UniProtKB - Q8C827 (ZFP62_MOUSE)
Protein
Zinc finger protein 62
Gene
Zfp62
Organism
Mus musculus (Mouse)
Status
Functioni
May play a role in differentiating skeletal muscle.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 131 – 153 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 159 – 181 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 187 – 209 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 215 – 237 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 243 – 265 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 271 – 293 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 299 – 321 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 327 – 349 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 355 – 377 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 383 – 405 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 411 – 433 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 439 – 461 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 467 – 489 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 495 – 517 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 523 – 545 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 551 – 573 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 579 – 601 | C2H2-type 17PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 607 – 629 | C2H2-type 18PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 635 – 657 | C2H2-type 19PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 663 – 685 | C2H2-type 20PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 691 – 713 | C2H2-type 21PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 719 – 741 | C2H2-type 22PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 747 – 769 | C2H2-type 23PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 775 – 797 | C2H2-type 24PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 803 – 824 | C2H2-type 25PROSITE-ProRule annotationAdd BLAST | 22 | |
Zinc fingeri | 830 – 852 | C2H2-type 26PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 62Short name: Zfp-62 Alternative name(s): ZT3 |
Gene namesi | Name:Zfp62 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:99662, Zfp62 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047306 | 1 – 914 | Zinc finger protein 62Add BLAST | 914 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 5 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 57 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 60 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 77 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 87 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 577 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 738 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 872 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 881 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | Q8C827 |
PRIDEi | Q8C827 |
PTM databases
iPTMneti | Q8C827 |
PhosphoSitePlusi | Q8C827 |
SwissPalmi | Q8C827 |
Expressioni
Tissue specificityi
Expressed in skeletal and cardiac muscle.1 Publication
Developmental stagei
At 8.5 dpc, expressed predominantly in neural tube and somites. At 9.5 dpc, expression is higher in the peripheral region of the brain, in the dorsal region of the neural tube, in the segmental plate and in the somites. In developing brain, expression is restricted to regions with actively proliferating cells. At later stages, expressed in many tissues of neuroectodermal and mesodermal origin. At 17 dpc, expression is high in the skeletal muscle fibers, which are mitotically arrested and terminally differentiated.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000046311, Expressed in head and 316 other tissues |
ExpressionAtlasi | Q8C827, baseline and differential |
Genevisiblei | Q8C827, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 204675, 39 interactors |
IntActi | Q8C827, 1 interactor |
STRINGi | 10090.ENSMUSP00000104820 |
Miscellaneous databases
RNActi | Q8C827, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 131 – 153 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 159 – 181 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 187 – 209 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 215 – 237 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 243 – 265 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 271 – 293 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 299 – 321 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 327 – 349 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 355 – 377 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 383 – 405 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 411 – 433 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 439 – 461 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 467 – 489 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 495 – 517 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 523 – 545 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 551 – 573 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 579 – 601 | C2H2-type 17PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 607 – 629 | C2H2-type 18PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 635 – 657 | C2H2-type 19PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 663 – 685 | C2H2-type 20PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 691 – 713 | C2H2-type 21PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 719 – 741 | C2H2-type 22PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 747 – 769 | C2H2-type 23PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 775 – 797 | C2H2-type 24PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 803 – 824 | C2H2-type 25PROSITE-ProRule annotationAdd BLAST | 22 | |
Zinc fingeri | 830 – 852 | C2H2-type 26PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162750 |
InParanoidi | Q8C827 |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8C827 |
TreeFami | TF343410 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 22 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 26 hits |
SUPFAMi | SSF57667, SSF57667, 16 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 25 hits PS50157, ZINC_FINGER_C2H2_2, 26 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8C827-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSYLKTTMED EESSKKNEND SNADSQCPSV GFFHKDHMQK SKTGDTCDLF
60 70 80 90 100
PKWKILKEGK SSIREMIDTH TNAANIKLEQ DDETSEKSFY PSTNTMHQTI
110 120 130 140 150
PTEPNCTKQG EHTENINGNV HPAHIADKKL HKCDECGKSF KYNSRLVQHK
160 170 180 190 200
IMHTGEKRYE CDDCRGTFRS SSSLRVHKRI HTGEKPYKCD ECGKAYMSYS
210 220 230 240 250
SLINHKSTHS GEKNCKCDEC GKSFNYSSVL DQHKRIHTGE KPYECGECGK
260 270 280 290 300
AFRNSSGLRV HKRIHTGEKP YECDTCGKTF SNSSGLRVHK RIHTGEKPYE
310 320 330 340 350
CDECGKAFIT CRTLLNHKSI HFGDKPYKCD ECEKSFNYSS LLIQHKVIHT
360 370 380 390 400
GEKPYECDEC GKAFRNSSGL IVHKRIHTGE KPYKCDICGK AFSYSSGLAV
410 420 430 440 450
HKSIHPGKKA HECKDCGKSF SYNSLLLQHK TIHTGERPYV CDVCGKTFRN
460 470 480 490 500
NSGLKVHRRL HTGEKPYKCD VCGKAYISRS SLKNHKGIHM GEKPYKCSYC
510 520 530 540 550
EKSFNYSSAL EQHKRIHTRE KPFGCDECGK AFRNNSGLKV HKRIHTGERP
560 570 580 590 600
YKCEECGKAY ISLSSLINHK SVHPGEKPFK CDECEKAFIT YRTLLNHKKI
610 620 630 640 650
HLGEKPYKCD VCEKSFNYTS LLSQHKRVHT REKPFECDRC EKVFRNNSSL
660 670 680 690 700
KVHKRIHTGE KPYECDICGK AYISHSSLIN HKSTHPGKTS YTCDECGKAF
710 720 730 740 750
FSSRTLISHK RVHLGEKPFK CVECGKSFSY SSLLSQHKRI HTGEKPYVCD
760 770 780 790 800
WCGKAFRNSS GLTVHKRIHT GEKPYGCDEC EKAYISHSSL INHKSVHRGK
810 820 830 840 850
QPYNCECGKS FNYRSVLDQH KRIHTGKKPY RCNDCGKAFN IRSNLTKHKR
860 870 880 890 900
IHTGEESLNM ANMESHSGTF QKMIYYEGGN SLDGTRMQMP VWEAEHAKSQ
910
RNQIEEKLYE YNNF
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3JS23 | J3JS23_MOUSE | Zinc finger protein 62 | Zfp62 | 893 | Annotation score: | ||
J3JS22 | J3JS22_MOUSE | Zinc finger protein 62 | Zfp62 | 195 | Annotation score: | ||
I7HPA9 | I7HPA9_MOUSE | Zinc finger protein 62 | Zfp62 | 80 | Annotation score: | ||
Q3UGK1 | Q3UGK1_MOUSE | Zinc finger protein 62 | Zfp62 | 31 | Annotation score: | ||
J3JS21 | J3JS21_MOUSE | Zinc finger protein 62 | Zfp62 | 65 | Annotation score: | ||
A0A0G2JDA7 | A0A0G2JDA7_MOUSE | Zinc finger protein 62 | Zfp62 | 9 | Annotation score: |
Sequence cautioni
The sequence AAH22935 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
The sequence BAC25897 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 540 – 541 | VH → EN in BAC40122 (PubMed:16141072).Curated | 2 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010137 | 1 – 7 | Missing in isoform 2. 2 Publications | 7 | |
Alternative sequenceiVSP_010138 | 292 – 304 | IHTGE…ECDEC → LSLSLSLSLSLSL in isoform 3. 1 PublicationAdd BLAST | 13 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK028351 mRNA Translation: BAC25897.1 Sequence problems. AK048619 mRNA Translation: BAC33395.1 AK088060 mRNA Translation: BAC40122.1 AK154767 mRNA Translation: BAE32816.1 BC022935 mRNA Translation: AAH22935.1 Sequence problems. BC065692 mRNA Translation: AAH65692.1 L36315 mRNA Translation: AAA40580.1 Z67747 mRNA Translation: CAA91560.1 |
CCDSi | CCDS24601.1 [Q8C827-2] |
RefSeqi | NP_001020017.1, NM_001024846.1 [Q8C827-2] NP_033588.2, NM_009562.2 [Q8C827-1] XP_006533258.1, XM_006533195.2 XP_006533261.1, XM_006533198.2 XP_006533262.1, XM_006533199.2 [Q8C827-2] XP_006533263.1, XM_006533200.2 XP_006533265.1, XM_006533202.3 XP_006533266.1, XM_006533203.2 XP_011247278.1, XM_011248976.2 XP_017169999.1, XM_017314510.1 [Q8C827-2] |
Genome annotation databases
Ensembli | ENSMUST00000061757; ENSMUSP00000056226; ENSMUSG00000046311 [Q8C827-2] ENSMUST00000109197; ENSMUSP00000104820; ENSMUSG00000046311 [Q8C827-2] ENSMUST00000109198; ENSMUSP00000104821; ENSMUSG00000046311 [Q8C827-2] ENSMUST00000180016; ENSMUSP00000137583; ENSMUSG00000046311 [Q8C827-2] |
GeneIDi | 22720 |
KEGGi | mmu:22720 |
UCSCi | uc007ipv.1, mouse [Q8C827-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK028351 mRNA Translation: BAC25897.1 Sequence problems. AK048619 mRNA Translation: BAC33395.1 AK088060 mRNA Translation: BAC40122.1 AK154767 mRNA Translation: BAE32816.1 BC022935 mRNA Translation: AAH22935.1 Sequence problems. BC065692 mRNA Translation: AAH65692.1 L36315 mRNA Translation: AAA40580.1 Z67747 mRNA Translation: CAA91560.1 |
CCDSi | CCDS24601.1 [Q8C827-2] |
RefSeqi | NP_001020017.1, NM_001024846.1 [Q8C827-2] NP_033588.2, NM_009562.2 [Q8C827-1] XP_006533258.1, XM_006533195.2 XP_006533261.1, XM_006533198.2 XP_006533262.1, XM_006533199.2 [Q8C827-2] XP_006533263.1, XM_006533200.2 XP_006533265.1, XM_006533202.3 XP_006533266.1, XM_006533203.2 XP_011247278.1, XM_011248976.2 XP_017169999.1, XM_017314510.1 [Q8C827-2] |
3D structure databases
SMRi | Q8C827 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 204675, 39 interactors |
IntActi | Q8C827, 1 interactor |
STRINGi | 10090.ENSMUSP00000104820 |
PTM databases
iPTMneti | Q8C827 |
PhosphoSitePlusi | Q8C827 |
SwissPalmi | Q8C827 |
Proteomic databases
PaxDbi | Q8C827 |
PRIDEi | Q8C827 |
Protocols and materials databases
Antibodypediai | 53012, 35 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000061757; ENSMUSP00000056226; ENSMUSG00000046311 [Q8C827-2] ENSMUST00000109197; ENSMUSP00000104820; ENSMUSG00000046311 [Q8C827-2] ENSMUST00000109198; ENSMUSP00000104821; ENSMUSG00000046311 [Q8C827-2] ENSMUST00000180016; ENSMUSP00000137583; ENSMUSG00000046311 [Q8C827-2] |
GeneIDi | 22720 |
KEGGi | mmu:22720 |
UCSCi | uc007ipv.1, mouse [Q8C827-1] |
Organism-specific databases
CTDi | 643836 |
MGIi | MGI:99662, Zfp62 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162750 |
InParanoidi | Q8C827 |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8C827 |
TreeFami | TF343410 |
Miscellaneous databases
BioGRID-ORCSi | 22720, 0 hits in 17 CRISPR screens |
PROi | PR:Q8C827 |
RNActi | Q8C827, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000046311, Expressed in head and 316 other tissues |
ExpressionAtlasi | Q8C827, baseline and differential |
Genevisiblei | Q8C827, MM |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 22 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 26 hits |
SUPFAMi | SSF57667, SSF57667, 16 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 25 hits PS50157, ZINC_FINGER_C2H2_2, 26 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZFP62_MOUSE | |
Accessioni | Q8C827Primary (citable) accession number: Q8C827 Secondary accession number(s): Q3U3H0 Q8R5D1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2004 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 10, 2021 | |
This is version 157 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families