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Protein

Liprin-beta-1

Gene

Ppfibp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A (By similarity).By similarity

Enzyme and pathway databases

ReactomeiR-MMU-388844 Receptor-type tyrosine-protein phosphatases

Names & Taxonomyi

Protein namesi
Recommended name:
Liprin-beta-1
Alternative name(s):
Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1
Short name:
PTPRF-interacting protein-binding protein 1
Gene namesi
Name:Ppfibp1
Synonyms:Kiaa1230
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1914783 Ppfibp1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910351 – 969Liprin-beta-1Add BLAST969

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37PhosphoserineBy similarity1
Modified residuei39PhosphothreonineBy similarity1
Modified residuei40PhosphoserineCombined sources1
Modified residuei291N6-acetyllysineBy similarity1
Modified residuei403PhosphoserineCombined sources1
Modified residuei435PhosphoserineBy similarity1
Cross-linki440Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei500PhosphoserineBy similarity1
Modified residuei538PhosphoserineCombined sources1
Modified residuei560PhosphoserineCombined sources1
Modified residuei595PhosphoserineCombined sources1
Modified residuei753PhosphoserineCombined sources1
Modified residuei757PhosphoserineCombined sources1
Modified residuei957PhosphoserineBy similarity1
Modified residuei959PhosphoserineBy similarity1
Modified residuei961PhosphoserineCombined sources1
Modified residuei963PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8C8U0
PaxDbiQ8C8U0
PeptideAtlasiQ8C8U0
PRIDEiQ8C8U0

PTM databases

iPTMnetiQ8C8U0
PhosphoSitePlusiQ8C8U0

Expressioni

Gene expression databases

BgeeiENSMUSG00000016487 Expressed in 249 organ(s), highest expression level in cumulus cell
ExpressionAtlasiQ8C8U0 baseline and differential
GenevisibleiQ8C8U0 MM

Interactioni

Subunit structurei

Forms homodimers and heterodimers. Interacts with S100A4 in a calcium-dependent mode (By similarity).By similarity

Protein-protein interaction databases

BioGridi212256, 1 interactor
IntActiQ8C8U0, 2 interactors
MINTiQ8C8U0
STRINGi10090.ENSMUSP00000107250

Structurei

Secondary structure

1969
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8C8U0
SMRiQ8C8U0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini606 – 670SAM 1PROSITE-ProRule annotationAdd BLAST65
Domaini678 – 741SAM 2PROSITE-ProRule annotationAdd BLAST64
Domaini763 – 835SAM 3PROSITE-ProRule annotationAdd BLAST73

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili99 – 310Sequence analysisAdd BLAST212

Domaini

The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type beta/beta. The C-terminal, non-coiled coil regions mediate heterodimerization type beta/alpha and interaction with S100A4 (By similarity).By similarity

Sequence similaritiesi

Belongs to the liprin family. Liprin-beta subfamily.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1899 Eukaryota
ENOG410XSFF LUCA
GeneTreeiENSGT00760000119138
HOGENOMiHOG000082535
HOVERGENiHBG052331
InParanoidiQ8C8U0
OMAiQVCNWLQ
OrthoDBiEOG091G01OJ
PhylomeDBiQ8C8U0
TreeFamiTF314207

Family and domain databases

CDDicd09563 SAM_liprin-beta1_2_repeat1, 1 hit
cd09566 SAM_liprin-beta1_2_repeat2, 1 hit
cd09569 SAM_liprin-beta1_2_repeat3, 1 hit
InterProiView protein in InterPro
IPR029515 Liprin
IPR037617 Liprin-beta_SAM_rpt_1
IPR037618 Liprin-beta_SAM_rpt_2
IPR037619 Liprin-beta_SAM_rpt_3
IPR030437 PPFIBP1
IPR001660 SAM
IPR013761 SAM/pointed_sf
PANTHERiPTHR12587 PTHR12587, 1 hit
PTHR12587:SF16 PTHR12587:SF16, 1 hit
PfamiView protein in Pfam
PF00536 SAM_1, 2 hits
PF07647 SAM_2, 1 hit
SMARTiView protein in SMART
SM00454 SAM, 3 hits
SUPFAMiSSF47769 SSF47769, 3 hits
PROSITEiView protein in PROSITE
PS50105 SAM_DOMAIN, 2 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8C8U0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMSDASDMLA AALEQMDGII AGSKALEYSN GIFDCQSPTS PFMGSLRALH
60 70 80 90 100
LVEDLRGLLE MMETDEKEGL RCQIPDSTAE VLIEWLQNQM TNGHLPGNGD
110 120 130 140 150
VYQERLARLE NDKESLVLQV SVLTDQVEAQ GEKIRDLEFC LEEHREKLNA
160 170 180 190 200
TEEMLQQELL SRTSLETQKL ELMAEISNLK LKLTAVEKDR LDYEDRFRDT
210 220 230 240 250
EGLIQEINDL RLKVNEMDGE RLQYEKKLKS TKDELASLKE QLEEKECEVK
260 270 280 290 300
RLQERLVCKA KGEGIEVLDR DIEVQKMKKA VESLMAANEE KERKIEDLRQ
310 320 330 340 350
CLSRYRKMQD PAVLAQGQDS ECEGLFHSSS ISTLLDAQGF SDLERSTSST
360 370 380 390 400
PGMGSPSRDL LHTSAPEEFH TSVLQASIPS LLPPSVDVDT CEKPKLPTKP
410 420 430 440 450
ETSFEEGDGR AILGAAAEVS LSDGVSTSSL QKSSSLGNLK KEASDGTDKA
460 470 480 490 500
PTDSRTFGTL PPKVPGHEAS VDDNPFGTRK ARSSFGRGFF KIKSGKRTAS
510 520 530 540 550
APNLAETEKE TAEHLNLAGT SRSKGSQGTS PFPMSPPSPD SRKKSRGIMR
560 570 580 590 600
LFGKLRRSQS TTFNPDDMSE PEFKRGGTRA TAGPRLGWSR DLGQSNSDLD
610 620 630 640 650
MPFAKWTKEQ VCSWLAEQGL GSYLSSGKHW IISGQTLLQA SQQDLEKELG
660 670 680 690 700
IKHSLHRKKL QLALQALGSE EETNYGKLDF NWVTRWLDDI GLPQYKTQFD
710 720 730 740 750
EGRVDGRMLH YMTVDDLLSL KVVSVLHHLS IKRAIQVLRI NNFEPNCLRR
760 770 780 790 800
RPSDENSITP SEVQQWTNHR VMEWLRSVDL AEYAPNLRGS GVHGGLMVLE
810 820 830 840 850
PRFNVETMAQ LLNIPPNKTL LRRHLATHFN LLIGAEAQHQ KRDAMELPDY
860 870 880 890 900
VLLTATAKVK PKKLTFSNFG NLRKKKHEDG EEYVCPMELG QASGSSQKGF
910 920 930 940 950
RPGLDMRLYE EDDLDRLEQM EDSEGTVRQI GAFSEGINNL THMLKEDDMF
960
KDFAARSPSA SITDEDSNV
Note: No experimental confirmation available.
Length:969
Mass (Da):108,540
Last modified:December 7, 2004 - v3
Checksum:i7322E25285DDF499
GO
Isoform 2 (identifier: Q8C8U0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-276: Missing.

Note: No experimental confirmation available.
Show »
Length:693
Mass (Da):76,921
Checksum:iDA531714968AEC25
GO
Isoform 3 (identifier: Q8C8U0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     271-271: D → DENIKKKLKEKN

Note: No experimental confirmation available.
Show »
Length:980
Mass (Da):109,894
Checksum:i867A8633F7167EAA
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7CUU8F7CUU8_MOUSE
Liprin-beta-1
Ppfibp1
242Annotation score:
A0A0N4SUZ5A0A0N4SUZ5_MOUSE
Liprin-beta-1
Ppfibp1
130Annotation score:
F6S1C4F6S1C4_MOUSE
Liprin-beta-1
Ppfibp1
254Annotation score:
F6YZ95F6YZ95_MOUSE
Liprin-beta-1
Ppfibp1
193Annotation score:
A0A0N4SVG3A0A0N4SVG3_MOUSE
Liprin-beta-1
Ppfibp1
25Annotation score:

Sequence cautioni

The sequence BAD32411 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti360L → P in BAD32411 (PubMed:15489334).Curated1
Sequence conflicti389D → E (PubMed:16141072).Curated1
Sequence conflicti389D → E (PubMed:15489334).Curated1
Sequence conflicti817 – 874NKTLL…GNLRK → CQQHLHLPLTVLFLYIFLNT CIYTVYRKQNLYFVTQGSKD HIKMKKPQYFNDHIPADS in BAC31950 (PubMed:16141072).CuratedAdd BLAST58
Sequence conflicti875 – 969Missing (PubMed:16141072).CuratedAdd BLAST95

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0120951 – 276Missing in isoform 2. 1 PublicationAdd BLAST276
Alternative sequenceiVSP_012096271D → DENIKKKLKEKN in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044496 mRNA Translation: BAC31950.1
AK014559 mRNA Translation: BAB29428.1
AK173133 mRNA Translation: BAD32411.1 Different initiation.
BC049862 mRNA Translation: AAH49862.1
BC058176 mRNA Translation: AAH58176.1
BC072603 mRNA Translation: AAH72603.1
CCDSiCCDS39715.1 [Q8C8U0-1]
CCDS51958.1 [Q8C8U0-3]
RefSeqiNP_001163904.1, NM_001170433.1 [Q8C8U0-3]
NP_080497.1, NM_026221.2 [Q8C8U0-1]
XP_017177208.1, XM_017321719.1
UniGeneiMm.103382

Genome annotation databases

EnsembliENSMUST00000016631; ENSMUSP00000016631; ENSMUSG00000016487 [Q8C8U0-1]
ENSMUST00000111623; ENSMUSP00000107250; ENSMUSG00000016487 [Q8C8U0-3]
GeneIDi67533
KEGGimmu:67533
UCSCiuc009esm.2 mouse [Q8C8U0-1]
uc009esn.2 mouse [Q8C8U0-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044496 mRNA Translation: BAC31950.1
AK014559 mRNA Translation: BAB29428.1
AK173133 mRNA Translation: BAD32411.1 Different initiation.
BC049862 mRNA Translation: AAH49862.1
BC058176 mRNA Translation: AAH58176.1
BC072603 mRNA Translation: AAH72603.1
CCDSiCCDS39715.1 [Q8C8U0-1]
CCDS51958.1 [Q8C8U0-3]
RefSeqiNP_001163904.1, NM_001170433.1 [Q8C8U0-3]
NP_080497.1, NM_026221.2 [Q8C8U0-1]
XP_017177208.1, XM_017321719.1
UniGeneiMm.103382

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TADX-ray2.90C/D593-853[»]
ProteinModelPortaliQ8C8U0
SMRiQ8C8U0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212256, 1 interactor
IntActiQ8C8U0, 2 interactors
MINTiQ8C8U0
STRINGi10090.ENSMUSP00000107250

PTM databases

iPTMnetiQ8C8U0
PhosphoSitePlusiQ8C8U0

Proteomic databases

EPDiQ8C8U0
PaxDbiQ8C8U0
PeptideAtlasiQ8C8U0
PRIDEiQ8C8U0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000016631; ENSMUSP00000016631; ENSMUSG00000016487 [Q8C8U0-1]
ENSMUST00000111623; ENSMUSP00000107250; ENSMUSG00000016487 [Q8C8U0-3]
GeneIDi67533
KEGGimmu:67533
UCSCiuc009esm.2 mouse [Q8C8U0-1]
uc009esn.2 mouse [Q8C8U0-3]

Organism-specific databases

CTDi8496
MGIiMGI:1914783 Ppfibp1
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1899 Eukaryota
ENOG410XSFF LUCA
GeneTreeiENSGT00760000119138
HOGENOMiHOG000082535
HOVERGENiHBG052331
InParanoidiQ8C8U0
OMAiQVCNWLQ
OrthoDBiEOG091G01OJ
PhylomeDBiQ8C8U0
TreeFamiTF314207

Enzyme and pathway databases

ReactomeiR-MMU-388844 Receptor-type tyrosine-protein phosphatases

Miscellaneous databases

ChiTaRSiPpfibp1 mouse
PROiPR:Q8C8U0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000016487 Expressed in 249 organ(s), highest expression level in cumulus cell
ExpressionAtlasiQ8C8U0 baseline and differential
GenevisibleiQ8C8U0 MM

Family and domain databases

CDDicd09563 SAM_liprin-beta1_2_repeat1, 1 hit
cd09566 SAM_liprin-beta1_2_repeat2, 1 hit
cd09569 SAM_liprin-beta1_2_repeat3, 1 hit
InterProiView protein in InterPro
IPR029515 Liprin
IPR037617 Liprin-beta_SAM_rpt_1
IPR037618 Liprin-beta_SAM_rpt_2
IPR037619 Liprin-beta_SAM_rpt_3
IPR030437 PPFIBP1
IPR001660 SAM
IPR013761 SAM/pointed_sf
PANTHERiPTHR12587 PTHR12587, 1 hit
PTHR12587:SF16 PTHR12587:SF16, 1 hit
PfamiView protein in Pfam
PF00536 SAM_1, 2 hits
PF07647 SAM_2, 1 hit
SMARTiView protein in SMART
SM00454 SAM, 3 hits
SUPFAMiSSF47769 SSF47769, 3 hits
PROSITEiView protein in PROSITE
PS50105 SAM_DOMAIN, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLIPB1_MOUSE
AccessioniPrimary (citable) accession number: Q8C8U0
Secondary accession number(s): Q69ZN5
, Q6GQV3, Q80VB4, Q9CUT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: December 7, 2004
Last modified: November 7, 2018
This is version 126 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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