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Protein

Active regulator of SIRT1

Gene

Rps19bp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity (By similarity).By similarity

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-MMU-3371453 Regulation of HSF1-mediated heat shock response

Names & Taxonomyi

Protein namesi
Recommended name:
Active regulator of SIRT1
Alternative name(s):
40S ribosomal protein S19-binding protein 1
Short name:
RPS19-binding protein 1
Short name:
S19BP
Gene namesi
Name:Rps19bp1
Synonyms:Aros
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1913788 Rps19bp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002523941 – 143Active regulator of SIRT1Add BLAST143

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7Citrulline1 Publication1
Modified residuei86PhosphoserineBy similarity1

Post-translational modificationi

Citrullinated by PADI4.1 Publication

Keywords - PTMi

Citrullination, Phosphoprotein

Proteomic databases

EPDiQ8C6B9
MaxQBiQ8C6B9
PaxDbiQ8C6B9
PeptideAtlasiQ8C6B9
PRIDEiQ8C6B9

PTM databases

iPTMnetiQ8C6B9
PhosphoSitePlusiQ8C6B9

Expressioni

Tissue specificityi

Widely expressed with higher levels in submaxillary gland and epididymis.1 Publication

Gene expression databases

BgeeiENSMUSG00000051518 Expressed in 238 organ(s), highest expression level in dorsal pancreas
CleanExiMM_RPS19BP1
GenevisibleiQ8C6B9 MM

Interactioni

Subunit structurei

Interacts with SIRT1 (By similarity). Interacts with RPS19.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211544, 4 interactors
IntActiQ8C6B9, 1 interactor
MINTiQ8C6B9
STRINGi10090.ENSMUSP00000061167

Family & Domainsi

Sequence similaritiesi

Belongs to the AROS family.Curated

Phylogenomic databases

eggNOGiENOG410J1DB Eukaryota
ENOG41126PZ LUCA
GeneTreeiENSGT00390000016774
HOGENOMiHOG000034068
HOVERGENiHBG097440
InParanoidiQ8C6B9
OMAiQGRKACD
OrthoDBiEOG091G0YGT
PhylomeDBiQ8C6B9
TreeFamiTF333429

Family and domain databases

InterProiView protein in InterPro
IPR023262 AROS
PANTHERiPTHR31454 PTHR31454, 1 hit
PfamiView protein in Pfam
PF15684 AROS, 1 hit
PRINTSiPR02029 ACTREGSIRT1

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8C6B9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAALVRRGL ELLAASEAPR AVPGQVQASG TPAKRTRRAR AKASQALKLR
60 70 80 90 100
NSAKGKAPKS ALAEYQKRQC RDHLKANLKF MTSMRSTVPE SVTQQILQQN
110 120 130 140
QGRKACDRLV AKTKNKKKKK KKAEGTVFTE EDFQKFQREY FGS
Length:143
Mass (Da):15,978
Last modified:March 1, 2003 - v1
Checksum:i6EBBF45EE0668116
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8VHY2A0A2R8VHY2_MOUSE
Active regulator of SIRT1
Rps19bp1
64Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti116Missing 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB233218 mRNA Translation: BAE53365.1
AB233219 Genomic DNA Translation: BAE53366.1
AK075974 mRNA Translation: BAC36088.1
BC038691 mRNA Translation: AAH38691.1
BC050115 mRNA Translation: AAH50115.1
CCDSiCCDS27662.1
RefSeqiNP_780318.1, NM_175109.3
UniGeneiMm.39485

Genome annotation databases

EnsembliENSMUST00000052499; ENSMUSP00000061167; ENSMUSG00000051518
GeneIDi66538
KEGGimmu:66538
UCSCiuc007wvm.1 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB233218 mRNA Translation: BAE53365.1
AB233219 Genomic DNA Translation: BAE53366.1
AK075974 mRNA Translation: BAC36088.1
BC038691 mRNA Translation: AAH38691.1
BC050115 mRNA Translation: AAH50115.1
CCDSiCCDS27662.1
RefSeqiNP_780318.1, NM_175109.3
UniGeneiMm.39485

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211544, 4 interactors
IntActiQ8C6B9, 1 interactor
MINTiQ8C6B9
STRINGi10090.ENSMUSP00000061167

PTM databases

iPTMnetiQ8C6B9
PhosphoSitePlusiQ8C6B9

Proteomic databases

EPDiQ8C6B9
MaxQBiQ8C6B9
PaxDbiQ8C6B9
PeptideAtlasiQ8C6B9
PRIDEiQ8C6B9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052499; ENSMUSP00000061167; ENSMUSG00000051518
GeneIDi66538
KEGGimmu:66538
UCSCiuc007wvm.1 mouse

Organism-specific databases

CTDi91582
MGIiMGI:1913788 Rps19bp1

Phylogenomic databases

eggNOGiENOG410J1DB Eukaryota
ENOG41126PZ LUCA
GeneTreeiENSGT00390000016774
HOGENOMiHOG000034068
HOVERGENiHBG097440
InParanoidiQ8C6B9
OMAiQGRKACD
OrthoDBiEOG091G0YGT
PhylomeDBiQ8C6B9
TreeFamiTF333429

Enzyme and pathway databases

ReactomeiR-MMU-3371453 Regulation of HSF1-mediated heat shock response

Miscellaneous databases

PROiPR:Q8C6B9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051518 Expressed in 238 organ(s), highest expression level in dorsal pancreas
CleanExiMM_RPS19BP1
GenevisibleiQ8C6B9 MM

Family and domain databases

InterProiView protein in InterPro
IPR023262 AROS
PANTHERiPTHR31454 PTHR31454, 1 hit
PfamiView protein in Pfam
PF15684 AROS, 1 hit
PRINTSiPR02029 ACTREGSIRT1
ProtoNetiSearch...

Entry informationi

Entry nameiAROS_MOUSE
AccessioniPrimary (citable) accession number: Q8C6B9
Secondary accession number(s): Q2WFQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: March 1, 2003
Last modified: October 10, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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