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UniProtKB - Q8C8V1 (ZXDC_MOUSE)

Protein

Zinc finger protein ZXDC

Gene

Zxdc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri176 – 200C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri209 – 233C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri239 – 263C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri269 – 291C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 322C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri329 – 353C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri359 – 383C2H2-type 7PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri389 – 413C2H2-type 8PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri419 – 443C2H2-type 9PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri452 – 477C2H2-type 10PROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ZXDC
Gene namesi
Name:Zxdc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1933108 Zxdc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002928041 – 858Zinc finger protein ZXDCAdd BLAST858

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki661Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

Post-translational modificationi

Sumoylated at Lys-661 with SUMO1, SUMO2 and SUMO3; sumoylation enhances the activity of the transcriptional activation domain.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ8C8V1
PRIDEiQ8C8V1

PTM databases

iPTMnetiQ8C8V1
PhosphoSitePlusiQ8C8V1

Expressioni

Gene expression databases

BgeeiENSMUSG00000034430 Expressed in 269 organ(s), highest expression level in primary oocyte
CleanExiMM_ZXDC
ExpressionAtlasiQ8C8V1 baseline and differential
GenevisibleiQ8C8V1 MM

Interactioni

Subunit structurei

Self-associates. Interacts with ZXDB and CIITA (By similarity).By similarity

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074619

Structurei

3D structure databases

ProteinModelPortaliQ8C8V1
SMRiQ8C8V1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ZXD family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri176 – 200C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri209 – 233C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri239 – 263C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri269 – 291C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 322C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri329 – 353C2H2-type 6PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri359 – 383C2H2-type 7PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri389 – 413C2H2-type 8PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri419 – 443C2H2-type 9PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri452 – 477C2H2-type 10PROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144040
HOVERGENiHBG002277
InParanoidiQ8C8V1
OMAiRKWGLSK
OrthoDBiEOG091G037W
PhylomeDBiQ8C8V1
TreeFamiTF330996

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8C8V1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDLPAVLAAP ATRGDQHGGG PSRLRRGAGP SLGAGPGRRR LLLLRGPEDG 
        60         70         80         90        100
GPGPRPEEAP GPSPPPPEDG GDSFVVLLEV PRAADTHGQE EAEPDSGASP 
       110        120        130        140        150
TEQVPAAAPG AALAGTVTIH NQDLLVRFDR GVFTLAAAPA PAAPSLHPAT 
       160        170        180        190        200
TPGLEPSSAA ASRRGPVAAS AGSPAYRCPE PQCALSFAKK HQLKVHLLTH 
       210        220        230        240        250
GSLQGRRPFK CPLDGCGWAF TTSYKLKRHL QSHDKLRPFS CPVGGCGKKF 
       260        270        280        290        300
TTVYNLKAHM KGHEQESLFK CEVCAERFPT HAKLNSHQRS HFEPERPYKC 
       310        320        330        340        350
DFPGCEKTFI TVSALFSHNR AHFREQELFS CSFPGCNKQY DKACRLKIHL 
       360        370        380        390        400
RSHTGERPFI CDSDSCGWTF TSMSKLLRHK RKHDDDRRFT CPVEGCGKSF 
       410        420        430        440        450
TRAEHLKGHS ITHLGTKPFE CPVEGCCARF SARSSLYIHS KKHLQDVGTP 
       460        470        480        490        500
KSRCPVSSCN RLFTSKHSMK AHVVRQHSRR QDLVPQLEAP SSLTPSSELS 
       510        520        530        540        550
SPGQSELTNI DLAALFSDTP ANSSSSTAGS DEALNSGILT IDVTSVSSSL 
       560        570        580        590        600
GGNLPTNNNS LGPMDPLVLV AHGDMPPSLD SPLVLGTSAT VLQPGSFSAD 
       610        620        630        640        650
DSQAMSTGAV GCLVALPVRN LNQDSPALTP SNNLTAPGTT PTSSDTTQET 
       660        670        680        690        700
GSVPDLLVPI KVEQDLSPVP DVVQGQKESH GPSQSVLSSS TERPGAQKDS 
       710        720        730        740        750
ELSAGTGSLY LESGGSARTD YRAIQLVKKK KQKGTGSDEG ASDSAHRKVK 
       760        770        780        790        800
GGTINPPHVH SGQHSCFCGT LMVPSGGLTV PAPAAGLQCV QIPVLQDDPS 
       810        820        830        840        850
GEGGLPLGLS PQRSAFHPYF TVDLPVYVLQ EVLPAPGGFA GLETAQVPGS 

TINLRDLE
Length:858
Mass (Da):90,755
Last modified:March 1, 2003 - v1
Checksum:iA7B31AFE64907C3B
GO
Isoform 2 (identifier: Q8C8V1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     712-712: E → V
     713-858: Missing.

Show »
Length:712
Mass (Da):75,647
Checksum:i4AE84A5E999223C5
GO
Isoform 3 (identifier: Q8C8V1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     505-512: SELTNIDL → RKWGLSKN
     513-858: Missing.

Note: No experimental confirmation available.
Show »
Length:512
Mass (Da):55,723
Checksum:i9197279E9EA609A7
GO
Isoform 4 (identifier: Q8C8V1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     356-363: ERPFICDS → MSCSVHLM
     364-858: Missing.

Note: No experimental confirmation available.
Show »
Length:363
Mass (Da):38,909
Checksum:i3C55853A64055511
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0N4SV82A0A0N4SV82_MOUSE
Zinc finger protein ZXDC
Zxdc
152Annotation score:

Sequence cautioni

The sequence AAH03332 differs from that shown. Reason: Frameshift at position 672.Curated
The sequence BAC31967 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC33082 differs from that shown. Reason: Frameshift at position 108.Curated
The sequence BAC38113 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti154L → Q in BAE24766 (PubMed:16141072).Curated1
Sequence conflicti576P → R in BAC38113 (PubMed:16141072).Curated1
Sequence conflicti608G → V in BAC37873 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026439356 – 363ERPFICDS → MSCSVHLM in isoform 4. 1 Publication8
Alternative sequenceiVSP_026440364 – 858Missing in isoform 4. 1 PublicationAdd BLAST495
Alternative sequenceiVSP_026441505 – 512SELTNIDL → RKWGLSKN in isoform 3. 1 Publication8
Alternative sequenceiVSP_026442513 – 858Missing in isoform 3. 1 PublicationAdd BLAST346
Alternative sequenceiVSP_026443712E → V in isoform 2. 2 Publications1
Alternative sequenceiVSP_026444713 – 858Missing in isoform 2. 2 PublicationsAdd BLAST146

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044429 mRNA Translation: BAC31914.1
AK044529 mRNA Translation: BAC31967.1 Different initiation.
AK047538 mRNA Translation: BAC33082.1 Frameshift.
AK080307 mRNA Translation: BAC37873.1
AK081005 mRNA Translation: BAC38113.1 Different initiation.
AK141613 mRNA Translation: BAE24766.1
AK169517 mRNA Translation: BAE41206.1
BC003332 mRNA Translation: AAH03332.1 Frameshift.
CCDSiCCDS20358.1 [Q8C8V1-1]
CCDS51848.1 [Q8C8V1-2]
RefSeqiNP_084536.2, NM_030260.3 [Q8C8V1-2]
NP_766590.1, NM_173002.3 [Q8C8V1-1]
UniGeneiMm.100116
Mm.473652

Genome annotation databases

EnsembliENSMUST00000045740; ENSMUSP00000036329; ENSMUSG00000034430 [Q8C8V1-3]
ENSMUST00000075117; ENSMUSP00000074619; ENSMUSG00000034430 [Q8C8V1-1]
ENSMUST00000113539; ENSMUSP00000109167; ENSMUSG00000034430 [Q8C8V1-2]
GeneIDi80292
KEGGimmu:80292
UCSCiuc009cxf.2 mouse [Q8C8V1-1]
uc012eoy.1 mouse [Q8C8V1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044429 mRNA Translation: BAC31914.1
AK044529 mRNA Translation: BAC31967.1 Different initiation.
AK047538 mRNA Translation: BAC33082.1 Frameshift.
AK080307 mRNA Translation: BAC37873.1
AK081005 mRNA Translation: BAC38113.1 Different initiation.
AK141613 mRNA Translation: BAE24766.1
AK169517 mRNA Translation: BAE41206.1
BC003332 mRNA Translation: AAH03332.1 Frameshift.
CCDSiCCDS20358.1 [Q8C8V1-1]
CCDS51848.1 [Q8C8V1-2]
RefSeqiNP_084536.2, NM_030260.3 [Q8C8V1-2]
NP_766590.1, NM_173002.3 [Q8C8V1-1]
UniGeneiMm.100116
Mm.473652

3D structure databases

ProteinModelPortaliQ8C8V1
SMRiQ8C8V1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074619

PTM databases

iPTMnetiQ8C8V1
PhosphoSitePlusiQ8C8V1

Proteomic databases

PaxDbiQ8C8V1
PRIDEiQ8C8V1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045740; ENSMUSP00000036329; ENSMUSG00000034430 [Q8C8V1-3]
ENSMUST00000075117; ENSMUSP00000074619; ENSMUSG00000034430 [Q8C8V1-1]
ENSMUST00000113539; ENSMUSP00000109167; ENSMUSG00000034430 [Q8C8V1-2]
GeneIDi80292
KEGGimmu:80292
UCSCiuc009cxf.2 mouse [Q8C8V1-1]
uc012eoy.1 mouse [Q8C8V1-2]

Organism-specific databases

CTDi79364
MGIiMGI:1933108 Zxdc

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144040
HOVERGENiHBG002277
InParanoidiQ8C8V1
OMAiRKWGLSK
OrthoDBiEOG091G037W
PhylomeDBiQ8C8V1
TreeFamiTF330996

Miscellaneous databases

PROiPR:Q8C8V1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034430 Expressed in 269 organ(s), highest expression level in primary oocyte
CleanExiMM_ZXDC
ExpressionAtlasiQ8C8V1 baseline and differential
GenevisibleiQ8C8V1 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZXDC_MOUSE
AccessioniPrimary (citable) accession number: Q8C8V1
Secondary accession number(s): Q3TEP2
, Q3URC2, Q8C4U7, Q8C4Z9, Q8C8C2, Q8C8T1, Q99J65
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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