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UniProtKB - Q8C963 (CC159_MOUSE)

Entry version 104 (23 Feb 2022)
Sequence version 1 (01 Mar 2003)
Previous versions | rss
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Protein

Coiled-coil domain-containing protein 159

Gene

Ccdc159

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 159
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ccdc159
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1914369, Ccdc159

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000006241

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003329971 – 411Coiled-coil domain-containing protein 159Add BLAST411

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8C963

PRoteomics IDEntifications database

More...PRIDEi		Q8C963

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		265292 [Q8C963-1]
265293 [Q8C963-2]
265294 [Q8C963-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8C963

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8C963

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000006241, Expressed in testis and 98 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8C963, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8C963, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000126474

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8C963, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8C963

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni84 – 113DisorderedSequence analysisAdd BLAST30
Regioni372 – 411DisorderedSequence analysisAdd BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili269 – 305Sequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi379 – 394Polar residuesSequence analysisAdd BLAST16

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S2FS, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000008201

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_686891_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8C963

Identification of Orthologs from Complete Genome Data

More...OMAi		PLLPSWD

Database of Orthologous Groups

More...OrthoDBi		1360515at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8C963

TreeFam database of animal gene trees

More...TreeFami		TF337495

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039284, CCDC159/163

The PANTHER Classification System

More...PANTHERi		PTHR34533, PTHR34533, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8C963-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGEHERVVCC SSDSLLAGLS RDSDDCVSHL CTPPLLAITS WAAKERSQYS 
        60         70         80         90        100
PPPGEPGPSS DKALDCMTHW SRVLEPEIVN TASEQAGKSG AWEKEWDSEP 
       110        120        130        140        150
QPHEGTPCSS SDVNKDHYHD QDLVKRNHCV AKKSLEPSSA KVKVKNTMII 
       160        170        180        190        200
PDSQKLLRCE LESLRSQLQA QSKAFEFLNH SVTMLEKESC LQQIKIQQLE 
       210        220        230        240        250
EVLSPTSRQG EKYGRKWSTE QELYGALAQG LQGLQKTLKE GEELQRARTT 
       260        270        280        290        300
RCLQLLAREI RDSKKFLWEE LELVREEVTF IYQKLQDQED EISENLLNIQ 
       310        320        330        340        350
KMQKTQVKCR KVLTKMKQQA YDSWPEAEGV PTEGNGCCKD DLQKELGDIW 
       360        370        380        390        400
SAVHSLQSSI DCLALSMGTR PRASSLRGQK GHQCKSSQCP SWDSDSDWER 
       410 
PFSKSGSYPP A
Length:411
Mass (Da):46,342
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8E9CA2940FC293AA
GO
Isoform 2 (identifier: Q8C963-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MGEHERVVCCSS → MNGC

Show »
Length:403
Mass (Da):45,429
Checksum:i120646241162B380
GO
Isoform 3 (identifier: Q8C963-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     263-267: SKKFL → RGPGG
     268-411: Missing.

Show »
Length:267
Mass (Da):29,781
Checksum:i0D10BBC517D7A397
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1SQ92A0A1L1SQ92_MOUSE
Coiled-coil domain-containing prote...
Ccdc159
280Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti55E → D in BAB27409 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0334271 – 12MGEHE…VCCSS → MNGC in isoform 2. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_033428263 – 267SKKFL → RGPGG in isoform 3. 1 Publication5
Alternative sequenceiVSP_033429268 – 411Missing in isoform 3. 1 PublicationAdd BLAST144

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK011114 mRNA Translation: BAB27409.1
AK016073 mRNA Translation: BAB30102.1
AK042884 mRNA Translation: BAC31391.1
BC120702 mRNA Translation: AAI20703.1
BC120704 mRNA Translation: AAI20705.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS40557.1 [Q8C963-2]
CCDS52738.1 [Q8C963-1]

NCBI Reference Sequences

More...RefSeqi		NP_001158086.1, NM_001164614.1 [Q8C963-1]
NP_080253.2, NM_025977.3 [Q8C963-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000006403; ENSMUSP00000006403; ENSMUSG00000006241 [Q8C963-2]
ENSMUST00000170304; ENSMUSP00000126474; ENSMUSG00000006241 [Q8C963-1]
ENSMUST00000214734; ENSMUSP00000150744; ENSMUSG00000006241 [Q8C963-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		67119

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:67119

UCSC genome browser

More...UCSCi		uc009omx.1, mouse [Q8C963-2]
uc009omy.2, mouse [Q8C963-3]
uc009omz.2, mouse [Q8C963-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011114 mRNA Translation: BAB27409.1
AK016073 mRNA Translation: BAB30102.1
AK042884 mRNA Translation: BAC31391.1
BC120702 mRNA Translation: AAI20703.1
BC120704 mRNA Translation: AAI20705.1
CCDSiCCDS40557.1 [Q8C963-2]
CCDS52738.1 [Q8C963-1]
RefSeqiNP_001158086.1, NM_001164614.1 [Q8C963-1]
NP_080253.2, NM_025977.3 [Q8C963-2]

3D structure databases

SMRiQ8C963
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000126474

PTM databases

iPTMnetiQ8C963
PhosphoSitePlusiQ8C963

Proteomic databases

PaxDbiQ8C963
PRIDEiQ8C963
ProteomicsDBi265292 [Q8C963-1]
265293 [Q8C963-2]
265294 [Q8C963-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		52093, 16 antibodies from 8 providers

Genome annotation databases

EnsembliENSMUST00000006403; ENSMUSP00000006403; ENSMUSG00000006241 [Q8C963-2]
ENSMUST00000170304; ENSMUSP00000126474; ENSMUSG00000006241 [Q8C963-1]
ENSMUST00000214734; ENSMUSP00000150744; ENSMUSG00000006241 [Q8C963-3]
GeneIDi67119
KEGGimmu:67119
UCSCiuc009omx.1, mouse [Q8C963-2]
uc009omy.2, mouse [Q8C963-3]
uc009omz.2, mouse [Q8C963-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		126075
MGIiMGI:1914369, Ccdc159
VEuPathDBiHostDB:ENSMUSG00000006241

Phylogenomic databases

eggNOGiENOG502S2FS, Eukaryota
GeneTreeiENSGT00390000008201
HOGENOMiCLU_686891_0_0_1
InParanoidiQ8C963
OMAiPLLPSWD
OrthoDBi1360515at2759
PhylomeDBiQ8C963
TreeFamiTF337495

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		67119, 0 hits in 64 CRISPR screens

Protein Ontology

More...PROi		PR:Q8C963
RNActiQ8C963, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000006241, Expressed in testis and 98 other tissues
ExpressionAtlasiQ8C963, baseline and differential
GenevisibleiQ8C963, MM

Family and domain databases

InterProiView protein in InterPro
IPR039284, CCDC159/163
PANTHERiPTHR34533, PTHR34533, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCC159_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8C963
Secondary accession number(s): Q0VBB7, Q9CXZ5, Q9D4W5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 1, 2003
Last modified: February 23, 2022
This is version 104 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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