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Entry version 105 (08 May 2019)
Sequence version 1 (01 Mar 2003)
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Protein

Coiled-coil domain-containing protein 187

Gene

Ccdc187

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 187Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ccdc187Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3045295 Ccdc187

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004353971 – 958Coiled-coil domain-containing protein 187Add BLAST958

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8C5V8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8C5V8

PRoteomics IDEntifications database

More...
PRIDEi
Q8C5V8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8C5V8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8C5V8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000048038 Expressed in 60 organ(s), highest expression level in seminiferous tubule of testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8C5V8 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000054283

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili718 – 743Sequence analysisAdd BLAST26

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J9FE Eukaryota
ENOG4111D5P LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000065015

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000147845

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8C5V8

Database of Orthologous Groups

More...
OrthoDBi
806866at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8C5V8

TreeFam database of animal gene trees

More...
TreeFami
TF338851

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028750 CEP350

The PANTHER Classification System

More...
PANTHERi
PTHR13958 PTHR13958, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8C5V8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTPLMGVMP TSLRATLQNC SRGNQQEGLF SPKAMGRMAG QKDSTKPRDE
60 70 80 90 100
VFHPHAAKDS LLATTLRWPV LSQQLSPPQT VPYVAWSGNI KDPSPYMKGC
110 120 130 140 150
SLPMWSPCLD TKDVDSSVSS GRMSGSSGGH ESCTLSHGPW KERPPLILGP
160 170 180 190 200
QRQPRKSDPR LEQLRDKIRA QAQWQASCAS LGTSAPSSAS CLYKTSTMLW
210 220 230 240 250
RKTPKVTNAL PVPAFPGSGV LRTAEHRGKD RASLSLRREL SKVPQHHTSV
260 270 280 290 300
PRTNFKKVKN ASCKREISKS SILRRTAKGR GSDRKAAAVK ASPAHTWLCK
310 320 330 340 350
PMSAHSDQQV SKHTPSLAFQ DQSATIHGAM ETLQDLRQQI QAGLELTRSP
360 370 380 390 400
RVDRKLSLSK PKPQNLVGKR DRGLQSTQDM QGSSKTAWTV TEGKNSSLHR
410 420 430 440 450
AGNLHSQQHR KKALAEHESC PRRTWTGQGQ DSSFPRPGST PEKPRFFSQR
460 470 480 490 500
PWSALARQTY PQRTWDAQGQ DISVQKSGSS LKKPSPFSQR PWSALAGRAY
510 520 530 540 550
SACEDREVFE PSPWNSLSRP HSALQDPWSN SFVQRSSPSS KGKSAVPPPS
560 570 580 590 600
KVKPAWPEPS QDLLQSKPAK EQDTPCPRPR GSLGQQHSSE SLRDFMRQKA
610 620 630 640 650
QARRQQALEQ KALAAHTLEL RNQRLQEVYR KQREAVLGKD IPVVSQRRPG
660 670 680 690 700
IVTFVPMQSG GMEAPGSLGS PREQTWSKVT SGMVLGDQEA PDSFCLCLNK
710 720 730 740 750
PWNRIETQDT GRPLEGYKQA RLQALETMAE ALRQRVDILT TKLDKPTSPD
760 770 780 790 800
TSGDLASDVL PLCPSTAPAT PTLVPPSYLR TLMSKGGRES PRDLVDSQAE
810 820 830 840 850
PLLLSTCFQD GEMLPWSPSW ELPNPNLGTH IESQPQGPVS STPASVSQVI
860 870 880 890 900
PHTQSCPAGS SSHGALSKEA IQGLEKKLQR EMATLQALGA CMKSSLGMPD
910 920 930 940 950
APDPTRGSLW QEEMPEVKKE GLVTPWTTRS CGKGEPADRP WAGWSGGQGG

LPWASSTA
Length:958
Mass (Da):104,957
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD167BF1D7A893624
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BPI0A0A2I3BPI0_MOUSE
Coiled-coil domain-containing prote...
Ccdc187
2,202Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1L1SUD9A0A1L1SUD9_MOUSE
Coiled-coil domain-containing prote...
Ccdc187
2,163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL773595 Genomic DNA No translation available.
AK077032 mRNA Translation: BAC36576.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS50539.1

NCBI Reference Sequences

More...
RefSeqi
NP_808509.1, NM_177841.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000057224; ENSMUSP00000054283; ENSMUSG00000048038

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
329366

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:329366

UCSC genome browser

More...
UCSCi
uc008ium.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL773595 Genomic DNA No translation available.
AK077032 mRNA Translation: BAC36576.1
CCDSiCCDS50539.1
RefSeqiNP_808509.1, NM_177841.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054283

PTM databases

iPTMnetiQ8C5V8
PhosphoSitePlusiQ8C5V8

Proteomic databases

MaxQBiQ8C5V8
PaxDbiQ8C5V8
PRIDEiQ8C5V8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057224; ENSMUSP00000054283; ENSMUSG00000048038
GeneIDi329366
KEGGimmu:329366
UCSCiuc008ium.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
399693
MGIiMGI:3045295 Ccdc187

Phylogenomic databases

eggNOGiENOG410J9FE Eukaryota
ENOG4111D5P LUCA
GeneTreeiENSGT00530000065015
HOGENOMiHOG000147845
InParanoidiQ8C5V8
OrthoDBi806866at2759
PhylomeDBiQ8C5V8
TreeFamiTF338851

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q8C5V8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000048038 Expressed in 60 organ(s), highest expression level in seminiferous tubule of testis
ExpressionAtlasiQ8C5V8 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR028750 CEP350
PANTHERiPTHR13958 PTHR13958, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCC187_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8C5V8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 17, 2016
Last sequence update: March 1, 2003
Last modified: May 8, 2019
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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