Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein LEG1 homolog

Gene

Leg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in early liver development.By similarity

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LEG1 homologBy similarity
Gene namesi
Name:Leg1By similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1914969 2310057J18Rik

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000025238621 – 337Protein LEG1 homologAdd BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi171N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8C6C9
PeptideAtlasiQ8C6C9
PRIDEiQ8C6C9

PTM databases

PhosphoSitePlusiQ8C6C9

Expressioni

Gene expression databases

BgeeiENSMUSG00000015519 Expressed in 25 organ(s), highest expression level in submandibular gland
CleanExiMM_2310057J18RIK
ExpressionAtlasiQ8C6C9 baseline and differential
GenevisibleiQ8C6C9 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015663

Structurei

3D structure databases

SMRiQ8C6C9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LEG1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJ51 Eukaryota
ENOG4111MHP LUCA
GeneTreeiENSGT00390000004904
HOVERGENiHBG081098
InParanoidiQ8C6C9
OMAiSWWADMN
OrthoDBiEOG091G0HCG
PhylomeDBiQ8C6C9
TreeFamiTF332991

Family and domain databases

InterProiView protein in InterPro
IPR008499 Leg1
PANTHERiPTHR18820 PTHR18820, 1 hit
PfamiView protein in Pfam
PF05612 Leg1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8C6C9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVLASWVWV LAGCFCAAVA EVSDSSDPYP PLWEDSPEQL SDYMMEDGNY
60 70 80 90 100
IINPWVYTDR MGMYRILLEE TAMYFAKYGP ENEQNLLWGL PLQFGWQYQS
110 120 130 140 150
GRLADPTGMT DCGNELNESL CVSVDSWWAD INYYLSVIPF LAAVDSGITG
160 170 180 190 200
ISPNQITILP PPKDQMRFCY NVSDCQSAVP GTMNRWRDFF QYMQLNSSDF
210 220 230 240 250
DGLLNYLWEA HASSLDYPTS AFGDRYNFYS EKEANFEENW AIAVNYLAAA
260 270 280 290 300
RLPTTQNRTY SFQRGLPPRV LVDTDIAPFI PDFTPLQNEV LVSLKLLGDT
310 320 330
DRNSGSLSLT LWENLMSTKL ARTLFLKAFE EFLATSS
Length:337
Mass (Da):38,284
Last modified:October 17, 2006 - v2
Checksum:iC3F366FAC48436B2
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z001D3Z001_MOUSE
RIKEN cDNA 2310057J18 gene
2310057J18Rik mCG_7192
246Annotation score:
D3YTP1D3YTP1_MOUSE
RIKEN cDNA 2310057J18 gene
2310057J18Rik mCG_7192
229Annotation score:

Sequence cautioni

The sequence AAH21783 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB26311 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB26664 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20A → S in BAB26334 (PubMed:16141072).Curated1
Sequence conflicti20A → S in BAC36026 (PubMed:16141072).Curated1
Sequence conflicti21E → G in BAC36026 (PubMed:16141072).Curated1
Sequence conflicti51I → K in BAC36026 (PubMed:16141072).Curated1
Sequence conflicti60R → K in BAC36026 (PubMed:16141072).Curated1
Sequence conflicti65R → K in BAC36026 (PubMed:16141072).Curated1
Sequence conflicti111D → N in BAC36026 (PubMed:16141072).Curated1
Sequence conflicti157T → M in BAB26334 (PubMed:16141072).Curated1
Sequence conflicti157T → M in BAC36026 (PubMed:16141072).Curated1
Sequence conflicti262F → C in BAB26189 (PubMed:16141072).Curated1
Sequence conflicti274T → A in BAB26391 (PubMed:16141072).Curated1
Sequence conflicti301D → E in BAB25653 (PubMed:16141072).Curated1
Sequence conflicti332F → S in BAB26653 (PubMed:16141072).Curated1
Sequence conflicti334A → V in AAH21783 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008407 mRNA Translation: BAB25653.1
AK009278 mRNA Translation: BAB26189.1
AK009369 mRNA Translation: BAB26247.1
AK009472 mRNA Translation: BAB26311.1 Different initiation.
AK009516 mRNA Translation: BAB26334.1
AK009594 mRNA Translation: BAB26380.1
AK009610 mRNA Translation: BAB26391.1
AK009872 mRNA Translation: BAB26555.1
AK009911 mRNA Translation: BAB26580.1
AK009921 mRNA Translation: BAB26585.1
AK010028 mRNA Translation: BAB26653.1
AK010037 mRNA Translation: BAB26657.1
AK010047 mRNA Translation: BAB26664.1 Different initiation.
AK010108 mRNA Translation: BAB26706.1
AK010222 mRNA Translation: BAB26777.1
AK075881 mRNA Translation: BAC36026.1
AK075892 mRNA Translation: BAC36034.1
AK075901 mRNA Translation: BAC36041.1
BC021783 mRNA Translation: AAH21783.1 Different initiation.
CCDSiCCDS23759.1
RefSeqiNP_080612.1, NM_026336.3
UniGeneiMm.440480

Genome annotation databases

EnsembliENSMUST00000015663; ENSMUSP00000015663; ENSMUSG00000015519
GeneIDi67719
KEGGimmu:67719
UCSCiuc007esr.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008407 mRNA Translation: BAB25653.1
AK009278 mRNA Translation: BAB26189.1
AK009369 mRNA Translation: BAB26247.1
AK009472 mRNA Translation: BAB26311.1 Different initiation.
AK009516 mRNA Translation: BAB26334.1
AK009594 mRNA Translation: BAB26380.1
AK009610 mRNA Translation: BAB26391.1
AK009872 mRNA Translation: BAB26555.1
AK009911 mRNA Translation: BAB26580.1
AK009921 mRNA Translation: BAB26585.1
AK010028 mRNA Translation: BAB26653.1
AK010037 mRNA Translation: BAB26657.1
AK010047 mRNA Translation: BAB26664.1 Different initiation.
AK010108 mRNA Translation: BAB26706.1
AK010222 mRNA Translation: BAB26777.1
AK075881 mRNA Translation: BAC36026.1
AK075892 mRNA Translation: BAC36034.1
AK075901 mRNA Translation: BAC36041.1
BC021783 mRNA Translation: AAH21783.1 Different initiation.
CCDSiCCDS23759.1
RefSeqiNP_080612.1, NM_026336.3
UniGeneiMm.440480

3D structure databases

SMRiQ8C6C9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015663

PTM databases

PhosphoSitePlusiQ8C6C9

Proteomic databases

PaxDbiQ8C6C9
PeptideAtlasiQ8C6C9
PRIDEiQ8C6C9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015663; ENSMUSP00000015663; ENSMUSG00000015519
GeneIDi67719
KEGGimmu:67719
UCSCiuc007esr.2 mouse

Organism-specific databases

MGIiMGI:1914969 2310057J18Rik

Phylogenomic databases

eggNOGiENOG410IJ51 Eukaryota
ENOG4111MHP LUCA
GeneTreeiENSGT00390000004904
HOVERGENiHBG081098
InParanoidiQ8C6C9
OMAiSWWADMN
OrthoDBiEOG091G0HCG
PhylomeDBiQ8C6C9
TreeFamiTF332991

Miscellaneous databases

ChiTaRSi2310057J18Rik mouse
PROiPR:Q8C6C9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015519 Expressed in 25 organ(s), highest expression level in submandibular gland
CleanExiMM_2310057J18RIK
ExpressionAtlasiQ8C6C9 baseline and differential
GenevisibleiQ8C6C9 MM

Family and domain databases

InterProiView protein in InterPro
IPR008499 Leg1
PANTHERiPTHR18820 PTHR18820, 1 hit
PfamiView protein in Pfam
PF05612 Leg1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLEG1H_MOUSE
AccessioniPrimary (citable) accession number: Q8C6C9
Secondary accession number(s): Q8C6D2
, Q8C6D6, Q8VDJ0, Q9CPV8, Q9CQ55, Q9D6S4, Q9D745, Q9D775, Q9D7F4, Q9D865
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: September 12, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again