UniProtKB - Q8C9X6 (EPC1_MOUSE)

BLAST

>sp|Q8C9X6|EPC1_MOUSE Enhancer of polycomb homolog 1 OS=Mus musculus OX=10090 GN=Epc1 PE=1 SV=1
MSKLSFRARALDASKPLPVFRCEDLPDLHEYASINRAVPQMPTGMEKEEESEHHLQRAIS
AQQVYGEKRDNMVIPVPEAESNIAYYESIYPGEFRMPKQLIHIQPFSLDAEQPDYDLDSE
DEVFVNKLKKKMDICPLQFEEMIDRLEKGSGQQPVSLQEAKLLLKEDDELIREVYEYWIK
KRKTCRGSSLIPLVKQEKRDGSSTNDPYVAFRRRTEKMQTRKNRKNDEASYEKMLKLRRD
LSRAVTILEMIKRREKSKRELLHLTLEIMEKRYNLGDYSGEIMSEVMAQRQPVKPTYAIP
IIPITNSSQFKHQDATDSKEFKVNKQDKADLIRPKRKYEKKPKVLPPSAAAPQQQSPAAL
PGFSAKDLNQYDFPSSDEEPLSQVLSGSSEAEEENDPDGPFAFRRKAGCQYYAPHLDQTG
NWPWTSPKDGGLGDVRYRYCLTTLTVPQRCLGFARRRVGRGGRVVLDRAHSDYDSMFHHL
DLDMLSSPQPSPVNQFANTSEPNTSDRSSSKDLSQILVDIKSCRWRHFRPRTPSLPDSDS
GELSSRKLHRSISRAGAAQPGAHTCSTSTQNRSSSGSAHCAFTAEQYQQHQQQLALMQQQ
QLAQTQQQQQANSSSSAAAQQGFVSKTLDSASAQFAASALMTSEQLLGFKVKDDVVLGLG
VNGVLPASGVYKGLHLSSTTPTALVHTSPSTAGSTLLQPSNITQTSGSHSSLSHQVTAAS
SATTQVLFGNNIRLTVPSSVPTVNSVTPINARHIPRTLSAVPPSALKLAAAANCQVSKVP
SSSSVDSVPRENHESEKPALNNIADNTVAMEVT

Align

Format
Add to basket Added to basket
History
Entry version 117 (07 Nov 2018)
Sequence version 1 (01 Mar 2003)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Enhancer of polycomb homolog 1

Gene

Epc1

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage (By similarity).By similarity

GO - Molecular functionⁱ

histone acetyltransferase activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

histone H2A acetylation Source: UniProtKB
histone H4 acetylation Source: UniProtKB
negative regulation of gene expression, epigenetic
Source: MGI
Inferred from sequence orthologyⁱ
- 10976108
negative regulation of transcription, DNA-templated Source: MGI
negative regulation of transcription by RNA polymerase II
Source: MGI
Inferred from sequence orthologyⁱ
- 10976108
positive regulation of striated muscle cell differentiation
Source: MGI
Inferred from sequence alignmentⁱ
- 17192267
positive regulation of transcription by RNA polymerase II
Source: MGI
Inferred from sequence alignmentⁱ
- 17192267
regulation of growth Source: UniProtKB-KW
regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
vascular smooth muscle cell differentiation Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Chromatin regulator
Biological process	Growth regulation, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-MMU-8953750 Transcriptional Regulation by E2F6

Reactomeⁱ

R-MMU-8953750 Transcriptional Regulation by E2F6

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Enhancer of polycomb homolog 1
Gene namesⁱ	Name:Epc1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 18

Organism-specific databases

MGIⁱ	MGI:1278322 Epc1

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000214154	1 – 813	Enhancer of polycomb homolog 1Add BLAST		813

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	319	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	538	PhosphoserineBy similarity	1
Cross-linkⁱ	650	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q8C9X6
PRIDEⁱ	Q8C9X6

PTM databases

iPTMnetⁱ	Q8C9X6
PhosphoSitePlusⁱ	Q8C9X6

Expressionⁱ

Tissue specificityⁱ

Expressed in adult brain, heart, kidney, liver, lung, skeletal muscle and testis.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000024240 Expressed in 284 organ(s), highest expression level in pituitary gland
CleanExⁱ	MM_EPC1
ExpressionAtlasⁱ	Q8C9X6 baseline and differential
Genevisibleⁱ	Q8C9X6 MM

Interactionⁱ

Subunit structureⁱ

Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. HTATTIP/TIP60, EPC1, and ING3 together constitute a minimal HAT complex termed Piccolo NuA4. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. The NuA4 complex interacts with MYC. EPC1 interacts with TRIM27 (By similarity).By similarity

Protein-protein interaction databases

BioGridⁱ	199466, 8 interactors
ComplexPortalⁱ	CPX-747 Piccolo NuA4 histone acetyltransferase complex CPX-990 NuA4 histone acetyltransferase complex
IntActⁱ	Q8C9X6, 3 interactors
STRINGⁱ	10090.ENSMUSP00000028100

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8C9X6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the enhancer of polycomb family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2261 Eukaryota ENOG410XSSX LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013262
HOGENOMⁱ	HOG000231800
HOVERGENⁱ	HBG051489
InParanoidⁱ	Q8C9X6
KEGG Orthology (KO) More...KOⁱ	K11322
OMAⁱ	DYDSMFR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0252
PhylomeDBⁱ	Q8C9X6
TreeFamⁱ	TF106438

Family and domain databases

InterProⁱ	View protein in InterPro IPR024943 Enhancer_polycomb IPR019542 Enhancer_polycomb-like_N IPR009607 Enhancer_polycomb_C
PANTHERⁱ	PTHR14898 PTHR14898, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06752 E_Pc_C, 1 hit PF10513 EPL1, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8C9X6-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKLSFRARA LDASKPLPVF RCEDLPDLHE YASINRAVPQ MPTGMEKEEE 
        60         70         80         90        100
SEHHLQRAIS AQQVYGEKRD NMVIPVPEAE SNIAYYESIY PGEFRMPKQL 
       110        120        130        140        150
IHIQPFSLDA EQPDYDLDSE DEVFVNKLKK KMDICPLQFE EMIDRLEKGS 
       160        170        180        190        200
GQQPVSLQEA KLLLKEDDEL IREVYEYWIK KRKTCRGSSL IPLVKQEKRD 
       210        220        230        240        250
GSSTNDPYVA FRRRTEKMQT RKNRKNDEAS YEKMLKLRRD LSRAVTILEM 
       260        270        280        290        300
IKRREKSKRE LLHLTLEIME KRYNLGDYSG EIMSEVMAQR QPVKPTYAIP 
       310        320        330        340        350
IIPITNSSQF KHQDATDSKE FKVNKQDKAD LIRPKRKYEK KPKVLPPSAA 
       360        370        380        390        400
APQQQSPAAL PGFSAKDLNQ YDFPSSDEEP LSQVLSGSSE AEEENDPDGP 
       410        420        430        440        450
FAFRRKAGCQ YYAPHLDQTG NWPWTSPKDG GLGDVRYRYC LTTLTVPQRC 
       460        470        480        490        500
LGFARRRVGR GGRVVLDRAH SDYDSMFHHL DLDMLSSPQP SPVNQFANTS 
       510        520        530        540        550
EPNTSDRSSS KDLSQILVDI KSCRWRHFRP RTPSLPDSDS GELSSRKLHR 
       560        570        580        590        600
SISRAGAAQP GAHTCSTSTQ NRSSSGSAHC AFTAEQYQQH QQQLALMQQQ 
       610        620        630        640        650
QLAQTQQQQQ ANSSSSAAAQ QGFVSKTLDS ASAQFAASAL MTSEQLLGFK 
       660        670        680        690        700
VKDDVVLGLG VNGVLPASGV YKGLHLSSTT PTALVHTSPS TAGSTLLQPS 
       710        720        730        740        750
NITQTSGSHS SLSHQVTAAS SATTQVLFGN NIRLTVPSSV PTVNSVTPIN 
       760        770        780        790        800
ARHIPRTLSA VPPSALKLAA AANCQVSKVP SSSSVDSVPR ENHESEKPAL 
       810 
NNIADNTVAM EVT

Length:813

Mass (Da):90,411

Last modified:March 1, 2003 - v1

Checksum:ⁱE6F3CD987FC55905

Isoform 2 (identifier: Q8C9X6-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-51: MSKLSFRARALDASKPLPVFRCEDLPDLHEYASINRAVPQMPTGMEKEEES → M

« Hide

        10         20         30         40         50
MEHHLQRAIS AQQVYGEKRD NMVIPVPEAE SNIAYYESIY PGEFRMPKQL 
        60         70         80         90        100
IHIQPFSLDA EQPDYDLDSE DEVFVNKLKK KMDICPLQFE EMIDRLEKGS 
       110        120        130        140        150
GQQPVSLQEA KLLLKEDDEL IREVYEYWIK KRKTCRGSSL IPLVKQEKRD 
       160        170        180        190        200
GSSTNDPYVA FRRRTEKMQT RKNRKNDEAS YEKMLKLRRD LSRAVTILEM 
       210        220        230        240        250
IKRREKSKRE LLHLTLEIME KRYNLGDYSG EIMSEVMAQR QPVKPTYAIP 
       260        270        280        290        300
IIPITNSSQF KHQDATDSKE FKVNKQDKAD LIRPKRKYEK KPKVLPPSAA 
       310        320        330        340        350
APQQQSPAAL PGFSAKDLNQ YDFPSSDEEP LSQVLSGSSE AEEENDPDGP 
       360        370        380        390        400
FAFRRKAGCQ YYAPHLDQTG NWPWTSPKDG GLGDVRYRYC LTTLTVPQRC 
       410        420        430        440        450
LGFARRRVGR GGRVVLDRAH SDYDSMFHHL DLDMLSSPQP SPVNQFANTS 
       460        470        480        490        500
EPNTSDRSSS KDLSQILVDI KSCRWRHFRP RTPSLPDSDS GELSSRKLHR 
       510        520        530        540        550
SISRAGAAQP GAHTCSTSTQ NRSSSGSAHC AFTAEQYQQH QQQLALMQQQ 
       560        570        580        590        600
QLAQTQQQQQ ANSSSSAAAQ QGFVSKTLDS ASAQFAASAL MTSEQLLGFK 
       610        620        630        640        650
VKDDVVLGLG VNGVLPASGV YKGLHLSSTT PTALVHTSPS TAGSTLLQPS 
       660        670        680        690        700
NITQTSGSHS SLSHQVTAAS SATTQVLFGN NIRLTVPSSV PTVNSVTPIN 
       710        720        730        740        750
ARHIPRTLSA VPPSALKLAA AANCQVSKVP SSSSVDSVPR ENHESEKPAL 
       760 
NNIADNTVAM EVT

Show »

Length:763

Mass (Da):84,767

Checksum:ⁱD13649721FFB41E2

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D3Z3Q6	D3Z3Q6_MOUSE	Enhancer of polycomb homolog 1 Enhancer of polycomb homolog 1	Epc1	193	Annotation score:
Q6PBH3	Q6PBH3_MOUSE	Enhancer of polycomb homolog 1 Enhancer of polycomb homolog 1 (Epc1 protein) (MCG147788)	Epc1 mCG_147788	61	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_012878	1 – 51	MSKLS…KEEES → M in isoform 2. 1 PublicationAdd BLAST		51

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF079765 mRNA Translation: AAC64272.1 AK040254 mRNA Translation: BAC30552.1 BC138622 mRNA Translation: AAI38623.1 BC138623 mRNA Translation: AAI38624.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS29041.1 [Q8C9X6-1] CCDS37726.1 [Q8C9X6-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001263279.1, NM_001276350.1 NP_031961.1, NM_007935.2 [Q8C9X6-2] NP_081773.1, NM_027497.3 [Q8C9X6-1]
UniGeneⁱ	Mm.312133

Genome annotation databases

Ensemblⁱ	ENSMUST00000028100; ENSMUSP00000028100; ENSMUSG00000024240 [Q8C9X6-1] ENSMUST00000115870; ENSMUSP00000111536; ENSMUSG00000024240 [Q8C9X6-2]
GeneIDⁱ	13831
KEGGⁱ	mmu:13831
UCSC genome browser More...UCSCⁱ	uc008dzi.2 mouse [Q8C9X6-1] uc008dzj.2 mouse [Q8C9X6-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8C9X6	Enhancer of polycomb homolog 1 (Fragment)		MOUSE		193	UniRef100_Q8C9X6

Protein	Similar proteins		Species	Score	Length	Source
Q8C9X6	Enhancer of polycomb homolog 1 (Fragment)		MOUSE		193	UniRef90_Q8C9X6
enhancer of polycomb homolog 1 isoform X2		BALAS		813
Enhancer of polycomb homolog		DELLE		813
Enhancer of polycomb homolog		PHYCD		813
Enhancer of polycomb homolog		LIPVE		813
+9
Q8C9X6-2	Enhancer of polycomb homolog		ODORO		815	UniRef90_Q8C9X6-2
Enhancer of polycomb homolog		Florida manatee		815
Enhancer of polycomb homolog		PANTR		813
Enhancer of polycomb homolog		PANPA		813
Enhancer of polycomb homolog		GORGO		813
+199

Protein	Similar proteins		Species	Score	Length	Source
Q8C9X6	Enhancer of polycomb homolog 2		MOUSE		808	UniRef50_Q8C9X6
Enhancer of polycomb homolog 2		HUMAN		807
Enhancer of polycomb homolog 2		XENTR		804
Enhancer of polycomb homolog 2		XENLA		804
enhancer of polycomb homolog 1 isoform X2		BALAS		813
+472
Q8C9X6-2	Enhancer of polycomb homolog 1		HUMAN		836	UniRef50_Q9H2F5
Enhancer of polycomb homolog		PANTR		836
Enhancer of polycomb homolog		PANPA		836
Enhancer of polycomb homolog		ODORO		844
Enhancer of polycomb homolog		Florida manatee		844
+712

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF079765 mRNA Translation: AAC64272.1 AK040254 mRNA Translation: BAC30552.1 BC138622 mRNA Translation: AAI38623.1 BC138623 mRNA Translation: AAI38624.1
CCDSⁱ	CCDS29041.1 [Q8C9X6-1] CCDS37726.1 [Q8C9X6-2]
RefSeqⁱ	NP_001263279.1, NM_001276350.1 NP_031961.1, NM_007935.2 [Q8C9X6-2] NP_081773.1, NM_027497.3 [Q8C9X6-1]
UniGeneⁱ	Mm.312133

3D structure databases

ProteinModelPortalⁱ	Q8C9X6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	199466, 8 interactors
ComplexPortalⁱ	CPX-747 Piccolo NuA4 histone acetyltransferase complex CPX-990 NuA4 histone acetyltransferase complex
IntActⁱ	Q8C9X6, 3 interactors
STRINGⁱ	10090.ENSMUSP00000028100

PTM databases

iPTMnetⁱ	Q8C9X6
PhosphoSitePlusⁱ	Q8C9X6

Proteomic databases

PaxDbⁱ	Q8C9X6
PRIDEⁱ	Q8C9X6

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000028100; ENSMUSP00000028100; ENSMUSG00000024240 [Q8C9X6-1] ENSMUST00000115870; ENSMUSP00000111536; ENSMUSG00000024240 [Q8C9X6-2]
GeneIDⁱ	13831
KEGGⁱ	mmu:13831
UCSCⁱ	uc008dzi.2 mouse [Q8C9X6-1] uc008dzj.2 mouse [Q8C9X6-2]

Organism-specific databases

CTDⁱ	80314
MGIⁱ	MGI:1278322 Epc1

Phylogenomic databases

eggNOGⁱ	KOG2261 Eukaryota ENOG410XSSX LUCA
GeneTreeⁱ	ENSGT00390000013262
HOGENOMⁱ	HOG000231800
HOVERGENⁱ	HBG051489
InParanoidⁱ	Q8C9X6
KOⁱ	K11322
OMAⁱ	DYDSMFR
OrthoDBⁱ	EOG091G0252
PhylomeDBⁱ	Q8C9X6
TreeFamⁱ	TF106438

Enzyme and pathway databases

Reactomeⁱ	R-MMU-8953750 Transcriptional Regulation by E2F6

Reactomeⁱ

R-MMU-8953750 Transcriptional Regulation by E2F6

Miscellaneous databases

ChiTaRSⁱ	Epc1 mouse
Protein Ontology More...PROⁱ	PR:Q8C9X6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000024240 Expressed in 284 organ(s), highest expression level in pituitary gland
CleanExⁱ	MM_EPC1
ExpressionAtlasⁱ	Q8C9X6 baseline and differential
Genevisibleⁱ	Q8C9X6 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR024943 Enhancer_polycomb IPR019542 Enhancer_polycomb-like_N IPR009607 Enhancer_polycomb_C
PANTHERⁱ	PTHR14898 PTHR14898, 1 hit
Pfamⁱ	View protein in Pfam PF06752 E_Pc_C, 1 hit PF10513 EPL1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EPC1_MOUSE
Accessionⁱ	Q8C9X6Primary (citable) accession number: Q8C9X6 Secondary accession number(s): B2RRY2, Q9Z299
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
	Last sequence update:	March 1, 2003
	Last modified:	November 7, 2018
	This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8C9X6 (EPC1_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Enhancer of polycomb homolog 1

Epc1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ