UniProtKB - Q8C8H8 (KY_MOUSE)
Protein
Kyphoscoliosis peptidase
Gene
Ky
Organism
Mus musculus (Mouse)
Status
Functioni
Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function, maturation and stabilization of the neuromuscular junction. May act by cleaving muscle-specific proteins such as FLNC.2 Publications
Miscellaneous
Used as a marker for 'occult' heart disease, as its absence does not cause heart pathology in heart.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 225 | By similarity | 1 | |
Active sitei | 267 | By similarity | 1 | |
Active sitei | 282 | By similarity | 1 |
GO - Molecular functioni
- peptidase activity Source: UniProtKB-KW
GO - Biological processi
- muscle organ development Source: MGI
- neuromuscular junction development Source: MGI
Keywordsi
Molecular function | Hydrolase, Protease |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:KyImported |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96709, Ky |
Subcellular locationi
Cytoskeleton
Other locations
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Other locations
- Z disc Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Disruption phenotypei
Mice exhibit a primary degenerative myopathy preceding chronic thoraco-lumbar kyphoscoliosis.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000288605 | 1 – 661 | Kyphoscoliosis peptidaseAdd BLAST | 661 |
Proteomic databases
PaxDbi | Q8C8H8 |
PRIDEi | Q8C8H8 |
PTM databases
iPTMneti | Q8C8H8 |
PhosphoSitePlusi | Q8C8H8 |
Expressioni
Tissue specificityi
Specifically expressed in skeletal and cardiac muscle.1 Publication
Interactioni
Subunit structurei
Interacts with IGFN1 and FLNC.
2 PublicationsProtein-protein interaction databases
CORUMi | Q8C8H8 |
STRINGi | 10090.ENSMUSP00000036032 |
Miscellaneous databases
RNActi | Q8C8H8, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the transglutaminase-like superfamily.Curated
Phylogenomic databases
eggNOGi | KOG4575, Eukaryota |
InParanoidi | Q8C8H8 |
PhylomeDBi | Q8C8H8 |
Family and domain databases
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR002931, Transglutaminase-like |
Pfami | View protein in Pfam PF01841, Transglut_core, 1 hit |
SMARTi | View protein in SMART SM00460, TGc, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8C8H8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MELKKDSNAV AIDMLLIVHS EKRRAAQATH LDPQANPGAL LQNRGGFQGV
60 70 80 90 100
RNGIRKWQEL EENSFQGNLP EKQCLQQPQV ITSYDNQGTQ LTVEIHPQDA
110 120 130 140 150
MPQLLKKFSL AKRLQGDKNG NMRPRQPGGK DAHAYPWDRS SLKSMPLDLR
160 170 180 190 200
LFEKLDASAS QVTVKSGLNE LVSDLLQEAH SDLERVRAIW IWICHHIEYD
210 220 230 240 250
VEAAQEKDRQ AFKPTDILRT QKTNCDGYAG LFERMCRVAG VQCVTVPGYS
260 270 280 290 300
KGFGYQTGQS FSGEFDHAWN AVYLEGRWHL VDSTWGSGLV DTTTSKFTFL
310 320 330 340 350
YNEFYFLTHP ALFIEDHFPD NKNWQLLKPP QSLRQFENSM YHKSEFYNKG
360 370 380 390 400
MLSAHPETSM IRTVNGKATI TIESRAPTLF MFMLNGKQEH GLLSLRKNGM
410 420 430 440 450
KLEVYPPTMG THKLQIFAKG NSEIYSSVLE YTLKCNYVDF SVQLPSELHQ
460 470 480 490 500
PVGPSWFSEQ MGITKPSHSD PIIHTSDGRC AISFSVEEGV SVLASLHGDD
510 520 530 540 550
GPITEETQRR YIFQLNRGKR TELKVQLPHA GKFALKIFVK KRQEQGNFIF
560 570 580 590 600
VFNYLLCCAN TKVNWPMFPE SFGNWGQDNE LLEPLSGVLP ANRNVAFKLK
610 620 630 640 650
LHGIAKALVK GQDTWPLTLN PEGYWEGSCN TAGCQEVYVM VLENANHNFY
660
SYILKYKVND Q
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF8VQF8 | F8VQF8_MOUSE | Kyphoscoliosis peptidase | Ky | 661 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 217 | I → V in CAC12744 (PubMed:11136708).Curated | 1 | |
Sequence conflicti | 440 | F → I in CAC12744 (PubMed:11136708).Curated | 1 | |
Sequence conflicti | 595 | V → I in CAC12744 (PubMed:11136708).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_025723 | 299 | F → LDL in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ293727 mRNA Translation: CAC12744.2 AK047076 mRNA Translation: BAC32951.1 |
CCDSi | CCDS23445.1 [Q8C8H8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ293727 mRNA Translation: CAC12744.2 AK047076 mRNA Translation: BAC32951.1 |
CCDSi | CCDS23445.1 [Q8C8H8-1] |
3D structure databases
SMRi | Q8C8H8 |
ModBasei | Search... |
Protein-protein interaction databases
CORUMi | Q8C8H8 |
STRINGi | 10090.ENSMUSP00000036032 |
PTM databases
iPTMneti | Q8C8H8 |
PhosphoSitePlusi | Q8C8H8 |
Proteomic databases
PaxDbi | Q8C8H8 |
PRIDEi | Q8C8H8 |
Organism-specific databases
MGIi | MGI:96709, Ky |
Phylogenomic databases
eggNOGi | KOG4575, Eukaryota |
InParanoidi | Q8C8H8 |
PhylomeDBi | Q8C8H8 |
Miscellaneous databases
PROi | PR:Q8C8H8 |
RNActi | Q8C8H8, protein |
SOURCEi | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR002931, Transglutaminase-like |
Pfami | View protein in Pfam PF01841, Transglut_core, 1 hit |
SMARTi | View protein in SMART SM00460, TGc, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KY_MOUSE | |
Accessioni | Q8C8H8Primary (citable) accession number: Q8C8H8 Secondary accession number(s): Q9EPK9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 24, 2007 |
Last sequence update: | March 1, 2003 | |
Last modified: | October 7, 2020 | |
This is version 85 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families