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Protein

Transmembrane protein 200A

Gene

Tmem200a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 200A
Gene namesi
Name:Tmem200a
Synonyms:Kiaa1913
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1924470 Tmem200a

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 61CytoplasmicSequence analysisAdd BLAST61
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 126ExtracellularSequence analysisAdd BLAST44
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Topological domaini148 – 491CytoplasmicSequence analysisAdd BLAST344

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002943411 – 491Transmembrane protein 200AAdd BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei350PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8C817
PRIDEiQ8C817

PTM databases

iPTMnetiQ8C817
PhosphoSitePlusiQ8C817

Expressioni

Gene expression databases

BgeeiENSMUSG00000049420 Expressed in 132 organ(s), highest expression level in dorsal pancreas
ExpressionAtlasiQ8C817 baseline and differential
GenevisibleiQ8C817 MM

Structurei

3D structure databases

ProteinModelPortaliQ8C817
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM200 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4823 Eukaryota
ENOG41106JF LUCA
GeneTreeiENSGT00530000063698
HOGENOMiHOG000013037
HOVERGENiHBG102357
InParanoidiQ8C817
OMAiDSARSQH
OrthoDBiEOG091G05JS
PhylomeDBiQ8C817
TreeFamiTF332635

Family and domain databases

InterProiView protein in InterPro
IPR018787 DUF2371_TMEM200
PANTHERiPTHR31815 PTHR31815, 1 hit
PfamiView protein in Pfam
PF10177 DUF2371, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8C817-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIATGGVITG LAALKRQDSA RSQQHINLSP LPATQDQKPV RRRPRADVVV
60 70 80 90 100
VRGKIRLYSP SGFFLILGVL VSIIGIAMAV LGYWPQKEHF IDAETTLSTN
110 120 130 140 150
ETQVVRNQGG VVVRFFEQHL HSDKMKMLGP FTMGIGIFIF ICANAILHEN
160 170 180 190 200
RDKETKIIHM RDIYSTVIDI HTLRLKEQKQ ANGLYAGLLG DTEVKQNGSP
210 220 230 240 250
CASRLAATTL ASFSGMRNSF RVDSSVEEDE LMLTESKSLG HLMPPLLSDS
260 270 280 290 300
AVSVFGLYPP PAKATDDKAS SSKKCDTKSI VSSSISAFTL PVIKLNNCVI
310 320 330 340 350
DEPSIDSITE VADNLKTRSR NLSMDSLVVP LPSSGESFQP AVTLLPRNNS
360 370 380 390 400
VGESLSSQYK SSVALGPGTG QLLSPGAARR QFGSNTSLHL LSSHSKSLDL
410 420 430 440 450
DRGPSTLTVH AEQRKHPSWP RLDRSNSKGY MRLENKEDPM DRLLVPQTAI
460 470 480 490
KKDFTNKEKL LMISRSHNNL SFEHDEFLSN NLKRGTSETR F
Length:491
Mass (Da):54,008
Last modified:March 1, 2003 - v1
Checksum:iA06DCE2D0CCC9E3B
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P725A0A1W2P725_MOUSE
Transmembrane protein 200A
Tmem200a
180Annotation score:
A0A1W2P803A0A1W2P803_MOUSE
Transmembrane protein 200A
Tmem200a
237Annotation score:
A0A1W2P792A0A1W2P792_MOUSE
Transmembrane protein 200A
Tmem200a
32Annotation score:

Sequence cautioni

The sequence BAD32577 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti194V → E in BAC27929 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173299 mRNA Translation: BAD32577.1 Different initiation.
AK032569 mRNA Translation: BAC27929.1
AK048673 mRNA Translation: BAC33418.1
CCDSiCCDS23755.1
RefSeqiNP_084157.2, NM_029881.3
XP_006512982.1, XM_006512919.3
XP_006512983.1, XM_006512920.2
XP_006512984.1, XM_006512921.3
UniGeneiMm.266260

Genome annotation databases

EnsembliENSMUST00000066049; ENSMUSP00000064080; ENSMUSG00000049420
ENSMUST00000218232; ENSMUSP00000151861; ENSMUSG00000049420
GeneIDi77220
KEGGimmu:77220
UCSCiuc007erw.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173299 mRNA Translation: BAD32577.1 Different initiation.
AK032569 mRNA Translation: BAC27929.1
AK048673 mRNA Translation: BAC33418.1
CCDSiCCDS23755.1
RefSeqiNP_084157.2, NM_029881.3
XP_006512982.1, XM_006512919.3
XP_006512983.1, XM_006512920.2
XP_006512984.1, XM_006512921.3
UniGeneiMm.266260

3D structure databases

ProteinModelPortaliQ8C817
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ8C817
PhosphoSitePlusiQ8C817

Proteomic databases

PaxDbiQ8C817
PRIDEiQ8C817

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066049; ENSMUSP00000064080; ENSMUSG00000049420
ENSMUST00000218232; ENSMUSP00000151861; ENSMUSG00000049420
GeneIDi77220
KEGGimmu:77220
UCSCiuc007erw.2 mouse

Organism-specific databases

CTDi114801
MGIiMGI:1924470 Tmem200a
RougeiSearch...

Phylogenomic databases

eggNOGiKOG4823 Eukaryota
ENOG41106JF LUCA
GeneTreeiENSGT00530000063698
HOGENOMiHOG000013037
HOVERGENiHBG102357
InParanoidiQ8C817
OMAiDSARSQH
OrthoDBiEOG091G05JS
PhylomeDBiQ8C817
TreeFamiTF332635

Miscellaneous databases

PROiPR:Q8C817
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049420 Expressed in 132 organ(s), highest expression level in dorsal pancreas
ExpressionAtlasiQ8C817 baseline and differential
GenevisibleiQ8C817 MM

Family and domain databases

InterProiView protein in InterPro
IPR018787 DUF2371_TMEM200
PANTHERiPTHR31815 PTHR31815, 1 hit
PfamiView protein in Pfam
PF10177 DUF2371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiT200A_MOUSE
AccessioniPrimary (citable) accession number: Q8C817
Secondary accession number(s): Q69Z67, Q8CCL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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