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Protein

Sorting nexin

Gene

Snx18

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei303Phosphatidylinositol 4,5-bisphosphateUniRule annotation1
Binding sitei305Phosphatidylinositol 4,5-bisphosphateUniRule annotation1
Binding sitei329Phosphatidylinositol 4,5-bisphosphateUniRule annotation1
Binding sitei343Phosphatidylinositol 4,5-bisphosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexinUniRule annotation
Gene namesi
Name:Snx18Imported
Synonyms:Snag1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2137642 Snx18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicleUniRule annotation, MembraneUniRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000042364 Expressed in 271 organ(s), highest expression level in renal medulla interstitium

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104864

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 61SH3InterPro annotationAdd BLAST61
Domaini267 – 377PXInterPro annotationAdd BLAST111

Sequence similaritiesi

Belongs to the sorting nexin family.UniRule annotation

Keywords - Domaini

SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2528 Eukaryota
ENOG410XPHZ LUCA
GeneTreeiENSGT00510000046469
HOGENOMiHOG000261633
HOVERGENiHBG009996
KOiK17923
OMAiAFEMDQQ
OrthoDBiEOG091G07IM
TreeFamiTF314082

Family and domain databases

CDDicd07286 PX_SNX18, 1 hit
cd11897 SH3_SNX18, 1 hit
Gene3Di1.20.1270.60, 1 hit
3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR001683 Phox
IPR036871 PX_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR035703 SNX18_PX
IPR035557 SNX18_SH3
IPR014536 Snx9_fam
IPR039358 Sorting_nexin-like
IPR019497 Sorting_nexin_WASP-bd-dom
PANTHERiPTHR10555 PTHR10555, 1 hit
PfamiView protein in Pfam
PF10456 BAR_3_WASP_bdg, 1 hit
PF00787 PX, 1 hit
PF14604 SH3_9, 1 hit
PIRSFiPIRSF027744 Snx9, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit
PS50002 SH3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8C788-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALRARALYD FKSENPGEIS LREHEVLSLC SEQDIEGWLE GINSRGDRGL
60 70 80 90 100
FPASYVQVIR APEPGPPADG GPGAPARYAN VPPGGFEPLP AAPPAAFPPL
110 120 130 140 150
LQPQASPGSF QPPGAGFPYG GGALQPSPQQ LYGGYQASLG SDDDWDDEWD
160 170 180 190 200
DSSTVADEPG ALGSGAYPDL DGSSSAGGGA AGRYRLSTRS DLSLGSRGVS
210 220 230 240 250
APPAHQASGA KSSATVSRNL NRFSTFVKSG GEAFVLGEAS GFVKDGDKLC
260 270 280 290 300
VVLGPYGPEW QENPYPFQCT IDDPTKQTKF KGMKSYISYK LVPTHTQVPV
310 320 330 340 350
HRRYKHFDWL YARLAEKFPV ISVPHLPEKQ ATGRFEEDFI SKRRKGLIWW
360 370 380 390 400
MNHMASHPVL AQCDVFQHFL TCPSSTDEKA WKQGKRKAEK DEMVGANFFL
410 420 430 440 450
TLSTPPAAAL DLQEVESKID GFKCFTKKMD DSALQLNHTA NEFARKQVTG
460 470 480 490 500
FKKEYQKVGQ SFRGLSQAFE LDQQAFSVGL NQAIAFTGDA YDAIGELFAE
510 520 530 540 550
QPRQDLDPVM DLLALYQGHL ANFPDIIHVQ KGALTKVKES RRHVEEGKME
560 570 580 590 600
VQKADGIQDR CNTISFATLA EIHHFHQIRV RDFKSQMQHF LQQQIIFFQK
610
VTQKLEEALH KYDSV
Length:615
Mass (Da):67,790
Last modified:March 1, 2003 - v1
Checksum:i98C6C8BC9F6D4758
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q91ZR2SNX18_MOUSE
Sorting nexin-18
Snx18 Snag1
614Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC168056 Genomic DNA No translation available.
BC063089 mRNA Translation: AAH63089.1
BC137801 mRNA Translation: AAI37802.1
BC145951 mRNA Translation: AAI45952.1
AK052343 mRNA Translation: BAC34945.1
RefSeqiNP_570614.2, NM_130796.4
UniGeneiMm.33721

Genome annotation databases

EnsembliENSMUST00000109241; ENSMUSP00000104864; ENSMUSG00000042364
GeneIDi170625
KEGGimmu:170625
UCSCiuc007rxg.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC168056 Genomic DNA No translation available.
BC063089 mRNA Translation: AAH63089.1
BC137801 mRNA Translation: AAI37802.1
BC145951 mRNA Translation: AAI45952.1
AK052343 mRNA Translation: BAC34945.1
RefSeqiNP_570614.2, NM_130796.4
UniGeneiMm.33721

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104864

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109241; ENSMUSP00000104864; ENSMUSG00000042364
GeneIDi170625
KEGGimmu:170625
UCSCiuc007rxg.2 mouse

Organism-specific databases

CTDi112574
MGIiMGI:2137642 Snx18

Phylogenomic databases

eggNOGiKOG2528 Eukaryota
ENOG410XPHZ LUCA
GeneTreeiENSGT00510000046469
HOGENOMiHOG000261633
HOVERGENiHBG009996
KOiK17923
OMAiAFEMDQQ
OrthoDBiEOG091G07IM
TreeFamiTF314082

Enzyme and pathway databases

ReactomeiR-MMU-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042364 Expressed in 271 organ(s), highest expression level in renal medulla interstitium

Family and domain databases

CDDicd07286 PX_SNX18, 1 hit
cd11897 SH3_SNX18, 1 hit
Gene3Di1.20.1270.60, 1 hit
3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR001683 Phox
IPR036871 PX_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR035703 SNX18_PX
IPR035557 SNX18_SH3
IPR014536 Snx9_fam
IPR039358 Sorting_nexin-like
IPR019497 Sorting_nexin_WASP-bd-dom
PANTHERiPTHR10555 PTHR10555, 1 hit
PfamiView protein in Pfam
PF10456 BAR_3_WASP_bdg, 1 hit
PF00787 PX, 1 hit
PF14604 SH3_9, 1 hit
PIRSFiPIRSF027744 Snx9, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ8C788_MOUSE
AccessioniPrimary (citable) accession number: Q8C788
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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