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Protein

SIN3-HDAC complex-associated factor

Gene

Sinhcaf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway (By similarity). Core component of a SIN3A complex (composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1) present in embryonic stem (ES) cells. Promotes the stability of SIN3A and its presence on chromatin and is essential for maintaining the potential of ES cells to proliferate rapidly, while ensuring a short G1-phase of the cell cycle, thereby preventing premature lineage priming (PubMed:28554894).By similarity1 Publication

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
SIN3-HDAC complex-associated factor
Alternative name(s):
Protein FAM60A
Tera protein1 Publication
Gene namesi
Name:Sinhcaf
Synonyms:Fam60a, Tera1 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1929091 Sinhcaf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001870871 – 221SIN3-HDAC complex-associated factorAdd BLAST221

Proteomic databases

EPDiQ8C8M1
MaxQBiQ8C8M1
PaxDbiQ8C8M1
PeptideAtlasiQ8C8M1
PRIDEiQ8C8M1

PTM databases

iPTMnetiQ8C8M1
PhosphoSitePlusiQ8C8M1

Expressioni

Tissue specificityi

Embryonic stem cells (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000039985 Expressed in 240 organ(s), highest expression level in embryonic stem cell
ExpressionAtlasiQ8C8M1 baseline and differential
GenevisibleiQ8C8M1 MM

Interactioni

Subunit structurei

Component of the Sin3/HDAC corepressor complex at least composed of BRMS1, BRMS1L, ING2, SAP30, SAP30L, HDAC1 (By similarity). Found in a complex composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1. Interacts with SIN3A and OGT (PubMed:28554894).By similarity1 Publication

Protein-protein interaction databases

BioGridi207890, 15 interactors
ComplexPortaliCPX-3441 SIN3A histone deacetylase complex, ES cell-specific variant
IntActiQ8C8M1, 15 interactors
STRINGi10090.ENSMUSP00000050952

Structurei

3D structure databases

ProteinModelPortaliQ8C8M1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SINHCAF family.Curated

Phylogenomic databases

eggNOGiENOG410IKPK Eukaryota
ENOG4111PRH LUCA
GeneTreeiENSGT00390000006485
HOGENOMiHOG000007347
HOVERGENiHBG053413
InParanoidiQ8C8M1
OMAiDFQNCFG
OrthoDBiEOG091G0YQC
PhylomeDBiQ8C8M1
TreeFamiTF323911

Family and domain databases

InterProiView protein in InterPro
IPR026065 FAM60A
PANTHERiPTHR13422 PTHR13422, 1 hit
PfamiView protein in Pfam
PF15396 FAM60A, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q8C8M1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFGFHKPKMY RSIEGCCICR AKSSSSRFTD SKRYEKDFQS CFGLHETRSG
60 70 80 90 100
DICNACVLLV KRWKKLPAGS KKNWNHVVDA RAGPSLKTTL KPKKVKTLSG
110 120 130 140 150
NRMKSNQISK LQKEFKRHNS DAHSTTSSAS PAQSPCYSNQ SDEGSDTEMA
160 170 180 190 200
SSSNRTPVFS FLDLTYWKRQ KICCGIIYKG RFGEVLIDTH LFKPCCSSKK
210 220
AAAEKPEEQG PAPLPISTQE W
Length:221
Mass (Da):24,829
Last modified:March 1, 2003 - v1
Checksum:i6A7CD621D86B72C8
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z0C1D3Z0C1_MOUSE
SIN3-HDAC complex-associated factor
Sinhcaf
156Annotation score:
D3YVY1D3YVY1_MOUSE
SIN3-HDAC complex-associated factor
Sinhcaf
53Annotation score:
D3Z1Z9D3Z1Z9_MOUSE
SIN3-HDAC complex-associated factor
Sinhcaf
94Annotation score:
A0A0N4SW48A0A0N4SW48_MOUSE
SIN3-HDAC complex-associated factor
Sinhcaf
142Annotation score:
A0A0N4SW91A0A0N4SW91_MOUSE
SIN3-HDAC complex-associated factor
Sinhcaf
44Annotation score:

Sequence cautioni

The sequence AAB09547 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29T → Q in AAB09547 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64033 mRNA Translation: AAB09547.1 Different initiation.
AK046519 mRNA Translation: BAC32768.1
AK145384 mRNA Translation: BAE26402.1
AK166569 mRNA Translation: BAE38860.1
BC076599 mRNA Translation: AAH76599.1
CCDSiCCDS20713.1
RefSeqiNP_062617.2, NM_019643.3
XP_006507137.1, XM_006507074.3
XP_006507138.1, XM_006507075.2
UniGeneiMm.18637

Genome annotation databases

EnsembliENSMUST00000054080; ENSMUSP00000050952; ENSMUSG00000039985
ENSMUST00000081956; ENSMUSP00000107188; ENSMUSG00000039985
ENSMUST00000111562; ENSMUSP00000107187; ENSMUSG00000039985
ENSMUST00000204435; ENSMUSP00000145487; ENSMUSG00000039985
GeneIDi56306
KEGGimmu:56306
UCSCiuc009etq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64033 mRNA Translation: AAB09547.1 Different initiation.
AK046519 mRNA Translation: BAC32768.1
AK145384 mRNA Translation: BAE26402.1
AK166569 mRNA Translation: BAE38860.1
BC076599 mRNA Translation: AAH76599.1
CCDSiCCDS20713.1
RefSeqiNP_062617.2, NM_019643.3
XP_006507137.1, XM_006507074.3
XP_006507138.1, XM_006507075.2
UniGeneiMm.18637

3D structure databases

ProteinModelPortaliQ8C8M1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207890, 15 interactors
ComplexPortaliCPX-3441 SIN3A histone deacetylase complex, ES cell-specific variant
IntActiQ8C8M1, 15 interactors
STRINGi10090.ENSMUSP00000050952

PTM databases

iPTMnetiQ8C8M1
PhosphoSitePlusiQ8C8M1

Proteomic databases

EPDiQ8C8M1
MaxQBiQ8C8M1
PaxDbiQ8C8M1
PeptideAtlasiQ8C8M1
PRIDEiQ8C8M1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054080; ENSMUSP00000050952; ENSMUSG00000039985
ENSMUST00000081956; ENSMUSP00000107188; ENSMUSG00000039985
ENSMUST00000111562; ENSMUSP00000107187; ENSMUSG00000039985
ENSMUST00000204435; ENSMUSP00000145487; ENSMUSG00000039985
GeneIDi56306
KEGGimmu:56306
UCSCiuc009etq.1 mouse

Organism-specific databases

CTDi58516
MGIiMGI:1929091 Sinhcaf

Phylogenomic databases

eggNOGiENOG410IKPK Eukaryota
ENOG4111PRH LUCA
GeneTreeiENSGT00390000006485
HOGENOMiHOG000007347
HOVERGENiHBG053413
InParanoidiQ8C8M1
OMAiDFQNCFG
OrthoDBiEOG091G0YQC
PhylomeDBiQ8C8M1
TreeFamiTF323911

Miscellaneous databases

PROiPR:Q8C8M1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039985 Expressed in 240 organ(s), highest expression level in embryonic stem cell
ExpressionAtlasiQ8C8M1 baseline and differential
GenevisibleiQ8C8M1 MM

Family and domain databases

InterProiView protein in InterPro
IPR026065 FAM60A
PANTHERiPTHR13422 PTHR13422, 1 hit
PfamiView protein in Pfam
PF15396 FAM60A, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSHCAF_MOUSE
AccessioniPrimary (citable) accession number: Q8C8M1
Secondary accession number(s): P70361, Q3TLD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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