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UniProtKB - Q8C827 (ZFP62_MOUSE)

Entry version 157 (10 Feb 2021)
Sequence version 1 (01 Mar 2003)
Previous versions | rss
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Protein

Zinc finger protein 62

Gene

Zfp62

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in differentiating skeletal muscle.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri131 – 153C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri159 – 181C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri187 – 209C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri215 – 237C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri243 – 265C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri523 – 545C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri551 – 573C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri579 – 601C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri607 – 629C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri635 – 657C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri663 – 685C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri691 – 713C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri719 – 741C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri747 – 769C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri775 – 797C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri803 – 824C2H2-type 25PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri830 – 852C2H2-type 26PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 62
Short name:
Zfp-62
Alternative name(s):
ZT3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Zfp62
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:99662, Zfp62

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000473061 – 914Zinc finger protein 62Add BLAST914

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki5Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki57Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki60Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki77Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki87Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki577Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki738Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki872Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei881PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8C827

PRoteomics IDEntifications database

More...PRIDEi		Q8C827

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8C827

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8C827

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q8C827

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in skeletal and cardiac muscle.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

At 8.5 dpc, expressed predominantly in neural tube and somites. At 9.5 dpc, expression is higher in the peripheral region of the brain, in the dorsal region of the neural tube, in the segmental plate and in the somites. In developing brain, expression is restricted to regions with actively proliferating cells. At later stages, expressed in many tissues of neuroectodermal and mesodermal origin. At 17 dpc, expression is high in the skeletal muscle fibers, which are mitotically arrested and terminally differentiated.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000046311, Expressed in head and 316 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8C827, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8C827, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		204675, 39 interactors

Protein interaction database and analysis system

More...IntActi		Q8C827, 1 interactor

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000104820

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8C827, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8C827

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri131 – 153C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri159 – 181C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri187 – 209C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri215 – 237C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri243 – 265C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri523 – 545C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri551 – 573C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri579 – 601C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri607 – 629C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri635 – 657C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri663 – 685C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri691 – 713C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri719 – 741C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri747 – 769C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri775 – 797C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri803 – 824C2H2-type 25PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri830 – 852C2H2-type 26PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162750

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8C827

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8C827

TreeFam database of animal gene trees

More...TreeFami		TF343410

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00096, zf-C2H2, 22 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355, ZnF_C2H2, 26 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667, SSF57667, 16 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 25 hits
PS50157, ZINC_FINGER_C2H2_2, 26 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8C827-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSYLKTTMED EESSKKNEND SNADSQCPSV GFFHKDHMQK SKTGDTCDLF 
        60         70         80         90        100
PKWKILKEGK SSIREMIDTH TNAANIKLEQ DDETSEKSFY PSTNTMHQTI 
       110        120        130        140        150
PTEPNCTKQG EHTENINGNV HPAHIADKKL HKCDECGKSF KYNSRLVQHK 
       160        170        180        190        200
IMHTGEKRYE CDDCRGTFRS SSSLRVHKRI HTGEKPYKCD ECGKAYMSYS 
       210        220        230        240        250
SLINHKSTHS GEKNCKCDEC GKSFNYSSVL DQHKRIHTGE KPYECGECGK 
       260        270        280        290        300
AFRNSSGLRV HKRIHTGEKP YECDTCGKTF SNSSGLRVHK RIHTGEKPYE 
       310        320        330        340        350
CDECGKAFIT CRTLLNHKSI HFGDKPYKCD ECEKSFNYSS LLIQHKVIHT 
       360        370        380        390        400
GEKPYECDEC GKAFRNSSGL IVHKRIHTGE KPYKCDICGK AFSYSSGLAV 
       410        420        430        440        450
HKSIHPGKKA HECKDCGKSF SYNSLLLQHK TIHTGERPYV CDVCGKTFRN 
       460        470        480        490        500
NSGLKVHRRL HTGEKPYKCD VCGKAYISRS SLKNHKGIHM GEKPYKCSYC 
       510        520        530        540        550
EKSFNYSSAL EQHKRIHTRE KPFGCDECGK AFRNNSGLKV HKRIHTGERP 
       560        570        580        590        600
YKCEECGKAY ISLSSLINHK SVHPGEKPFK CDECEKAFIT YRTLLNHKKI 
       610        620        630        640        650
HLGEKPYKCD VCEKSFNYTS LLSQHKRVHT REKPFECDRC EKVFRNNSSL 
       660        670        680        690        700
KVHKRIHTGE KPYECDICGK AYISHSSLIN HKSTHPGKTS YTCDECGKAF 
       710        720        730        740        750
FSSRTLISHK RVHLGEKPFK CVECGKSFSY SSLLSQHKRI HTGEKPYVCD 
       760        770        780        790        800
WCGKAFRNSS GLTVHKRIHT GEKPYGCDEC EKAYISHSSL INHKSVHRGK 
       810        820        830        840        850
QPYNCECGKS FNYRSVLDQH KRIHTGKKPY RCNDCGKAFN IRSNLTKHKR 
       860        870        880        890        900
IHTGEESLNM ANMESHSGTF QKMIYYEGGN SLDGTRMQMP VWEAEHAKSQ 
       910 
RNQIEEKLYE YNNF
Length:914
Mass (Da):104,812
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i196A50D47205E9B9
GO
Isoform 2 (identifier: Q8C827-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: Missing.

Show »
Length:907
Mass (Da):103,987
Checksum:iC0D98A5D4769FBB3
GO
Isoform 3 (identifier: Q8C827-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     292-304: IHTGEKPYECDEC → LSLSLSLSLSLSL

Show »
Length:914
Mass (Da):104,621
Checksum:i210E509F62DF532B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3JS23J3JS23_MOUSE
Zinc finger protein 62
Zfp62
893Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3JS22J3JS22_MOUSE
Zinc finger protein 62
Zfp62
195Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I7HPA9I7HPA9_MOUSE
Zinc finger protein 62
Zfp62
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q3UGK1Q3UGK1_MOUSE
Zinc finger protein 62
Zfp62
31Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3JS21J3JS21_MOUSE
Zinc finger protein 62
Zfp62
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JDA7A0A0G2JDA7_MOUSE
Zinc finger protein 62
Zfp62
9Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH22935 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
The sequence BAC25897 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti540 – 541VH → EN in BAC40122 (PubMed:16141072).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0101371 – 7Missing in isoform 2. 2 Publications7
Alternative sequenceiVSP_010138292 – 304IHTGE…ECDEC → LSLSLSLSLSLSL in isoform 3. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK028351 mRNA Translation: BAC25897.1 Sequence problems.
AK048619 mRNA Translation: BAC33395.1
AK088060 mRNA Translation: BAC40122.1
AK154767 mRNA Translation: BAE32816.1
BC022935 mRNA Translation: AAH22935.1 Sequence problems.
BC065692 mRNA Translation: AAH65692.1
L36315 mRNA Translation: AAA40580.1
Z67747 mRNA Translation: CAA91560.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS24601.1 [Q8C827-2]

NCBI Reference Sequences

More...RefSeqi		NP_001020017.1, NM_001024846.1 [Q8C827-2]
NP_033588.2, NM_009562.2 [Q8C827-1]
XP_006533258.1, XM_006533195.2
XP_006533261.1, XM_006533198.2
XP_006533262.1, XM_006533199.2 [Q8C827-2]
XP_006533263.1, XM_006533200.2
XP_006533265.1, XM_006533202.3
XP_006533266.1, XM_006533203.2
XP_011247278.1, XM_011248976.2
XP_017169999.1, XM_017314510.1 [Q8C827-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000061757; ENSMUSP00000056226; ENSMUSG00000046311 [Q8C827-2]
ENSMUST00000109197; ENSMUSP00000104820; ENSMUSG00000046311 [Q8C827-2]
ENSMUST00000109198; ENSMUSP00000104821; ENSMUSG00000046311 [Q8C827-2]
ENSMUST00000180016; ENSMUSP00000137583; ENSMUSG00000046311 [Q8C827-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		22720

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:22720

UCSC genome browser

More...UCSCi		uc007ipv.1, mouse [Q8C827-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028351 mRNA Translation: BAC25897.1 Sequence problems.
AK048619 mRNA Translation: BAC33395.1
AK088060 mRNA Translation: BAC40122.1
AK154767 mRNA Translation: BAE32816.1
BC022935 mRNA Translation: AAH22935.1 Sequence problems.
BC065692 mRNA Translation: AAH65692.1
L36315 mRNA Translation: AAA40580.1
Z67747 mRNA Translation: CAA91560.1
CCDSiCCDS24601.1 [Q8C827-2]
RefSeqiNP_001020017.1, NM_001024846.1 [Q8C827-2]
NP_033588.2, NM_009562.2 [Q8C827-1]
XP_006533258.1, XM_006533195.2
XP_006533261.1, XM_006533198.2
XP_006533262.1, XM_006533199.2 [Q8C827-2]
XP_006533263.1, XM_006533200.2
XP_006533265.1, XM_006533202.3
XP_006533266.1, XM_006533203.2
XP_011247278.1, XM_011248976.2
XP_017169999.1, XM_017314510.1 [Q8C827-2]

3D structure databases

SMRiQ8C827
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi204675, 39 interactors
IntActiQ8C827, 1 interactor
STRINGi10090.ENSMUSP00000104820

PTM databases

iPTMnetiQ8C827
PhosphoSitePlusiQ8C827
SwissPalmiQ8C827

Proteomic databases

PaxDbiQ8C827
PRIDEiQ8C827

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		53012, 35 antibodies

Genome annotation databases

EnsembliENSMUST00000061757; ENSMUSP00000056226; ENSMUSG00000046311 [Q8C827-2]
ENSMUST00000109197; ENSMUSP00000104820; ENSMUSG00000046311 [Q8C827-2]
ENSMUST00000109198; ENSMUSP00000104821; ENSMUSG00000046311 [Q8C827-2]
ENSMUST00000180016; ENSMUSP00000137583; ENSMUSG00000046311 [Q8C827-2]
GeneIDi22720
KEGGimmu:22720
UCSCiuc007ipv.1, mouse [Q8C827-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		643836
MGIiMGI:99662, Zfp62

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000162750
InParanoidiQ8C827
OrthoDBi1318335at2759
PhylomeDBiQ8C827
TreeFamiTF343410

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		22720, 0 hits in 17 CRISPR screens

Protein Ontology

More...PROi		PR:Q8C827
RNActiQ8C827, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000046311, Expressed in head and 316 other tissues
ExpressionAtlasiQ8C827, baseline and differential
GenevisibleiQ8C827, MM

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 22 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 26 hits
SUPFAMiSSF57667, SSF57667, 16 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 25 hits
PS50157, ZINC_FINGER_C2H2_2, 26 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZFP62_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8C827
Secondary accession number(s): Q3U3H0
, Q62510, Q8BT00, Q8C2S6, Q8R5D1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: March 1, 2003
Last modified: February 10, 2021
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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