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Protein

Cilia- and flagella-associated protein 36

Gene

Cfap36

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as an effector for ARL3.By similarity

GO - Molecular functioni

  • protein N-terminus binding Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Cilia- and flagella-associated protein 36Imported
Alternative name(s):
Coiled-coil domain-containing protein 104Imported
Gene namesi
Name:Cfap36Imported
Synonyms:Ccdc104Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1913994 Cfap36

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Flagellum, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002786391 – 343Cilia- and flagella-associated protein 36Add BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei85PhosphoserineCombined sources1
Modified residuei147PhosphoserineCombined sources1
Modified residuei201PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8C6E0
MaxQBiQ8C6E0
PaxDbiQ8C6E0
PeptideAtlasiQ8C6E0
PRIDEiQ8C6E0

PTM databases

iPTMnetiQ8C6E0
PhosphoSitePlusiQ8C6E0

Expressioni

Gene expression databases

BgeeiENSMUSG00000020462 Expressed in 271 organ(s), highest expression level in testis
CleanExiMM_CCDC104
ExpressionAtlasiQ8C6E0 baseline and differential
GenevisibleiQ8C6E0 MM

Interactioni

Subunit structurei

Interacts with ARL3.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Arl3Q9WUL75EBI-16180842,EBI-6860857

GO - Molecular functioni

Protein-protein interaction databases

BioGridi229767, 1 interactor
DIPiDIP-61817N
IntActiQ8C6E0, 2 interactors
STRINGi10090.ENSMUSP00000020754

Structurei

Secondary structure

1343
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8C6E0
SMRiQ8C6E0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili147 – 187Sequence analysisAdd BLAST41

Sequence similaritiesi

Belongs to the CFAP36 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4511 Eukaryota
ENOG41116YE LUCA
GeneTreeiENSGT00390000012785
HOGENOMiHOG000007745
HOVERGENiHBG062543
InParanoidiQ8C6E0
OMAiIWAANEY
OrthoDBiEOG091G09GK
PhylomeDBiQ8C6E0
TreeFamiTF315143

Family and domain databases

InterProiView protein in InterPro
IPR023379 BART_dom
IPR038888 CFAP36
PANTHERiPTHR21532 PTHR21532, 1 hit
PfamiView protein in Pfam
PF11527 ARL2_Bind_BART, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8C6E0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAEEEDEVE WVVESIAGFL RGPDWSIPIL DFVEQKCEVF DDEEESKLTY
60 70 80 90 100
TEIHQEYKEL VEKLLESYLK EIGINEDQFQ EACTSPLAKT RTSQAILQPV
110 120 130 140 150
LAAEDFTIFK AMMVQKNIEM QLQAIRIIQE RNGVLPDCLT DGADVVSDLE
160 170 180 190 200
QEEMKILREV LRKSKEEYDQ EEERKRKKQS SEAKMEELPV YTSEAEKMSN
210 220 230 240 250
SQGDGEHFVQ PPSEVKVHFA NQSVQPLARK MELLPETSSL TQKGLKIPGL
260 270 280 290 300
EHASMEGPIA NLSALGTEEL RQREHYLKQK RDKLLSMRKD TRTKQIQNTE
310 320 330 340
QKGKPTREAE EMTEKPEMTA EEKQTLLKRR LLAEKLKEEV INK
Length:343
Mass (Da):39,600
Last modified:March 1, 2003 - v1
Checksum:iD276DEDCB7400271
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SNY8Q5SNY8_MOUSE
Cilia- and flagella-associated prot...
Cfap36 Ccdc104
137Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti225Q → H in BAB26962 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010468 mRNA Translation: BAB26962.1
AK075858 mRNA Translation: BAC36009.1
BX294116, AL935054 Genomic DNA Translation: CAI35920.1
AL935054, BX294116 Genomic DNA Translation: CAI24882.1
CCDSiCCDS24493.1
RefSeqiNP_080016.1, NM_025740.3
UniGeneiMm.128663

Genome annotation databases

EnsembliENSMUST00000020754; ENSMUSP00000020754; ENSMUSG00000020462
GeneIDi216618
KEGGimmu:216618
UCSCiuc007igu.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010468 mRNA Translation: BAB26962.1
AK075858 mRNA Translation: BAC36009.1
BX294116, AL935054 Genomic DNA Translation: CAI35920.1
AL935054, BX294116 Genomic DNA Translation: CAI24882.1
CCDSiCCDS24493.1
RefSeqiNP_080016.1, NM_025740.3
UniGeneiMm.128663

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ZI2X-ray2.20C/D1-133[»]
4ZI3X-ray2.00C/D1-133[»]
ProteinModelPortaliQ8C6E0
SMRiQ8C6E0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229767, 1 interactor
DIPiDIP-61817N
IntActiQ8C6E0, 2 interactors
STRINGi10090.ENSMUSP00000020754

PTM databases

iPTMnetiQ8C6E0
PhosphoSitePlusiQ8C6E0

Proteomic databases

EPDiQ8C6E0
MaxQBiQ8C6E0
PaxDbiQ8C6E0
PeptideAtlasiQ8C6E0
PRIDEiQ8C6E0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020754; ENSMUSP00000020754; ENSMUSG00000020462
GeneIDi216618
KEGGimmu:216618
UCSCiuc007igu.1 mouse

Organism-specific databases

CTDi112942
MGIiMGI:1913994 Cfap36

Phylogenomic databases

eggNOGiKOG4511 Eukaryota
ENOG41116YE LUCA
GeneTreeiENSGT00390000012785
HOGENOMiHOG000007745
HOVERGENiHBG062543
InParanoidiQ8C6E0
OMAiIWAANEY
OrthoDBiEOG091G09GK
PhylomeDBiQ8C6E0
TreeFamiTF315143

Miscellaneous databases

ChiTaRSiCfap36 mouse
PROiPR:Q8C6E0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020462 Expressed in 271 organ(s), highest expression level in testis
CleanExiMM_CCDC104
ExpressionAtlasiQ8C6E0 baseline and differential
GenevisibleiQ8C6E0 MM

Family and domain databases

InterProiView protein in InterPro
IPR023379 BART_dom
IPR038888 CFAP36
PANTHERiPTHR21532 PTHR21532, 1 hit
PfamiView protein in Pfam
PF11527 ARL2_Bind_BART, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCFA36_MOUSE
AccessioniPrimary (citable) accession number: Q8C6E0
Secondary accession number(s): Q9CWQ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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