UniProtKB - Q8C6G8 (WDR26_MOUSE)

BLAST

>sp|Q8C6G8|WDR26_MOUSE WD repeat-containing protein 26 OS=Mus musculus OX=10090 GN=Wdr26 PE=1 SV=3
MQANGAGGGGGGGGGGQGQTPELACLSAQNGESSPSATSAGDLAHANGLLPAAPSAAGNN
SNSLSVNNGVPGGAAAASATAAAAQATPELGSSLKKKKRLSQSDEDVIRLIGQHLNGLGL
NQTVDLLMQESGCRLEHPSATKFRNHVMEGDWDKAENDLNELKPLVHSPHAIVVRGALEI
SQTLLGIIVRMKFLLLQQKYLEYLEDGKVLEALQVLRCELTPLKYNTERIHVLSGYLMCS
HAEDLRAKAEWEGKGTASRSKLLDKLQTYLPPSVMLPPRRLQTLLRQAVELQRDRCLYHN
TKLDNNLDSVSLLIDHVCSRRQFPCYTQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVI
IWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPDDSYLVACGPDDCSELWLWNVQTGELRTK
MSQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCDLDGNLLDSWEGVRVQCLWCLSDGKTV
LASDTHQRVRGYNFEDLTDRNIVQEDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVL
VRKYQGVTQGFYTIHSCFGGHNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVS
WNPQIPSMMASASDDGTVRIWGPAPFIDHQNIEEECSSMDS

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History
Entry version 127 (07 Nov 2018)
Sequence version 3 (27 Jul 2011)
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Protein

WD repeat-containing protein 26

Gene

Wdr26

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (By similarity). Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation. Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration. Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria (By similarity). Protects also cells by promoting hypoxia-mediated autophagy and mitophagy (By similarity).By similarity

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: WD repeat-containing protein 26
Gene namesⁱ	Name:Wdr26
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 1

Organism-specific databases

MGIⁱ	MGI:1923825 Wdr26

Keywords - Cellular componentⁱ

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000051374	1 – 641	WD repeat-containing protein 26Add BLAST		641

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	101	PhosphoserineCombined sources		1
Modified residueⁱ	103	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q8C6G8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8C6G8
PaxDbⁱ	Q8C6G8
PRIDEⁱ	Q8C6G8

PTM databases

iPTMnetⁱ	Q8C6G8
PhosphoSitePlusⁱ	Q8C6G8
SwissPalmⁱ	Q8C6G8

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000038733 Expressed in 295 organ(s), highest expression level in blood
CleanExⁱ	MM_WDR26
ExpressionAtlasⁱ	Q8C6G8 baseline and differential
Genevisibleⁱ	Q8C6G8 MM

Interactionⁱ

Subunit structureⁱ

Forms homooligomers. Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5. Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles. Interacts with DDB1-CUL4A/B E3 ligase complexes. Forms a complex composed of at least WDR26, a G-beta:gamma unit, and PLCB2. Interacts with AXIN1.By similarity

Protein-protein interaction databases

BioGridⁱ	230551, 3 interactors
IntActⁱ	Q8C6G8, 2 interactors
STRINGⁱ	10090.ENSMUSP00000124592

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8C6G8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	103 – 135	LisHPROSITE-ProRule annotationAdd BLAST	33
Domainⁱ	136 – 211	CTLHPROSITE-ProRule annotationAdd BLAST	76
Repeatⁱ	333 – 372	WD 1Add BLAST	40
Repeatⁱ	379 – 418	WD 2Add BLAST	40
Repeatⁱ	424 – 464	WD 3Add BLAST	41
Repeatⁱ	504 – 543	WD 4Add BLAST	40
Repeatⁱ	546 – 588	WD 5Add BLAST	43
Repeatⁱ	591 – 631	WD 6Add BLAST	41

Keywords - Domainⁱ

Repeat, WD repeat

Phylogenomic databases

eggNOGⁱ	KOG0293 Eukaryota ENOG410XQ2U LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000111021
HOVERGENⁱ	HBG083958
InParanoidⁱ	Q8C6G8
KEGG Orthology (KO) More...KOⁱ	K22382
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05NI
TreeFamⁱ	TF314869

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR006595 CTLH_C IPR006594 LisH IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00400 WD40, 5 hits
SMARTⁱ	View protein in SMART SM00668 CTLH, 1 hit SM00320 WD40, 5 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS50897 CTLH, 1 hit PS50896 LISH, 1 hit PS50082 WD_REPEATS_2, 3 hits PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

Q8C6G8-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MQANGAGGGG GGGGGGQGQT PELACLSAQN GESSPSATSA GDLAHANGLL 
        60         70         80         90        100
PAAPSAAGNN SNSLSVNNGV PGGAAAASAT AAAAQATPEL GSSLKKKKRL 
       110        120        130        140        150
SQSDEDVIRL IGQHLNGLGL NQTVDLLMQE SGCRLEHPSA TKFRNHVMEG 
       160        170        180        190        200
DWDKAENDLN ELKPLVHSPH AIVVRGALEI SQTLLGIIVR MKFLLLQQKY 
       210        220        230        240        250
LEYLEDGKVL EALQVLRCEL TPLKYNTERI HVLSGYLMCS HAEDLRAKAE 
       260        270        280        290        300
WEGKGTASRS KLLDKLQTYL PPSVMLPPRR LQTLLRQAVE LQRDRCLYHN 
       310        320        330        340        350
TKLDNNLDSV SLLIDHVCSR RQFPCYTQQI LTEHCNEVWF CKFSNDGTKL 
       360        370        380        390        400
ATGSKDTTVI IWQVDPDTHL LKLLKTLEGH AYGVSYIAWS PDDSYLVACG 
       410        420        430        440        450
PDDCSELWLW NVQTGELRTK MSQSHEDSLT SVAWNPDGKR FVTGGQRGQF 
       460        470        480        490        500
YQCDLDGNLL DSWEGVRVQC LWCLSDGKTV LASDTHQRVR GYNFEDLTDR 
       510        520        530        540        550
NIVQEDHPIM SFTISKNGRL ALLNVATQGV HLWDLQDRVL VRKYQGVTQG 
       560        570        580        590        600
FYTIHSCFGG HNEDFIASGS EDHKVYIWHK RSELPIAELT GHTRTVNCVS 
       610        620        630        640 
WNPQIPSMMA SASDDGTVRI WGPAPFIDHQ NIEEECSSMD S

Length:641

Mass (Da):70,543

Last modified:July 27, 2011 - v3

Checksum:ⁱ053BAFF901088CFA

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E0CYH4	E0CYH4_MOUSE	WD repeat-containing protein 26 WD repeat-containing protein 26	Wdr26	625	Annotation score:
F7DFQ2	F7DFQ2_MOUSE	WD repeat-containing protein 26 WD repeat-containing protein 26	Wdr26	147	Annotation score:
F6UT94	F6UT94_MOUSE	WD repeat-containing protein 26 WD repeat-containing protein 26	Wdr26	120	Annotation score:
F8WH48	F8WH48_MOUSE	WD repeat-containing protein 26 WD repeat-containing protein 26	Wdr26	183	Annotation score:

Sequence cautionⁱ

The sequence BAC35923 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC113084 Genomic DNA No translation available. AK075743 mRNA Translation: BAC35923.1 Different initiation. AK167116 mRNA Translation: BAE39264.1 AK167017 mRNA Translation: BAE39191.1 BC020044 mRNA Translation: AAH20044.2 BC058601 mRNA Translation: AAH58601.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS15583.2
NCBI Reference Sequences More...RefSeqⁱ	NP_663489.4, NM_145514.5
UniGeneⁱ	Mm.289082

Genome annotation databases

Ensemblⁱ	ENSMUST00000162819; ENSMUSP00000124592; ENSMUSG00000038733
GeneIDⁱ	226757
KEGGⁱ	mmu:226757
UCSC genome browser More...UCSCⁱ	uc007dxf.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8C6G8	WD repeat domain 26		MOUSE		514	UniRef100_Q8C6G8
WD repeat-containing-like protein (Fragment)		Daphnia magna		177

Protein	Similar proteins		Species	Score	Length	Source
Q8C6G8	WD repeat-containing protein 26		HUMAN		661	UniRef90_Q9H7D7
WD repeat domain 26		PANTR		705
Uncharacterized protein		PANPA		704
WD repeat domain 26		MACMU		661
WD repeat domain 26		GORGO		661
+171

Protein	Similar proteins		Species	Score	Length	Source
Q8C6G8	WD repeat-containing protein 26		HUMAN		661	UniRef50_Q9H7D7
WD repeat domain 26		PANTR		705
Uncharacterized protein		PANPA		704
WD repeat domain 26		MACMU		661
WD repeat domain 26		GORGO		661
+179

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC113084 Genomic DNA No translation available. AK075743 mRNA Translation: BAC35923.1 Different initiation. AK167116 mRNA Translation: BAE39264.1 AK167017 mRNA Translation: BAE39191.1 BC020044 mRNA Translation: AAH20044.2 BC058601 mRNA Translation: AAH58601.1
CCDSⁱ	CCDS15583.2
RefSeqⁱ	NP_663489.4, NM_145514.5
UniGeneⁱ	Mm.289082

3D structure databases

ProteinModelPortalⁱ	Q8C6G8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	230551, 3 interactors
IntActⁱ	Q8C6G8, 2 interactors
STRINGⁱ	10090.ENSMUSP00000124592

PTM databases

iPTMnetⁱ	Q8C6G8
PhosphoSitePlusⁱ	Q8C6G8
SwissPalmⁱ	Q8C6G8

Proteomic databases

EPDⁱ	Q8C6G8
MaxQBⁱ	Q8C6G8
PaxDbⁱ	Q8C6G8
PRIDEⁱ	Q8C6G8

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000162819; ENSMUSP00000124592; ENSMUSG00000038733
GeneIDⁱ	226757
KEGGⁱ	mmu:226757
UCSCⁱ	uc007dxf.2 mouse

Organism-specific databases

CTDⁱ	80232
MGIⁱ	MGI:1923825 Wdr26

Phylogenomic databases

eggNOGⁱ	KOG0293 Eukaryota ENOG410XQ2U LUCA
GeneTreeⁱ	ENSGT00730000111021
HOVERGENⁱ	HBG083958
InParanoidⁱ	Q8C6G8
KOⁱ	K22382
OrthoDBⁱ	EOG091G05NI
TreeFamⁱ	TF314869

Miscellaneous databases

ChiTaRSⁱ	Wdr26 mouse
Protein Ontology More...PROⁱ	PR:Q8C6G8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000038733 Expressed in 295 organ(s), highest expression level in blood
CleanExⁱ	MM_WDR26
ExpressionAtlasⁱ	Q8C6G8 baseline and differential
Genevisibleⁱ	Q8C6G8 MM

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR006595 CTLH_C IPR006594 LisH IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfamⁱ	View protein in Pfam PF00400 WD40, 5 hits
SMARTⁱ	View protein in SMART SM00668 CTLH, 1 hit SM00320 WD40, 5 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS50897 CTLH, 1 hit PS50896 LISH, 1 hit PS50082 WD_REPEATS_2, 3 hits PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	WDR26_MOUSE
Accessionⁱ	Q8C6G8Primary (citable) accession number: Q8C6G8 Secondary accession number(s): E9PX83 , Q3TK81, Q8C4F3, Q8VDZ6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 24, 2004
	Last sequence update:	July 27, 2011
	Last modified:	November 7, 2018
	This is version 127 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8C6G8 (WDR26_MOUSE)

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WD repeat-containing protein 26

Wdr26

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Mitochondrion

Other locations

Cytosol

Mitochondrion

Nucleus

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ