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Protein

Transmembrane protein 163

Gene

Tmem163

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May bind zinc and other divalent cations and recruit them to vesicular organelles.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandZinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 163
Alternative name(s):
Synaptic vesicle membrane protein of 31 kDa
Gene namesi
Name:Tmem163
Synonyms:Sv31
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1919410 Tmem163

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 87CytoplasmicSequence analysisAdd BLAST87
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 115ExtracellularSequence analysis7
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Topological domaini137 – 149CytoplasmicSequence analysisAdd BLAST13
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Topological domaini171 – 186ExtracellularSequence analysisAdd BLAST16
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Topological domaini208 – 216CytoplasmicSequence analysis9
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Topological domaini238 – 254ExtracellularSequence analysisAdd BLAST17
Transmembranei255 – 275HelicalSequence analysisAdd BLAST21
Topological domaini276 – 288CytoplasmicSequence analysisAdd BLAST13

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Endosome, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002785401 – 288Transmembrane protein 163Add BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphoserineBy similarity1
Modified residuei45PhosphoserineCombined sources1
Modified residuei54PhosphoserineCombined sources1
Modified residuei56PhosphoserineCombined sources1
Modified residuei60PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8C996
MaxQBiQ8C996
PaxDbiQ8C996
PeptideAtlasiQ8C996
PRIDEiQ8C996

PTM databases

iPTMnetiQ8C996
PhosphoSitePlusiQ8C996

Expressioni

Tissue specificityi

Specifically expressed in brain. Mainly expressed in the glutaminergic neuron subpopulations.1 Publication

Gene expression databases

BgeeiENSMUSG00000026347 Expressed in 147 organ(s), highest expression level in heart
CleanExiMM_TMEM163
GenevisibleiQ8C996 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027585

Structurei

3D structure databases

ProteinModelPortaliQ8C996
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM163 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE9N Eukaryota
ENOG410Z7QG LUCA
GeneTreeiENSGT00390000001170
HOGENOMiHOG000294211
HOVERGENiHBG094063
InParanoidiQ8C996
OMAiVIKFMLG
OrthoDBiEOG091G0JXN
PhylomeDBiQ8C996
TreeFamiTF330782

Family and domain databases

InterProiView protein in InterPro
IPR027469 Cation_efflux_TMD_sf
IPR026765 Tmem163
PANTHERiPTHR31937 PTHR31937, 1 hit
SUPFAMiSSF161111 SSF161111, 1 hit

Sequencei

Sequence statusi: Complete.

Q8C996-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPALGSERR SPPGPGVPRP PPRGHAPSTA APAPSPAPMS SSVQSDEERQ
60 70 80 90 100
PRISESGQFS DGLEDRGLLE SSTRLKPHEA QNYRKKALWV SWLSIIVTLA
110 120 130 140 150
LAVAAFTVSV MRYSASAFGF AFDAILDVLS SAIVLWRYSN AAAVHSANRE
160 170 180 190 200
YIACVILGVI FLLSSICIVV KAIHDLSTRL LPEVDDFLFS VSILSGILCS
210 220 230 240 250
VLAVLKFMLG KVLTSRALIT DGFNSLVGGV MGFSILLSAE VFKHNAAVWY
260 270 280
LDGSIGVLIG LTIFAYGVKL LIDMVPRVRQ TRHYEMFE
Length:288
Mass (Da):31,193
Last modified:March 1, 2003 - v1
Checksum:i39552DEE746C4221
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21P → S in BAC32940 (PubMed:16141072).Curated1
Sequence conflicti288E → K in BAB27676 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011522 mRNA Translation: BAB27676.1
AK042650 mRNA Translation: BAC31320.1
AK047006 mRNA Translation: BAC32940.1
BC046234 mRNA Translation: AAH46234.1
BC059048 mRNA Translation: AAH59048.1
CCDSiCCDS35696.1
RefSeqiNP_082411.1, NM_028135.2
UniGeneiMm.281287

Genome annotation databases

EnsembliENSMUST00000027585; ENSMUSP00000027585; ENSMUSG00000026347
ENSMUST00000160616; ENSMUSP00000124307; ENSMUSG00000026347
ENSMUST00000185560; ENSMUSP00000140828; ENSMUSG00000026347
GeneIDi72160
KEGGimmu:72160
UCSCiuc011wqz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011522 mRNA Translation: BAB27676.1
AK042650 mRNA Translation: BAC31320.1
AK047006 mRNA Translation: BAC32940.1
BC046234 mRNA Translation: AAH46234.1
BC059048 mRNA Translation: AAH59048.1
CCDSiCCDS35696.1
RefSeqiNP_082411.1, NM_028135.2
UniGeneiMm.281287

3D structure databases

ProteinModelPortaliQ8C996
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027585

PTM databases

iPTMnetiQ8C996
PhosphoSitePlusiQ8C996

Proteomic databases

EPDiQ8C996
MaxQBiQ8C996
PaxDbiQ8C996
PeptideAtlasiQ8C996
PRIDEiQ8C996

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027585; ENSMUSP00000027585; ENSMUSG00000026347
ENSMUST00000160616; ENSMUSP00000124307; ENSMUSG00000026347
ENSMUST00000185560; ENSMUSP00000140828; ENSMUSG00000026347
GeneIDi72160
KEGGimmu:72160
UCSCiuc011wqz.1 mouse

Organism-specific databases

CTDi81615
MGIiMGI:1919410 Tmem163

Phylogenomic databases

eggNOGiENOG410IE9N Eukaryota
ENOG410Z7QG LUCA
GeneTreeiENSGT00390000001170
HOGENOMiHOG000294211
HOVERGENiHBG094063
InParanoidiQ8C996
OMAiVIKFMLG
OrthoDBiEOG091G0JXN
PhylomeDBiQ8C996
TreeFamiTF330782

Miscellaneous databases

PROiPR:Q8C996
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026347 Expressed in 147 organ(s), highest expression level in heart
CleanExiMM_TMEM163
GenevisibleiQ8C996 MM

Family and domain databases

InterProiView protein in InterPro
IPR027469 Cation_efflux_TMD_sf
IPR026765 Tmem163
PANTHERiPTHR31937 PTHR31937, 1 hit
SUPFAMiSSF161111 SSF161111, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTM163_MOUSE
AccessioniPrimary (citable) accession number: Q8C996
Secondary accession number(s): Q8C8I2, Q9D0E0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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