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Protein

Gigaxonin

Gene

Gan

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB (By similarity). Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival.By similarity2 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
GigaxoninImported
Gene namesi
Name:GanImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1890619 Gan

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Disruption phenotypei

Mice have a relatively normal life span. However, they display deterioration in motor function with onset varying from 6 to 10 months as well as abnormalities in non-neuronal tissues. The prominent pathological features include limb weakness, muscular atrophy, axonal degeneration, neurofilament accumulation, an abnormal microtubule network, mitochondrial swelling and thinned myelin sheaths.2 Publications

Keywords - Diseasei

Neurodegeneration

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003585921 – 597GigaxoninAdd BLAST597

Post-translational modificationi

Ubiquitinated by E3 ubiquitin ligase complex formed by CUL3 and RBX1 and probably targeted for proteasome-independent degradation.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQBiQ8CA72
PaxDbiQ8CA72
PeptideAtlasiQ8CA72
PRIDEiQ8CA72

PTM databases

iPTMnetiQ8CA72
PhosphoSitePlusiQ8CA72

Expressioni

Tissue specificityi

Expressed in brain, heart and muscle (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000052557 Expressed in 228 organ(s), highest expression level in ear
ExpressionAtlasiQ8CA72 baseline and differential
GenevisibleiQ8CA72 MM

Interactioni

Subunit structurei

Interacts with TBCB. Interacts with CUL3. Part of a complex that contains CUL3, RBX1 and GAN. Interacts (via BTB domain) with UBA1 (By similarity). Interacts (via Kelch domains) with MAP1B (via C-terminus) and MAP1S (via C-terminus).By similarity2 Publications

Protein-protein interaction databases

IntActiQ8CA72, 1 interactor
MINTiQ8CA72
STRINGi10090.ENSMUSP00000070168

Structurei

3D structure databases

ProteinModelPortaliQ8CA72
SMRiQ8CA72
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 99BTBPROSITE-ProRule annotationAdd BLAST70
Domaini134 – 236BACKSequence analysisAdd BLAST103
Repeati274 – 326Kelch 1Sequence analysisAdd BLAST53
Repeati327 – 374Kelch 2Sequence analysisAdd BLAST48
Repeati376 – 421Kelch 3Sequence analysisAdd BLAST46
Repeati422 – 468Kelch 4Sequence analysisAdd BLAST47
Repeati470 – 522Kelch 5Sequence analysisAdd BLAST53
Repeati528 – 574Kelch 6Sequence analysisAdd BLAST47

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441 Eukaryota
ENOG410XNX8 LUCA
GeneTreeiENSGT00760000118825
HOGENOMiHOG000290709
HOVERGENiHBG005802
InParanoidiQ8CA72
KOiK10453
OMAiNEMVTCK
OrthoDBiEOG091G0FDQ
PhylomeDBiQ8CA72
TreeFamiTF329218

Family and domain databases

Gene3Di2.120.10.80, 1 hit
InterProiView protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR030579 KLHL16
IPR011333 SKP1/BTB/POZ_sf
PANTHERiPTHR24412:SF232 PTHR24412:SF232, 1 hit
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 3 hits
PIRSFiPIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 5 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8CA72-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEGSAVSDP QHAARLLRAL SSFREEARFC DAHLVLDGEE IPVQKNILAA
60 70 80 90 100
ASPYIRTKLN YNPPKDDGST YKIELEGISV MVMREILDYI FSGQIRLNED
110 120 130 140 150
TIQDVVQAAD LLLLTDLKTL CCEFLEGCIA AENCIGIRDF ALHYCLHHVH
160 170 180 190 200
YLATEYLETH FRDVSSTEEF LELSPQKLKE VISLEKLNVG NERYVFEAVI
210 220 230 240 250
RWIAHDVEMR KVHMKDVMSA LWVSGLDSSY LREQMLNEPL VREIVKECSN
260 270 280 290 300
IPLSQPQQGE AMLASFKPRG YSECIVTIGG EERVSRKPTA AMRCMCPLYD
310 320 330 340 350
PNRQLWIELA PLSMPRINHG VLSAEGFLFV LGGQDENKQT LSSGEKYDPD
360 370 380 390 400
ANTWTALPPM HEARHNFGIV EIDGMLYILG GEDGDRELIS MECYDIYSKT
410 420 430 440 450
WTKQPDLTMV RKIGCYAAMK KKIYAMGGGS YGKLFESVEC YDPRTQQWTA
460 470 480 490 500
ICPLKERRFG AVACGVAMEL YVFGGVRSRE DIQGSEMVTC KSEFYHDEFK
510 520 530 540 550
RWIYLNDQNL CIPASSSFVY GAVPIGASIY VIGDLDTGTN YDYVREFKRS
560 570 580 590
TGTWHHTKPL LPSDLRRTGC AALRIANCKL FRLQLQQGLF RIRVHSP
Length:597
Mass (Da):67,671
Last modified:December 16, 2008 - v2
Checksum:i6A7DE61945B64F98
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6TZU3F6TZU3_MOUSE
Gigaxonin
Gan
597Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121116 mRNA No translation available.
AK039455 mRNA Translation: BAC30353.1
BC112432 mRNA Translation: AAI12433.1
CCDSiCCDS40490.1
RefSeqiNP_001074620.1, NM_001081151.1
UniGeneiMm.132992

Genome annotation databases

EnsembliENSMUST00000064488; ENSMUSP00000070168; ENSMUSG00000052557
GeneIDi209239
KEGGimmu:209239
UCSCiuc009nox.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121116 mRNA No translation available.
AK039455 mRNA Translation: BAC30353.1
BC112432 mRNA Translation: AAI12433.1
CCDSiCCDS40490.1
RefSeqiNP_001074620.1, NM_001081151.1
UniGeneiMm.132992

3D structure databases

ProteinModelPortaliQ8CA72
SMRiQ8CA72
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8CA72, 1 interactor
MINTiQ8CA72
STRINGi10090.ENSMUSP00000070168

PTM databases

iPTMnetiQ8CA72
PhosphoSitePlusiQ8CA72

Proteomic databases

MaxQBiQ8CA72
PaxDbiQ8CA72
PeptideAtlasiQ8CA72
PRIDEiQ8CA72

Protocols and materials databases

DNASUi209239
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064488; ENSMUSP00000070168; ENSMUSG00000052557
GeneIDi209239
KEGGimmu:209239
UCSCiuc009nox.1 mouse

Organism-specific databases

CTDi8139
MGIiMGI:1890619 Gan

Phylogenomic databases

eggNOGiKOG4441 Eukaryota
ENOG410XNX8 LUCA
GeneTreeiENSGT00760000118825
HOGENOMiHOG000290709
HOVERGENiHBG005802
InParanoidiQ8CA72
KOiK10453
OMAiNEMVTCK
OrthoDBiEOG091G0FDQ
PhylomeDBiQ8CA72
TreeFamiTF329218

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

PROiPR:Q8CA72
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052557 Expressed in 228 organ(s), highest expression level in ear
ExpressionAtlasiQ8CA72 baseline and differential
GenevisibleiQ8CA72 MM

Family and domain databases

Gene3Di2.120.10.80, 1 hit
InterProiView protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR030579 KLHL16
IPR011333 SKP1/BTB/POZ_sf
PANTHERiPTHR24412:SF232 PTHR24412:SF232, 1 hit
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 3 hits
PIRSFiPIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 5 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGAN_MOUSE
AccessioniPrimary (citable) accession number: Q8CA72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: December 16, 2008
Last modified: November 7, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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