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Entry version 100 (05 Jun 2019)
Sequence version 2 (23 Oct 2007)
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Protein

Coiled-coil domain-containing protein 15

Gene

Ccdc15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 15
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ccdc15
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2444488 Ccdc15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003077161 – 810Coiled-coil domain-containing protein 15Add BLAST810

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8C9M2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8C9M2

PRoteomics IDEntifications database

More...
PRIDEi
Q8C9M2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8C9M2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8C9M2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000034303 Expressed in 21 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8C9M2 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
232850, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q8C9M2, 15 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000036784

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili65 – 89Sequence analysisAdd BLAST25
Coiled coili160 – 189Sequence analysisAdd BLAST30
Coiled coili638 – 669Sequence analysisAdd BLAST32

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IKKY Eukaryota
ENOG410Z3J8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00500000044966

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111403

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8C9M2

KEGG Orthology (KO)

More...
KOi
K16752

Identification of Orthologs from Complete Genome Data

More...
OMAi
QNILPIC

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8C9M2

TreeFam database of animal gene trees

More...
TreeFami
TF329047

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037693 CCDC15

The PANTHER Classification System

More...
PANTHERi
PTHR14817 PTHR14817, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8C9M2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPGGMAPLKK PRNPTKLPLA LNPTKSKDVL AVLAERNQAI IPVGAWVEPA
60 70 80 90 100
SPNWSGIPAH TSAYVVEEEI KEQQRRKQES LRHFQRQVRH RVNQRVKLRK
110 120 130 140 150
KQQLHKSYKA AEKEGSIAMQ YSDLAHLSSK RTSVFPSNLN AAVGRFRLPT
160 170 180 190 200
SQVLGDAIED GENQLFQQQA QALSQTMKQA RHQLASFKTV SEKKTPVLPN
210 220 230 240 250
GGRKGCPTQE GLGCGKISFV AVSEERDALF VSCQQDFLSE DKEKAFSKVQ
260 270 280 290 300
KVKFKNPLSV VIKEDERKQL HPHSLQAVLP EAQDYFVEVQ SGLPESQSDV
310 320 330 340 350
IDVQNVEPKA SRIEPKTLGV EPDTQATGVE CQTTEPEGQA VKTGIQDVPK
360 370 380 390 400
VQTVELDGNT ELEAQDFLPS HQAFLSRDTD CLPNCQYQDS LPKGHCVLPN
410 420 430 440 450
YWNVLPKYQN QHFLPVDQEF LPRNQLALPK EQNHPLQCQK QDLLPREQFP
460 470 480 490 500
LLLRHQDQRE PHVLPKCQEH DVLSKAQNYL HNYQEQDLQL QNQEVNSKEP
510 520 530 540 550
LSDITDGKGR EIFSLDMFSK KPSTFMRRER GDEELPLDSP QCAPPQIQDQ
560 570 580 590 600
VFLREQSQQP SVRTAERWQE DLYLSGHECL PPRQRRDTCS RQQQVYEEYR
610 620 630 640 650
SGLSTEQQAL LAFQSGVDQE EDKKERQKQY LRHRRLFMDI EREQVKEQNR
660 670 680 690 700
QRERKRRIEK IKKKKEQQRY AEEQRLLRMN CHEEPYSEEK ISDVLAQLQL
710 720 730 740 750
EEIKGAREKQ QQREKEYIRY VEALRAQVQE KMKLYNITLP PLCCCGPDFW
760 770 780 790 800
DAHPDTCANN CIFYKNYRAY NRALHSVINS SDISEGNATL RNAIRNFASA
810
HRRTPKQSLH
Length:810
Mass (Da):93,527
Last modified:October 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4F9FDC5B2E57F327
GO
Isoform 2 (identifier: Q8C9M2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLTSGQAFISQKSM

Show »
Length:823
Mass (Da):94,907
Checksum:i779175396AF378FC
GO
Isoform 3 (identifier: Q8C9M2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLTSGQAFISQKSM
     173-189: LSQTMKQARHQLASFKT → VSTGTIYFLSSCFSSVL
     190-810: Missing.

Show »
Length:202
Mass (Da):22,494
Checksum:iBD9DE29CD9DBC545
GO
Isoform 4 (identifier: Q8C9M2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     173-189: LSQTMKQARHQLASFKT → VSTGTIYFLSSCFSSVL
     190-810: Missing.

Show »
Length:189
Mass (Da):21,114
Checksum:iFBABC2F8832BF713
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1SS86A0A1L1SS86_MOUSE
Coiled-coil domain-containing prote...
Ccdc15
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0287971M → MLTSGQAFISQKSM in isoform 2 and isoform 3. 1 Publication1
Alternative sequenceiVSP_028798173 – 189LSQTM…ASFKT → VSTGTIYFLSSCFSSVL in isoform 3 and isoform 4. 2 PublicationsAdd BLAST17
Alternative sequenceiVSP_028799190 – 810Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST621

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK035850 mRNA Translation: BAC29211.1
AK041803 mRNA Translation: BAC31071.1
AK045055 mRNA Translation: BAC32199.1
AK051119 mRNA Translation: BAC34530.1
AC138284 Genomic DNA No translation available.
BC032924 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS40584.1 [Q8C9M2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001074898.1, NM_001081429.1 [Q8C9M2-1]
XP_006510404.1, XM_006510341.3 [Q8C9M2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000037275; ENSMUSP00000036784; ENSMUSG00000034303 [Q8C9M2-2]
ENSMUST00000213633; ENSMUSP00000150207; ENSMUSG00000034303 [Q8C9M2-1]
ENSMUST00000216042; ENSMUSP00000150095; ENSMUSG00000034303 [Q8C9M2-4]
ENSMUST00000217238; ENSMUSP00000149429; ENSMUSG00000034303 [Q8C9M2-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
245902

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:245902

UCSC genome browser

More...
UCSCi
uc009oum.1 mouse [Q8C9M2-2]
uc009oun.1 mouse [Q8C9M2-1]
uc009oup.1 mouse [Q8C9M2-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035850 mRNA Translation: BAC29211.1
AK041803 mRNA Translation: BAC31071.1
AK045055 mRNA Translation: BAC32199.1
AK051119 mRNA Translation: BAC34530.1
AC138284 Genomic DNA No translation available.
BC032924 mRNA No translation available.
CCDSiCCDS40584.1 [Q8C9M2-1]
RefSeqiNP_001074898.1, NM_001081429.1 [Q8C9M2-1]
XP_006510404.1, XM_006510341.3 [Q8C9M2-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi232850, 12 interactors
IntActiQ8C9M2, 15 interactors
STRINGi10090.ENSMUSP00000036784

PTM databases

iPTMnetiQ8C9M2
PhosphoSitePlusiQ8C9M2

Proteomic databases

EPDiQ8C9M2
PaxDbiQ8C9M2
PRIDEiQ8C9M2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037275; ENSMUSP00000036784; ENSMUSG00000034303 [Q8C9M2-2]
ENSMUST00000213633; ENSMUSP00000150207; ENSMUSG00000034303 [Q8C9M2-1]
ENSMUST00000216042; ENSMUSP00000150095; ENSMUSG00000034303 [Q8C9M2-4]
ENSMUST00000217238; ENSMUSP00000149429; ENSMUSG00000034303 [Q8C9M2-3]
GeneIDi245902
KEGGimmu:245902
UCSCiuc009oum.1 mouse [Q8C9M2-2]
uc009oun.1 mouse [Q8C9M2-1]
uc009oup.1 mouse [Q8C9M2-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80071
MGIiMGI:2444488 Ccdc15

Phylogenomic databases

eggNOGiENOG410IKKY Eukaryota
ENOG410Z3J8 LUCA
GeneTreeiENSGT00500000044966
HOGENOMiHOG000111403
InParanoidiQ8C9M2
KOiK16752
OMAiQNILPIC
PhylomeDBiQ8C9M2
TreeFamiTF329047

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8C9M2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000034303 Expressed in 21 organ(s), highest expression level in testis
ExpressionAtlasiQ8C9M2 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR037693 CCDC15
PANTHERiPTHR14817 PTHR14817, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCD15_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8C9M2
Secondary accession number(s): Q8BQB1, Q8BRD7, Q8CBK5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: June 5, 2019
This is version 100 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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