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Protein

Putative homeodomain transcription factor 2

Gene

Phtf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in transcription regulation.

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Putative homeodomain transcription factor 2
Gene namesi
Name:Phtf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1916020 Phtf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003185101 – 747Putative homeodomain transcription factor 2Add BLAST747

Proteomic databases

PaxDbiQ8CB19
PRIDEiQ8CB19

PTM databases

iPTMnetiQ8CB19
PhosphoSitePlusiQ8CB19

Expressioni

Gene expression databases

CleanExiMM_PHTF2

Structurei

3D structure databases

ProteinModelPortaliQ8CB19
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IF1F Eukaryota
ENOG410ZM0V LUCA
HOGENOMiHOG000030907
HOVERGENiHBG061164
InParanoidiQ8CB19
PhylomeDBiQ8CB19
TreeFamiTF323570

Family and domain databases

InterProiView protein in InterPro
IPR039775 PHTF1/2
IPR021980 TF_homeodomain_male
PANTHERiPTHR12680 PTHR12680, 1 hit
PfamiView protein in Pfam
PF12129 Phtf-FEM1B_bdg, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8CB19-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASRVTDAIV WYQKKIGAYD QQIWEKSVEQ REIKGLRNKP KKTAHVKPDL
60 70 80 90 100
IDVDLVRGSA FAKAKPESPW TSLTRKGIVR VVFFPFFSRW WLQVTSRVIF
110 120 130 140 150
SWLLVLYLLQ VAAIVLFCSA PSPHSIPLTE VIGPIWLMLL LGTVHCQIVS
160 170 180 190 200
TRTPKPPLGT GGKRRRKLRK AAHLEVHREG DGSSTTDNTQ EGAVQSYGAG
210 220 230 240 250
APYSVGTVFR DLWLAAFFLS GSKKAKNSID KSTETDNGYV SLDGKRTVKS
260 270 280 290 300
SEDGAQYHEL QCETVGPEDA AWATRTPRSV PAKDTQRKIT NVSDEVSSEE
310 320 330 340 350
GPETGYPLRG HVDRTSESGL RNRKPHHYKK HYANEDAPKS GTSCSSRCSS
360 370 380 390 400
SRQDSESTRP ESETEGVLWE DLLHCAECRS SCTSETDVGN PQINPCGKKE
410 420 430 440 450
YRDDPFHQSH LPWLHSSHPG LEKISAIVWE GNDCKKADMS VLEISGMIMN
460 470 480 490 500
RVNNHVPGIG YQVFGNAISL ILGLTPFVFR LSQATDLEQL TAHSASELYV
510 520 530 540 550
IAFGSNEDVM VLSMVLISFV VRVSLVWIFF FLLCVAERTY KQRLLFAKLF
560 570 580 590 600
GHLTSARRAR KSEVPHFRLK KVQNIKMWLS LRSYLKRRGP QRSVDVIVSS
610 620 630 640 650
AFLLTISVVF ICCAQLLHVH EIFLDCHCNW ELVIWCISLT LFLLRFVTLG
660 670 680 690 700
SETSKKYSNT SILLTEQINL YLKMEKKPNK KEELTLVNNV LKLATKLLKE
710 720 730 740
LDSPFRLYGL TMNPLLYNIT QVVILSAVSG VISDLLGFNL KLWKIKS
Length:747
Mass (Da):84,105
Last modified:February 5, 2008 - v2
Checksum:i0994F8C14D29A889
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J1Q1A0A0R4J1Q1_MOUSE
Putative homeodomain transcription ...
Phtf2 mCG_131947
747Annotation score:
F6X6S4F6X6S4_MOUSE
Putative homeodomain transcription ...
Phtf2
169Annotation score:
D6RJJ1D6RJJ1_MOUSE
Putative homeodomain transcription ...
Phtf2
53Annotation score:
F6W0Y3F6W0Y3_MOUSE
Putative homeodomain transcription ...
Phtf2
20Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti197Y → H in BAC29673 (PubMed:16141072).Curated1
Sequence conflicti260L → P in BAC29673 (PubMed:16141072).Curated1
Sequence conflicti366G → D in BAC29673 (PubMed:16141072).Curated1
Sequence conflicti628C → Y in BAC29673 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK037021 mRNA Translation: BAC29673.1
BC052841 mRNA Translation: AAH52841.1
CCDSiCCDS51426.1
RefSeqiNP_766580.3, NM_172992.3
UniGeneiMm.86410

Genome annotation databases

GeneIDi68770
KEGGimmu:68770
UCSCiuc008wnz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK037021 mRNA Translation: BAC29673.1
BC052841 mRNA Translation: AAH52841.1
CCDSiCCDS51426.1
RefSeqiNP_766580.3, NM_172992.3
UniGeneiMm.86410

3D structure databases

ProteinModelPortaliQ8CB19
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ8CB19
PhosphoSitePlusiQ8CB19

Proteomic databases

PaxDbiQ8CB19
PRIDEiQ8CB19

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi68770
KEGGimmu:68770
UCSCiuc008wnz.2 mouse

Organism-specific databases

CTDi57157
MGIiMGI:1916020 Phtf2

Phylogenomic databases

eggNOGiENOG410IF1F Eukaryota
ENOG410ZM0V LUCA
HOGENOMiHOG000030907
HOVERGENiHBG061164
InParanoidiQ8CB19
PhylomeDBiQ8CB19
TreeFamiTF323570

Miscellaneous databases

ChiTaRSiPhtf2 mouse
PROiPR:Q8CB19
SOURCEiSearch...

Gene expression databases

CleanExiMM_PHTF2

Family and domain databases

InterProiView protein in InterPro
IPR039775 PHTF1/2
IPR021980 TF_homeodomain_male
PANTHERiPTHR12680 PTHR12680, 1 hit
PfamiView protein in Pfam
PF12129 Phtf-FEM1B_bdg, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPHTF2_MOUSE
AccessioniPrimary (citable) accession number: Q8CB19
Secondary accession number(s): Q7TPX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 7, 2018
This is version 86 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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