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UniProtKB - Q8C6D4 (BEND5_MOUSE)
Protein
BEN domain-containing protein 5
Gene
Bend5
Organism
Mus musculus (Mouse)
Status
Functioni
Acts as a transcriptional repressor.
By similarityGO - Molecular functioni
- DNA binding Source: UniProtKB-KW
GO - Biological processi
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: BEN domain-containing protein 5 |
Gene namesi | Name:Bend5 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1914871, Bend5 |
VEuPathDBi | HostDB:ENSMUSG00000028545 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000274280 | 1 – 421 | BEN domain-containing protein 5Add BLAST | 421 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 133 | N6-acetyllysineBy similarity | 1 | |
Cross-linki | 258 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Acetylation, Isopeptide bond, Ubl conjugationProteomic databases
MaxQBi | Q8C6D4 |
PaxDbi | Q8C6D4 |
PRIDEi | Q8C6D4 |
ProteomicsDBi | 273481 [Q8C6D4-1] 273482 [Q8C6D4-2] |
PTM databases
iPTMneti | Q8C6D4 |
PhosphoSitePlusi | Q8C6D4 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000028545, Expressed in embryonic facial prominence and 235 other tissues |
ExpressionAtlasi | Q8C6D4, baseline and differential |
Genevisiblei | Q8C6D4, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000030274 |
Miscellaneous databases
RNActi | Q8C6D4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 302 – 408 | BENPROSITE-ProRule annotationAdd BLAST | 107 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 180 – 243 | Sequence analysisAdd BLAST | 64 |
Domaini
The BEN domain mediates DNA-binding.By similarity
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QTVS, Eukaryota |
GeneTreei | ENSGT00390000001724 |
HOGENOMi | CLU_739568_0_0_1 |
InParanoidi | Q8C6D4 |
OMAi | HNTCPEE |
OrthoDBi | 727836at2759 |
PhylomeDBi | Q8C6D4 |
TreeFami | TF331898 |
Family and domain databases
InterProi | View protein in InterPro IPR018379, BEN_domain IPR040391, BEND5 |
PANTHERi | PTHR14628, PTHR14628, 1 hit |
Pfami | View protein in Pfam PF10523, BEN, 1 hit |
SMARTi | View protein in SMART SM01025, BEN, 1 hit |
PROSITEi | View protein in PROSITE PS51457, BEN, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8C6D4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MYAFVRFLED NVCYALPVSC VRDFSPRSRL DFDNQKVYAV YRGPEELGAE
60 70 80 90 100
PESPPRAPRD WGALLLHKAQ ILALAEDKSD LENSVMQKKI KIPKLSLSHV
110 120 130 140 150
EDDGEVKDYG EEDLQLRHIK RPEGRKPSEA AHKSIEAVVA RLERQNGLSL
160 170 180 190 200
GHSTCPEEVF VEASPGTEDM DSLEDAVVPR ALYEELLRNY QQQQEEMRHL
210 220 230 240 250
QQELERTRRQ LVQQAKKLKE YGALVSEMKE LRDLNRRLQD VLLLRLGSGP
260 270 280 290 300
AIDLEKVKSE CLEPEPELRS TFSEEANTSS YYPAPAPVMD KYILDNGKVH
310 320 330 340 350
LGSGIWVDEE KWHQLQVTQG DSKYTKNLAV MIWGTDVLKN RSVTGVATKK
360 370 380 390 400
KKDAIPKPPL SPHKLSIVRE CLYDRIAQET VDETEIAQRL SKVNKYICEK
410 420
IMDINKSCKN EERREAKYNL Q
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF6Q2G7 | F6Q2G7_MOUSE | BEN domain-containing protein 5 | Bend5 | 171 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_022696 | 1 – 169 | Missing in isoform 2. 1 PublicationAdd BLAST | 169 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK014057 mRNA Translation: BAB29136.1 AK075885 mRNA Translation: BAC36030.1 AK156708 mRNA Translation: BAE33814.1 AK167425 mRNA Translation: BAE39513.1 BC037633 mRNA Translation: AAH37633.1 BC051512 mRNA Translation: AAH51512.1 |
CCDSi | CCDS18472.1 [Q8C6D4-1] |
RefSeqi | NP_080555.1, NM_026279.3 [Q8C6D4-1] XP_011238896.1, XM_011240594.2 [Q8C6D4-2] XP_017175855.1, XM_017320366.1 [Q8C6D4-2] |
Genome annotation databases
Ensembli | ENSMUST00000030274; ENSMUSP00000030274; ENSMUSG00000028545 [Q8C6D4-1] |
GeneIDi | 67621 |
KEGGi | mmu:67621 |
UCSCi | uc008ude.2, mouse [Q8C6D4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK014057 mRNA Translation: BAB29136.1 AK075885 mRNA Translation: BAC36030.1 AK156708 mRNA Translation: BAE33814.1 AK167425 mRNA Translation: BAE39513.1 BC037633 mRNA Translation: AAH37633.1 BC051512 mRNA Translation: AAH51512.1 |
CCDSi | CCDS18472.1 [Q8C6D4-1] |
RefSeqi | NP_080555.1, NM_026279.3 [Q8C6D4-1] XP_011238896.1, XM_011240594.2 [Q8C6D4-2] XP_017175855.1, XM_017320366.1 [Q8C6D4-2] |
3D structure databases
AlphaFoldDBi | Q8C6D4 |
SMRi | Q8C6D4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000030274 |
PTM databases
iPTMneti | Q8C6D4 |
PhosphoSitePlusi | Q8C6D4 |
Proteomic databases
MaxQBi | Q8C6D4 |
PaxDbi | Q8C6D4 |
PRIDEi | Q8C6D4 |
ProteomicsDBi | 273481 [Q8C6D4-1] 273482 [Q8C6D4-2] |
Protocols and materials databases
Antibodypediai | 53655, 67 antibodies from 24 providers |
DNASUi | 67621 |
Genome annotation databases
Ensembli | ENSMUST00000030274; ENSMUSP00000030274; ENSMUSG00000028545 [Q8C6D4-1] |
GeneIDi | 67621 |
KEGGi | mmu:67621 |
UCSCi | uc008ude.2, mouse [Q8C6D4-1] |
Organism-specific databases
CTDi | 79656 |
MGIi | MGI:1914871, Bend5 |
VEuPathDBi | HostDB:ENSMUSG00000028545 |
Phylogenomic databases
eggNOGi | ENOG502QTVS, Eukaryota |
GeneTreei | ENSGT00390000001724 |
HOGENOMi | CLU_739568_0_0_1 |
InParanoidi | Q8C6D4 |
OMAi | HNTCPEE |
OrthoDBi | 727836at2759 |
PhylomeDBi | Q8C6D4 |
TreeFami | TF331898 |
Miscellaneous databases
BioGRID-ORCSi | 67621, 1 hit in 69 CRISPR screens |
PROi | PR:Q8C6D4 |
RNActi | Q8C6D4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000028545, Expressed in embryonic facial prominence and 235 other tissues |
ExpressionAtlasi | Q8C6D4, baseline and differential |
Genevisiblei | Q8C6D4, MM |
Family and domain databases
InterProi | View protein in InterPro IPR018379, BEN_domain IPR040391, BEND5 |
PANTHERi | PTHR14628, PTHR14628, 1 hit |
Pfami | View protein in Pfam PF10523, BEN, 1 hit |
SMARTi | View protein in SMART SM01025, BEN, 1 hit |
PROSITEi | View protein in PROSITE PS51457, BEN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | BEND5_MOUSE | |
Accessioni | Q8C6D4Primary (citable) accession number: Q8C6D4 Secondary accession number(s): Q3TJI2 Q9CRW0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 6, 2007 |
Last sequence update: | March 1, 2003 | |
Last modified: | May 25, 2022 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot