UniProtKB - Q8C6G8 (WDR26_MOUSE)
WD repeat-containing protein 26
Wdr26
Functioni
G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (By similarity).
Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation. Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration. Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria (By similarity).
Protects also cells by promoting hypoxia-mediated autophagy and mitophagy (By similarity).
By similarityGO - Biological processi
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: WD repeat-containing protein 26 |
Gene namesi | Name:Wdr26 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1923825, Wdr26 |
VEuPathDBi | HostDB:ENSMUSG00000038733 |
Subcellular locationi
Mitochondrion
- Mitochondrion By similarity
Cytoplasm and Cytosol
- Cytoplasm By similarity
Nucleus
- Nucleus By similarity
Cytosol
- cytosol Source: MGI
Mitochondrion
- mitochondrion Source: MGI
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: MGI
Other locations
- cytoplasm Source: MGI
- GID complex Source: GO_Central
- ubiquitin ligase complex Source: MGI
Keywords - Cellular componenti
Cytoplasm, Mitochondrion, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051374 | 1 – 641 | WD repeat-containing protein 26Add BLAST | 641 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 101 | PhosphoserineCombined sources | 1 | |
Modified residuei | 103 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8C6G8 |
jPOSTi | Q8C6G8 |
MaxQBi | Q8C6G8 |
PaxDbi | Q8C6G8 |
PRIDEi | Q8C6G8 |
ProteomicsDBi | 297640 |
PTM databases
iPTMneti | Q8C6G8 |
PhosphoSitePlusi | Q8C6G8 |
SwissPalmi | Q8C6G8 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000038733, Expressed in blood and 316 other tissues |
Genevisiblei | Q8C6G8, MM |
Interactioni
Subunit structurei
Forms homooligomers. Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5. Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles.
Interacts with DDB1-CUL4A/B E3 ligase complexes.
Forms a complex composed of at least WDR26, a G-beta:gamma unit, and PLCB2.
Interacts with AXIN1.
By similarityProtein-protein interaction databases
BioGRIDi | 230551, 10 interactors |
IntActi | Q8C6G8, 2 interactors |
STRINGi | 10090.ENSMUSP00000124592 |
Miscellaneous databases
RNActi | Q8C6G8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 103 – 135 | LisHPROSITE-ProRule annotationAdd BLAST | 33 | |
Domaini | 136 – 211 | CTLHPROSITE-ProRule annotationAdd BLAST | 76 | |
Repeati | 333 – 372 | WD 1Add BLAST | 40 | |
Repeati | 379 – 418 | WD 2Add BLAST | 40 | |
Repeati | 424 – 464 | WD 3Add BLAST | 41 | |
Repeati | 504 – 543 | WD 4Add BLAST | 40 | |
Repeati | 546 – 588 | WD 5Add BLAST | 43 | |
Repeati | 591 – 631 | WD 6Add BLAST | 41 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 45 | DisorderedSequence analysisAdd BLAST | 45 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 22 – 41 | Polar residuesSequence analysisAdd BLAST | 20 |
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0293, Eukaryota |
GeneTreei | ENSGT00940000153634 |
InParanoidi | Q8C6G8 |
OMAi | KHEFIRI |
OrthoDBi | 349428at2759 |
PhylomeDBi | Q8C6G8 |
TreeFami | TF314869 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR006595, CTLH_C IPR006594, LisH IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 5 hits |
SMARTi | View protein in SMART SM00668, CTLH, 1 hit SM00320, WD40, 5 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50897, CTLH, 1 hit PS50896, LISH, 1 hit PS50082, WD_REPEATS_2, 3 hits PS50294, WD_REPEATS_REGION, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MQANGAGGGG GGGGGGQGQT PELACLSAQN GESSPSATSA GDLAHANGLL
60 70 80 90 100
PAAPSAAGNN SNSLSVNNGV PGGAAAASAT AAAAQATPEL GSSLKKKKRL
110 120 130 140 150
SQSDEDVIRL IGQHLNGLGL NQTVDLLMQE SGCRLEHPSA TKFRNHVMEG
160 170 180 190 200
DWDKAENDLN ELKPLVHSPH AIVVRGALEI SQTLLGIIVR MKFLLLQQKY
210 220 230 240 250
LEYLEDGKVL EALQVLRCEL TPLKYNTERI HVLSGYLMCS HAEDLRAKAE
260 270 280 290 300
WEGKGTASRS KLLDKLQTYL PPSVMLPPRR LQTLLRQAVE LQRDRCLYHN
310 320 330 340 350
TKLDNNLDSV SLLIDHVCSR RQFPCYTQQI LTEHCNEVWF CKFSNDGTKL
360 370 380 390 400
ATGSKDTTVI IWQVDPDTHL LKLLKTLEGH AYGVSYIAWS PDDSYLVACG
410 420 430 440 450
PDDCSELWLW NVQTGELRTK MSQSHEDSLT SVAWNPDGKR FVTGGQRGQF
460 470 480 490 500
YQCDLDGNLL DSWEGVRVQC LWCLSDGKTV LASDTHQRVR GYNFEDLTDR
510 520 530 540 550
NIVQEDHPIM SFTISKNGRL ALLNVATQGV HLWDLQDRVL VRKYQGVTQG
560 570 580 590 600
FYTIHSCFGG HNEDFIASGS EDHKVYIWHK RSELPIAELT GHTRTVNCVS
610 620 630 640
WNPQIPSMMA SASDDGTVRI WGPAPFIDHQ NIEEECSSMD S
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE0CYH4 | E0CYH4_MOUSE | WD repeat-containing protein 26 | Wdr26 | 625 | Annotation score: | ||
F8WH48 | F8WH48_MOUSE | WD repeat-containing protein 26 | Wdr26 | 183 | Annotation score: | ||
A0A494BB75 | A0A494BB75_MOUSE | WD repeat-containing protein 26 | Wdr26 | 729 | Annotation score: | ||
F6UT94 | F6UT94_MOUSE | WD repeat-containing protein 26 | Wdr26 | 120 | Annotation score: | ||
F7DFQ2 | F7DFQ2_MOUSE | WD repeat-containing protein 26 | Wdr26 | 147 | Annotation score: |
Sequence cautioni
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC113084 Genomic DNA No translation available. AK075743 mRNA Translation: BAC35923.1 Different initiation. AK167116 mRNA Translation: BAE39264.1 AK167017 mRNA Translation: BAE39191.1 BC020044 mRNA Translation: AAH20044.2 BC058601 mRNA Translation: AAH58601.1 |
CCDSi | CCDS15583.2 |
RefSeqi | NP_663489.4, NM_145514.5 |
Genome annotation databases
Ensembli | ENSMUST00000162819; ENSMUSP00000124592; ENSMUSG00000038733 |
GeneIDi | 226757 |
KEGGi | mmu:226757 |
UCSCi | uc007dxf.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC113084 Genomic DNA No translation available. AK075743 mRNA Translation: BAC35923.1 Different initiation. AK167116 mRNA Translation: BAE39264.1 AK167017 mRNA Translation: BAE39191.1 BC020044 mRNA Translation: AAH20044.2 BC058601 mRNA Translation: AAH58601.1 |
CCDSi | CCDS15583.2 |
RefSeqi | NP_663489.4, NM_145514.5 |
3D structure databases
SMRi | Q8C6G8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 230551, 10 interactors |
IntActi | Q8C6G8, 2 interactors |
STRINGi | 10090.ENSMUSP00000124592 |
PTM databases
iPTMneti | Q8C6G8 |
PhosphoSitePlusi | Q8C6G8 |
SwissPalmi | Q8C6G8 |
Proteomic databases
EPDi | Q8C6G8 |
jPOSTi | Q8C6G8 |
MaxQBi | Q8C6G8 |
PaxDbi | Q8C6G8 |
PRIDEi | Q8C6G8 |
ProteomicsDBi | 297640 |
Protocols and materials databases
Antibodypediai | 34639, 90 antibodies from 18 providers |
DNASUi | 226757 |
Genome annotation databases
Ensembli | ENSMUST00000162819; ENSMUSP00000124592; ENSMUSG00000038733 |
GeneIDi | 226757 |
KEGGi | mmu:226757 |
UCSCi | uc007dxf.2, mouse |
Organism-specific databases
CTDi | 80232 |
MGIi | MGI:1923825, Wdr26 |
VEuPathDBi | HostDB:ENSMUSG00000038733 |
Phylogenomic databases
eggNOGi | KOG0293, Eukaryota |
GeneTreei | ENSGT00940000153634 |
InParanoidi | Q8C6G8 |
OMAi | KHEFIRI |
OrthoDBi | 349428at2759 |
PhylomeDBi | Q8C6G8 |
TreeFami | TF314869 |
Miscellaneous databases
BioGRID-ORCSi | 226757, 7 hits in 65 CRISPR screens |
ChiTaRSi | Wdr26, mouse |
PROi | PR:Q8C6G8 |
RNActi | Q8C6G8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000038733, Expressed in blood and 316 other tissues |
Genevisiblei | Q8C6G8, MM |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR006595, CTLH_C IPR006594, LisH IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 5 hits |
SMARTi | View protein in SMART SM00668, CTLH, 1 hit SM00320, WD40, 5 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS50897, CTLH, 1 hit PS50896, LISH, 1 hit PS50082, WD_REPEATS_2, 3 hits PS50294, WD_REPEATS_REGION, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | WDR26_MOUSE | |
Accessioni | Q8C6G8Primary (citable) accession number: Q8C6G8 Secondary accession number(s): E9PX83 Q8VDZ6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 24, 2004 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 23, 2022 | |
This is version 143 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot