UniProtKB - Q8C7R7 (RFX6_MOUSE)

BLAST

>sp|Q8C7R7|RFX6_MOUSE DNA-binding protein RFX6 OS=Mus musculus OX=10090 GN=Rfx6 PE=1 SV=2
MAKVRELEEAFVQEQPSPQLPSEIAEECCAQLLGKGLLVYPEDSAYLLAETAAGARSSGE
KGGDPGLQVGVKSEMQLNNGNFSSEEEDADTQESKTKAADPQLSQKKSITQMMKDKKKQT
QLTLQWLEDNYIVCEGVCLPRCILYAHYLDFCRKEKLEPACAATFGKTIRQKFPLLTTRR
LGTRGHSKYHYYGIGIKESSAYYHSVYSGKGLTRFSGSKLKNEGGFTRKYSLSSKTGTLL
PEFPSAQHLVYQGCISKDKVDTLIMMYKTHCQCILDNAINGNFEEIQHFLLHFWQGMPDH
LLPLLENPVIIDIFCVCDSILYKVLTDVLIPATMQEMPESLLADIRNFAKNWEQWVVSSL
ENLPEALIDKKIPILRRFVSSLKRQTSFLHLAQIARPALFDQHVVNAMVSDIEKVDLNSI
GSQALLTISNSTDTESDIYSEHDSITVFQELKDLLKKNATVEAFIEWLDTVVEQRVIKMS
KQNGRSLKKRAQDFLLKWSFFGARVMHNLTLNNASSFGSFHLIRMLLDEYILLAMETQFN
NDKEQELQNLLDKYMKNSDASKAAFTASPSSCFLANRNKASSLASDTVKNESHVETSYVP
LPSSQPGAIPPALHPFSTEDTDNMPLPGQIELSQSTGHLMTPPISPAIASRGSVINQGPM
ASRPPSVGTVLSAPTHCSTYAEPIYPTLSPANHDFYGTNSNYQTMFRTQSHPASSLYAHR
AEHGRCMAWTEQQLSRDFFGGSCAGSPYNCRPPSSYGPSTHTQESHSMQVLNTGSFNFLS
NAGAGSCQGSTLPSNSPNGYYGNNINYSEAHRLGSMVNQHVSVISSVRSLPPYSDIHDPL
NILDDSSRKQNNSFYADTLSPVACRTTVVASNLQTQIPSSSSQCMYGTSNQYPVQDSLDS
NAASNREMVSSLPPINTVFMGTAAGDT

Align

Format
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History
Entry version 124 (07 Nov 2018)
Sequence version 2 (15 Jan 2008)
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Protein

DNA-binding protein RFX6

Gene

Rfx6

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes (PubMed:20148032). Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription (By similarity).By similarity1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	123 – 198	RFX-type winged-helixPROSITE-ProRule annotationAdd BLAST		76

GO - Molecular functionⁱ

DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
DNA-binding transcription factor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
transcription regulatory region DNA binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

endocrine pancreas development Source: MGI
glucose homeostasis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20148032
pancreatic A cell differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20148032
pancreatic D cell differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20148032
pancreatic epsilon cell differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20148032
positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: UniProtKB
positive regulation of transcription, DNA-templated Source: UniProtKB
positive regulation of transcription by RNA polymerase II Source: UniProtKB
regulation of insulin secretion
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20148032
regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
type B pancreatic cell differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20148032

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Differentiation, Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: DNA-binding protein RFX6 Alternative name(s): Regulatory factor X 6 Regulatory factor X domain-containing protein 1
Gene namesⁱ	Name:Rfx6 Synonyms:Rfxdc1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 10

Organism-specific databases

MGIⁱ	MGI:2445208 Rfx6

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Mice were born at the expected Mendelian ratio, but fail to feed normally, exhibit gross bowel distension due to small bowel obstruction and die within 2 days post partum. Some, but not all, of the animals also have reduced pancreas size. pancreata had almost no expression of the islet hormones genes, except for PP (polypeptide-producing).1 Publication

Keywords - Diseaseⁱ

Diabetes mellitus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000313722	1 – 927	DNA-binding protein RFX6Add BLAST		927

Proteomic databases

PaxDbⁱ	Q8C7R7
PRIDEⁱ	Q8C7R7

PTM databases

iPTMnetⁱ	Q8C7R7
PhosphoSitePlusⁱ	Q8C7R7

Expressionⁱ

Tissue specificityⁱ

In the adult pancreas, expression is restricted to the islets where it could be detected in all endocrine lineages.2 Publications

Developmental stageⁱ

Expressed initially broadly in the definitive endoderm after gastrulation, becomes restricted to the gut and pancreatic bud at mid gestation, and is reactivated by Neurog3 in islet progenitor cells and is ultimately restricted to pancreatic islets in the mature pancreas (at protein level).2 Publications

Inductionⁱ

By Neurog3.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000019900 Expressed in 17 organ(s), highest expression level in endoderm
ExpressionAtlasⁱ	Q8C7R7 baseline and differential

Interactionⁱ

Subunit structureⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000116057

STRINGⁱ

10090.ENSMUSP00000116057

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8C7R7
SMRⁱ	Q8C7R7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the RFX family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG3712 Eukaryota ENOG410XSKJ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074532
HOGENOMⁱ	HOG000154105
HOVERGENⁱ	HBG108402
InParanoidⁱ	Q8C7R7
KEGG Orthology (KO) More...KOⁱ	K19521
OMAⁱ	NYPESHR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01JI
PhylomeDBⁱ	Q8C7R7
TreeFamⁱ	TF321340

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR003150 DNA-bd_RFX IPR039779 RFX-like IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
PANTHERⁱ	PTHR12619 PTHR12619, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02257 RFX_DNA_binding, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS51526 RFX_DBD, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8C7R7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKVRELEEA FVQEQPSPQL PSEIAEECCA QLLGKGLLVY PEDSAYLLAE 
        60         70         80         90        100
TAAGARSSGE KGGDPGLQVG VKSEMQLNNG NFSSEEEDAD TQESKTKAAD 
       110        120        130        140        150
PQLSQKKSIT QMMKDKKKQT QLTLQWLEDN YIVCEGVCLP RCILYAHYLD 
       160        170        180        190        200
FCRKEKLEPA CAATFGKTIR QKFPLLTTRR LGTRGHSKYH YYGIGIKESS 
       210        220        230        240        250
AYYHSVYSGK GLTRFSGSKL KNEGGFTRKY SLSSKTGTLL PEFPSAQHLV 
       260        270        280        290        300
YQGCISKDKV DTLIMMYKTH CQCILDNAIN GNFEEIQHFL LHFWQGMPDH 
       310        320        330        340        350
LLPLLENPVI IDIFCVCDSI LYKVLTDVLI PATMQEMPES LLADIRNFAK 
       360        370        380        390        400
NWEQWVVSSL ENLPEALIDK KIPILRRFVS SLKRQTSFLH LAQIARPALF 
       410        420        430        440        450
DQHVVNAMVS DIEKVDLNSI GSQALLTISN STDTESDIYS EHDSITVFQE 
       460        470        480        490        500
LKDLLKKNAT VEAFIEWLDT VVEQRVIKMS KQNGRSLKKR AQDFLLKWSF 
       510        520        530        540        550
FGARVMHNLT LNNASSFGSF HLIRMLLDEY ILLAMETQFN NDKEQELQNL 
       560        570        580        590        600
LDKYMKNSDA SKAAFTASPS SCFLANRNKA SSLASDTVKN ESHVETSYVP 
       610        620        630        640        650
LPSSQPGAIP PALHPFSTED TDNMPLPGQI ELSQSTGHLM TPPISPAIAS 
       660        670        680        690        700
RGSVINQGPM ASRPPSVGTV LSAPTHCSTY AEPIYPTLSP ANHDFYGTNS 
       710        720        730        740        750
NYQTMFRTQS HPASSLYAHR AEHGRCMAWT EQQLSRDFFG GSCAGSPYNC 
       760        770        780        790        800
RPPSSYGPST HTQESHSMQV LNTGSFNFLS NAGAGSCQGS TLPSNSPNGY 
       810        820        830        840        850
YGNNINYSEA HRLGSMVNQH VSVISSVRSL PPYSDIHDPL NILDDSSRKQ 
       860        870        880        890        900
NNSFYADTLS PVACRTTVVA SNLQTQIPSS SSQCMYGTSN QYPVQDSLDS 
       910        920 
NAASNREMVS SLPPINTVFM GTAAGDT

Length:927

Mass (Da):102,566

Last modified:January 15, 2008 - v2

Checksum:ⁱ787F0837902D3E21

Isoform 2 (identifier: Q8C7R7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
519-524: SFHLIR → IQCVLQ
525-927: Missing.

« Hide

        10         20         30         40         50
MAKVRELEEA FVQEQPSPQL PSEIAEECCA QLLGKGLLVY PEDSAYLLAE 
        60         70         80         90        100
TAAGARSSGE KGGDPGLQVG VKSEMQLNNG NFSSEEEDAD TQESKTKAAD 
       110        120        130        140        150
PQLSQKKSIT QMMKDKKKQT QLTLQWLEDN YIVCEGVCLP RCILYAHYLD 
       160        170        180        190        200
FCRKEKLEPA CAATFGKTIR QKFPLLTTRR LGTRGHSKYH YYGIGIKESS 
       210        220        230        240        250
AYYHSVYSGK GLTRFSGSKL KNEGGFTRKY SLSSKTGTLL PEFPSAQHLV 
       260        270        280        290        300
YQGCISKDKV DTLIMMYKTH CQCILDNAIN GNFEEIQHFL LHFWQGMPDH 
       310        320        330        340        350
LLPLLENPVI IDIFCVCDSI LYKVLTDVLI PATMQEMPES LLADIRNFAK 
       360        370        380        390        400
NWEQWVVSSL ENLPEALIDK KIPILRRFVS SLKRQTSFLH LAQIARPALF 
       410        420        430        440        450
DQHVVNAMVS DIEKVDLNSI GSQALLTISN STDTESDIYS EHDSITVFQE 
       460        470        480        490        500
LKDLLKKNAT VEAFIEWLDT VVEQRVIKMS KQNGRSLKKR AQDFLLKWSF 
       510        520 
FGARVMHNLT LNNASSFGIQ CVLQ

Note: No experimental confirmation available.

Show »

Length:524

Mass (Da):59,136

Checksum:ⁱ7A30A23C7A863604

Isoform 3 (identifier: Q8C7R7-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-264: Missing.

« Hide

        10         20         30         40         50
MMYKTHCQCI LDNAINGNFE EIQHFLLHFW QGMPDHLLPL LENPVIIDIF 
        60         70         80         90        100
CVCDSILYKV LTDVLIPATM QEMPESLLAD IRNFAKNWEQ WVVSSLENLP 
       110        120        130        140        150
EALIDKKIPI LRRFVSSLKR QTSFLHLAQI ARPALFDQHV VNAMVSDIEK 
       160        170        180        190        200
VDLNSIGSQA LLTISNSTDT ESDIYSEHDS ITVFQELKDL LKKNATVEAF 
       210        220        230        240        250
IEWLDTVVEQ RVIKMSKQNG RSLKKRAQDF LLKWSFFGAR VMHNLTLNNA 
       260        270        280        290        300
SSFGSFHLIR MLLDEYILLA METQFNNDKE QELQNLLDKY MKNSDASKAA 
       310        320        330        340        350
FTASPSSCFL ANRNKASSLA SDTVKNESHV ETSYVPLPSS QPGAIPPALH 
       360        370        380        390        400
PFSTEDTDNM PLPGQIELSQ STGHLMTPPI SPAIASRGSV INQGPMASRP 
       410        420        430        440        450
PSVGTVLSAP THCSTYAEPI YPTLSPANHD FYGTNSNYQT MFRTQSHPAS 
       460        470        480        490        500
SLYAHRAEHG RCMAWTEQQL SRDFFGGSCA GSPYNCRPPS SYGPSTHTQE 
       510        520        530        540        550
SHSMQVLNTG SFNFLSNAGA GSCQGSTLPS NSPNGYYGNN INYSEAHRLG 
       560        570        580        590        600
SMVNQHVSVI SSVRSLPPYS DIHDPLNILD DSSRKQNNSF YADTLSPVAC 
       610        620        630        640        650
RTTVVASNLQ TQIPSSSSQC MYGTSNQYPV QDSLDSNAAS NREMVSSLPP 
       660 
INTVFMGTAA GDT

Note: No experimental confirmation available.

Show »

Length:663

Mass (Da):73,265

Checksum:ⁱC8C29794548143B6

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D5FLC2	D5FLC2_MOUSE	DNA-binding protein RFX6 DNA-binding protein RFX6 (RFX6)	Rfx6	893	Annotation score:
A0A1W2P7F2	A0A1W2P7F2_MOUSE	DNA-binding protein RFX6 DNA-binding protein RFX6	Rfx6	270	Annotation score:

Sequence cautionⁱ

The sequence AAI32105 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAI32295 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_030121	1 – 264	Missing in isoform 3. 1 PublicationAdd BLAST	264
Alternative sequenceⁱVSP_030122	519 – 524	SFHLIR → IQCVLQ in isoform 2. 1 Publication	6
Alternative sequenceⁱVSP_030123	525 – 927	Missing in isoform 2. 1 PublicationAdd BLAST	403

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK029809 mRNA Translation: BAC26627.1 AK049380 mRNA Translation: BAC33722.1 AC153527 Genomic DNA No translation available. BC132104 mRNA Translation: AAI32105.1 Different initiation. BC132294 mRNA Translation: AAI32295.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS23835.1 [Q8C7R7-3] CCDS48558.1 [Q8C7R7-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001152861.1, NM_001159389.1 [Q8C7R7-1] NP_796280.1, NM_177306.3 [Q8C7R7-3]
UniGeneⁱ	Mm.109190

Genome annotation databases

Ensemblⁱ	ENSMUST00000050455; ENSMUSP00000057384; ENSMUSG00000019900 [Q8C7R7-3] ENSMUST00000122922; ENSMUSP00000116057; ENSMUSG00000019900 [Q8C7R7-1]
GeneIDⁱ	320995
KEGGⁱ	mmu:320995
UCSC genome browser More...UCSCⁱ	uc007fax.2 mouse [Q8C7R7-2] uc007fay.1 mouse [Q8C7R7-1] uc011xdt.1 mouse [Q8C7R7-3]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8C7R7	Isoform 3 of DNA-binding protein RFX6		MOUSE		663	UniRef90_Q8C7R7
DNA-binding protein RFX6		MESAU		926
Regulatory factor X domain containing 1 (Predicted), isoform CRA_a		RAT		747
UPI00038C57D2		MICOH		927
UPI0004544075		CRIGR		927
+7

Protein	Similar proteins		Species	Score	Length	Source
Q8C7R7	DNA-binding protein RFX6		HUMAN		928	UniRef50_Q8HWS3
DNA-binding protein RFX6		AILME		928
DNA-binding protein RFX6		DANRE		848
Uncharacterized protein		MACMU		932
Uncharacterized protein		MACFA		932
+338
Q8C7R7-2	Regulatory factor X, 6		ORYLA		558	UniRef50_Q8C7R7-2
Uncharacterized protein		BIOGL		651
UPI0009A3AF42		whale shark		561

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK029809 mRNA Translation: BAC26627.1 AK049380 mRNA Translation: BAC33722.1 AC153527 Genomic DNA No translation available. BC132104 mRNA Translation: AAI32105.1 Different initiation. BC132294 mRNA Translation: AAI32295.1 Different initiation.
CCDSⁱ	CCDS23835.1 [Q8C7R7-3] CCDS48558.1 [Q8C7R7-1]
RefSeqⁱ	NP_001152861.1, NM_001159389.1 [Q8C7R7-1] NP_796280.1, NM_177306.3 [Q8C7R7-3]
UniGeneⁱ	Mm.109190

3D structure databases

ProteinModelPortalⁱ	Q8C7R7
SMRⁱ	Q8C7R7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000116057

STRINGⁱ

10090.ENSMUSP00000116057

PTM databases

iPTMnetⁱ	Q8C7R7
PhosphoSitePlusⁱ	Q8C7R7

Proteomic databases

PaxDbⁱ	Q8C7R7
PRIDEⁱ	Q8C7R7

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000050455; ENSMUSP00000057384; ENSMUSG00000019900 [Q8C7R7-3] ENSMUST00000122922; ENSMUSP00000116057; ENSMUSG00000019900 [Q8C7R7-1]
GeneIDⁱ	320995
KEGGⁱ	mmu:320995
UCSCⁱ	uc007fax.2 mouse [Q8C7R7-2] uc007fay.1 mouse [Q8C7R7-1] uc011xdt.1 mouse [Q8C7R7-3]

Organism-specific databases

CTDⁱ	222546
MGIⁱ	MGI:2445208 Rfx6

Phylogenomic databases

eggNOGⁱ	KOG3712 Eukaryota ENOG410XSKJ LUCA
GeneTreeⁱ	ENSGT00550000074532
HOGENOMⁱ	HOG000154105
HOVERGENⁱ	HBG108402
InParanoidⁱ	Q8C7R7
KOⁱ	K19521
OMAⁱ	NYPESHR
OrthoDBⁱ	EOG091G01JI
PhylomeDBⁱ	Q8C7R7
TreeFamⁱ	TF321340

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q8C7R7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000019900 Expressed in 17 organ(s), highest expression level in endoderm
ExpressionAtlasⁱ	Q8C7R7 baseline and differential

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR003150 DNA-bd_RFX IPR039779 RFX-like IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
PANTHERⁱ	PTHR12619 PTHR12619, 1 hit
Pfamⁱ	View protein in Pfam PF02257 RFX_DNA_binding, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS51526 RFX_DBD, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RFX6_MOUSE
Accessionⁱ	Q8C7R7Primary (citable) accession number: Q8C7R7 Secondary accession number(s): Q8CDN5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
	Last sequence update:	January 15, 2008
	Last modified:	November 7, 2018
	This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8C7R7 (RFX6_MOUSE)

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DNA-binding protein RFX6

Rfx6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ