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UniProtKB - Q8C9X6 (EPC1_MOUSE)

Entry version 136 (25 May 2022)
Sequence version 1 (01 Mar 2003)
Previous versions | rss
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Protein

Enhancer of polycomb homolog 1

Gene

Epc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the NuA4 histone acetyltransferase (HAT) complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:28694333).

The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR) (By similarity).

The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone acetylation is required for histone replacement during the transition from round to elongating spermatids (PubMed:28694333).

In the NuA4 complex, EPC1 is required to recruit MBTD1 into the complex (By similarity).

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Chromatin regulator
Biological processDifferentiation, Growth regulation, Spermatogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-8953750, Transcriptional Regulation by E2F6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Enhancer of polycomb homolog 1Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Epc11 PublicationImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1278322, Epc1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000024240

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice are viable but display growth retardation, homeotic transformations of the axis and sterility in both males and females (PubMed:28694333). Male sterility is caused by defects in generation of elongating spermatids (PubMed:28694333).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002141541 – 813Enhancer of polycomb homolog 1Add BLAST813

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki319Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei538PhosphoserineBy similarity1
Cross-linki650Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8C9X6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8C9X6

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8C9X6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8C9X6

PRoteomics IDEntifications database

More...PRIDEi		Q8C9X6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		275930 [Q8C9X6-1]
275931 [Q8C9X6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8C9X6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8C9X6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in adult brain, heart, kidney, liver, lung, skeletal muscle and testis (PubMed:9735366). Expressed in male germ cells, present in round spermatids of steps 1 to 4 (PubMed:28694333).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000024240, Expressed in pituitary gland and 307 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8C9X6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8C9X6, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6 (By similarity). KAT5/TIP60, EPC1, and ING3 together constitute a minimal HAT complex termed Piccolo NuA4 (By similarity).

Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41 (By similarity).

Interacts with TRIM27 (By similarity).

Interacts with MBTD1; interaction is direct and promotes recruitment of MBTD1 into the NuA4 histone acetyltransferase complex (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		199466, 11 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-747, Piccolo NuA4 histone acetyltransferase complex
CPX-990, NuA4 histone acetyltransferase complex

Protein interaction database and analysis system

More...IntActi		Q8C9X6, 5 interactors

Molecular INTeraction database

More...MINTi		Q8C9X6

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000028100

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8C9X6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q8C9X6

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni310 – 403DisorderedSequence analysisAdd BLAST94
Regioni484 – 513DisorderedSequence analysisAdd BLAST30
Regioni528 – 577DisorderedSequence analysisAdd BLAST50
Regioni779 – 813DisorderedSequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi313 – 343Basic and acidic residuesSequence analysisAdd BLAST31
Compositional biasi369 – 390Polar residuesSequence analysisAdd BLAST22
Compositional biasi487 – 513Polar residuesSequence analysisAdd BLAST27
Compositional biasi560 – 577Polar residuesSequence analysisAdd BLAST18
Compositional biasi799 – 813Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the enhancer of polycomb family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2261, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155003

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_012781_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8C9X6

Identification of Orthologs from Complete Genome Data

More...OMAi		XENHESE

Database of Orthologous Groups

More...OrthoDBi		957492at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8C9X6

TreeFam database of animal gene trees

More...TreeFami		TF106438

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR024943, Enhancer_polycomb
IPR019542, Enhancer_polycomb-like_N
IPR009607, Enhancer_polycomb_C

The PANTHER Classification System

More...PANTHERi		PTHR14898, PTHR14898, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06752, E_Pc_C, 1 hit
PF10513, EPL1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8C9X6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKLSFRARA LDASKPLPVF RCEDLPDLHE YASINRAVPQ MPTGMEKEEE 
        60         70         80         90        100
SEHHLQRAIS AQQVYGEKRD NMVIPVPEAE SNIAYYESIY PGEFRMPKQL 
       110        120        130        140        150
IHIQPFSLDA EQPDYDLDSE DEVFVNKLKK KMDICPLQFE EMIDRLEKGS 
       160        170        180        190        200
GQQPVSLQEA KLLLKEDDEL IREVYEYWIK KRKTCRGSSL IPLVKQEKRD 
       210        220        230        240        250
GSSTNDPYVA FRRRTEKMQT RKNRKNDEAS YEKMLKLRRD LSRAVTILEM 
       260        270        280        290        300
IKRREKSKRE LLHLTLEIME KRYNLGDYSG EIMSEVMAQR QPVKPTYAIP 
       310        320        330        340        350
IIPITNSSQF KHQDATDSKE FKVNKQDKAD LIRPKRKYEK KPKVLPPSAA 
       360        370        380        390        400
APQQQSPAAL PGFSAKDLNQ YDFPSSDEEP LSQVLSGSSE AEEENDPDGP 
       410        420        430        440        450
FAFRRKAGCQ YYAPHLDQTG NWPWTSPKDG GLGDVRYRYC LTTLTVPQRC 
       460        470        480        490        500
LGFARRRVGR GGRVVLDRAH SDYDSMFHHL DLDMLSSPQP SPVNQFANTS 
       510        520        530        540        550
EPNTSDRSSS KDLSQILVDI KSCRWRHFRP RTPSLPDSDS GELSSRKLHR 
       560        570        580        590        600
SISRAGAAQP GAHTCSTSTQ NRSSSGSAHC AFTAEQYQQH QQQLALMQQQ 
       610        620        630        640        650
QLAQTQQQQQ ANSSSSAAAQ QGFVSKTLDS ASAQFAASAL MTSEQLLGFK 
       660        670        680        690        700
VKDDVVLGLG VNGVLPASGV YKGLHLSSTT PTALVHTSPS TAGSTLLQPS 
       710        720        730        740        750
NITQTSGSHS SLSHQVTAAS SATTQVLFGN NIRLTVPSSV PTVNSVTPIN 
       760        770        780        790        800
ARHIPRTLSA VPPSALKLAA AANCQVSKVP SSSSVDSVPR ENHESEKPAL 
       810 
NNIADNTVAM EVT
Length:813
Mass (Da):90,411
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE6F3CD987FC55905
GO
Isoform 2 (identifier: Q8C9X6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-51: MSKLSFRARALDASKPLPVFRCEDLPDLHEYASINRAVPQMPTGMEKEEES → M

Show »
Length:763
Mass (Da):84,767
Checksum:iD13649721FFB41E2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6PBH3Q6PBH3_MOUSE
Enhancer of polycomb homolog 1
Epc1
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0128781 – 51MSKLS…KEEES → M in isoform 2. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF079765 mRNA Translation: AAC64272.1
AK040254 mRNA Translation: BAC30552.1
BC138622 mRNA Translation: AAI38623.1
BC138623 mRNA Translation: AAI38624.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS29041.1 [Q8C9X6-1]
CCDS37726.1 [Q8C9X6-2]

NCBI Reference Sequences

More...RefSeqi		NP_001263279.1, NM_001276350.1
NP_031961.1, NM_007935.2 [Q8C9X6-2]
NP_081773.1, NM_027497.3 [Q8C9X6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000028100; ENSMUSP00000028100; ENSMUSG00000024240 [Q8C9X6-1]
ENSMUST00000115870; ENSMUSP00000111536; ENSMUSG00000024240 [Q8C9X6-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		13831

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:13831

UCSC genome browser

More...UCSCi		uc008dzi.2, mouse [Q8C9X6-1]
uc008dzj.2, mouse [Q8C9X6-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079765 mRNA Translation: AAC64272.1
AK040254 mRNA Translation: BAC30552.1
BC138622 mRNA Translation: AAI38623.1
BC138623 mRNA Translation: AAI38624.1
CCDSiCCDS29041.1 [Q8C9X6-1]
CCDS37726.1 [Q8C9X6-2]
RefSeqiNP_001263279.1, NM_001276350.1
NP_031961.1, NM_007935.2 [Q8C9X6-2]
NP_081773.1, NM_027497.3 [Q8C9X6-1]

3D structure databases

AlphaFoldDBiQ8C9X6
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

BioGRIDi199466, 11 interactors
ComplexPortaliCPX-747, Piccolo NuA4 histone acetyltransferase complex
CPX-990, NuA4 histone acetyltransferase complex
IntActiQ8C9X6, 5 interactors
MINTiQ8C9X6
STRINGi10090.ENSMUSP00000028100

PTM databases

iPTMnetiQ8C9X6
PhosphoSitePlusiQ8C9X6

Proteomic databases

EPDiQ8C9X6
jPOSTiQ8C9X6
MaxQBiQ8C9X6
PaxDbiQ8C9X6
PRIDEiQ8C9X6
ProteomicsDBi275930 [Q8C9X6-1]
275931 [Q8C9X6-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26401, 87 antibodies from 20 providers

The DNASU plasmid repository

More...DNASUi		13831

Genome annotation databases

EnsembliENSMUST00000028100; ENSMUSP00000028100; ENSMUSG00000024240 [Q8C9X6-1]
ENSMUST00000115870; ENSMUSP00000111536; ENSMUSG00000024240 [Q8C9X6-2]
GeneIDi13831
KEGGimmu:13831
UCSCiuc008dzi.2, mouse [Q8C9X6-1]
uc008dzj.2, mouse [Q8C9X6-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		80314
MGIiMGI:1278322, Epc1
VEuPathDBiHostDB:ENSMUSG00000024240

Phylogenomic databases

eggNOGiKOG2261, Eukaryota
GeneTreeiENSGT00940000155003
HOGENOMiCLU_012781_0_0_1
InParanoidiQ8C9X6
OMAiXENHESE
OrthoDBi957492at2759
PhylomeDBiQ8C9X6
TreeFamiTF106438

Enzyme and pathway databases

ReactomeiR-MMU-8953750, Transcriptional Regulation by E2F6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		13831, 3 hits in 75 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Epc1, mouse

Protein Ontology

More...PROi		PR:Q8C9X6
RNActiQ8C9X6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000024240, Expressed in pituitary gland and 307 other tissues
ExpressionAtlasiQ8C9X6, baseline and differential
GenevisibleiQ8C9X6, MM

Family and domain databases

InterProiView protein in InterPro
IPR024943, Enhancer_polycomb
IPR019542, Enhancer_polycomb-like_N
IPR009607, Enhancer_polycomb_C
PANTHERiPTHR14898, PTHR14898, 1 hit
PfamiView protein in Pfam
PF06752, E_Pc_C, 1 hit
PF10513, EPL1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEPC1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8C9X6
Secondary accession number(s): B2RRY2, Q9Z299
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: March 1, 2003
Last modified: May 25, 2022
This is version 136 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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