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Protein

Sterile alpha motif domain-containing protein 7

Gene

Samd7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the regulation of gene expression in the retina. It functions as a negative regulator of CRX-controlled genes.1 Publication

GO - Biological processi

  • negative regulation of gene expression Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Sterile alpha motif domain-containing protein 7
Short name:
SAM domain-containing protein 7
Gene namesi
Name:Samd7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1923203 Samd7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002631031 – 445Sterile alpha motif domain-containing protein 7Add BLAST445

Proteomic databases

PaxDbiQ8C8Y5
PRIDEiQ8C8Y5

PTM databases

PhosphoSitePlusiQ8C8Y5

Expressioni

Tissue specificityi

Expressed in the retina and the pineal gland. In the retina, it is predominantly expressed in the outer nuclear layer.1 Publication

Inductioni

Transcriptionally regulated by CRX.1 Publication

Gene expression databases

BgeeiENSMUSG00000051860 Expressed in 72 organ(s), highest expression level in retina
CleanExiMM_SAMD7
ExpressionAtlasiQ8C8Y5 baseline and differential
GenevisibleiF8WHA0 MM

Structurei

3D structure databases

ProteinModelPortaliQ8C8Y5
SMRiQ8C8Y5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini324 – 378SAMPROSITE-ProRule annotationAdd BLAST55

Phylogenomic databases

eggNOGiKOG3829 Eukaryota
ENOG410XQEJ LUCA
GeneTreeiENSGT00550000074459
HOGENOMiHOG000154252
HOVERGENiHBG093934
InParanoidiQ8C8Y5
OMAiDLHFHRS
OrthoDBiEOG091G15HQ
PhylomeDBiQ8C8Y5
TreeFamiTF331299

Family and domain databases

InterProiView protein in InterPro
IPR001660 SAM
IPR013761 SAM/pointed_sf
PfamiView protein in Pfam
PF00536 SAM_1, 1 hit
SMARTiView protein in SMART
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS50105 SAM_DOMAIN, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8C8Y5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTNPMMSVSS LLTSGQQKVP MVPSPFGPPI VDRDVLSSSI APTDPSQFCV
60 70 80 90 100
PSQFGSSGLP NANMPNPLSS HFYSGWGILP PEPIKAVTTR NEMFERHHAA
110 120 130 140 150
RAEMEMYSLY QQRRMERVNP KGLSGLGIPL FYGSSCLGGP TGFQGRSTLP
160 170 180 190 200
ASDVHLHRST FRHLQGNPIL LATRPHFTEC WGQKYRLRRG AVYQKPPESD
210 220 230 240 250
TESFKSQAEE KSSSQMPTLS YEEEEYIKDP DIEVDNQQKP RVADGKPTTV
260 270 280 290 300
PANPHGELHT HQRKPSSLEA NAWDDGKGKP SEQVYEGCDG KNGVFRPVSI
310 320 330 340 350
LPLSGTHEQV ALRENCSLSD IQKWTVDDVY NFIRSLPGCS DYAQVFKDHA
360 370 380 390 400
IDGETLPLLT EQHLRGTMGL KLGPALKIQS QVSQHVGNMF CKKLPSLPTH
410 420 430 440
ARQAFDQPAD TSPLLDMSSW SDGLSIPGPQ DLLSPKRTEQ DVMRN
Length:445
Mass (Da):49,259
Last modified:September 27, 2017 - v4
Checksum:iB861CEA5D859B812
GO
Isoform 2 (identifier: Q8C8Y5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-39: DVLSSS → LGHFTT
     40-445: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:39
Mass (Da):4,187
Checksum:i72592D30EF8BFD47
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UWL1G3UWL1_MOUSE
Sterile alpha motif domain-containi...
Samd7
102Annotation score:

Sequence cautioni

The sequence BAC31828 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05909234 – 39DVLSSS → LGHFTT in isoform 2. 6
Alternative sequenceiVSP_05909340 – 445Missing in isoform 2. Add BLAST406

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044227 mRNA Translation: BAC31828.1 Sequence problems.
AC158135 Genomic DNA No translation available.
CK618776 mRNA No translation available.
CCDSiCCDS17285.2 [Q8C8Y5-1]
RefSeqiNP_083765.2, NM_029489.3 [Q8C8Y5-1]
XP_017175280.1, XM_017319791.1 [Q8C8Y5-1]
UniGeneiMm.308084

Genome annotation databases

EnsembliENSMUST00000108262; ENSMUSP00000103897; ENSMUSG00000051860 [Q8C8Y5-1]
ENSMUST00000174395; ENSMUSP00000133687; ENSMUSG00000051860 [Q8C8Y5-3]
GeneIDi75953
KEGGimmu:75953
UCSCiuc008ovg.2 mouse [Q8C8Y5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044227 mRNA Translation: BAC31828.1 Sequence problems.
AC158135 Genomic DNA No translation available.
CK618776 mRNA No translation available.
CCDSiCCDS17285.2 [Q8C8Y5-1]
RefSeqiNP_083765.2, NM_029489.3 [Q8C8Y5-1]
XP_017175280.1, XM_017319791.1 [Q8C8Y5-1]
UniGeneiMm.308084

3D structure databases

ProteinModelPortaliQ8C8Y5
SMRiQ8C8Y5
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSitePlusiQ8C8Y5

Proteomic databases

PaxDbiQ8C8Y5
PRIDEiQ8C8Y5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000108262; ENSMUSP00000103897; ENSMUSG00000051860 [Q8C8Y5-1]
ENSMUST00000174395; ENSMUSP00000133687; ENSMUSG00000051860 [Q8C8Y5-3]
GeneIDi75953
KEGGimmu:75953
UCSCiuc008ovg.2 mouse [Q8C8Y5-1]

Organism-specific databases

CTDi344658
MGIiMGI:1923203 Samd7

Phylogenomic databases

eggNOGiKOG3829 Eukaryota
ENOG410XQEJ LUCA
GeneTreeiENSGT00550000074459
HOGENOMiHOG000154252
HOVERGENiHBG093934
InParanoidiQ8C8Y5
OMAiDLHFHRS
OrthoDBiEOG091G15HQ
PhylomeDBiQ8C8Y5
TreeFamiTF331299

Miscellaneous databases

PROiPR:Q8C8Y5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051860 Expressed in 72 organ(s), highest expression level in retina
CleanExiMM_SAMD7
ExpressionAtlasiQ8C8Y5 baseline and differential
GenevisibleiF8WHA0 MM

Family and domain databases

InterProiView protein in InterPro
IPR001660 SAM
IPR013761 SAM/pointed_sf
PfamiView protein in Pfam
PF00536 SAM_1, 1 hit
SMARTiView protein in SMART
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS50105 SAM_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSAMD7_MOUSE
AccessioniPrimary (citable) accession number: Q8C8Y5
Secondary accession number(s): F8WHA0, G3UXH0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: September 27, 2017
Last modified: October 10, 2018
This is version 97 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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