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Protein

Cleavage stimulation factor subunit 2 tau variant

Gene

Cstf2t

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs.1 Publication

GO - Molecular functioni

  • mRNA binding Source: GO_Central
  • RNA binding Source: MGI

GO - Biological processi

  • mRNA polyadenylation Source: MGI
  • pre-mRNA cleavage required for polyadenylation Source: GO_Central

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing

Enzyme and pathway databases

ReactomeiR-MMU-109688 Cleavage of Growing Transcript in the Termination Region
R-MMU-72163 mRNA Splicing - Major Pathway
R-MMU-72187 mRNA 3'-end processing
R-MMU-77595 Processing of Intronless Pre-mRNAs

Names & Taxonomyi

Protein namesi
Recommended name:
Cleavage stimulation factor subunit 2 tau variant
Alternative name(s):
CF-1 64 kDa subunit tau variant
Cleavage stimulation factor 64 kDa subunit tau variant
Short name:
CSTF 64 kDa subunit tau variant
TauCstF-64
Gene namesi
Name:Cstf2t
Synonyms:Kiaa0689
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1932622 Cstf2t

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000815351 – 632Cleavage stimulation factor subunit 2 tau variantAdd BLAST632

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei579PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8C7E9
MaxQBiQ8C7E9
PaxDbiQ8C7E9
PeptideAtlasiQ8C7E9
PRIDEiQ8C7E9

2D gel databases

REPRODUCTION-2DPAGEiIPI00467932

PTM databases

iPTMnetiQ8C7E9
PhosphoSitePlusiQ8C7E9

Expressioni

Tissue specificityi

Expressed in testes, where it is restricted to pachytene spermatocytes and spermatids, and in the brain (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000053536 Expressed in 285 organ(s), highest expression level in pineal body
GenevisibleiQ8C7E9 MM

Interactioni

Protein-protein interaction databases

IntActiQ8C7E9, 1 interactor
MINTiQ8C7E9
STRINGi10090.ENSMUSP00000093831

Structurei

3D structure databases

ProteinModelPortaliQ8C7E9
SMRiQ8C7E9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 94RRMPROSITE-ProRule annotationAdd BLAST79
Repeati428 – 4321-1; approximate5
Repeati433 – 4371-2; approximate5
Repeati438 – 4421-3; approximate5
Repeati443 – 4461-4; approximate4
Repeati447 – 4511-5; approximate5
Repeati452 – 4561-65
Repeati457 – 4611-7; approximate5
Repeati462 – 4661-8; approximate5
Repeati508 – 5122-1; approximate5
Repeati513 – 5172-25
Repeati518 – 5222-3; approximate5
Repeati523 – 5272-45
Repeati528 – 5322-5; approximate5
Repeati533 – 5372-65
Repeati538 – 5422-7; approximate5
Repeati543 – 5472-85
Repeati548 – 5512-9; approximate4
Repeati552 – 5562-10; approximate5
Repeati557 – 5602-11; approximate4
Repeati561 – 5652-125

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni428 – 4668 X 5 AA tandem repeats of M-E-T-R-[AG]Add BLAST39
Regioni508 – 56512 X 5 AA tandem repeats of G-[AT]-G-[MI]-QAdd BLAST58

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi271 – 572Gly-richAdd BLAST302

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0108 Eukaryota
ENOG410XZHK LUCA
GeneTreeiENSGT00890000139457
HOGENOMiHOG000214373
HOVERGENiHBG051145
InParanoidiQ8C7E9
KOiK14407
OMAiIQGTGMQ
OrthoDBiEOG091G0A7G
PhylomeDBiQ8C7E9
TreeFamiTF314948

Family and domain databases

Gene3Di1.10.20.70, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR038192 CSTF2_C_sf
IPR025742 CSTF2_hinge
IPR026896 CSTF_C
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF14327 CSTF2_hinge, 1 hit
PF14304 CSTF_C, 1 hit
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequencei

Sequence statusi: Complete.

Q8C7E9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSLAVRDPA MDRSLRSVFV GNIPYEATEE QLKDIFSEVG SVVSFRLVYD
60 70 80 90 100
RETGKPKGYG FCEYQDQETA LSAMRNLNGR EFSGRALRVD NAASEKNKEE
110 120 130 140 150
LKSLGPAAPI IDSPYGDPID PEDAPESITR AVASLPPEQM FELMKQMKLC
160 170 180 190 200
VQNSHQEARN MLLQNPQLAY ALLQAQVVMR IMDPEIALKI LHRKIHVTPL
210 220 230 240 250
IPGKSQPVSG PGPGGPGPSG PGGPGPGPAP GLCPGPNVML NQQNPPAPQP
260 270 280 290 300
QHLPRRPVKD IPPLMQTSIQ GGIPAPGPIP AAVPGPGPGS LTPGGAMQPQ
310 320 330 340 350
VGMPVVGPVP LERGQMQISD PRPPMPRGPM PSGGIPPRGL LGDAPNDPRG
360 370 380 390 400
GTLLSVTGEV EPRGYMGPPH QGPPMHHGHD NRGPASHDMR GGPLAADPRM
410 420 430 440 450
LIGEPRGPMI DQRGLPMDGR GGRESRGMET RPMETEVLEP RGMERRMETC
460 470 480 490 500
AMETRGMDAR GLEMRGPGPS SRGPMTGGIQ GPGPINMGAG GPQGPRQVPN
510 520 530 540 550
IAGVGNPGGT MQGAGIQGGG MQGAGMQGGG MQGAGMQGGG MQGAGMQAGM
560 570 580 590 600
QGASMQGGMQ GAGMQGASKQ GGGQPSSFSP GQSQVTPQDQ EKAALIMQVL
610 620 630
QLTADQIAML PPEQRQSILI LKEQIQKSTG AS
Length:632
Mass (Da):65,862
Last modified:July 19, 2005 - v2
Checksum:i1CDB48EEC5B814B8
GO

Sequence cautioni

The sequence BAC39256 differs from that shown. Reason: Frameshift at position 583.Curated
The sequence BAD32280 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti213 – 227PGGPG…GPGPG → LVGWASGLAAGPA (PubMed:11113135).CuratedAdd BLAST15
Sequence conflicti214 – 216GGP → WWAL in BAC39256 (PubMed:16141072).Curated3
Sequence conflicti221P → S in BAC34240 (PubMed:16141072).Curated1
Sequence conflicti457M → MEARGM in AAH26995 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322194 mRNA Translation: AAG40327.1
AK173002 mRNA Translation: BAD32280.1 Different initiation.
AK034853 mRNA Translation: BAC28855.1
AK050407 mRNA Translation: BAC34240.1
AK082910 mRNA Translation: BAC38683.1
AK084696 mRNA Translation: BAC39256.1 Frameshift.
BC026995 mRNA Translation: AAH26995.1
CCDSiCCDS37958.1
RefSeqiNP_112539.2, NM_031249.2
UniGeneiMm.22031

Genome annotation databases

EnsembliENSMUST00000066039; ENSMUSP00000093831; ENSMUSG00000053536
GeneIDi83410
KEGGimmu:83410
UCSCiuc008her.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322194 mRNA Translation: AAG40327.1
AK173002 mRNA Translation: BAD32280.1 Different initiation.
AK034853 mRNA Translation: BAC28855.1
AK050407 mRNA Translation: BAC34240.1
AK082910 mRNA Translation: BAC38683.1
AK084696 mRNA Translation: BAC39256.1 Frameshift.
BC026995 mRNA Translation: AAH26995.1
CCDSiCCDS37958.1
RefSeqiNP_112539.2, NM_031249.2
UniGeneiMm.22031

3D structure databases

ProteinModelPortaliQ8C7E9
SMRiQ8C7E9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8C7E9, 1 interactor
MINTiQ8C7E9
STRINGi10090.ENSMUSP00000093831

PTM databases

iPTMnetiQ8C7E9
PhosphoSitePlusiQ8C7E9

2D gel databases

REPRODUCTION-2DPAGEiIPI00467932

Proteomic databases

EPDiQ8C7E9
MaxQBiQ8C7E9
PaxDbiQ8C7E9
PeptideAtlasiQ8C7E9
PRIDEiQ8C7E9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066039; ENSMUSP00000093831; ENSMUSG00000053536
GeneIDi83410
KEGGimmu:83410
UCSCiuc008her.1 mouse

Organism-specific databases

CTDi23283
MGIiMGI:1932622 Cstf2t
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0108 Eukaryota
ENOG410XZHK LUCA
GeneTreeiENSGT00890000139457
HOGENOMiHOG000214373
HOVERGENiHBG051145
InParanoidiQ8C7E9
KOiK14407
OMAiIQGTGMQ
OrthoDBiEOG091G0A7G
PhylomeDBiQ8C7E9
TreeFamiTF314948

Enzyme and pathway databases

ReactomeiR-MMU-109688 Cleavage of Growing Transcript in the Termination Region
R-MMU-72163 mRNA Splicing - Major Pathway
R-MMU-72187 mRNA 3'-end processing
R-MMU-77595 Processing of Intronless Pre-mRNAs

Miscellaneous databases

PROiPR:Q8C7E9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053536 Expressed in 285 organ(s), highest expression level in pineal body
GenevisibleiQ8C7E9 MM

Family and domain databases

Gene3Di1.10.20.70, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR038192 CSTF2_C_sf
IPR025742 CSTF2_hinge
IPR026896 CSTF_C
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF14327 CSTF2_hinge, 1 hit
PF14304 CSTF_C, 1 hit
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCSTFT_MOUSE
AccessioniPrimary (citable) accession number: Q8C7E9
Secondary accession number(s): Q6A016
, Q8BHH7, Q8C3W7, Q8R2Y1, Q9EPU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 7, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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