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Protein

WD repeat-containing protein 26

Gene

Wdr26

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (By similarity). Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation. Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration. Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria (By similarity). Protects also cells by promoting hypoxia-mediated autophagy and mitophagy (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 26
Gene namesi
Name:Wdr26
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1923825 Wdr26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513741 – 641WD repeat-containing protein 26Add BLAST641

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei101PhosphoserineCombined sources1
Modified residuei103PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8C6G8
MaxQBiQ8C6G8
PaxDbiQ8C6G8
PRIDEiQ8C6G8

PTM databases

iPTMnetiQ8C6G8
PhosphoSitePlusiQ8C6G8
SwissPalmiQ8C6G8

Expressioni

Gene expression databases

BgeeiENSMUSG00000038733 Expressed in 295 organ(s), highest expression level in blood
CleanExiMM_WDR26
ExpressionAtlasiQ8C6G8 baseline and differential
GenevisibleiQ8C6G8 MM

Interactioni

Subunit structurei

Forms homooligomers. Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5. Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles. Interacts with DDB1-CUL4A/B E3 ligase complexes. Forms a complex composed of at least WDR26, a G-beta:gamma unit, and PLCB2. Interacts with AXIN1.By similarity

Protein-protein interaction databases

BioGridi230551, 3 interactors
IntActiQ8C6G8, 2 interactors
STRINGi10090.ENSMUSP00000124592

Structurei

3D structure databases

ProteinModelPortaliQ8C6G8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini103 – 135LisHPROSITE-ProRule annotationAdd BLAST33
Domaini136 – 211CTLHPROSITE-ProRule annotationAdd BLAST76
Repeati333 – 372WD 1Add BLAST40
Repeati379 – 418WD 2Add BLAST40
Repeati424 – 464WD 3Add BLAST41
Repeati504 – 543WD 4Add BLAST40
Repeati546 – 588WD 5Add BLAST43
Repeati591 – 631WD 6Add BLAST41

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0293 Eukaryota
ENOG410XQ2U LUCA
GeneTreeiENSGT00730000111021
HOVERGENiHBG083958
InParanoidiQ8C6G8
KOiK22382
OrthoDBiEOG091G05NI
TreeFamiTF314869

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR006595 CTLH_C
IPR006594 LisH
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 5 hits
SMARTiView protein in SMART
SM00668 CTLH, 1 hit
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50897 CTLH, 1 hit
PS50896 LISH, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8C6G8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQANGAGGGG GGGGGGQGQT PELACLSAQN GESSPSATSA GDLAHANGLL
60 70 80 90 100
PAAPSAAGNN SNSLSVNNGV PGGAAAASAT AAAAQATPEL GSSLKKKKRL
110 120 130 140 150
SQSDEDVIRL IGQHLNGLGL NQTVDLLMQE SGCRLEHPSA TKFRNHVMEG
160 170 180 190 200
DWDKAENDLN ELKPLVHSPH AIVVRGALEI SQTLLGIIVR MKFLLLQQKY
210 220 230 240 250
LEYLEDGKVL EALQVLRCEL TPLKYNTERI HVLSGYLMCS HAEDLRAKAE
260 270 280 290 300
WEGKGTASRS KLLDKLQTYL PPSVMLPPRR LQTLLRQAVE LQRDRCLYHN
310 320 330 340 350
TKLDNNLDSV SLLIDHVCSR RQFPCYTQQI LTEHCNEVWF CKFSNDGTKL
360 370 380 390 400
ATGSKDTTVI IWQVDPDTHL LKLLKTLEGH AYGVSYIAWS PDDSYLVACG
410 420 430 440 450
PDDCSELWLW NVQTGELRTK MSQSHEDSLT SVAWNPDGKR FVTGGQRGQF
460 470 480 490 500
YQCDLDGNLL DSWEGVRVQC LWCLSDGKTV LASDTHQRVR GYNFEDLTDR
510 520 530 540 550
NIVQEDHPIM SFTISKNGRL ALLNVATQGV HLWDLQDRVL VRKYQGVTQG
560 570 580 590 600
FYTIHSCFGG HNEDFIASGS EDHKVYIWHK RSELPIAELT GHTRTVNCVS
610 620 630 640
WNPQIPSMMA SASDDGTVRI WGPAPFIDHQ NIEEECSSMD S
Length:641
Mass (Da):70,543
Last modified:July 27, 2011 - v3
Checksum:i053BAFF901088CFA
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CYH4E0CYH4_MOUSE
WD repeat-containing protein 26
Wdr26
625Annotation score:
F7DFQ2F7DFQ2_MOUSE
WD repeat-containing protein 26
Wdr26
147Annotation score:
F6UT94F6UT94_MOUSE
WD repeat-containing protein 26
Wdr26
120Annotation score:
F8WH48F8WH48_MOUSE
WD repeat-containing protein 26
Wdr26
183Annotation score:

Sequence cautioni

The sequence BAC35923 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113084 Genomic DNA No translation available.
AK075743 mRNA Translation: BAC35923.1 Different initiation.
AK167116 mRNA Translation: BAE39264.1
AK167017 mRNA Translation: BAE39191.1
BC020044 mRNA Translation: AAH20044.2
BC058601 mRNA Translation: AAH58601.1
CCDSiCCDS15583.2
RefSeqiNP_663489.4, NM_145514.5
UniGeneiMm.289082

Genome annotation databases

EnsembliENSMUST00000162819; ENSMUSP00000124592; ENSMUSG00000038733
GeneIDi226757
KEGGimmu:226757
UCSCiuc007dxf.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113084 Genomic DNA No translation available.
AK075743 mRNA Translation: BAC35923.1 Different initiation.
AK167116 mRNA Translation: BAE39264.1
AK167017 mRNA Translation: BAE39191.1
BC020044 mRNA Translation: AAH20044.2
BC058601 mRNA Translation: AAH58601.1
CCDSiCCDS15583.2
RefSeqiNP_663489.4, NM_145514.5
UniGeneiMm.289082

3D structure databases

ProteinModelPortaliQ8C6G8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230551, 3 interactors
IntActiQ8C6G8, 2 interactors
STRINGi10090.ENSMUSP00000124592

PTM databases

iPTMnetiQ8C6G8
PhosphoSitePlusiQ8C6G8
SwissPalmiQ8C6G8

Proteomic databases

EPDiQ8C6G8
MaxQBiQ8C6G8
PaxDbiQ8C6G8
PRIDEiQ8C6G8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000162819; ENSMUSP00000124592; ENSMUSG00000038733
GeneIDi226757
KEGGimmu:226757
UCSCiuc007dxf.2 mouse

Organism-specific databases

CTDi80232
MGIiMGI:1923825 Wdr26

Phylogenomic databases

eggNOGiKOG0293 Eukaryota
ENOG410XQ2U LUCA
GeneTreeiENSGT00730000111021
HOVERGENiHBG083958
InParanoidiQ8C6G8
KOiK22382
OrthoDBiEOG091G05NI
TreeFamiTF314869

Miscellaneous databases

ChiTaRSiWdr26 mouse
PROiPR:Q8C6G8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038733 Expressed in 295 organ(s), highest expression level in blood
CleanExiMM_WDR26
ExpressionAtlasiQ8C6G8 baseline and differential
GenevisibleiQ8C6G8 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR006595 CTLH_C
IPR006594 LisH
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 5 hits
SMARTiView protein in SMART
SM00668 CTLH, 1 hit
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50897 CTLH, 1 hit
PS50896 LISH, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWDR26_MOUSE
AccessioniPrimary (citable) accession number: Q8C6G8
Secondary accession number(s): E9PX83
, Q3TK81, Q8C4F3, Q8VDZ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 127 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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