGPGT LIMAAGVQDF NRTEFDRLNE IKGHLEIALL EKHFLQEELR
160 170 180 190 200
KLREETNSEM LRQELDRERQ RRIELEQKMQ EVLKARSEEQ PAQPQQPPKG
210 220 230 240 250
QSQASNGTGT ERRSQGLASR VQKWFYERFG EYIEDFRFQP EENTVETEEP
260 270 280 290 300
LSARRLTENM RRLKRGAKPV TNFVKNLSAL SDWYSIYTSA IAFTVYMNAV
310 320 330 340 350
WHGWAIPMFL FLAILRLSLN YLIARGWRIQ WSIVPEVSEA VEPAKEDLTV
360 370 380 390 400
SEKFQLVLDV AQKAQNLFGK MADILEKIKN LFMWVQPETT QKLYVALWAA
410 420 430 440 450
FLASCFFPYR LVGLAVGLYA GIKFFLIDFI FKRCPRLRAK YDTPYIIWRS
460 470 480 490 500
LPTDPQLKER AGATVSRRLQ TASSRSYVSS APAGLSKDED AGRFHSTKKG
510 520 530 540 550
NFHEIFNLTE NERPLAVCEN GWRCCLINRD RKMPTDYIRN GVLYVTENYL
560 570 580 590 600
CFESSKSGSS KRNKVIKLMD ITDIQKYKVL SVLPGSGMGI AVSTPSTQKP
610 620 630
LVFGAMVHRD EAFETIFSQY VKITSAAASG GDS
Length:633
Mass (Da):72,264
Last modified:March 1, 2003 - v1
Checksum:iC961FEE9749B3AD3
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YUE7D3YUE7_MOUSE
GRAM domain-containing protein 4
Gramd4
627Annotation score:
D6RET7D6RET7_MOUSE
GRAM domain-containing protein 4
Gramd4
323Annotation score:

Sequence cautioni

The sequence AAH21523 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC98019 differs from that shown. The sequence differs from that shown because it seems to be derived from a pre-mRNA.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036832 mRNA Translation: BAC29597.1
AK129209 Transcribed RNA Translation: BAC98019.1 Sequence problems.
BC021523 mRNA Translation: AAH21523.1 Different initiation.
BC139228 mRNA Translation: AAI39229.1
BC139229 mRNA Translation: AAI39230.1
CCDSiCCDS27727.1
RefSeqiNP_766199.1, NM_172611.4
UniGeneiMm.24442

Genome annotation databases

EnsembliENSMUST00000088931; ENSMUSP00000086321; ENSMUSG00000035900
GeneIDi223752
KEGGimmu:223752
UCSCiuc007xdv.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036832 mRNA Translation: BAC29597.1
AK129209 Transcribed RNA Translation: BAC98019.1 Sequence problems.
BC021523 mRNA Translation: AAH21523.1 Different initiation.
BC139228 mRNA Translation: AAI39229.1
BC139229 mRNA Translation: AAI39230.1
CCDSiCCDS27727.1
RefSeqiNP_766199.1, NM_172611.4
UniGeneiMm.24442

3D structure databases

ProteinModelPortaliQ8CB44
SMRiQ8CB44
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230188, 1 interactor

PTM databases

iPTMnetiQ8CB44
PhosphoSitePlusiQ8CB44

Proteomic databases

EPDiQ8CB44
MaxQBiQ8CB44
PaxDbiQ8CB44
PeptideAtlasiQ8CB44
PRIDEiQ8CB44

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000088931; ENSMUSP00000086321; ENSMUSG00000035900
GeneIDi223752
KEGGimmu:223752
UCSCiuc007xdv.3 mouse

Organism-specific databases

CTDi23151
MGIiMGI:2676308 Gramd4
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IEG4 Eukaryota
ENOG410ZXGG LUCA
GeneTreeiENSGT00390000010968
HOGENOMiHOG000060209
HOVERGENiHBG098114
InParanoidiQ8CB44
OMAiVKFFLID
OrthoDBiEOG091G06UI
PhylomeDBiQ8CB44
TreeFamiTF320445

Miscellaneous databases

ChiTaRSiGramd4 mouse
PROiPR:Q8CB44
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035900 Expressed in 262 organ(s), highest expression level in interventricular septum
ExpressionAtlasiQ8CB44 baseline and differential
GenevisibleiQ8CB44 MM

Family and domain databases

CDDicd13221 PH-GRAM_GRAMDC4, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR004182 GRAM
IPR037847 GRAMDC4
IPR037845 GRAMDC4_PH-GRAM
IPR011993 PH-like_dom_sf
PANTHERiPTHR44704 PTHR44704, 1 hit
PfamiView protein in Pfam
PF02893 GRAM, 1 hit
SMARTiView protein in SMART
SM00568 GRAM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGRAM4_MOUSE
AccessioniPrimary (citable) accession number: Q8CB44
Secondary accession number(s): B2RTC1, Q6ZQ52, Q8VDL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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