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Protein

Podocalyxin-like protein 2

Gene

Podxl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandSialic acid

Names & Taxonomyi

Protein namesi
Recommended name:
Podocalyxin-like protein 2
Alternative name(s):
Endoglycan
Gene namesi
Name:Podxl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2442488 Podxl2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 499ExtracellularSequence analysisAdd BLAST471
Transmembranei500 – 520HelicalSequence analysisAdd BLAST21
Topological domaini521 – 603CytoplasmicSequence analysisAdd BLAST83

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000025213029 – 603Podocalyxin-like protein 2Add BLAST575

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei93SulfotyrosineBy similarity1
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei113SulfotyrosineBy similarity1
Glycosylationi260N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi394N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei569PhosphoserineBy similarity1
Modified residuei594PhosphoserineCombined sources1

Post-translational modificationi

Glycosylated; contains chondroitin sulfate. Displays sialylated O-linked oligosaccharides (By similarity).By similarity
Sulfation is necessary for interaction with SELL. Sialylated O-linked oligosaccharides are necessary for interaction with SELL, SELE and SELP (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

Proteomic databases

PaxDbiQ8CAE9
PRIDEiQ8CAE9

PTM databases

iPTMnetiQ8CAE9
PhosphoSitePlusiQ8CAE9

Expressioni

Gene expression databases

CleanExiMM_PODXL2

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with SELL, SELE and SELP (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040417

Structurei

3D structure databases

ProteinModelPortaliQ8CAE9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi157 – 186Glu-richAdd BLAST30

Sequence similaritiesi

Belongs to the podocalyxin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFKB Eukaryota
ENOG410YCG4 LUCA
HOGENOMiHOG000054210
HOVERGENiHBG082114
InParanoidiQ8CAE9
KOiK06818
PhylomeDBiQ8CAE9

Family and domain databases

InterProiView protein in InterPro
IPR013836 CD34/Podocalyxin
PfamiView protein in Pfam
PF06365 CD34_antigen, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8CAE9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARPLRAARL PPPLLLLLAA GASLGAYAVG VDEPGPEGLT STSLLDLLLP
60 70 80 90 100
TDFEPLDSEE PSEAMGLDAG LAPGSGFPSE DSEESRLLQP PQYFWEEEEL
110 120 130 140 150
NGSSLDLGPT ADYVFPDLTE KVASMEDPGQ APDLPNLPSI LPKMDLAEPP
160 170 180 190 200
WHMPLQEEEE EEEEEEEERE EEEREKEAEE EEEEEELLPV SGSPGATAQA
210 220 230 240 250
HAPSPSTSSS TSSQSPGATR HRQEDSGDQA TSGMEVESSV KPTLSVPSVT
260 270 280 290 300
PSTVAPGVQN YSQESGGTEW PTGGLGVQSE VPQGAGEGAT VGAADFDGQQ
310 320 330 340 350
GALPSSSLPQ TVPPSGTEVP SEGPLYPRIP DSLPPGPQDT ESTPSSATWG
360 370 380 390 400
QEGLSEQPLE GQAAEAHSLT PWDSTQVICK DWSNLAGKSY IILNMTQNID
410 420 430 440 450
CEVFRRHRGL RLLALVEEVL PRHRSGHRGD WHISLSKPSE KEQHLLMTLV
460 470 480 490 500
GEQGVVPTQD VLSMLSGIRR SLEEIGIQNY STTSSCQARA TQVRSDYGTL
510 520 530 540 550
FVVLVIIGVI CFIIIVLGLL YNCWQRRMPK LKHVSHGEEL RFVENGCHDN
560 570 580 590 600
PTLDVASDSQ SEMQEKQPSL NGGAINGPSS WSALMGSKRD PEDSDVFEED

THL
Length:603
Mass (Da):64,973
Last modified:October 3, 2006 - v2
Checksum:i1FF3CF9472E1BCE3
GO
Isoform 2 (identifier: Q8CAE9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-131: DYVFPDLTEKVASMEDPGQA → GSSAHLPLHRISGVIHGEGP
     132-603: Missing.

Note: No experimental confirmation available.
Show »
Length:131
Mass (Da):13,607
Checksum:i439D88FDF826B9B6
GO
Isoform 3 (identifier: Q8CAE9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-64: Missing.

Note: No experimental confirmation available.
Show »
Length:539
Mass (Da):58,394
Checksum:i195BF06FBC983369
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YW47D3YW47_MOUSE
Podocalyxin-like protein 2
Podxl2
603Annotation score:
G3X9D3G3X9D3_MOUSE
Podocalyxin-like 2
Podxl2 mCG_130620
539Annotation score:
D3YZ50D3YZ50_MOUSE
Podocalyxin-like protein 2
Podxl2
150Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0208771 – 64Missing in isoform 3. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_020878112 – 131DYVFP…DPGQA → GSSAHLPLHRISGVIHGEGP in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_020879132 – 603Missing in isoform 2. 1 PublicationAdd BLAST472

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038943 mRNA Translation: BAC30176.1
AC153923 Genomic DNA No translation available.
BC033384 mRNA Translation: AAH33384.1
CCDSiCCDS20340.1 [Q8CAE9-3]
CCDS85093.1 [Q8CAE9-1]
RefSeqiNP_795947.3, NM_176973.4
UniGeneiMm.302613
Mm.442704
Mm.483545

Genome annotation databases

GeneIDi319655
KEGGimmu:319655
UCSCiuc009cvw.1 mouse [Q8CAE9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038943 mRNA Translation: BAC30176.1
AC153923 Genomic DNA No translation available.
BC033384 mRNA Translation: AAH33384.1
CCDSiCCDS20340.1 [Q8CAE9-3]
CCDS85093.1 [Q8CAE9-1]
RefSeqiNP_795947.3, NM_176973.4
UniGeneiMm.302613
Mm.442704
Mm.483545

3D structure databases

ProteinModelPortaliQ8CAE9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040417

PTM databases

iPTMnetiQ8CAE9
PhosphoSitePlusiQ8CAE9

Proteomic databases

PaxDbiQ8CAE9
PRIDEiQ8CAE9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi319655
KEGGimmu:319655
UCSCiuc009cvw.1 mouse [Q8CAE9-2]

Organism-specific databases

CTDi50512
MGIiMGI:2442488 Podxl2

Phylogenomic databases

eggNOGiENOG410IFKB Eukaryota
ENOG410YCG4 LUCA
HOGENOMiHOG000054210
HOVERGENiHBG082114
InParanoidiQ8CAE9
KOiK06818
PhylomeDBiQ8CAE9

Miscellaneous databases

PROiPR:Q8CAE9
SOURCEiSearch...

Gene expression databases

CleanExiMM_PODXL2

Family and domain databases

InterProiView protein in InterPro
IPR013836 CD34/Podocalyxin
PfamiView protein in Pfam
PF06365 CD34_antigen, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPDXL2_MOUSE
AccessioniPrimary (citable) accession number: Q8CAE9
Secondary accession number(s): Q8CFW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: May 10, 2017
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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