UniProtKB - Q8CAX3 (Q8CAX3_MOUSE)
Protein
T-cell surface glycoprotein CD8 alpha chain
Gene
Cd8a
Organism
Mus musculus (Mouse)
Status
Names & Taxonomyi
Protein namesi | Recommended name: T-cell surface glycoprotein CD8 alpha chainARBA annotation |
Gene namesi | Name:Cd8aImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:88346, Cd8a |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 195 – 219 | HelicalSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Sequence analysisAdd BLAST | 27 | |
ChainiPRO_5015099101 | 28 – 222 | T-cell surface glycoprotein CD8 alpha chainSequence analysisAdd BLAST | 195 |
Keywords - PTMi
Disulfide bondARBA annotation, GlycoproteinARBA annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000053977, Expressed in thymus and 134 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 140 | Ig-likeInterPro annotationAdd BLAST | 109 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 156 – 182 | DisorderedSequence analysisAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 156 – 176 | PolarSequence analysisAdd BLAST | 21 |
Keywords - Domaini
SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000156588 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR015468, CD8_asu IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set |
PANTHERi | PTHR10441, PTHR10441, 1 hit |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8CAX3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASPLTRFLS LNLLLLGESI ILGSGEAKPQ APELRIFPKK MDAELGQKVD
60 70 80 90 100
LVCEVLGSVS QGCSWLFQNS SSKLPQPTFV VYMASSHNKI TWDEKLNSSK
110 120 130 140 150
LFSAMRDTNN KYVLTLNKFS KENEGYYFCS VISNSVMYFS SVVPVLQKVN
160 170 180 190 200
STTTKPVLRT PSPVHPTGTS QPQRPEDCRP RGSVKGTGLD FACDIYIWAP
210 220
LAGICVALLL SLIITLICYH SR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketP01731 | CD8A_MOUSE | T-cell surface glycoprotein CD8 alp... | Cd8a Lyt-2, Lyt2 | 247 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC160090 Genomic DNA No translation available. AK037467 mRNA Translation: BAC29812.1 |
RefSeqi | NP_033987.1, NM_009857.1 |
Genome annotation databases
Ensembli | ENSMUST00000172321; ENSMUSP00000131873; ENSMUSG00000053977 |
GeneIDi | 12525 |
UCSCi | uc009cgs.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC160090 Genomic DNA No translation available. AK037467 mRNA Translation: BAC29812.1 |
RefSeqi | NP_033987.1, NM_009857.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 3495, 5131 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000172321; ENSMUSP00000131873; ENSMUSG00000053977 |
GeneIDi | 12525 |
UCSCi | uc009cgs.1, mouse |
Organism-specific databases
CTDi | 925 |
MGIi | MGI:88346, Cd8a |
Phylogenomic databases
GeneTreei | ENSGT00940000156588 |
Miscellaneous databases
BioGRID-ORCSi | 12525, 0 hits in 19 CRISPR screens |
ChiTaRSi | Cd8a, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000053977, Expressed in thymus and 134 other tissues |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR015468, CD8_asu IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set |
PANTHERi | PTHR10441, PTHR10441, 1 hit |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8CAX3_MOUSE | |
Accessioni | Q8CAX3Primary (citable) accession number: Q8CAX3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 141 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |