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Entry version 173 (02 Jun 2021)
Sequence version 4 (10 Jul 2007)
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Protein

Death-inducer obliterator 1

Gene

Dido1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for early embryonic stem cell development (By similarity).

Putative transcription factor, weakly pro-apoptotic when overexpressed.

By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri265 – 319PHD-typePROSITE-ProRule annotationAdd BLAST55

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Death-inducer obliterator 1
Short name:
DIO-1
Alternative name(s):
Death-associated transcription factor 1
Short name:
DATF-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dido1
Synonyms:Datf1, Dio1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1344352, Dido1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000593251 – 2256Death-inducer obliterator 1Add BLAST2256

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei58PhosphoserineBy similarity1
Modified residuei112PhosphoserineCombined sources1
Modified residuei148PhosphothreonineCombined sources1
Modified residuei149PhosphoserineCombined sources1
Modified residuei151PhosphoserineBy similarity1
Modified residuei522PhosphoserineBy similarity1
Modified residuei802PhosphoserineCombined sources1
Modified residuei806PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki876Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei886PhosphoserineCombined sources1
Modified residuei1016PhosphoserineCombined sources1
Modified residuei1027PhosphoserineBy similarity1
Modified residuei1035PhosphoserineCombined sources1
Modified residuei1239PhosphotyrosineBy similarity1
Modified residuei1252PhosphothreonineCombined sources1
Modified residuei1256PhosphoserineCombined sources1
Modified residuei1307PhosphoserineBy similarity1
Modified residuei1514PhosphoserineBy similarity1
Modified residuei1726PhosphoserineBy similarity1
Modified residuei1848Omega-N-methylarginineBy similarity1
Modified residuei1904Asymmetric dimethylarginineBy similarity1
Modified residuei1905Asymmetric dimethylarginineBy similarity1
Modified residuei1988Asymmetric dimethylarginineBy similarity1
Modified residuei1993Asymmetric dimethylarginineBy similarity1
Modified residuei2004Asymmetric dimethylarginineBy similarity1
Modified residuei2019Asymmetric dimethylarginineBy similarity1
Modified residuei2035Asymmetric dimethylarginineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8C9B9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8C9B9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8C9B9

PeptideAtlas

More...
PeptideAtlasi
Q8C9B9

PRoteomics IDEntifications database

More...
PRIDEi
Q8C9B9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
279662 [Q8C9B9-1]
279663 [Q8C9B9-2]
279664 [Q8C9B9-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8C9B9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8C9B9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Expressed at intermediate levels.

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated during apoptosis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000038914, Expressed in paneth cell and 322 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8C9B9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8C9B9, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts specifically (via PHD-type zinc finger) with histone H3 that is trimethylated at 'Lys-4' (H3K4me3), histone phosphorylation at 'Thr-3' or 'Thr-6' disrupts this binding and promotes translocation of DIDO1 from chromatin to the mitotic spindle during mitosis.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
204761, 8 interactors

Protein interaction database and analysis system

More...
IntActi
Q8C9B9, 5 interactors

Molecular INTeraction database

More...
MINTi
Q8C9B9

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000084794

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8C9B9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12256
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
Q8C9B9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8C9B9

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8C9B9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini667 – 787TFIIS centralPROSITE-ProRule annotationAdd BLAST121

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 256DisorderedSequence analysisAdd BLAST256
Regioni481 – 535DisorderedSequence analysisAdd BLAST55
Regioni598 – 624DisorderedSequence analysisAdd BLAST27
Regioni641 – 668DisorderedSequence analysisAdd BLAST28
Regioni778 – 822DisorderedSequence analysisAdd BLAST45
Regioni856 – 970DisorderedSequence analysisAdd BLAST115
Regioni1011 – 1039DisorderedSequence analysisAdd BLAST29
Regioni1197 – 1218DisorderedSequence analysisAdd BLAST22
Regioni1245 – 1288DisorderedSequence analysisAdd BLAST44
Regioni1320 – 1347DisorderedSequence analysisAdd BLAST28
Regioni1362 – 1421DisorderedSequence analysisAdd BLAST60
Regioni1509 – 1609DisorderedSequence analysisAdd BLAST101
Regioni1630 – 2256DisorderedSequence analysisAdd BLAST627

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi162 – 170Nuclear localization signalSequence analysis9
Motifi182 – 190Nuclear localization signalSequence analysis9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 44Basic and acidic residuesSequence analysisAdd BLAST44
Compositional biasi46 – 60Polar residuesSequence analysisAdd BLAST15
Compositional biasi63 – 89Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi91 – 123Polar residuesSequence analysisAdd BLAST33
Compositional biasi131 – 145Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi152 – 196Basic and acidic residuesSequence analysisAdd BLAST45
Compositional biasi218 – 247Polar residuesSequence analysisAdd BLAST30
Compositional biasi489 – 505Polar residuesSequence analysisAdd BLAST17
Compositional biasi601 – 616Polar residuesSequence analysisAdd BLAST16
Compositional biasi778 – 795Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi863 – 885Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi909 – 924Polar residuesSequence analysisAdd BLAST16
Compositional biasi939 – 970Polar residuesSequence analysisAdd BLAST32
Compositional biasi1198 – 1216Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi1252 – 1268Pro residuesSequence analysisAdd BLAST17
Compositional biasi1274 – 1288Polar residuesSequence analysisAdd BLAST15
Compositional biasi1521 – 1548Polar residuesSequence analysisAdd BLAST28
Compositional biasi1549 – 1563Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1569 – 1585Polar residuesSequence analysisAdd BLAST17
Compositional biasi1662 – 1677Pro residuesSequence analysisAdd BLAST16
Compositional biasi1678 – 1717Polar residuesSequence analysisAdd BLAST40
Compositional biasi1740 – 1754Polar residuesSequence analysisAdd BLAST15
Compositional biasi1853 – 1871Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi2027 – 2041Pro residuesSequence analysisAdd BLAST15
Compositional biasi2077 – 2245Basic and acidic residuesSequence analysisAdd BLAST169

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PHD-type zinc finger forms an aromatic cage around H3K4me3.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri265 – 319PHD-typePROSITE-ProRule annotationAdd BLAST55

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1632, Eukaryota
KOG1634, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155532

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000673_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8C9B9

Identification of Orthologs from Complete Genome Data

More...
OMAi
RTFGMSG

Database of Orthologous Groups

More...
OrthoDBi
174961at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8C9B9

TreeFam database of animal gene trees

More...
TreeFami
TF350578

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.472.30, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033082, DIDO1
IPR012921, SPOC_C
IPR003618, TFIIS_cen_dom
IPR036575, TFIIS_cen_dom_sf
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR11477:SF13, PTHR11477:SF13, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00628, PHD, 1 hit
PF07744, SPOC, 1 hit
PF07500, TFIIS_M, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00249, PHD, 1 hit
SM00510, TFS2M, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46942, SSF46942, 1 hit
SSF57903, SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51321, TFIIS_CENTRAL, 1 hit
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8C9B9-1) [UniParc]FASTAAdd to basket
Also known as: Dido3

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDDKGHLSNE EAPKAIKPTS KEFRKTWGFR RTTIAKREGA GDTEVDPSEQ
60 70 80 90 100
QPQQHNLSLR RSGRQPKRTE RVEEFLTTVR RRGKKNVPVS LEDSSEPTSS
110 120 130 140 150
TVTDVETASE GSVESSSEIR SGPVSDSLGK EHPASSEKAK GGEEEEDTSD
160 170 180 190 200
SDSDGLTLKE LQNRLRRKRE QEPVERSLRG SQNRLRKKRR EEDSAETGSV
210 220 230 240 250
QIGSAEQDRP LCKQEPEASQ GPVSQSETDD IENQLEGKAT QGNTEENPRE
260 270 280 290 300
AGKPKPECEV YDPNALYCIC RQPHNNRFMI CCDRCEEWFH GDCVGISEAR
310 320 330 340 350
GRLLERNGED YICPNCTILQ VQDETNGSAT DEQDSGCRSV GADGTDCTSI
360 370 380 390 400
GTVEQKSGED QGIKGRIEKA ANPSGKKKLK IFQPVVEAPG APKCIGPGCS
410 420 430 440 450
SVAQPDSVYC SNDCILKHAA ATMRFLSSGK EQKTKPKEKV KTKPEKFSLP
460 470 480 490 500
KCSVQVGIKI SSVHKRLASE KRENPVKKVM LASRSETSGK EAACESSTPS
510 520 530 540 550
WASDHNYNAV KPEKPEKPTA LSPTLLSKSM KDDRRVEDRT MAAVTIPKKA
560 570 580 590 600
LPSASLVGRQ TSPRNLVPKK LPPYSNMAGA KPAIKKLPSG FKGTIPKRPW
610 620 630 640 650
PSATLSGTSA RQAGPTPMTA ASKKLPGSAA VVGVTRKPMS ANVPAASPAP
660 670 680 690 700
GRLGPVSPAP SQPNSQIRQN IRRSLKEILW KRVNDSDDLI MTENEVGKIA
710 720 730 740 750
LHIEKEMFNL FQVTDNRYKS KYRSIMFNLK DPKNQGLFHR VLREEISLAK
760 770 780 790 800
LVRMKPEELV SKELSMWTEK PTKSVIESRT KLLNESKKNT TKPETIPDME
810 820 830 840 850
DSPPVSDSEE QQESVRAAPE KSAAPLLDVF SSMLKDTTSQ HRAHLFDLNC
860 870 880 890 900
KICTGQVPSS EDEPAPKKQK LSASSKKEDF KPRHDSSPPN AVPNTADEGI
910 920 930 940 950
ADTLPENASE PDPESTSSLN QERKCFPESP GDSHPEPSSL GGLSPSSASG
960 970 980 990 1000
GSGVVTTVTM SGRDPRTALS GSCTVTASMA AHLDNSQASE TKLDMIKPAL
1010 1020 1030 1040 1050
TSAVVPKSIL AKPSSSPDPR YLSVPPSPSI SESRSPPEGD TTLFLSRLNT
1060 1070 1080 1090 1100
IWKGFINMQS VAKFVTKAYP VSGCLDYLSE DLPDTIHIGG RIAPKTVWDY
1110 1120 1130 1140 1150
VGKLKSSVSK ELCLIRFHPA TEEEEVAYIS LYSYFSSRGR FGVVANNNRH
1160 1170 1180 1190 1200
VKDLYLIPLS AKDPVPSKLL PFEGPGLESP RPNIILGLVI CQKVKRPSSA
1210 1220 1230 1240 1250
GELDKTDEKR TRLQQEELET SVYPKVTAAL PSEKKPPKYS VHSIDTAATS
1260 1270 1280 1290 1300
TTPPGSPPPP PPLPEPPVLK ILSSLKPGST STVTAPTTAA ITTTASPVTA
1310 1320 1330 1340 1350
ATSKTASPLE HILQTLFGKK KSFEPSGKES VGSTLSPHQD SKAKGEDTMS
1360 1370 1380 1390 1400
AAPLLDPIVQ QFGQFSKDKA LEEEEEDDRP YDPEEEYNPD RAFHTLLAEP
1410 1420 1430 1440 1450
GRPHDVQSVS ETAEREEVAY DPEDETILEE AKVTIDDLPN RMCMKVSATE
1460 1470 1480 1490 1500
RPADFTTDAS SASLVEQQKM LEELNKQIEE QKRQLEEQEE ALRQQRAAVG
1510 1520 1530 1540 1550
VSMAHFSVSD ALMSPPPKSS LGKTELFSQE QQAPDPSQGA PNTNHNLDSR
1560 1570 1580 1590 1600
QSRDPRQARR LAAENTENES LPRAPTGSTP GPQGTLPARE TPAGTAVVQG
1610 1620 1630 1640 1650
PGLAAEAKES MAVPWAPGEN AVLRPEHDIQ KCEHPGNPVS LPLDTSHLPT
1660 1670 1680 1690 1700
AGDGAARPAP PRRVLLPTPP STTFPPSFPL QPKAQNFSSG SREPFSGPTF
1710 1720 1730 1740 1750
MSQETSLGSS QYEDPRGAQS AGKNDSPVAD MEDSREPQPR PGESTTSFPQ
1760 1770 1780 1790 1800
PGQRGGGPQP QFPGQREPAP RTFGMSGHHG PSFPGPRGPV PPYSEENLVP
1810 1820 1830 1840 1850
NSDGPRGPPP ARFGAQKPPI PSLFSGQHGP PPYGDNRGLS PSYLGGPRGG
1860 1870 1880 1890 1900
APAQFEDRKD PHGEKREFQD TPYNEMTGAP AQCEGPDQAQ FMGNRAPFQF
1910 1920 1930 1940 1950
GGQRRPLLTQ MKGPRGGPPP SQFGAQRGPP PGHFVGPRGP HPSQFENSRG
1960 1970 1980 1990 2000
THPGQFEGAR GQAPGFMPGP RGIQPQQFEE QRVNSPPRFA GQRASAPLPY
2010 2020 2030 2040 2050
GGPRGPAPFP EKNEQPPSRF HFQGPSSQPV KPPPRPLLEL PSHPPQHRKD
2060 2070 2080 2090 2100
RWDEAGPATA LPSSAGPGQG HEADGQWATS EFREGKGHEY RSPAFEGRQR
2110 2120 2130 2140 2150
ERFEAGSKEK PLDEPEAQGL ESRQGRAFED RRRERERGRN WSRERDWERS
2160 2170 2180 2190 2200
RDWDRHREWD KGRDRSSNRD RERDNDRAKE WDRSRERSRN RDRDRERRRD
2210 2220 2230 2240 2250
RDRSRSRDRD RDRERARDRD RDRGRDRKDR SKSRESPRDQ KPEARTSEGG

PAAAQA
Length:2,256
Mass (Da):247,176
Last modified:July 10, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCB4F6F6D3FE53747
GO
Isoform 2 (identifier: Q8C9B9-2) [UniParc]FASTAAdd to basket
Also known as: Dido1

The sequence of this isoform differs from the canonical sequence as follows:
     529-614: SMKDDRRVED...LSGTSARQAG → CTYHPKAGFP...AISYFSFRPW
     615-2256: Missing.

Show »
Length:614
Mass (Da):67,395
Checksum:i15A20A74BAEBC9E9
GO
Isoform 3 (identifier: Q8C9B9-3) [UniParc]FASTAAdd to basket
Also known as: Dido2

The sequence of this isoform differs from the canonical sequence as follows:
     1177-1183: LESPRPN → KHPVSGR
     1184-2256: Missing.

Show »
Length:1,183
Mass (Da):129,171
Checksum:i5D808FD9C763F72D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J0L7A0A0R4J0L7_MOUSE
Death-inducer obliterator 1
Dido1
643Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH44755 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC28053 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC97927 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti45V → A in CAB48401 (PubMed:10393935).Curated1
Sequence conflicti331D → N in CAB48401 (PubMed:10393935).Curated1
Sequence conflicti353V → I in BAC31270 (PubMed:16141072).Curated1
Sequence conflicti436P → K in AAH29110 (PubMed:15489334).Curated1
Sequence conflicti688D → Y in AAR84049 (PubMed:16127461).Curated1
Sequence conflicti688D → Y in AAR84050 (PubMed:16127461).Curated1
Sequence conflicti718Y → F in AAR84049 (PubMed:16127461).Curated1
Sequence conflicti718Y → F in AAR84050 (PubMed:16127461).Curated1
Sequence conflicti1739P → L in AAR84050 (PubMed:16127461).Curated1
Sequence conflicti2046Q → H in AAR84050 (PubMed:16127461).Curated1
Sequence conflicti2049K → T in AAR84050 (PubMed:16127461).Curated1
Sequence conflicti2054E → K in AAR84050 (PubMed:16127461).Curated1
Sequence conflicti2058A → P in AAR84050 (PubMed:16127461).Curated1
Sequence conflicti2118Q → L in BAC28053 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_012363529 – 614SMKDD…ARQAG → CTYHPKAGFPGPSHHLGGCL GLSRTRVLGVLVLIVASSSL PARSRYQDASGPQVFLPSLW SLSGWFLKSCVGLMLEAISY FSFRPW in isoform 2. 3 PublicationsAdd BLAST86
Alternative sequenceiVSP_012364615 – 2256Missing in isoform 2. 3 PublicationsAdd BLAST1642
Alternative sequenceiVSP_0266061177 – 1183LESPRPN → KHPVSGR in isoform 3. 3 Publications7
Alternative sequenceiVSP_0266071184 – 2256Missing in isoform 3. 3 PublicationsAdd BLAST1073

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ238332 mRNA Translation: CAB48401.1
AY425951 mRNA Translation: AAR84049.1
AY425952 mRNA Translation: AAR84050.1
AK129117 mRNA Translation: BAC97927.1 Different initiation.
AK032843 mRNA Translation: BAC28053.1 Different initiation.
AK042474 mRNA Translation: BAC31270.1
AK044919 mRNA Translation: BAC32141.1
AL732560 Genomic DNA No translation available.
BC029110 mRNA Translation: AAH29110.1
BC044755 mRNA Translation: AAH44755.1 Different initiation.
BC096662 mRNA Translation: AAH96662.1
BC138712 mRNA Translation: AAI38713.1
BC138713 mRNA Translation: AAI38714.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS17182.1 [Q8C9B9-1]
CCDS17183.1 [Q8C9B9-3]
CCDS17184.1 [Q8C9B9-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001278361.1, NM_001291432.1 [Q8C9B9-2]
NP_001278362.1, NM_001291433.1 [Q8C9B9-3]
NP_035935.2, NM_011805.3 [Q8C9B9-2]
NP_780760.2, NM_175551.4 [Q8C9B9-1]
NP_808520.2, NM_177852.4 [Q8C9B9-3]
XP_006500671.1, XM_006500608.3 [Q8C9B9-1]
XP_006500672.1, XM_006500609.3 [Q8C9B9-1]
XP_006500673.1, XM_006500610.3 [Q8C9B9-1]
XP_006500674.1, XM_006500611.3 [Q8C9B9-1]
XP_006500675.1, XM_006500612.3 [Q8C9B9-1]
XP_006500678.1, XM_006500615.3 [Q8C9B9-1]
XP_006500679.1, XM_006500616.3 [Q8C9B9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000087517; ENSMUSP00000084794; ENSMUSG00000038914 [Q8C9B9-1]
ENSMUST00000103055; ENSMUSP00000099344; ENSMUSG00000038914 [Q8C9B9-2]
ENSMUST00000103056; ENSMUSP00000099345; ENSMUSG00000038914 [Q8C9B9-3]
ENSMUST00000103057; ENSMUSP00000099346; ENSMUSG00000038914 [Q8C9B9-3]
ENSMUST00000130986; ENSMUSP00000119689; ENSMUSG00000038914 [Q8C9B9-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23856

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:23856

UCSC genome browser

More...
UCSCi
uc008ojq.2, mouse [Q8C9B9-1]
uc008ojr.2, mouse [Q8C9B9-3]
uc008oju.2, mouse [Q8C9B9-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238332 mRNA Translation: CAB48401.1
AY425951 mRNA Translation: AAR84049.1
AY425952 mRNA Translation: AAR84050.1
AK129117 mRNA Translation: BAC97927.1 Different initiation.
AK032843 mRNA Translation: BAC28053.1 Different initiation.
AK042474 mRNA Translation: BAC31270.1
AK044919 mRNA Translation: BAC32141.1
AL732560 Genomic DNA No translation available.
BC029110 mRNA Translation: AAH29110.1
BC044755 mRNA Translation: AAH44755.1 Different initiation.
BC096662 mRNA Translation: AAH96662.1
BC138712 mRNA Translation: AAI38713.1
BC138713 mRNA Translation: AAI38714.1
CCDSiCCDS17182.1 [Q8C9B9-1]
CCDS17183.1 [Q8C9B9-3]
CCDS17184.1 [Q8C9B9-2]
RefSeqiNP_001278361.1, NM_001291432.1 [Q8C9B9-2]
NP_001278362.1, NM_001291433.1 [Q8C9B9-3]
NP_035935.2, NM_011805.3 [Q8C9B9-2]
NP_780760.2, NM_175551.4 [Q8C9B9-1]
NP_808520.2, NM_177852.4 [Q8C9B9-3]
XP_006500671.1, XM_006500608.3 [Q8C9B9-1]
XP_006500672.1, XM_006500609.3 [Q8C9B9-1]
XP_006500673.1, XM_006500610.3 [Q8C9B9-1]
XP_006500674.1, XM_006500611.3 [Q8C9B9-1]
XP_006500675.1, XM_006500612.3 [Q8C9B9-1]
XP_006500678.1, XM_006500615.3 [Q8C9B9-1]
XP_006500679.1, XM_006500616.3 [Q8C9B9-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WEMNMR-A257-319[»]
BMRBiQ8C9B9
SMRiQ8C9B9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi204761, 8 interactors
IntActiQ8C9B9, 5 interactors
MINTiQ8C9B9
STRINGi10090.ENSMUSP00000084794

PTM databases

iPTMnetiQ8C9B9
PhosphoSitePlusiQ8C9B9

Proteomic databases

EPDiQ8C9B9
jPOSTiQ8C9B9
PaxDbiQ8C9B9
PeptideAtlasiQ8C9B9
PRIDEiQ8C9B9
ProteomicsDBi279662 [Q8C9B9-1]
279663 [Q8C9B9-2]
279664 [Q8C9B9-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
3820, 258 antibodies

The DNASU plasmid repository

More...
DNASUi
23856

Genome annotation databases

EnsembliENSMUST00000087517; ENSMUSP00000084794; ENSMUSG00000038914 [Q8C9B9-1]
ENSMUST00000103055; ENSMUSP00000099344; ENSMUSG00000038914 [Q8C9B9-2]
ENSMUST00000103056; ENSMUSP00000099345; ENSMUSG00000038914 [Q8C9B9-3]
ENSMUST00000103057; ENSMUSP00000099346; ENSMUSG00000038914 [Q8C9B9-3]
ENSMUST00000130986; ENSMUSP00000119689; ENSMUSG00000038914 [Q8C9B9-2]
GeneIDi23856
KEGGimmu:23856
UCSCiuc008ojq.2, mouse [Q8C9B9-1]
uc008ojr.2, mouse [Q8C9B9-3]
uc008oju.2, mouse [Q8C9B9-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11083
MGIiMGI:1344352, Dido1

Phylogenomic databases

eggNOGiKOG1632, Eukaryota
KOG1634, Eukaryota
GeneTreeiENSGT00940000155532
HOGENOMiCLU_000673_1_0_1
InParanoidiQ8C9B9
OMAiRTFGMSG
OrthoDBi174961at2759
PhylomeDBiQ8C9B9
TreeFamiTF350578

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
23856, 8 hits in 55 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Dido1, mouse
EvolutionaryTraceiQ8C9B9

Protein Ontology

More...
PROi
PR:Q8C9B9
RNActiQ8C9B9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000038914, Expressed in paneth cell and 322 other tissues
ExpressionAtlasiQ8C9B9, baseline and differential
GenevisibleiQ8C9B9, MM

Family and domain databases

Gene3Di1.10.472.30, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR033082, DIDO1
IPR012921, SPOC_C
IPR003618, TFIIS_cen_dom
IPR036575, TFIIS_cen_dom_sf
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR11477:SF13, PTHR11477:SF13, 1 hit
PfamiView protein in Pfam
PF00628, PHD, 1 hit
PF07744, SPOC, 1 hit
PF07500, TFIIS_M, 1 hit
SMARTiView protein in SMART
SM00249, PHD, 1 hit
SM00510, TFS2M, 1 hit
SUPFAMiSSF46942, SSF46942, 1 hit
SSF57903, SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51321, TFIIS_CENTRAL, 1 hit
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDIDO1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8C9B9
Secondary accession number(s): A2AJ47
, A2AJ48, B2RS46, Q05C59, Q3ZTP5, Q3ZTP6, Q4V9W1, Q6ZQD7, Q80V34, Q8BMD0, Q8BRG2, Q8CHR5, Q9WV00
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: July 10, 2007
Last modified: June 2, 2021
This is version 173 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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