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Protein

U3 small nucleolar RNA-associated protein 15 homolog

Gene

Utp15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I.By similarity

GO - Biological processi

Keywordsi

Biological processRibosome biogenesis, rRNA processing, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar RNA-associated protein 15 homolog
Alternative name(s):
Src-associated protein SAW
Gene namesi
Name:Utp15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2145443 Utp15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000513222 – 528U3 small nucleolar RNA-associated protein 15 homologAdd BLAST527

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Cross-linki249Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ8C7V3
MaxQBiQ8C7V3
PaxDbiQ8C7V3
PeptideAtlasiQ8C7V3
PRIDEiQ8C7V3

PTM databases

iPTMnetiQ8C7V3
PhosphoSitePlusiQ8C7V3

Expressioni

Gene expression databases

BgeeiENSMUSG00000041747 Expressed in 246 organ(s), highest expression level in blastocyst
GenevisibleiQ8C7V3 MM

Interactioni

Subunit structurei

Interacts directly with UTP4 and WDR43 (). May be a component of the proposed t-UTP subcomplex of the ribosomal small subunit (SSU) processome containing at least UTP4, WDR43, HEATR1, UTP15, WDR75.By similarity

Protein-protein interaction databases

BioGridi222829, 1 interactor
IntActiQ8C7V3, 1 interactor
STRINGi10090.ENSMUSP00000048204

Structurei

3D structure databases

ProteinModelPortaliQ8C7V3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati36 – 75WD 1Add BLAST40
Repeati78 – 117WD 2Add BLAST40
Repeati120 – 159WD 3Add BLAST40
Repeati162 – 202WD 4Add BLAST41
Repeati204 – 242WD 5Add BLAST39
Repeati246 – 285WD 6Add BLAST40
Repeati287 – 326WD 7Add BLAST40

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0310 Eukaryota
ENOG410XNZ0 LUCA
GeneTreeiENSGT00390000004228
HOGENOMiHOG000185028
HOVERGENiHBG080690
InParanoidiQ8C7V3
KOiK14549
OMAiEHTDYIR
OrthoDBiEOG091G0524
PhylomeDBiQ8C7V3
TreeFamiTF319494

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR018983 U3_snoRNA-assocProt_15_C
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF09384 UTP15_C, 1 hit
PF00400 WD40, 4 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8C7V3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGYKPVAIQ TYPVLGEKIT QDTLYWNNYK TPVQIKEFGA VSKVDFSPQL
60 70 80 90 100
PYNYAVTASS RIHIYGRYSQ EPVKTFSRFK DTAYCATFRQ DGQLLVAGSE
110 120 130 140 150
DGVVQLFDIN GRAPLRQFEG HTKAVHTVDF TADNYHVVSG ADDYTVKLWD
160 170 180 190 200
IPNSKEILTF KEHSDYVRCG CASKLNPDLF VTGSYDHTVK IFDARTNKNV
210 220 230 240 250
LCVEHGQPVE SVLLFPSGGL LVSAGGRYVK VWDMLKGGQL LVSLKNHHKT
260 270 280 290 300
VTCLCLSSSG QRLLSGSLDR KVKVYSTTSY KVVHSFDYAA SILSLALSHQ
310 320 330 340 350
DETIVVGMTN GILSVKHRKS EAKKTSLPRR RRPAYRTFIK GKNYLKQRDD
360 370 380 390 400
IMVSRPAKKH LEGYDKDLKS FRVSQALDRV LEPKCVIRTP EVTVSIIKEL
410 420 430 440 450
TRRGVLANAL AGRDEKEVTR VLNFLIRNLS QPRFAPVLIN AAEIIIDIYL
460 470 480 490 500
PVIGQSSVVD KKFIVLQELV EKEIDYQREL LETLGMMDML FATMTRNDSD
510 520
PVPEHVPAEL PEEKTESPTQ PSDTDKNS
Length:528
Mass (Da):59,375
Last modified:March 1, 2003 - v1
Checksum:i6C1691522D1919C5
GO

Sequence cautioni

The sequence AAH34372 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti479E → K in AAH34372 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY151261 mRNA Translation: AAN71642.1
AK049186 mRNA Translation: BAC33596.1
AK162794 mRNA Translation: BAE37061.1
BC034372 mRNA Translation: AAH34372.1 Different initiation.
BC065057 mRNA Translation: AAH65057.1
CCDSiCCDS26712.1
RefSeqiNP_849249.1, NM_178918.3
UniGeneiMm.28221
Mm.297905

Genome annotation databases

EnsembliENSMUST00000040972; ENSMUSP00000048204; ENSMUSG00000041747
GeneIDi105372
KEGGimmu:105372
UCSCiuc007rom.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY151261 mRNA Translation: AAN71642.1
AK049186 mRNA Translation: BAC33596.1
AK162794 mRNA Translation: BAE37061.1
BC034372 mRNA Translation: AAH34372.1 Different initiation.
BC065057 mRNA Translation: AAH65057.1
CCDSiCCDS26712.1
RefSeqiNP_849249.1, NM_178918.3
UniGeneiMm.28221
Mm.297905

3D structure databases

ProteinModelPortaliQ8C7V3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222829, 1 interactor
IntActiQ8C7V3, 1 interactor
STRINGi10090.ENSMUSP00000048204

PTM databases

iPTMnetiQ8C7V3
PhosphoSitePlusiQ8C7V3

Proteomic databases

EPDiQ8C7V3
MaxQBiQ8C7V3
PaxDbiQ8C7V3
PeptideAtlasiQ8C7V3
PRIDEiQ8C7V3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040972; ENSMUSP00000048204; ENSMUSG00000041747
GeneIDi105372
KEGGimmu:105372
UCSCiuc007rom.1 mouse

Organism-specific databases

CTDi84135
MGIiMGI:2145443 Utp15

Phylogenomic databases

eggNOGiKOG0310 Eukaryota
ENOG410XNZ0 LUCA
GeneTreeiENSGT00390000004228
HOGENOMiHOG000185028
HOVERGENiHBG080690
InParanoidiQ8C7V3
KOiK14549
OMAiEHTDYIR
OrthoDBiEOG091G0524
PhylomeDBiQ8C7V3
TreeFamiTF319494

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRSiUtp15 mouse
PROiPR:Q8C7V3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041747 Expressed in 246 organ(s), highest expression level in blastocyst
GenevisibleiQ8C7V3 MM

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR018983 U3_snoRNA-assocProt_15_C
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF09384 UTP15_C, 1 hit
PF00400 WD40, 4 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUTP15_MOUSE
AccessioniPrimary (citable) accession number: Q8C7V3
Secondary accession number(s): Q3TRG8, Q8K231
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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