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Protein

Receptor-transporting protein 1

Gene

Rtp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs.1 Publication

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-transporting protein 1
Gene namesi
Name:Rtp1
Synonyms:Gm604
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2685450 Rtp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 238CytoplasmicSequence analysisAdd BLAST238
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Topological domaini260 – 263ExtracellularSequence analysis4

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001819901 – 263Receptor-transporting protein 1Add BLAST263

Proteomic databases

PaxDbiQ8C8C1
PRIDEiQ8C8C1

PTM databases

PhosphoSitePlusiQ8C8C1

Expressioni

Tissue specificityi

Predominantly expressed in olfactory and vomeronasal organs, in mature olfactory sensory neurons.1 Publication

Gene expression databases

BgeeiENSMUSG00000033383 Expressed in 7 organ(s), highest expression level in cerebellum
CleanExiMM_RTP1
ExpressionAtlasiQ8C8C1 baseline and differential

Interactioni

Subunit structurei

Interacts with olfactory receptors.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

CORUMiQ8C8C1
STRINGi10090.ENSMUSP00000043416

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM7 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE69 Eukaryota
ENOG41119VJ LUCA
GeneTreeiENSGT00530000063222
HOGENOMiHOG000060180
HOVERGENiHBG079158
InParanoidiQ8C8C1
OMAiQDTRRHR
OrthoDBiEOG091G0DS4
PhylomeDBiQ8C8C1
TreeFamiTF333246

Family and domain databases

InterProiView protein in InterPro
IPR026096 R-trans_p
IPR026692 RTP1
IPR027377 Znf-3CxxC
PANTHERiPTHR14402 PTHR14402, 1 hit
PTHR14402:SF19 PTHR14402:SF19, 1 hit
PfamiView protein in Pfam
PF13695 zf-3CxxC, 1 hit
SMARTiView protein in SMART
SM01328 zf-3CxxC, 1 hit

Sequencei

Sequence statusi: Complete.

Q8C8C1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRIFRPWRLR CPALHLPSFP TFSIKCSLPP LPTDEDMCKS VTTGEWKKVF
60 70 80 90 100
YEKMEEVKPA DSWDFIIDPN LKHNVLAPGW KQYLELHASG RFHCSWCWHT
110 120 130 140 150
WQSPHVVILF HMYLDKAQRA GSVRMRVFKQ LCYECGTARL DESSMLEENI
160 170 180 190 200
ESLVDNLITS LREQCYGERG GHYRIHVASR QDNRRHRGEF CEACQEGIVH
210 220 230 240 250
WKPSEKLLEE EATTYTFSRA PSPTKPQAET GSGCNFCSIP WCLFWATVLM
260
LIIYLQFSFR TSV
Length:263
Mass (Da):30,732
Last modified:March 1, 2003 - v1
Checksum:iBA12E392354F33D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY562225 mRNA Translation: AAT70670.1
AK047543 mRNA Translation: BAC33083.1
CCDSiCCDS28078.1
RefSeqiNP_001004151.1, NM_001004151.2
UniGeneiMm.208751

Genome annotation databases

EnsembliENSMUST00000038730; ENSMUSP00000043416; ENSMUSG00000033383
GeneIDi239766
KEGGimmu:239766
UCSCiuc007ytq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY562225 mRNA Translation: AAT70670.1
AK047543 mRNA Translation: BAC33083.1
CCDSiCCDS28078.1
RefSeqiNP_001004151.1, NM_001004151.2
UniGeneiMm.208751

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiQ8C8C1
STRINGi10090.ENSMUSP00000043416

PTM databases

PhosphoSitePlusiQ8C8C1

Proteomic databases

PaxDbiQ8C8C1
PRIDEiQ8C8C1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038730; ENSMUSP00000043416; ENSMUSG00000033383
GeneIDi239766
KEGGimmu:239766
UCSCiuc007ytq.1 mouse

Organism-specific databases

CTDi132112
MGIiMGI:2685450 Rtp1

Phylogenomic databases

eggNOGiENOG410IE69 Eukaryota
ENOG41119VJ LUCA
GeneTreeiENSGT00530000063222
HOGENOMiHOG000060180
HOVERGENiHBG079158
InParanoidiQ8C8C1
OMAiQDTRRHR
OrthoDBiEOG091G0DS4
PhylomeDBiQ8C8C1
TreeFamiTF333246

Enzyme and pathway databases

ReactomeiR-MMU-381753 Olfactory Signaling Pathway

Miscellaneous databases

PROiPR:Q8C8C1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033383 Expressed in 7 organ(s), highest expression level in cerebellum
CleanExiMM_RTP1
ExpressionAtlasiQ8C8C1 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR026096 R-trans_p
IPR026692 RTP1
IPR027377 Znf-3CxxC
PANTHERiPTHR14402 PTHR14402, 1 hit
PTHR14402:SF19 PTHR14402:SF19, 1 hit
PfamiView protein in Pfam
PF13695 zf-3CxxC, 1 hit
SMARTiView protein in SMART
SM01328 zf-3CxxC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRTP1_MOUSE
AccessioniPrimary (citable) accession number: Q8C8C1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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