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UniProtKB - Q8C8V1 (ZXDC_MOUSE)
Protein
Zinc finger protein ZXDC
Gene
Zxdc
Organism
Mus musculus (Mouse)
Status
Functioni
Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 176 – 200 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 209 – 233 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 239 – 263 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 269 – 291 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 298 – 322 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 329 – 353 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 359 – 383 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 389 – 413 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 419 – 443 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 452 – 477 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 26 |
GO - Molecular functioni
- C2H2 zinc finger domain binding Source: UniProtKB
- LRR domain binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- transcription coactivator activity Source: UniProtKB
- transcription coregulator activity Source: GO_Central
GO - Biological processi
- positive regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein ZXDC |
Gene namesi | Name:Zxdc |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1933108, Zxdc |
VEuPathDBi | HostDB:ENSMUSG00000034430 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000292804 | 1 – 858 | Zinc finger protein ZXDCAdd BLAST | 858 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 661 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity |
Post-translational modificationi
Sumoylated at Lys-661 with SUMO1, SUMO2 and SUMO3; sumoylation enhances the activity of the transcriptional activation domain.By similarity
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
MaxQBi | Q8C8V1 |
PaxDbi | Q8C8V1 |
PRIDEi | Q8C8V1 |
ProteomicsDBi | 275250 [Q8C8V1-1] 275251 [Q8C8V1-2] 275252 [Q8C8V1-3] 275253 [Q8C8V1-4] |
PTM databases
iPTMneti | Q8C8V1 |
PhosphoSitePlusi | Q8C8V1 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000034430, Expressed in primary oocyte and 292 other tissues |
ExpressionAtlasi | Q8C8V1, baseline and differential |
Genevisiblei | Q8C8V1, MM |
Interactioni
Subunit structurei
Self-associates.
Interacts with ZXDB and CIITA (By similarity).
By similarityGO - Molecular functioni
- C2H2 zinc finger domain binding Source: UniProtKB
- LRR domain binding Source: UniProtKB
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000074619 |
Miscellaneous databases
RNActi | Q8C8V1, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 73 | DisorderedSequence analysisAdd BLAST | 73 | |
Regioni | 85 – 108 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 142 – 175 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 624 – 652 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 671 – 714 | DisorderedSequence analysisAdd BLAST | 44 | |
Regioni | 727 – 751 | DisorderedSequence analysisAdd BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 53 – 69 | Pro residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 677 – 713 | Polar residuesSequence analysisAdd BLAST | 37 | |
Compositional biasi | 727 – 746 | Basic and acidic residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the ZXD family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 176 – 200 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 209 – 233 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 239 – 263 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 269 – 291 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 298 – 322 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 329 – 353 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 359 – 383 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 389 – 413 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 419 – 443 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 452 – 477 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 26 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162216 |
HOGENOMi | CLU_007312_0_0_1 |
InParanoidi | Q8C8V1 |
OMAi | QCAGSTI |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8C8V1 |
TreeFami | TF330996 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 10 hits |
SUPFAMi | SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 10 hits PS50157, ZINC_FINGER_C2H2_2, 10 hits |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8C8V1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDLPAVLAAP ATRGDQHGGG PSRLRRGAGP SLGAGPGRRR LLLLRGPEDG
60 70 80 90 100
GPGPRPEEAP GPSPPPPEDG GDSFVVLLEV PRAADTHGQE EAEPDSGASP
110 120 130 140 150
TEQVPAAAPG AALAGTVTIH NQDLLVRFDR GVFTLAAAPA PAAPSLHPAT
160 170 180 190 200
TPGLEPSSAA ASRRGPVAAS AGSPAYRCPE PQCALSFAKK HQLKVHLLTH
210 220 230 240 250
GSLQGRRPFK CPLDGCGWAF TTSYKLKRHL QSHDKLRPFS CPVGGCGKKF
260 270 280 290 300
TTVYNLKAHM KGHEQESLFK CEVCAERFPT HAKLNSHQRS HFEPERPYKC
310 320 330 340 350
DFPGCEKTFI TVSALFSHNR AHFREQELFS CSFPGCNKQY DKACRLKIHL
360 370 380 390 400
RSHTGERPFI CDSDSCGWTF TSMSKLLRHK RKHDDDRRFT CPVEGCGKSF
410 420 430 440 450
TRAEHLKGHS ITHLGTKPFE CPVEGCCARF SARSSLYIHS KKHLQDVGTP
460 470 480 490 500
KSRCPVSSCN RLFTSKHSMK AHVVRQHSRR QDLVPQLEAP SSLTPSSELS
510 520 530 540 550
SPGQSELTNI DLAALFSDTP ANSSSSTAGS DEALNSGILT IDVTSVSSSL
560 570 580 590 600
GGNLPTNNNS LGPMDPLVLV AHGDMPPSLD SPLVLGTSAT VLQPGSFSAD
610 620 630 640 650
DSQAMSTGAV GCLVALPVRN LNQDSPALTP SNNLTAPGTT PTSSDTTQET
660 670 680 690 700
GSVPDLLVPI KVEQDLSPVP DVVQGQKESH GPSQSVLSSS TERPGAQKDS
710 720 730 740 750
ELSAGTGSLY LESGGSARTD YRAIQLVKKK KQKGTGSDEG ASDSAHRKVK
760 770 780 790 800
GGTINPPHVH SGQHSCFCGT LMVPSGGLTV PAPAAGLQCV QIPVLQDDPS
810 820 830 840 850
GEGGLPLGLS PQRSAFHPYF TVDLPVYVLQ EVLPAPGGFA GLETAQVPGS
TINLRDLE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0N4SV82 | A0A0N4SV82_MOUSE | Zinc finger protein ZXDC | Zxdc | 152 | Annotation score: |
Sequence cautioni
The sequence AAH03332 differs from that shown. Reason: Frameshift.Curated
The sequence BAC31967 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAC33082 differs from that shown. Reason: Frameshift.Curated
The sequence BAC38113 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 154 | L → Q in BAE24766 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 576 | P → R in BAC38113 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 608 | G → V in BAC37873 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_026439 | 356 – 363 | ERPFICDS → MSCSVHLM in isoform 4. 1 Publication | 8 | |
Alternative sequenceiVSP_026440 | 364 – 858 | Missing in isoform 4. 1 PublicationAdd BLAST | 495 | |
Alternative sequenceiVSP_026441 | 505 – 512 | SELTNIDL → RKWGLSKN in isoform 3. 1 Publication | 8 | |
Alternative sequenceiVSP_026442 | 513 – 858 | Missing in isoform 3. 1 PublicationAdd BLAST | 346 | |
Alternative sequenceiVSP_026443 | 712 | E → V in isoform 2. 2 Publications | 1 | |
Alternative sequenceiVSP_026444 | 713 – 858 | Missing in isoform 2. 2 PublicationsAdd BLAST | 146 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK044429 mRNA Translation: BAC31914.1 AK044529 mRNA Translation: BAC31967.1 Different initiation. AK047538 mRNA Translation: BAC33082.1 Frameshift. AK080307 mRNA Translation: BAC37873.1 AK081005 mRNA Translation: BAC38113.1 Different initiation. AK141613 mRNA Translation: BAE24766.1 AK169517 mRNA Translation: BAE41206.1 BC003332 mRNA Translation: AAH03332.1 Frameshift. |
CCDSi | CCDS20358.1 [Q8C8V1-1] CCDS51848.1 [Q8C8V1-2] |
RefSeqi | NP_084536.2, NM_030260.3 [Q8C8V1-2] NP_766590.1, NM_173002.3 [Q8C8V1-1] |
Genome annotation databases
Ensembli | ENSMUST00000045740; ENSMUSP00000036329; ENSMUSG00000034430 [Q8C8V1-3] ENSMUST00000075117; ENSMUSP00000074619; ENSMUSG00000034430 [Q8C8V1-1] ENSMUST00000113539; ENSMUSP00000109167; ENSMUSG00000034430 [Q8C8V1-2] |
GeneIDi | 80292 |
KEGGi | mmu:80292 |
UCSCi | uc009cxf.2, mouse [Q8C8V1-1] uc012eoy.1, mouse [Q8C8V1-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK044429 mRNA Translation: BAC31914.1 AK044529 mRNA Translation: BAC31967.1 Different initiation. AK047538 mRNA Translation: BAC33082.1 Frameshift. AK080307 mRNA Translation: BAC37873.1 AK081005 mRNA Translation: BAC38113.1 Different initiation. AK141613 mRNA Translation: BAE24766.1 AK169517 mRNA Translation: BAE41206.1 BC003332 mRNA Translation: AAH03332.1 Frameshift. |
CCDSi | CCDS20358.1 [Q8C8V1-1] CCDS51848.1 [Q8C8V1-2] |
RefSeqi | NP_084536.2, NM_030260.3 [Q8C8V1-2] NP_766590.1, NM_173002.3 [Q8C8V1-1] |
3D structure databases
SMRi | Q8C8V1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000074619 |
PTM databases
iPTMneti | Q8C8V1 |
PhosphoSitePlusi | Q8C8V1 |
Proteomic databases
MaxQBi | Q8C8V1 |
PaxDbi | Q8C8V1 |
PRIDEi | Q8C8V1 |
ProteomicsDBi | 275250 [Q8C8V1-1] 275251 [Q8C8V1-2] 275252 [Q8C8V1-3] 275253 [Q8C8V1-4] |
Protocols and materials databases
Antibodypediai | 33073, 110 antibodies from 20 providers |
DNASUi | 80292 |
Genome annotation databases
Ensembli | ENSMUST00000045740; ENSMUSP00000036329; ENSMUSG00000034430 [Q8C8V1-3] ENSMUST00000075117; ENSMUSP00000074619; ENSMUSG00000034430 [Q8C8V1-1] ENSMUST00000113539; ENSMUSP00000109167; ENSMUSG00000034430 [Q8C8V1-2] |
GeneIDi | 80292 |
KEGGi | mmu:80292 |
UCSCi | uc009cxf.2, mouse [Q8C8V1-1] uc012eoy.1, mouse [Q8C8V1-2] |
Organism-specific databases
CTDi | 79364 |
MGIi | MGI:1933108, Zxdc |
VEuPathDBi | HostDB:ENSMUSG00000034430 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162216 |
HOGENOMi | CLU_007312_0_0_1 |
InParanoidi | Q8C8V1 |
OMAi | QCAGSTI |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8C8V1 |
TreeFami | TF330996 |
Miscellaneous databases
BioGRID-ORCSi | 80292, 1 hit in 64 CRISPR screens |
PROi | PR:Q8C8V1 |
RNActi | Q8C8V1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000034430, Expressed in primary oocyte and 292 other tissues |
ExpressionAtlasi | Q8C8V1, baseline and differential |
Genevisiblei | Q8C8V1, MM |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 10 hits |
SUPFAMi | SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 10 hits PS50157, ZINC_FINGER_C2H2_2, 10 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZXDC_MOUSE | |
Accessioni | Q8C8V1Primary (citable) accession number: Q8C8V1 Secondary accession number(s): Q3TEP2 Q99J65 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 26, 2007 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 23, 2022 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families